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Protein

Thymosin beta-10

Gene

TMSB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000034510-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-10
Gene namesi
Name:TMSB10
Synonyms:PTMB10, THYB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11879. TMSB10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi9168.
OpenTargetsiENSG00000034510.
PharmGKBiPA36580.

Polymorphism and mutation databases

BioMutaiTMSB10.
DMDMi54039778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000459312 – 44Thymosin beta-10Add BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4N6-acetyllysineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei15N6-acetyllysineCombined sources1
Modified residuei21PhosphothreonineBy similarity1
Modified residuei23PhosphothreonineCombined sources1
Modified residuei34PhosphothreonineCombined sources1
Modified residuei39N6-acetyllysineCombined sources1
Modified residuei41PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP63313.
PaxDbiP63313.
PeptideAtlasiP63313.
PRIDEiP63313.
TopDownProteomicsiP63313.

PTM databases

iPTMnetiP63313.
PhosphoSitePlusiP63313.

Expressioni

Developmental stagei

Found to decrease dramatically after birth.1 Publication

Gene expression databases

BgeeiENSG00000034510.
CleanExiHS_TMSB10.
GenevisibleiP63313. HS.

Organism-specific databases

HPAiCAB018548.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131963EBI-2688673,EBI-3905054
KRTAP9-2Q9BYQ43EBI-2688673,EBI-1044640
POT1Q9NUX52EBI-2688673,EBI-752420

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114609. 14 interactors.
IntActiP63313. 11 interactors.
STRINGi9606.ENSP00000233143.

Structurei

3D structure databases

ProteinModelPortaliP63313.
SMRiP63313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOVERGENiHBG012534.
InParanoidiP63313.
KOiK13785.
OrthoDBiEOG091G1AVI.
PhylomeDBiP63313.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS
Length:44
Mass (Da):5,026
Last modified:January 23, 2007 - v2
Checksum:i5485277C275A1C70
GO

Sequence cautioni

The sequence AAA36746 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC41691 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0523047M → R.Corresponds to variant rs1804515dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20259 mRNA. Translation: AAA36744.1.
M92381 mRNA. Translation: AAC41691.1. Different initiation.
S54005 mRNA. Translation: AAB25225.1.
M92383 Genomic DNA. Translation: AAA36746.1. Different initiation.
AY453400 mRNA. Translation: AAS47517.1.
AK311952 mRNA. Translation: BAG34892.1.
AC022210 Genomic DNA. Translation: AAY24191.1.
BC016025 mRNA. Translation: AAH16025.1.
BC016731 mRNA. Translation: AAH16731.1.
CCDSiCCDS1970.1.
PIRiA27704.
RefSeqiNP_066926.1. NM_021103.3.
UniGeneiHs.446574.

Genome annotation databases

EnsembliENST00000233143; ENSP00000233143; ENSG00000034510.
GeneIDi9168.
KEGGihsa:9168.
UCSCiuc002sow.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20259 mRNA. Translation: AAA36744.1.
M92381 mRNA. Translation: AAC41691.1. Different initiation.
S54005 mRNA. Translation: AAB25225.1.
M92383 Genomic DNA. Translation: AAA36746.1. Different initiation.
AY453400 mRNA. Translation: AAS47517.1.
AK311952 mRNA. Translation: BAG34892.1.
AC022210 Genomic DNA. Translation: AAY24191.1.
BC016025 mRNA. Translation: AAH16025.1.
BC016731 mRNA. Translation: AAH16731.1.
CCDSiCCDS1970.1.
PIRiA27704.
RefSeqiNP_066926.1. NM_021103.3.
UniGeneiHs.446574.

3D structure databases

ProteinModelPortaliP63313.
SMRiP63313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114609. 14 interactors.
IntActiP63313. 11 interactors.
STRINGi9606.ENSP00000233143.

PTM databases

iPTMnetiP63313.
PhosphoSitePlusiP63313.

Polymorphism and mutation databases

BioMutaiTMSB10.
DMDMi54039778.

Proteomic databases

EPDiP63313.
PaxDbiP63313.
PeptideAtlasiP63313.
PRIDEiP63313.
TopDownProteomicsiP63313.

Protocols and materials databases

DNASUi9168.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233143; ENSP00000233143; ENSG00000034510.
GeneIDi9168.
KEGGihsa:9168.
UCSCiuc002sow.2. human.

Organism-specific databases

CTDi9168.
DisGeNETi9168.
GeneCardsiTMSB10.
HGNCiHGNC:11879. TMSB10.
HPAiCAB018548.
MIMi188399. gene.
neXtProtiNX_P63313.
OpenTargetsiENSG00000034510.
PharmGKBiPA36580.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOVERGENiHBG012534.
InParanoidiP63313.
KOiK13785.
OrthoDBiEOG091G1AVI.
PhylomeDBiP63313.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000034510-MONOMER.

Miscellaneous databases

ChiTaRSiTMSB10. human.
GeneWikiiTMSB10.
GenomeRNAii9168.
PROiP63313.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000034510.
CleanExiHS_TMSB10.
GenevisibleiP63313. HS.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYB10_HUMAN
AccessioniPrimary (citable) accession number: P63313
Secondary accession number(s): P13472, Q596K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.