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Protein

Selenoprotein W

Gene

SELENOW

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAntioxidant

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein W2 Publications
Short name:
SelW1 Publication
Gene namesi
Name:SELENOW1 PublicationImported
Synonyms:SELW1 Publication, SEPW11 PublicationImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000178980.14
HGNCiHGNC:10752 SELENOW
MIMi603235 gene
neXtProtiNX_P63302

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6415
OpenTargetsiENSG00000178980
PharmGKBiPA35673

Polymorphism and mutation databases

BioMutaiSEPW1
DMDMi190358772

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976781 – 87Selenoprotein WAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki10 ↔ 13Cysteinyl-selenocysteine (Cys-Sec); redox-activeBy similarity
Modified residuei37S-glutathionyl cysteineBy similarity1

Keywords - PTMi

Glutathionylation

Proteomic databases

PaxDbiP63302
PeptideAtlasiP63302
PRIDEiP63302

PTM databases

iPTMnetiP63302
PhosphoSitePlusiP63302

Expressioni

Tissue specificityi

Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.2 Publications

Gene expression databases

BgeeiENSG00000178980
CleanExiHS_SEPW1
ExpressionAtlasiP63302 baseline and differential
GenevisibleiP63302 HS

Interactioni

Subunit structurei

Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.By similarity

Protein-protein interaction databases

BioGridi112314, 1 interactor
STRINGi9606.ENSP00000422644

Structurei

3D structure databases

ProteinModelPortaliP63302
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG410J485 Eukaryota
ENOG41127WK LUCA
GeneTreeiENSGT00530000064138
HOGENOMiHOG000286957
HOVERGENiHBG059755
InParanoidiP63302
PhylomeDBiP63302

Family and domain databases

InterProiView protein in InterPro
IPR011893 Selenoprotein_Rdx-typ
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF10262 Rdx, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02174 CXXU_selWTH, 1 hit

Sequencei

Sequence statusi: Complete.

P63302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAVRVVYC GAUGYKSKYL QLKKKLEDEF PGRLDICGEG TPQATGFFEV
60 70 80
MVAGKLIHSK KKGDGYVDTE SKFLKLVAAI KAALAQG
Length:87
Mass (Da):9,448
Last modified:February 26, 2008 - v3
Checksum:iF8FDF3194B0654E9
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei13Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67171 mRNA Translation: AAC51665.1
AF015283 mRNA Translation: AAB69859.1
AF247455, AF247454 Genomic DNA Translation: AAL00898.1
AC008745 Genomic DNA No translation available.
BC000581 mRNA Translation: AAH00581.1
BC032546 mRNA Translation: AAH32546.1
BC039597 mRNA Translation: AAH39597.1
BC047893 mRNA Translation: AAH47893.2
CCDSiCCDS59402.1
RefSeqiNP_003000.1, NM_003009.2
UniGeneiHs.631549

Genome annotation databases

EnsembliENST00000593892; ENSP00000471149; ENSG00000178980
ENST00000595615; ENSP00000470941; ENSG00000178980
ENST00000601048; ENSP00000473185; ENSG00000178980
GeneIDi6415
KEGGihsa:6415
UCSCiuc021uwp.2 human

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSELW_HUMAN
AccessioniPrimary (citable) accession number: P63302
Secondary accession number(s): A8MRR7
, O15532, O19096, Q86TI9, Q96KM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 26, 2008
Last modified: February 28, 2018
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health