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P63319

- KPCG_RAT

UniProt

P63319 - KPCG_RAT

Protein

Protein kinase C gamma type

Gene

Prkcg

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domain By similarity.By similarity

    Enzyme regulationi

    Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full activation.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi186 – 1861Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi187 – 1871Calcium 1By similarity
    Metal bindingi187 – 1871Calcium 2By similarity
    Metal bindingi193 – 1931Calcium 2By similarity
    Metal bindingi246 – 2461Calcium 1By similarity
    Metal bindingi246 – 2461Calcium 2By similarity
    Metal bindingi247 – 2471Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi248 – 2481Calcium 1By similarity
    Metal bindingi248 – 2481Calcium 2By similarity
    Metal bindingi248 – 2481Calcium 3By similarity
    Metal bindingi251 – 2511Calcium 3By similarity
    Metal bindingi252 – 2521Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi254 – 2541Calcium 1By similarity
    Metal bindingi254 – 2541Calcium 3By similarity
    Binding sitei380 – 3801ATPPROSITE-ProRule annotation
    Active sitei480 – 4801Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri35 – 8551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri100 – 15051Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi357 – 3659ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium-dependent protein kinase C activity Source: RGD
    3. protein binding Source: UniProtKB
    4. protein kinase C activity Source: RGD
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. chemosensory behavior Source: Ensembl
    2. innervation Source: Ensembl
    3. intracellular signal transduction Source: RGD
    4. learning or memory Source: RGD
    5. negative regulation of neuron apoptotic process Source: UniProtKB
    6. negative regulation of protein catabolic process Source: Ensembl
    7. negative regulation of protein ubiquitination Source: Ensembl
    8. positive regulation of mismatch repair Source: Ensembl
    9. protein autophosphorylation Source: RGD
    10. response to morphine Source: UniProtKB
    11. response to pain Source: UniProtKB
    12. response to stress Source: UniProtKB
    13. synaptic transmission Source: RGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198398. WNT5A-dependent internalization of FZD4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C gamma type (EC:2.7.11.13)
    Short name:
    PKC-gamma
    Gene namesi
    Name:Prkcg
    Synonyms:Pkcc, Pkcg, Prkcc
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi3397. Prkcg.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytosol Source: UniProtKB
    3. dendrite Source: UniProtKB
    4. neuron projection Source: RGD
    5. nucleus Source: Ensembl
    6. perinuclear region of cytoplasm Source: UniProtKB
    7. plasma membrane Source: UniProtKB
    8. synaptic membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse, Synaptosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 697697Protein kinase C gamma typePRO_0000055692Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei250 – 2501Phosphothreonine; by autocatalysisBy similarity
    Modified residuei514 – 5141Phosphothreonine; by PDPK1By similarity
    Modified residuei648 – 6481Phosphothreonine; by autocatalysisBy similarity
    Modified residuei655 – 6551Phosphothreonine; by autocatalysisSequence Analysis
    Modified residuei674 – 6741Phosphothreonine; by autocatalysisBy similarity
    Modified residuei675 – 6751Phosphotyrosine; by SYKBy similarity

    Post-translational modificationi

    Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4.By similarity
    Ubiquitinated.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP63319.
    PRIDEiP63319.

    PTM databases

    PhosphoSiteiP63319.

    Expressioni

    Gene expression databases

    GenevestigatoriP63319.

    Interactioni

    Subunit structurei

    Interacts with CDCP1 By similarity. Interacts with GRIA4. Interacts with TP53INP1 and p53/TP53 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi246813. 17 interactions.
    STRINGi10116.ENSRNOP00000019825.

    Structurei

    Secondary structure

    1
    697
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi103 – 1053
    Beta strandi108 – 1103
    Beta strandi115 – 1173
    Beta strandi125 – 1273
    Beta strandi129 – 1313
    Turni132 – 1343
    Turni140 – 1456

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1TBNNMR-A91-172[»]
    1TBONMR-A91-172[»]
    ProteinModelPortaliP63319.
    SMRiP63319. Positions 36-683.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP63319.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini170 – 26091C2PROSITE-ProRule annotationAdd
    BLAST
    Domaini351 – 614264Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini615 – 68571AGC-kinase C-terminalAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri35 – 8551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri100 – 15051Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117339.
    HOGENOMiHOG000233022.
    HOVERGENiHBG108317.
    InParanoidiP63319.
    KOiK02677.
    OMAiAIRAHGF.
    OrthoDBiEOG77M8QM.
    PhylomeDBiP63319.
    TreeFamiTF351133.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000961. AGC-kinase_C.
    IPR000008. C2_dom.
    IPR020454. DAG/PE-bd.
    IPR011009. Kinase-like_dom.
    IPR017892. Pkinase_C.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR014375. Protein_kinase_C_a/b/g.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF00168. C2. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000550. PKC_alpha. 1 hit.
    PRINTSiPR00360. C2DOMAIN.
    PR00008. DAGPEDOMAIN.
    SMARTiSM00109. C1. 2 hits.
    SM00239. C2. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS50004. C2. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63319-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLGPGGGD SEGGPRPLFC RKGALRQKVV HEVKSHKFTA RFFKQPTFCS    50
    HCTDFIWGIG KQGLQCQVCS FVVHRRCHEF VTFECPGAGK GPQTDDPRNK 100
    HKFRLHSYSS PTFCDHCGSL LYGLVHQGMK CSCCEMNVHR RCVRSVPSLC 150
    GVDHTERRGR LQLEIRAPTS DEIHITVGEA RNLIPMDPNG LSDPYVKLKL 200
    IPDPRNLTKQ KTKTVKATLN PVWNETFVFN LKPGDVERRL SVEVWDWDRT 250
    SRNDFMGAMS FGVSELLKAP VDGWYKLLNQ EEGEYYNVPV ADADNCSLLQ 300
    KFEACNYPLE LYERVRMGPS SSPIPSPSPS PTDSKRCFFG ASPGRLHISD 350
    FSFLMVLGKG SFGKVMLAER RGSDELYAIK ILKKDVIVQD DDVDCTLVEK 400
    RVLALGGRGP GGRPHFLTQL HSTFQTPDRL YFVMEYVTGG DLMYHIQQLG 450
    KFKEPHAAFY AAEIAIGLFF LHNQGIIYRD LKLDNVMLDA EGHIKITDFG 500
    MCKENVFPGS TTRTFCGTPD YIAPEIIAYQ PYGKSVDWWS FGVLLYEMLA 550
    GQPPFDGEDE EELFQAIMEQ TVTYPKSLSR EAVAICKGFL TKHPGKRLGS 600
    GPDGEPTIRA HGFFRWIDWE RLERLEIAPP FRPRPCGRSG ENFDKFFTRA 650
    APALTPPDRL VLASIDQADF QGFTYVNPDF VHPDARSPTS PVPVPVM 697
    Length:697
    Mass (Da):78,358
    Last modified:October 11, 2004 - v1
    Checksum:iE6E2F7A3B93042FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07287 mRNA. Translation: CAA30267.1.
    M13707 mRNA. Translation: AAA41874.1.
    BC089226 mRNA. Translation: AAH89226.1.
    M55417 Genomic DNA. Translation: AAA41873.1.
    PIRiA05105. KIRTGC.
    RefSeqiNP_036760.1. NM_012628.1.
    UniGeneiRn.9747.

    Genome annotation databases

    EnsembliENSRNOT00000019825; ENSRNOP00000019825; ENSRNOG00000014688.
    GeneIDi24681.
    KEGGirno:24681.
    UCSCiRGD:3397. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07287 mRNA. Translation: CAA30267.1 .
    M13707 mRNA. Translation: AAA41874.1 .
    BC089226 mRNA. Translation: AAH89226.1 .
    M55417 Genomic DNA. Translation: AAA41873.1 .
    PIRi A05105. KIRTGC.
    RefSeqi NP_036760.1. NM_012628.1.
    UniGenei Rn.9747.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1TBN NMR - A 91-172 [» ]
    1TBO NMR - A 91-172 [» ]
    ProteinModelPortali P63319.
    SMRi P63319. Positions 36-683.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246813. 17 interactions.
    STRINGi 10116.ENSRNOP00000019825.

    Chemistry

    BindingDBi P63319.
    ChEMBLi CHEMBL3604.

    PTM databases

    PhosphoSitei P63319.

    Proteomic databases

    PaxDbi P63319.
    PRIDEi P63319.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000019825 ; ENSRNOP00000019825 ; ENSRNOG00000014688 .
    GeneIDi 24681.
    KEGGi rno:24681.
    UCSCi RGD:3397. rat.

    Organism-specific databases

    CTDi 5582.
    RGDi 3397. Prkcg.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117339.
    HOGENOMi HOG000233022.
    HOVERGENi HBG108317.
    InParanoidi P63319.
    KOi K02677.
    OMAi AIRAHGF.
    OrthoDBi EOG77M8QM.
    PhylomeDBi P63319.
    TreeFami TF351133.

    Enzyme and pathway databases

    Reactomei REACT_198398. WNT5A-dependent internalization of FZD4.

    Miscellaneous databases

    EvolutionaryTracei P63319.
    NextBioi 294925.
    PROi P63319.

    Gene expression databases

    Genevestigatori P63319.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000961. AGC-kinase_C.
    IPR000008. C2_dom.
    IPR020454. DAG/PE-bd.
    IPR011009. Kinase-like_dom.
    IPR017892. Pkinase_C.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR014375. Protein_kinase_C_a/b/g.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF00168. C2. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000550. PKC_alpha. 1 hit.
    PRINTSi PR00360. C2DOMAIN.
    PR00008. DAGPEDOMAIN.
    SMARTi SM00109. C1. 2 hits.
    SM00239. C2. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS50004. C2. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C."
      Ono Y., Fujii T., Igarashi K., Kikkawa U., Ogita K., Nishizuka Y.
      Nucleic Acids Res. 16:5199-5200(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Cloning and expression of multiple protein kinase C cDNAs."
      Knopf J.L., Lee M.-H., Sultzman L.A., Kriz R.W., Loomis C.R., Hewick R.M., Bell R.M.
      Cell 46:491-502(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Characterization of the 5'-flanking region of the rat protein kinase C gamma gene."
      Chen K.H., Widen S.G., Wilson S.H., Huang K.P.
      J. Biol. Chem. 265:19961-19965(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
    5. "Exposure to chronic psychosocial stress and corticosterone in the rat: effects on spatial discrimination learning and hippocampal protein kinase Cgamma immunoreactivity."
      Krugers H.J., Douma B.R., Andringa G., Bohus B., Korf J., Luiten P.G.
      Hippocampus 7:427-436(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Inflammation-induced up-regulation of protein kinase Cgamma immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing."
      Martin W.J., Liu H., Wang H., Malmberg A.B., Basbaum A.I.
      Neuroscience 88:1267-1274(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN INFLAMMATORY PAIN.
    7. "Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation."
      Correia S.S., Duarte C.B., Faro C.J., Pires E.V., Carvalho A.L.
      J. Biol. Chem. 278:6307-6313(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF GRIA4/GLUR4, INTERACTION WITH GRIA4/GLUR4, SUBCELLULAR LOCATION.
    8. "Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion."
      Matsumoto S., Shamloo M., Matsumoto E., Isshiki A., Wieloch T.
      J. Cereb. Blood Flow Metab. 24:54-61(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms."
      Sanchez-Perez A.M., Felipo V.
      Neurochem. Int. 47:84-91(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF GRIN1/NMDAR1.
    10. "Insulin receptor-protein kinase C-gamma signaling mediates inhibition of hypoxia-induced necrosis of cortical neurons."
      Hamabe W., Fujita R., Ueda H.
      J. Pharmacol. Exp. Ther. 313:1027-1034(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CELL SURVIVAL.
    11. "NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions."
      Xu R.X., Pawelczyk T., Xia T.-H., Brown S.C.
      Biochemistry 36:10709-10717(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 91-172 IN COMPLEX WITH PHORBOL-12,13-DIBUTYRATE, FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiKPCG_RAT
    AccessioniPrimary (citable) accession number: P63319
    Secondary accession number(s): P05697, Q5FWS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3