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P63318

- KPCG_MOUSE

UniProt

P63318 - KPCG_MOUSE

Protein

Protein kinase C gamma type

Gene

Prkcg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contribute to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domain By similarity.By similarity

    Enzyme regulationi

    Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full activation.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi186 – 1861Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi187 – 1871Calcium 1By similarity
    Metal bindingi187 – 1871Calcium 2By similarity
    Metal bindingi193 – 1931Calcium 2By similarity
    Metal bindingi246 – 2461Calcium 1By similarity
    Metal bindingi246 – 2461Calcium 2By similarity
    Metal bindingi247 – 2471Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi248 – 2481Calcium 1By similarity
    Metal bindingi248 – 2481Calcium 2By similarity
    Metal bindingi248 – 2481Calcium 3By similarity
    Metal bindingi251 – 2511Calcium 3By similarity
    Metal bindingi252 – 2521Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi254 – 2541Calcium 1By similarity
    Metal bindingi254 – 2541Calcium 3By similarity
    Binding sitei380 – 3801ATPPROSITE-ProRule annotation
    Active sitei480 – 4801Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri35 – 8551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri100 – 15051Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi357 – 3659ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium-dependent protein kinase C activity Source: Ensembl
    3. protein serine/threonine/tyrosine kinase activity Source: MGI
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. chemosensory behavior Source: MGI
    2. innervation Source: UniProtKB
    3. intracellular signal transduction Source: InterPro
    4. learning or memory Source: Ensembl
    5. negative regulation of neuron apoptotic process Source: UniProtKB
    6. negative regulation of protein catabolic process Source: Ensembl
    7. negative regulation of protein ubiquitination Source: Ensembl
    8. positive regulation of mismatch repair Source: Ensembl
    9. protein autophosphorylation Source: Ensembl
    10. response to morphine Source: UniProtKB
    11. response to pain Source: UniProtKB
    12. synaptic transmission Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_206166. Response to elevated platelet cytosolic Ca2+.
    REACT_215302. Disinhibition of SNARE formation.
    REACT_215587. Calmodulin induced events.
    REACT_222404. WNT5A-dependent internalization of FZD4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C gamma type (EC:2.7.11.13)
    Short name:
    PKC-gamma
    Gene namesi
    Name:Prkcg
    Synonyms:Pkcc, Pkcg, Prkcc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:97597. Prkcg.

    Subcellular locationi

    Cytoplasm. Cytoplasmperinuclear region By similarity. Cell membrane; Peripheral membrane protein. Cell junctionsynapsesynaptosome. Cell projectiondendrite By similarity
    Note: Translocates to synaptic membranes on stimulation.

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. cytoplasm Source: UniProtKB
    3. cytosol Source: UniProtKB
    4. dendrite Source: MGI
    5. nucleus Source: MGI
    6. perinuclear region of cytoplasm Source: UniProtKB
    7. plasma membrane Source: UniProtKB
    8. synaptic membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Disruption phenotypei

    Mice exhibit impaired motor coordination due to the inability to eliminate multiple climbing fibers during innervation of Purkinje cells. 40% of Purkinje cells are still innervated by multiple climbing fibers.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 697697Protein kinase C gamma typePRO_0000055690Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei250 – 2501Phosphothreonine; by autocatalysisBy similarity
    Modified residuei514 – 5141Phosphothreonine; by PDPK11 Publication
    Modified residuei648 – 6481Phosphothreonine; by autocatalysisSequence Analysis
    Modified residuei655 – 6551Phosphothreonine; by autocatalysis1 Publication
    Modified residuei674 – 6741Phosphothreonine; by autocatalysis1 Publication
    Modified residuei675 – 6751Phosphotyrosine; by SYKBy similarity

    Post-translational modificationi

    Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4.1 Publication
    Ubiquitinated.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP63318.
    PaxDbiP63318.
    PRIDEiP63318.

    Expressioni

    Tissue specificityi

    Expressed in brain cerebellum and cortex. Highly expressed in Purkinje cells.1 Publication

    Gene expression databases

    ArrayExpressiP63318.
    BgeeiP63318.
    CleanExiMM_PRKCC.
    GenevestigatoriP63318.

    Interactioni

    Subunit structurei

    Interacts with CDCP1 and GRIA4. Interacts with TP53INP1 and p53/TP53.By similarity

    Protein-protein interaction databases

    BioGridi202196. 3 interactions.
    IntActiP63318. 10 interactions.
    MINTiMINT-98016.

    Structurei

    3D structure databases

    ProteinModelPortaliP63318.
    SMRiP63318. Positions 36-683.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini170 – 26091C2PROSITE-ProRule annotationAdd
    BLAST
    Domaini351 – 614264Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini615 – 68571AGC-kinase C-terminalAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri35 – 8551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri100 – 15051Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233022.
    HOVERGENiHBG108317.
    InParanoidiP63318.
    KOiK02677.
    OMAiAIRAHGF.
    OrthoDBiEOG77M8QM.
    PhylomeDBiP63318.
    TreeFamiTF351133.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000961. AGC-kinase_C.
    IPR000008. C2_dom.
    IPR020454. DAG/PE-bd.
    IPR011009. Kinase-like_dom.
    IPR017892. Pkinase_C.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR014375. Protein_kinase_C_a/b/g.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF00168. C2. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000550. PKC_alpha. 1 hit.
    PRINTSiPR00360. C2DOMAIN.
    PR00008. DAGPEDOMAIN.
    SMARTiSM00109. C1. 2 hits.
    SM00239. C2. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS50004. C2. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63318-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLGPGGGD SEGGPRPLFC RKGALRQKVV HEVKSHKFTA RFFKQPTFCS    50
    HCTDFIWGIG KQGLQCQVCS FVVHRRCHEF VTFECPGAGK GPQTDDPRNK 100
    HKFRLHSYSS PTFCDHCGSL LYGLVHQGMK CSCCEMNVHR RCVRSVPSLC 150
    GVDHTERRGR LQLEIRAPTS DEIHITVGEA RNLIPMDPNG LSDPYVKLKL 200
    IPDPRNLTKQ KTKTVKATLN PVWNETFVFN LKPGDVERRL SVEVWDWDRT 250
    SRNDFMGAMS FGVSELLKAP VDGWYKLLNQ EEGEYYNVPV ADADNCSLLQ 300
    KFEACNYPLE LYERVRMGPS SSPIPSPSPS PTDSKRCFFG ASPGRLHISD 350
    FSFLMVLGKG SFGKVMLAER RGSDELYAIK ILKKDVIVQD DDVDCTLVEK 400
    RVLALGGRGP GGRPHFLTQL HSTFQTPDRL YFVMEYVTGG DLMYHIQQLG 450
    KFKEPHAAFY AAEIAIGLFF LHNQGIIYRD LKLDNVMLDA EGHIKITDFG 500
    MCKENVFPGS TTRTFCGTPD YIAPEIIAYQ PYGKSVDWWS FGVLLYEMLA 550
    GQPPFDGEDE EELFQAIMEQ TVTYPKSLSR EAVAICKGFL TKHPGKRLGS 600
    GPDGEPTIRA HGFFRWIDWE RLERLEIAPP FRPRPCGRSG ENFDKFFTRA 650
    APALTPPDRL VLASIDQADF QGFTYVNPDF VHPDARSPTS PVPVPVM 697
    Length:697
    Mass (Da):78,358
    Last modified:October 11, 2004 - v1
    Checksum:iE6E2F7A3B93042FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67129 mRNA. Translation: CAA47608.1.
    L28035 mRNA. Translation: AAA39939.1.
    CCDSiCCDS57470.1.
    PIRiJN0548.
    RefSeqiNP_035232.1. NM_011102.4.
    UniGeneiMm.7980.

    Genome annotation databases

    EnsembliENSMUST00000100301; ENSMUSP00000097874; ENSMUSG00000078816.
    ENSMUST00000181455; ENSMUSP00000137923; ENSMUSG00000097449.
    GeneIDi18752.
    KEGGimmu:18752.
    UCSCiuc029wcz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67129 mRNA. Translation: CAA47608.1 .
    L28035 mRNA. Translation: AAA39939.1 .
    CCDSi CCDS57470.1.
    PIRi JN0548.
    RefSeqi NP_035232.1. NM_011102.4.
    UniGenei Mm.7980.

    3D structure databases

    ProteinModelPortali P63318.
    SMRi P63318. Positions 36-683.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202196. 3 interactions.
    IntActi P63318. 10 interactions.
    MINTi MINT-98016.

    Chemistry

    BindingDBi P63318.

    Proteomic databases

    MaxQBi P63318.
    PaxDbi P63318.
    PRIDEi P63318.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000100301 ; ENSMUSP00000097874 ; ENSMUSG00000078816 .
    ENSMUST00000181455 ; ENSMUSP00000137923 ; ENSMUSG00000097449 .
    GeneIDi 18752.
    KEGGi mmu:18752.
    UCSCi uc029wcz.1. mouse.

    Organism-specific databases

    CTDi 5582.
    MGIi MGI:97597. Prkcg.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233022.
    HOVERGENi HBG108317.
    InParanoidi P63318.
    KOi K02677.
    OMAi AIRAHGF.
    OrthoDBi EOG77M8QM.
    PhylomeDBi P63318.
    TreeFami TF351133.

    Enzyme and pathway databases

    Reactomei REACT_206166. Response to elevated platelet cytosolic Ca2+.
    REACT_215302. Disinhibition of SNARE formation.
    REACT_215587. Calmodulin induced events.
    REACT_222404. WNT5A-dependent internalization of FZD4.

    Miscellaneous databases

    NextBioi 294925.
    PROi P63318.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63318.
    Bgeei P63318.
    CleanExi MM_PRKCC.
    Genevestigatori P63318.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000961. AGC-kinase_C.
    IPR000008. C2_dom.
    IPR020454. DAG/PE-bd.
    IPR011009. Kinase-like_dom.
    IPR017892. Pkinase_C.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR014375. Protein_kinase_C_a/b/g.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF00168. C2. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000550. PKC_alpha. 1 hit.
    PRINTSi PR00360. C2DOMAIN.
    PR00008. DAGPEDOMAIN.
    SMARTi SM00109. C1. 2 hits.
    SM00239. C2. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS50004. C2. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence of a mouse brain cDNA coding for protein kinase C-gamma isozyme."
      Bowers B.J., Parham C.L., Sikela J.M., Wehner J.M.
      Gene 123:263-265(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Tseng C.P., Verma A.
      Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    3. "Modified hippocampal long-term potentiation in PKC gamma-mutant mice."
      Abeliovich A., Chen C., Goda Y., Silva A.J., Stevens C.F., Tonegawa S.
      Cell 75:1253-1262(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN LONG-TERM POTENTIATION.
    4. "Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice."
      Chen C., Kano M., Abeliovich A., Chen L., Bao S., Kim J.J., Hashimoto K., Thompson R.F., Tonegawa S.
      Cell 83:1233-1242(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    5. "Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma."
      Malmberg A.B., Chen C., Tonegawa S., Basbaum A.I.
      Science 278:279-283(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN NEUROPATHIC PAIN.
    6. "Enhanced mu-opioid responses in the spinal cord of mice lacking protein kinase Cgamma isoform."
      Narita M., Mizoguchi H., Suzuki T., Narita M., Dun N.J., Imai S., Yajima Y., Nagase H., Suzuki T., Tseng L.F.
      J. Biol. Chem. 276:15409-15414(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN OPIOID SIGNALING.
    7. "Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin."
      Narita M., Mizoguchi H., Narita M., Nagase H., Suzuki T., Tseng L.F.
      J. Neurosci. 21:3715-3720(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN OPIOID SIGNALING.
    8. "Involvement of protein kinase Cgamma isoform in morphine-induced reinforcing effects."
      Narita M., Aoki T., Ozaki S., Yajima Y., Suzuki T.
      Neuroscience 103:309-314(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN OPIOID SIGNALING.
    9. "Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice."
      Zeitz K.P., Malmberg A.B., Gilbert H., Basbaum A.I.
      Pain 94:245-253(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN OPIOID SIGNALING.
    10. Cited for: PHOSPHORYLATION AT THR-514; THR-655 AND THR-674, SUBCELLULAR LOCATION, FUNCTION, TISSUE SPECIFICITY.
    11. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    12. "Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains."
      Matsumoto S., Murozono M., Nagaoka D., Matsuoka S., Takeda A., Narita H., Watanabe S., Isshiki A., Watanabe Y.
      Neurochem. Res. 33:2302-2309(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiKPCG_MOUSE
    AccessioniPrimary (citable) accession number: P63318
    Secondary accession number(s): P05697
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3