ID   RALA_MOUSE              Reviewed;         206 AA.
AC   P63321; P05810;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-NOV-2009, entry version 52.
DE   RecName: Full=Ras-related protein Ral-A;
DE   Flags: Precursor;
GN   Name=Rala; Synonyms=Ral, Ral-a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/c; TISSUE=Spleen;
RA   Roger T.T.;
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=20480378; PubMed=11025226; DOI=10.1016/S0925-4773(00)00427-5;
RA   Zhao Z., Rivkees S.A.;
RT   "Tissue-specific expression of GTPas RalA and RalB during
RT   embryogenesis and regulation by epithelial-mesenchymal interaction.";
RL   Mech. Dev. 97:201-204(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 8-16; 28-47; 114-128 AND 167-173, AND MASS
RP   SPECTROMETRY.
RC   STRAIN=C57BL/6; TISSUE=Brain;
RA   Lubec G., Kang S.U.;
RL   Submitted (APR-2007) to UniProtKB.
RN   [5]
RP   INTERACTION WITH RALBP1.
RX   MEDLINE=96112637; PubMed=8570186;
RA   Park S.-H., Weinberg R.A.;
RT   "A putative effector of Ral has homology to Rho/Rac GTPase activating
RT   proteins.";
RL   Oncogene 11:2349-2355(1995).
CC   -!- SUBUNIT: Interacts with CDC42 (By similarity). Interacts with
CC       EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites
CC       and compete for RALA binding (By similarity). Interacts with
CC       RALGPS1 (By similarity). Interacts with RALBP1 via its effector
CC       domain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
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DR   EMBL; Z48587; CAA88488.1; -; mRNA.
DR   EMBL; AF244951; AAG23136.1; -; mRNA.
DR   EMBL; BC031741; AAH31741.1; -; mRNA.
DR   IPI; IPI00124282; -.
DR   RefSeq; NP_062364.3; -.
DR   UniGene; Mm.27348; -.
DR   HSSP; P11233; 1UAD.
DR   SMR; P63321; 11-183.
DR   STRING; P63321; -.
DR   PhosphoSite; P63321; -.
DR   PRIDE; P63321; -.
DR   Ensembl; ENSMUST00000009003; ENSMUSP00000009003; ENSMUSG00000008859; Mus musculus.
DR   GeneID; 56044; -.
DR   KEGG; mmu:56044; -.
DR   UCSC; uc007pof.1; mouse.
DR   CTD; 56044; -.
DR   MGI; MGI:1927243; Rala.
DR   HOGENOM; P63321; -.
DR   HOVERGEN; P63321; -.
DR   OMA; AKPKGQN; -.
DR   NextBio; 311812; -.
DR   ArrayExpress; P63321; -.
DR   Bgee; P63321; -.
DR   Genevestigator; P63321; -.
DR   GermOnline; ENSMUSG00000008859; Mus musculus.
DR   GO; GO:0009898; C:internal side of plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR003577; GTPase_Ras.
DR   InterPro; IPR013753; Ras.
DR   InterPro; IPR001806; Ras_GTPase.
DR   InterPro; IPR015591; Ras_Ral_related.
DR   InterPro; IPR005225; Small_GTP_bd.
DR   PANTHER; PTHR11708:SF124; Ras_Ral_related; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00173; RAS; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; GTP-binding; Lipoprotein;
KW   Membrane; Methylation; Nucleotide-binding; Prenylation.
FT   CHAIN         1    203       Ras-related protein Ral-A.
FT                                /FTId=PRO_0000082694.
FT   PROPEP      204    206       Removed in mature form (By similarity).
FT                                /FTId=PRO_0000281345.
FT   NP_BIND      21     28       GTP (By similarity).
FT   NP_BIND      68     72       GTP (By similarity).
FT   NP_BIND     127    130       GTP (By similarity).
FT   MOTIF        43     51       Effector region (By similarity).
FT   MOD_RES     203    203       Cysteine methyl ester (By similarity).
FT   LIPID       203    203       S-geranylgeranyl cysteine (By
FT                                similarity).
SQ   SEQUENCE   206 AA;  23553 MW;  6974341FA08C1874 CRC64;
     MAANKPKGQN SLALHKVIMV GSGGVGKSAL TLQFMYDEFV EDYEPTKADS YRKKVVLDGE
     EVQIDILDTA GQEDYAAIRD NYFRSGEGFL CVFSITEMES FAATADFREQ ILRVKEDENV
     PFLLVGNKSD LEDKRQVSVE EAKNRADQWN VNYVETSAKT RANVDKVFFD LMREIRARKM
     EDSKEKNGKK KRKSLAKRIR ERCCIL
//