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P63310 (IFNG_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon gamma

Short name=IFN-gamma
Gene names
Name:IFNG
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Subunit structure

Homodimer.

Subcellular location

Secreted.

Tissue specificity

Released primarily from activated T lymphocytes.

Sequence similarities

Belongs to the type II (or gamma) interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
Growth regulation
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCD8-positive, alpha-beta T cell differentiation involved in immune response

Inferred from electronic annotation. Source: Ensembl

adaptive immune response

Inferred from electronic annotation. Source: Ensembl

antigen processing and presentation

Inferred from electronic annotation. Source: Ensembl

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-18

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

defense response to bacterium

Inferred from electronic annotation. Source: Ensembl

defense response to protozoan

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

endoplasmic reticulum unfolded protein response

Inferred from electronic annotation. Source: Ensembl

extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

humoral immune response

Inferred from electronic annotation. Source: Ensembl

negative regulation of growth of symbiont in host

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of myelination

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

neutrophil apoptotic process

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of MHC class II biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcidiol 1-monooxygenase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemokine biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of fructose 1,6-bisphosphate metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-1 beta secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-23 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of isotype switching to IgG isotypes

Inferred from electronic annotation. Source: Ensembl

positive regulation of killing of cells of other organism

Inferred from electronic annotation. Source: Ensembl

positive regulation of membrane protein ectodomain proteolysis

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric oxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoclast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat1 protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of vitamin D biosynthetic process

Inferred from electronic annotation. Source: Ensembl

protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 165142Interferon gamma
PRO_0000016447

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid By similarity
Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation1201N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P63310 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 37AA9FF7FC2E948F

FASTA16519,332
        10         20         30         40         50         60 
MKYTSYILAF QLCIVLGSLG CYCQDPYVKE AENLKKYFNA GDPDVADNGT LFLDILRNWK 

        70         80         90        100        110        120 
EESDRKIMQS QIVSFYFKLF KNFKDDQRIQ KSVETIKEDI NVKFFNSNKK KRDDFEKLTN 

       130        140        150        160 
YSVTDSNVQR KAVHELIQVM AELSPAAKIG KRKRSQMFRG RRASQ 

« Hide

References

[1]"Comparative sequence analysis of cytokine genes from human and nonhuman primates."
Villinger F.J., Brar S.S., Mayne A.E., Chikkala N., Ansari A.A.
J. Immunol. 155:3946-3954(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma."
Stahl-Hennig C., Gundlach B.R., Dittmer U., ten Haaft P., Heeney J., Zou W., Emilie D., Sopper S., Uberla K.
Virology 305:473-485(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L26024 mRNA. Translation: AAA99973.1.
AY376145 mRNA. Translation: AAQ87963.1.
RefSeqNP_001028077.1. NM_001032905.1.
UniGeneMmu.3373.

3D structure databases

ProteinModelPortalP63310.
SMRP63310. Positions 24-155.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMMUT00000027007; ENSMMUP00000025266; ENSMMUG00000019225.
GeneID574282.
KEGGmcc:574282.

Organism-specific databases

CTD3458.

Phylogenomic databases

eggNOGNOG45353.
GeneTreeENSGT00390000007831.
HOGENOMHOG000254784.
HOVERGENHBG056912.
InParanoidQ53Z08.
KOK04687.
OMAKEYFNAS.
OrthoDBEOG7VHSZM.
TreeFamTF336308.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERPTHR11419. PTHR11419. 1 hit.
PfamPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFPIRSF001936. IFN-gamma. 1 hit.
ProDomPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio19970875.

Entry information

Entry nameIFNG_MACMU
AccessionPrimary (citable) accession number: P63310
Secondary accession number(s): P42163, P42164, Q53Z08
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families