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Protein

Interferon gamma

Gene

IFNG

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 165142Interferon gammaPRO_0000016447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000025266.

Structurei

3D structure databases

ProteinModelPortaliP63310.
SMRiP63310. Positions 24-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP63310.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYTSYILAF QLCIVLGSLG CYCQDPYVKE AENLKKYFNA GDPDVADNGT
60 70 80 90 100
LFLDILRNWK EESDRKIMQS QIVSFYFKLF KNFKDDQRIQ KSVETIKEDI
110 120 130 140 150
NVKFFNSNKK KRDDFEKLTN YSVTDSNVQR KAVHELIQVM AELSPAAKIG
160
KRKRSQMFRG RRASQ
Length:165
Mass (Da):19,332
Last modified:October 11, 2004 - v1
Checksum:i37AA9FF7FC2E948F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26024 mRNA. Translation: AAA99973.1.
AY376145 mRNA. Translation: AAQ87963.1.
RefSeqiNP_001028077.1. NM_001032905.1.
UniGeneiMmu.3373.

Genome annotation databases

EnsembliENSMMUT00000027007; ENSMMUP00000025266; ENSMMUG00000019225.
GeneIDi574282.
KEGGimcc:574282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26024 mRNA. Translation: AAA99973.1.
AY376145 mRNA. Translation: AAQ87963.1.
RefSeqiNP_001028077.1. NM_001032905.1.
UniGeneiMmu.3373.

3D structure databases

ProteinModelPortaliP63310.
SMRiP63310. Positions 24-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000025266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000027007; ENSMMUP00000025266; ENSMMUG00000019225.
GeneIDi574282.
KEGGimcc:574282.

Organism-specific databases

CTDi3458.

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP63310.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Miscellaneous databases

NextBioi19970875.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative sequence analysis of cytokine genes from human and nonhuman primates."
    Villinger F.J., Brar S.S., Mayne A.E., Chikkala N., Ansari A.A.
    J. Immunol. 155:3946-3954(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma."
    Stahl-Hennig C., Gundlach B.R., Dittmer U., ten Haaft P., Heeney J., Zou W., Emilie D., Sopper S., Uberla K.
    Virology 305:473-485(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIFNG_MACMU
AccessioniPrimary (citable) accession number: P63310
Secondary accession number(s): P42163, P42164, Q53Z08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.