Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein kinase C gamma type

Gene

Prkcg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contribute to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (PubMed:23185022).8 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domain.By similarity

Enzyme regulationi

Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full activation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi186 – 1861Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi187 – 1871Calcium 1By similarity
Metal bindingi187 – 1871Calcium 2By similarity
Metal bindingi193 – 1931Calcium 2By similarity
Metal bindingi246 – 2461Calcium 1By similarity
Metal bindingi246 – 2461Calcium 2By similarity
Metal bindingi247 – 2471Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi248 – 2481Calcium 1By similarity
Metal bindingi248 – 2481Calcium 2By similarity
Metal bindingi248 – 2481Calcium 3By similarity
Metal bindingi251 – 2511Calcium 3By similarity
Metal bindingi252 – 2521Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi254 – 2541Calcium 1By similarity
Metal bindingi254 – 2541Calcium 3By similarity
Binding sitei380 – 3801ATPPROSITE-ProRule annotation
Active sitei480 – 4801Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri35 – 8551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri100 – 15051Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi357 – 3659ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium-dependent protein kinase C activity Source: Ensembl
  3. protein kinase activity Source: MGI
  4. protein serine/threonine/tyrosine kinase activity Source: MGI
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. chemosensory behavior Source: MGI
  2. innervation Source: UniProtKB
  3. intracellular signal transduction Source: InterPro
  4. learning or memory Source: Ensembl
  5. negative regulation of neuron apoptotic process Source: UniProtKB
  6. negative regulation of proteasomal protein catabolic process Source: UniProtKB
  7. negative regulation of protein catabolic process Source: MGI
  8. negative regulation of protein ubiquitination Source: UniProtKB
  9. phosphorylation Source: MGI
  10. positive regulation of mismatch repair Source: MGI
  11. protein autophosphorylation Source: Ensembl
  12. regulation of circadian rhythm Source: UniProtKB
  13. regulation of response to food Source: UniProtKB
  14. response to morphine Source: UniProtKB
  15. response to pain Source: UniProtKB
  16. synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Biological rhythms

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_206166. Response to elevated platelet cytosolic Ca2+.
REACT_215302. Disinhibition of SNARE formation.
REACT_215587. Calmodulin induced events.
REACT_222404. WNT5A-dependent internalization of FZD4.
REACT_253367. Trafficking of GluR2-containing AMPA receptors.
REACT_258013. G alpha (z) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C gamma type (EC:2.7.11.13)
Short name:
PKC-gamma
Gene namesi
Name:Prkcg
Synonyms:Pkcc, Pkcg, Prkcc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7, UP000000589: Unplaced

Organism-specific databases

MGIiMGI:97597. Prkcg.

Subcellular locationi

Cytoplasm 1 Publication. Cytoplasmperinuclear region By similarity. Cell membrane 2 Publications; Peripheral membrane protein. Cell junctionsynapsesynaptosome 1 Publication. Cell projectiondendrite By similarity
Note: Translocates to synaptic membranes on stimulation.1 Publication

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: UniProtKB
  4. dendrite Source: MGI
  5. neuronal postsynaptic density Source: MGI
  6. nucleus Source: MGI
  7. perinuclear region of cytoplasm Source: UniProtKB
  8. plasma membrane Source: UniProtKB
  9. synaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Disruption phenotypei

Mice exhibit impaired motor coordination due to the inability to eliminate multiple climbing fibers during innervation of Purkinje cells. 40% of Purkinje cells are still innervated by multiple climbing fibers. Exhibit food-anticipatory activity comparable to that of wild type mice but they do not reduce their late night activity or adapt their food intake amount to restricted feeding as efficiently as wild type mice.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Protein kinase C gamma typePRO_0000055690Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei250 – 2501Phosphothreonine; by autocatalysisBy similarity
Modified residuei514 – 5141Phosphothreonine; by PDPK11 Publication
Modified residuei648 – 6481Phosphothreonine; by autocatalysisSequence Analysis
Modified residuei655 – 6551Phosphothreonine; by autocatalysis2 Publications
Modified residuei674 – 6741Phosphothreonine; by autocatalysis1 Publication
Modified residuei675 – 6751Phosphotyrosine; by SYKBy similarity

Post-translational modificationi

Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4.1 Publication
Ubiquitinated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP63318.
PaxDbiP63318.
PRIDEiP63318.

Expressioni

Tissue specificityi

Expressed in the cerebellum, cerebral cortex and hippocampus (at protein level). Highly expressed in Purkinje cells.2 Publications

Gene expression databases

BgeeiP63318.
CleanExiMM_PRKCC.
ExpressionAtlasiP63318. baseline and differential.
GenevestigatoriP63318.

Interactioni

Subunit structurei

Interacts with CDCP1 and GRIA4 (By similarity). Interacts with TP53INP1 and p53/TP53 (By similarity). Interacts with ARNTL/BMAL1.By similarity1 Publication

Protein-protein interaction databases

BioGridi202196. 3 interactions.
IntActiP63318. 10 interactions.
MINTiMINT-98016.

Structurei

3D structure databases

ProteinModelPortaliP63318.
SMRiP63318. Positions 36-683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 26091C2PROSITE-ProRule annotationAdd
BLAST
Domaini351 – 614264Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini615 – 68571AGC-kinase C-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri35 – 8551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri100 – 15051Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233022.
HOVERGENiHBG108317.
InParanoidiP63318.
KOiK02677.
OMAiMDWERLE.
OrthoDBiEOG77M8QM.
PhylomeDBiP63318.
TreeFamiTF351133.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014375. Protein_kinase_C_a/b/g.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00168. C2. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000550. PKC_alpha. 1 hit.
PRINTSiPR00360. C2DOMAIN.
PR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50004. C2. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63318-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGLGPGGGD SEGGPRPLFC RKGALRQKVV HEVKSHKFTA RFFKQPTFCS
60 70 80 90 100
HCTDFIWGIG KQGLQCQVCS FVVHRRCHEF VTFECPGAGK GPQTDDPRNK
110 120 130 140 150
HKFRLHSYSS PTFCDHCGSL LYGLVHQGMK CSCCEMNVHR RCVRSVPSLC
160 170 180 190 200
GVDHTERRGR LQLEIRAPTS DEIHITVGEA RNLIPMDPNG LSDPYVKLKL
210 220 230 240 250
IPDPRNLTKQ KTKTVKATLN PVWNETFVFN LKPGDVERRL SVEVWDWDRT
260 270 280 290 300
SRNDFMGAMS FGVSELLKAP VDGWYKLLNQ EEGEYYNVPV ADADNCSLLQ
310 320 330 340 350
KFEACNYPLE LYERVRMGPS SSPIPSPSPS PTDSKRCFFG ASPGRLHISD
360 370 380 390 400
FSFLMVLGKG SFGKVMLAER RGSDELYAIK ILKKDVIVQD DDVDCTLVEK
410 420 430 440 450
RVLALGGRGP GGRPHFLTQL HSTFQTPDRL YFVMEYVTGG DLMYHIQQLG
460 470 480 490 500
KFKEPHAAFY AAEIAIGLFF LHNQGIIYRD LKLDNVMLDA EGHIKITDFG
510 520 530 540 550
MCKENVFPGS TTRTFCGTPD YIAPEIIAYQ PYGKSVDWWS FGVLLYEMLA
560 570 580 590 600
GQPPFDGEDE EELFQAIMEQ TVTYPKSLSR EAVAICKGFL TKHPGKRLGS
610 620 630 640 650
GPDGEPTIRA HGFFRWIDWE RLERLEIAPP FRPRPCGRSG ENFDKFFTRA
660 670 680 690
APALTPPDRL VLASIDQADF QGFTYVNPDF VHPDARSPTS PVPVPVM
Length:697
Mass (Da):78,358
Last modified:October 11, 2004 - v1
Checksum:iE6E2F7A3B93042FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67129 mRNA. Translation: CAA47608.1.
L28035 mRNA. Translation: AAA39939.1.
CCDSiCCDS57470.1.
PIRiJN0548.
RefSeqiNP_035232.1. NM_011102.4.
UniGeneiMm.7980.

Genome annotation databases

EnsembliENSMUST00000100301; ENSMUSP00000097874; ENSMUSG00000078816.
ENSMUST00000181455; ENSMUSP00000137923; ENSMUSG00000097449.
GeneIDi18752.
KEGGimmu:18752.
UCSCiuc029wcz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67129 mRNA. Translation: CAA47608.1.
L28035 mRNA. Translation: AAA39939.1.
CCDSiCCDS57470.1.
PIRiJN0548.
RefSeqiNP_035232.1. NM_011102.4.
UniGeneiMm.7980.

3D structure databases

ProteinModelPortaliP63318.
SMRiP63318. Positions 36-683.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202196. 3 interactions.
IntActiP63318. 10 interactions.
MINTiMINT-98016.

Chemistry

BindingDBiP63318.

Proteomic databases

MaxQBiP63318.
PaxDbiP63318.
PRIDEiP63318.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100301; ENSMUSP00000097874; ENSMUSG00000078816.
ENSMUST00000181455; ENSMUSP00000137923; ENSMUSG00000097449.
GeneIDi18752.
KEGGimmu:18752.
UCSCiuc029wcz.1. mouse.

Organism-specific databases

CTDi5582.
MGIiMGI:97597. Prkcg.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233022.
HOVERGENiHBG108317.
InParanoidiP63318.
KOiK02677.
OMAiMDWERLE.
OrthoDBiEOG77M8QM.
PhylomeDBiP63318.
TreeFamiTF351133.

Enzyme and pathway databases

ReactomeiREACT_206166. Response to elevated platelet cytosolic Ca2+.
REACT_215302. Disinhibition of SNARE formation.
REACT_215587. Calmodulin induced events.
REACT_222404. WNT5A-dependent internalization of FZD4.
REACT_253367. Trafficking of GluR2-containing AMPA receptors.
REACT_258013. G alpha (z) signalling events.

Miscellaneous databases

NextBioi294925.
PROiP63318.
SOURCEiSearch...

Gene expression databases

BgeeiP63318.
CleanExiMM_PRKCC.
ExpressionAtlasiP63318. baseline and differential.
GenevestigatoriP63318.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014375. Protein_kinase_C_a/b/g.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00168. C2. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000550. PKC_alpha. 1 hit.
PRINTSiPR00360. C2DOMAIN.
PR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50004. C2. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequence of a mouse brain cDNA coding for protein kinase C-gamma isozyme."
    Bowers B.J., Parham C.L., Sikela J.M., Wehner J.M.
    Gene 123:263-265(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Tseng C.P., Verma A.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  3. "Modified hippocampal long-term potentiation in PKC gamma-mutant mice."
    Abeliovich A., Chen C., Goda Y., Silva A.J., Stevens C.F., Tonegawa S.
    Cell 75:1253-1262(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LONG-TERM POTENTIATION.
  4. "Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice."
    Chen C., Kano M., Abeliovich A., Chen L., Bao S., Kim J.J., Hashimoto K., Thompson R.F., Tonegawa S.
    Cell 83:1233-1242(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  5. "Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma."
    Malmberg A.B., Chen C., Tonegawa S., Basbaum A.I.
    Science 278:279-283(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN NEUROPATHIC PAIN.
  6. "Enhanced mu-opioid responses in the spinal cord of mice lacking protein kinase Cgamma isoform."
    Narita M., Mizoguchi H., Suzuki T., Narita M., Dun N.J., Imai S., Yajima Y., Nagase H., Suzuki T., Tseng L.F.
    J. Biol. Chem. 276:15409-15414(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN OPIOID SIGNALING.
  7. "Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin."
    Narita M., Mizoguchi H., Narita M., Nagase H., Suzuki T., Tseng L.F.
    J. Neurosci. 21:3715-3720(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN OPIOID SIGNALING.
  8. "Involvement of protein kinase Cgamma isoform in morphine-induced reinforcing effects."
    Narita M., Aoki T., Ozaki S., Yajima Y., Suzuki T.
    Neuroscience 103:309-314(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN OPIOID SIGNALING.
  9. "Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice."
    Zeitz K.P., Malmberg A.B., Gilbert H., Basbaum A.I.
    Pain 94:245-253(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN OPIOID SIGNALING.
  10. Cited for: PHOSPHORYLATION AT THR-514; THR-655 AND THR-674, SUBCELLULAR LOCATION, FUNCTION, TISSUE SPECIFICITY.
  11. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  12. "Isoflurane inhibits protein kinase Cgamma and calcium/calmodulin dependent protein kinase ii-alpha translocation to synaptic membranes in ischemic mice brains."
    Matsumoto S., Murozono M., Nagaoka D., Matsuoka S., Takeda A., Narita H., Watanabe S., Isshiki A., Watanabe Y.
    Neurochem. Res. 33:2302-2309(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. Cited for: FUNCTION, INTERACTION WITH ARNTL, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, PHOSPHORYLATION AT THR-655.

Entry informationi

Entry nameiKPCG_MOUSE
AccessioniPrimary (citable) accession number: P63318
Secondary accession number(s): P05697
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: February 4, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.