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P63310

- IFNG_MACMU

UniProt

P63310 - IFNG_MACMU

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Protein

Interferon gamma

Gene

IFNG

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Biological processi

  1. adaptive immune response Source: Ensembl
  2. antigen processing and presentation Source: Ensembl
  3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
  4. cell cycle arrest Source: Ensembl
  5. cellular response to interleukin-18 Source: Ensembl
  6. cellular response to lipopolysaccharide Source: Ensembl
  7. defense response to bacterium Source: Ensembl
  8. defense response to protozoan Source: Ensembl
  9. defense response to virus Source: UniProtKB-KW
  10. endoplasmic reticulum unfolded protein response Source: Ensembl
  11. extrinsic apoptotic signaling pathway Source: Ensembl
  12. humoral immune response Source: Ensembl
  13. negative regulation of growth of symbiont in host Source: Ensembl
  14. negative regulation of interleukin-17 production Source: Ensembl
  15. negative regulation of myelination Source: Ensembl
  16. negative regulation of smooth muscle cell proliferation Source: Ensembl
  17. neutrophil apoptotic process Source: Ensembl
  18. neutrophil chemotaxis Source: Ensembl
  19. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  20. positive regulation of chemokine biosynthetic process Source: Ensembl
  21. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
  22. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
  23. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
  24. positive regulation of interleukin-12 production Source: Ensembl
  25. positive regulation of interleukin-1 beta secretion Source: Ensembl
  26. positive regulation of interleukin-23 production Source: Ensembl
  27. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
  28. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  29. positive regulation of killing of cells of other organism Source: Ensembl
  30. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  31. positive regulation of MHC class II biosynthetic process Source: Ensembl
  32. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  33. positive regulation of osteoclast differentiation Source: Ensembl
  34. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
  35. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
  36. positive regulation of T cell proliferation Source: Ensembl
  37. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  38. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
  39. positive regulation of tumor necrosis factor production Source: Ensembl
  40. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  41. positive regulation of vitamin D biosynthetic process Source: Ensembl
  42. protein import into nucleus, translocation Source: Ensembl
  43. regulation of insulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 165142Interferon gammaPRO_0000016447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP63310.
SMRiP63310. Positions 24-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45353.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP63310.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63310-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYTSYILAF QLCIVLGSLG CYCQDPYVKE AENLKKYFNA GDPDVADNGT
60 70 80 90 100
LFLDILRNWK EESDRKIMQS QIVSFYFKLF KNFKDDQRIQ KSVETIKEDI
110 120 130 140 150
NVKFFNSNKK KRDDFEKLTN YSVTDSNVQR KAVHELIQVM AELSPAAKIG
160
KRKRSQMFRG RRASQ
Length:165
Mass (Da):19,332
Last modified:October 11, 2004 - v1
Checksum:i37AA9FF7FC2E948F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26024 mRNA. Translation: AAA99973.1.
AY376145 mRNA. Translation: AAQ87963.1.
RefSeqiNP_001028077.1. NM_001032905.1.
UniGeneiMmu.3373.

Genome annotation databases

EnsembliENSMMUT00000027007; ENSMMUP00000025266; ENSMMUG00000019225.
GeneIDi574282.
KEGGimcc:574282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26024 mRNA. Translation: AAA99973.1 .
AY376145 mRNA. Translation: AAQ87963.1 .
RefSeqi NP_001028077.1. NM_001032905.1.
UniGenei Mmu.3373.

3D structure databases

ProteinModelPortali P63310.
SMRi P63310. Positions 24-155.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMMUT00000027007 ; ENSMMUP00000025266 ; ENSMMUG00000019225 .
GeneIDi 574282.
KEGGi mcc:574282.

Organism-specific databases

CTDi 3458.

Phylogenomic databases

eggNOGi NOG45353.
GeneTreei ENSGT00390000007831.
HOGENOMi HOG000254784.
HOVERGENi HBG056912.
InParanoidi P63310.
KOi K04687.
OMAi KEYFNAS.
OrthoDBi EOG7VHSZM.
TreeFami TF336308.

Miscellaneous databases

NextBioi 19970875.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view ]
PANTHERi PTHR11419. PTHR11419. 1 hit.
Pfami PF00714. IFN-gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF001936. IFN-gamma. 1 hit.
ProDomi PD002435. Interferon_gamma. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative sequence analysis of cytokine genes from human and nonhuman primates."
    Villinger F.J., Brar S.S., Mayne A.E., Chikkala N., Ansari A.A.
    J. Immunol. 155:3946-3954(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma."
    Stahl-Hennig C., Gundlach B.R., Dittmer U., ten Haaft P., Heeney J., Zou W., Emilie D., Sopper S., Uberla K.
    Virology 305:473-485(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIFNG_MACMU
AccessioniPrimary (citable) accession number: P63310
Secondary accession number(s): P42163, P42164, Q53Z08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3