P63312 (TYB10_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymosin beta-10

Gene names

Name:	Tmsb10
Synonyms:	Ptmb10, Thyb10

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	44 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization By similarity.
Subcellular location	Cytoplasm › cytoskeleton.
Developmental stage	Found to decrease dramatically after birth.
Sequence similarities	Belongs to the thymosin beta family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Traceable author statement Ref.3. Source: RGD sequestering of actin monomers Inferred from electronic annotation. Source: InterPro spermatid development Traceable author statement Ref.3. Source: ProtInc
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	actin monomer binding Traceable author statement Ref.3. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 44	43	Thymosin beta-10		PRO_0000045933
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	4	1	N6-acetyllysine By similarity
	Modified residue	15	1	N6-acetyllysine By similarity
	Modified residue	23	1	Phosphothreonine By similarity
	Modified residue	39	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63312 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 5485277C275A1C70	FASTA	44	5,026
	10 20 30 40 MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS

References

[1]	"Molecular cloning of the cDNA for rat spleen thymosin beta 10 and the deduced amino acid sequence." Goodall G.J., Horecker B.L. Arch. Biochem. Biophys. 256:402-405(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Developmental regulation of beta-thymosins in the rat central nervous system." Lugo D.I., Chen S.C., Hall A.K., Ziai R., Hempstead J.L., Morgan J.I. J. Neurochem. 56:457-461(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells." Lin S.-C., Morrison-Bogorad M. J. Biol. Chem. 266:23347-23353(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M17698 mRNA. Translation: AAA42244.1. M58404 mRNA. Translation: AAA42247.1. M58405 mRNA. Translation: AAA42248.1.
IPI	IPI00231695.
PIR	A27266.
RefSeq	NP_067084.1. NM_021261.2. XP_002726998.1. XM_002726952.2. XP_003750434.1. XM_003750386.1.
UniGene	Rn.5983.
3D structure databases
ProteinModelPortal	P63312.
SMR	P63312. Positions 2-42.
ModBase	Search...
PTM databases
PhosphoSite	P63312.
Proteomic databases
PRIDE	P63312.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000022846; ENSRNOP00000022846; ENSRNOG00000042499. ENSRNOT00000041880; ENSRNOP00000051221; ENSRNOG00000042499. ENSRNOT00000055447; ENSRNOP00000052313; ENSRNOG00000036921.
GeneID	100364435. 50665.
KEGG	rno:100364435. rno:50665.
UCSC	RGD:62022. rat.
Organism-specific databases
CTD	9168.
RGD	62022. Tmsb10.
Phylogenomic databases
eggNOG	NOG298015.
GeneTree	ENSGT00390000007040.
HOVERGEN	HBG012534.
InParanoid	P63312.
KO	K13785.
OrthoDB	EOG4HDSWB.
Gene expression databases
Genevestigator	P63312.
GermOnline	ENSRNOG00000033360. Rattus norvegicus.
Family and domain databases
Gene3D	1.20.5.520. 1 hit.
InterPro	IPR001152. Thymosin_b4. IPR016323. Thymosin_b4_chordata. [Graphical view]
PANTHER	PTHR12021. PTHR12021. 1 hit.
Pfam	PF01290. Thymosin. 1 hit. [Graphical view]
PIRSF	PIRSF001828. Thymosin_beta. 1 hit.
ProDom	PD005116. Thymosin_b4. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00152. THY. 1 hit. [Graphical view]
PROSITE	PS00500. THYMOSIN_B4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610490.

Entry information

Entry name

TYB10_RAT

Accession

Primary (citable) accession number: P63312
Secondary accession number(s): P13472

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program