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P63310

- IFNG_MACMU

UniProt

P63310 - IFNG_MACMU

Protein

Interferon gamma

Gene

IFNG

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

    GO - Biological processi

    1. adaptive immune response Source: Ensembl
    2. antigen processing and presentation Source: Ensembl
    3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: Ensembl
    4. cell cycle arrest Source: Ensembl
    5. cellular response to interleukin-18 Source: Ensembl
    6. cellular response to lipopolysaccharide Source: Ensembl
    7. defense response to bacterium Source: Ensembl
    8. defense response to protozoan Source: Ensembl
    9. defense response to virus Source: UniProtKB-KW
    10. endoplasmic reticulum unfolded protein response Source: Ensembl
    11. extrinsic apoptotic signaling pathway Source: Ensembl
    12. humoral immune response Source: Ensembl
    13. negative regulation of growth of symbiont in host Source: Ensembl
    14. negative regulation of interleukin-17 production Source: Ensembl
    15. negative regulation of myelination Source: Ensembl
    16. negative regulation of smooth muscle cell proliferation Source: Ensembl
    17. neutrophil apoptotic process Source: Ensembl
    18. neutrophil chemotaxis Source: Ensembl
    19. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    20. positive regulation of chemokine biosynthetic process Source: Ensembl
    21. positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
    22. positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
    23. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
    24. positive regulation of interleukin-12 production Source: Ensembl
    25. positive regulation of interleukin-1 beta secretion Source: Ensembl
    26. positive regulation of interleukin-23 production Source: Ensembl
    27. positive regulation of interleukin-6 biosynthetic process Source: Ensembl
    28. positive regulation of isotype switching to IgG isotypes Source: Ensembl
    29. positive regulation of killing of cells of other organism Source: Ensembl
    30. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    31. positive regulation of MHC class II biosynthetic process Source: Ensembl
    32. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    33. positive regulation of osteoclast differentiation Source: Ensembl
    34. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
    35. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
    36. positive regulation of T cell proliferation Source: Ensembl
    37. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    38. positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
    39. positive regulation of tumor necrosis factor production Source: Ensembl
    40. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    41. positive regulation of vitamin D biosynthetic process Source: Ensembl
    42. protein import into nucleus, translocation Source: Ensembl
    43. regulation of insulin secretion Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense, Growth regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon gamma
    Short name:
    IFN-gamma
    Gene namesi
    Name:IFNG
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Chromosome 11

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 165142Interferon gammaPRO_0000016447Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Pyrrolidone carboxylic acid

    Expressioni

    Tissue specificityi

    Released primarily from activated T lymphocytes.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP63310.
    SMRiP63310. Positions 24-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45353.
    GeneTreeiENSGT00390000007831.
    HOGENOMiHOG000254784.
    HOVERGENiHBG056912.
    InParanoidiQ53Z08.
    KOiK04687.
    OMAiKEYFNAS.
    OrthoDBiEOG7VHSZM.
    TreeFamiTF336308.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view]
    PANTHERiPTHR11419. PTHR11419. 1 hit.
    PfamiPF00714. IFN-gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001936. IFN-gamma. 1 hit.
    ProDomiPD002435. Interferon_gamma. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P63310-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYTSYILAF QLCIVLGSLG CYCQDPYVKE AENLKKYFNA GDPDVADNGT    50
    LFLDILRNWK EESDRKIMQS QIVSFYFKLF KNFKDDQRIQ KSVETIKEDI 100
    NVKFFNSNKK KRDDFEKLTN YSVTDSNVQR KAVHELIQVM AELSPAAKIG 150
    KRKRSQMFRG RRASQ 165
    Length:165
    Mass (Da):19,332
    Last modified:October 11, 2004 - v1
    Checksum:i37AA9FF7FC2E948F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26024 mRNA. Translation: AAA99973.1.
    AY376145 mRNA. Translation: AAQ87963.1.
    RefSeqiNP_001028077.1. NM_001032905.1.
    UniGeneiMmu.3373.

    Genome annotation databases

    EnsembliENSMMUT00000027007; ENSMMUP00000025266; ENSMMUG00000019225.
    GeneIDi574282.
    KEGGimcc:574282.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26024 mRNA. Translation: AAA99973.1 .
    AY376145 mRNA. Translation: AAQ87963.1 .
    RefSeqi NP_001028077.1. NM_001032905.1.
    UniGenei Mmu.3373.

    3D structure databases

    ProteinModelPortali P63310.
    SMRi P63310. Positions 24-155.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000027007 ; ENSMMUP00000025266 ; ENSMMUG00000019225 .
    GeneIDi 574282.
    KEGGi mcc:574282.

    Organism-specific databases

    CTDi 3458.

    Phylogenomic databases

    eggNOGi NOG45353.
    GeneTreei ENSGT00390000007831.
    HOGENOMi HOG000254784.
    HOVERGENi HBG056912.
    InParanoidi Q53Z08.
    KOi K04687.
    OMAi KEYFNAS.
    OrthoDBi EOG7VHSZM.
    TreeFami TF336308.

    Miscellaneous databases

    NextBioi 19970875.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002069. Interferon_gamma.
    [Graphical view ]
    PANTHERi PTHR11419. PTHR11419. 1 hit.
    Pfami PF00714. IFN-gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001936. IFN-gamma. 1 hit.
    ProDomi PD002435. Interferon_gamma. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative sequence analysis of cytokine genes from human and nonhuman primates."
      Villinger F.J., Brar S.S., Mayne A.E., Chikkala N., Ansari A.A.
      J. Immunol. 155:3946-3954(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma."
      Stahl-Hennig C., Gundlach B.R., Dittmer U., ten Haaft P., Heeney J., Zou W., Emilie D., Sopper S., Uberla K.
      Virology 305:473-485(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiIFNG_MACMU
    AccessioniPrimary (citable) accession number: P63310
    Secondary accession number(s): P42163, P42164, Q53Z08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3