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Protein

Selenoprotein W

Gene

SELENOW

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAntioxidant

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein W2 Publications
Short name:
SelW1 Publication
Gene namesi
Name:SELENOW1 PublicationImported
Synonyms:SELW1 Publication, SEPW11 PublicationImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000178980.14.
HGNCiHGNC:10752. SELENOW.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6415.
OpenTargetsiENSG00000178980.
PharmGKBiPA35673.

Polymorphism and mutation databases

BioMutaiSEPW1.
DMDMi190358772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976781 – 87Selenoprotein WAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki10 ↔ 13Cysteinyl-selenocysteine (Cys-Sec); redox-activeBy similarity
Modified residuei37S-glutathionyl cysteineBy similarity1

Keywords - PTMi

Glutathionylation

Proteomic databases

EPDiP63302.
PaxDbiP63302.
PeptideAtlasiP63302.
PRIDEiP63302.

PTM databases

iPTMnetiP63302.
PhosphoSitePlusiP63302.

Expressioni

Tissue specificityi

Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.2 Publications

Gene expression databases

BgeeiENSG00000178980.
CleanExiHS_SEPW1.
ExpressionAtlasiP63302. baseline and differential.
GenevisibleiP63302. HS.

Interactioni

Subunit structurei

Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.By similarity

Protein-protein interaction databases

BioGridi112314. 1 interactor.
STRINGi9606.ENSP00000422644.

Structurei

3D structure databases

ProteinModelPortaliP63302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG410J485. Eukaryota.
ENOG41127WK. LUCA.
GeneTreeiENSGT00530000064138.
HOGENOMiHOG000286957.
HOVERGENiHBG059755.
InParanoidiP63302.
PhylomeDBiP63302.

Family and domain databases

InterProiView protein in InterPro
IPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF10262. Rdx. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.

Sequencei

Sequence statusi: Complete.

P63302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAVRVVYC GAUGYKSKYL QLKKKLEDEF PGRLDICGEG TPQATGFFEV
60 70 80
MVAGKLIHSK KKGDGYVDTE SKFLKLVAAI KAALAQG
Length:87
Mass (Da):9,448
Last modified:February 26, 2008 - v3
Checksum:iF8FDF3194B0654E9
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei13Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67171 mRNA. Translation: AAC51665.1.
AF015283 mRNA. Translation: AAB69859.1.
AF247455, AF247454 Genomic DNA. Translation: AAL00898.1.
AC008745 Genomic DNA. No translation available.
BC000581 mRNA. Translation: AAH00581.1.
BC032546 mRNA. Translation: AAH32546.1.
BC039597 mRNA. Translation: AAH39597.1.
BC047893 mRNA. Translation: AAH47893.2.
CCDSiCCDS59402.1.
RefSeqiNP_003000.1. NM_003009.2.
UniGeneiHs.631549.

Genome annotation databases

EnsembliENST00000593892; ENSP00000471149; ENSG00000178980.
ENST00000595615; ENSP00000470941; ENSG00000178980.
ENST00000601048; ENSP00000473185; ENSG00000178980.
GeneIDi6415.
KEGGihsa:6415.
UCSCiuc021uwp.2. human.

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSELW_HUMAN
AccessioniPrimary (citable) accession number: P63302
Secondary accession number(s): A8MRR7
, O15532, O19096, Q86TI9, Q96KM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 26, 2008
Last modified: September 27, 2017
This is version 98 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families