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Protein

Thymosin beta-10

Gene

Tmsb10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Molecular functioni

  • actin monomer binding Source: RGD

GO - Biological processi

  • actin cytoskeleton organization Source: RGD
  • actin filament organization Source: InterPro
  • spermatid development Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-10
Gene namesi
Name:Tmsb10
Synonyms:Ptmb10, Thyb10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 4, Chromosome 7

Organism-specific databases

RGDi62022. Tmsb10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 4443Thymosin beta-10PRO_0000045933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei4 – 41N6-acetyllysineBy similarity
Modified residuei12 – 121PhosphoserineCombined sources
Modified residuei15 – 151N6-acetyllysineBy similarity
Modified residuei21 – 211PhosphothreonineBy similarity
Modified residuei23 – 231PhosphothreonineBy similarity
Modified residuei34 – 341PhosphothreonineCombined sources
Modified residuei39 – 391N6-acetyllysineBy similarity
Modified residuei41 – 411PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP63312.
PRIDEiP63312.

PTM databases

iPTMnetiP63312.
PhosphoSiteiP63312.

Expressioni

Developmental stagei

Found to decrease dramatically after birth.

Gene expression databases

GenevisibleiP63312. RN.

Interactioni

GO - Molecular functioni

  • actin monomer binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052313.

Structurei

3D structure databases

ProteinModelPortaliP63312.
SMRiP63312. Positions 6-41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOVERGENiHBG012534.
InParanoidiP63312.
KOiK13785.
OrthoDBiEOG7TJ3MT.
PhylomeDBiP63312.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS
Length:44
Mass (Da):5,026
Last modified:January 23, 2007 - v2
Checksum:i5485277C275A1C70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17698 mRNA. Translation: AAA42244.1.
M58404 mRNA. Translation: AAA42247.1.
M58405 mRNA. Translation: AAA42248.1.
PIRiA27266.
RefSeqiNP_067084.1. NM_021261.2.
XP_002726998.1. XM_002726952.4.
XP_006236754.1. XM_006236692.2.
UniGeneiRn.5983.

Genome annotation databases

EnsembliENSRNOT00000022846; ENSRNOP00000022846; ENSRNOG00000042499.
ENSRNOT00000041880; ENSRNOP00000051221; ENSRNOG00000042499.
ENSRNOT00000055447; ENSRNOP00000052313; ENSRNOG00000036921.
GeneIDi100364435.
50665.
KEGGirno:100364435.
rno:50665.
UCSCiRGD:62022. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17698 mRNA. Translation: AAA42244.1.
M58404 mRNA. Translation: AAA42247.1.
M58405 mRNA. Translation: AAA42248.1.
PIRiA27266.
RefSeqiNP_067084.1. NM_021261.2.
XP_002726998.1. XM_002726952.4.
XP_006236754.1. XM_006236692.2.
UniGeneiRn.5983.

3D structure databases

ProteinModelPortaliP63312.
SMRiP63312. Positions 6-41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052313.

PTM databases

iPTMnetiP63312.
PhosphoSiteiP63312.

Proteomic databases

PaxDbiP63312.
PRIDEiP63312.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022846; ENSRNOP00000022846; ENSRNOG00000042499.
ENSRNOT00000041880; ENSRNOP00000051221; ENSRNOG00000042499.
ENSRNOT00000055447; ENSRNOP00000052313; ENSRNOG00000036921.
GeneIDi100364435.
50665.
KEGGirno:100364435.
rno:50665.
UCSCiRGD:62022. rat.

Organism-specific databases

CTDi9168.
RGDi62022. Tmsb10.

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOVERGENiHBG012534.
InParanoidiP63312.
KOiK13785.
OrthoDBiEOG7TJ3MT.
PhylomeDBiP63312.

Miscellaneous databases

PROiP63312.

Gene expression databases

GenevisibleiP63312. RN.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cDNA for rat spleen thymosin beta 10 and the deduced amino acid sequence."
    Goodall G.J., Horecker B.L.
    Arch. Biochem. Biophys. 256:402-405(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Developmental regulation of beta-thymosins in the rat central nervous system."
    Lugo D.I., Chen S.C., Hall A.K., Ziai R., Hempstead J.L., Morgan J.I.
    J. Neurochem. 56:457-461(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells."
    Lin S.-C., Morrison-Bogorad M.
    J. Biol. Chem. 266:23347-23353(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Testis.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; THR-34 AND SER-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTYB10_RAT
AccessioniPrimary (citable) accession number: P63312
Secondary accession number(s): P13472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.