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Protein

Selenoprotein W

Gene

SEPW1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein W
Short name:
SelW
Gene namesi
Name:SEPW1
Synonyms:SELW
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10752. SEPW1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35673.

Polymorphism and mutation databases

BioMutaiSEPW1.
DMDMi190358772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 8786Selenoprotein WPRO_0000097678Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki10 ↔ 13Cysteinyl-selenocysteine (Cys-Sec); redox-activeBy similarity
Modified residuei37 – 371S-glutathionyl cysteineBy similarity

Keywords - PTMi

Glutathionylation

Proteomic databases

EPDiP63302.
PaxDbiP63302.
PeptideAtlasiP63302.
PRIDEiP63302.

PTM databases

iPTMnetiP63302.
PhosphoSiteiP63302.

Expressioni

Tissue specificityi

Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.2 Publications

Gene expression databases

CleanExiHS_SEPW1.
ExpressionAtlasiP63302. baseline and differential.
GenevisibleiP63302. HS.

Interactioni

Subunit structurei

Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.By similarity

Protein-protein interaction databases

BioGridi112314. 1 interaction.
STRINGi9606.ENSP00000422644.

Structurei

3D structure databases

ProteinModelPortaliP63302.
SMRiP63302. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SelWTH family. SELW subfamily.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG410J485. Eukaryota.
ENOG41127WK. LUCA.
GeneTreeiENSGT00530000064138.
HOGENOMiHOG000286957.
HOVERGENiHBG059755.
InParanoidiP63302.
OrthoDBiEOG7QRQXF.
PhylomeDBiP63302.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAVRVVYC GAUGYKSKYL QLKKKLEDEF PGRLDICGEG TPQATGFFEV
60 70 80
MVAGKLIHSK KKGDGYVDTE SKFLKLVAAI KAALAQG
Length:87
Mass (Da):9,448
Last modified:February 26, 2008 - v3
Checksum:iF8FDF3194B0654E9
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei13 – 131Selenocysteine

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67171 mRNA. Translation: AAC51665.1.
AF015283 mRNA. Translation: AAB69859.1.
AF247455, AF247454 Genomic DNA. Translation: AAL00898.1.
AC008745 Genomic DNA. No translation available.
BC000581 mRNA. Translation: AAH00581.1.
BC032546 mRNA. Translation: AAH32546.1.
BC039597 mRNA. Translation: AAH39597.1.
BC047893 mRNA. Translation: AAH47893.2.
CCDSiCCDS59402.1.
RefSeqiNP_003000.1. NM_003009.2.
UniGeneiHs.631549.

Genome annotation databases

EnsembliENST00000593892; ENSP00000471149; ENSG00000178980.
ENST00000595615; ENSP00000470941; ENSG00000178980.
ENST00000601048; ENSP00000473185; ENSG00000178980.
GeneIDi6415.
KEGGihsa:6415.
UCSCiuc021uwp.2. human.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67171 mRNA. Translation: AAC51665.1.
AF015283 mRNA. Translation: AAB69859.1.
AF247455, AF247454 Genomic DNA. Translation: AAL00898.1.
AC008745 Genomic DNA. No translation available.
BC000581 mRNA. Translation: AAH00581.1.
BC032546 mRNA. Translation: AAH32546.1.
BC039597 mRNA. Translation: AAH39597.1.
BC047893 mRNA. Translation: AAH47893.2.
CCDSiCCDS59402.1.
RefSeqiNP_003000.1. NM_003009.2.
UniGeneiHs.631549.

3D structure databases

ProteinModelPortaliP63302.
SMRiP63302. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112314. 1 interaction.
STRINGi9606.ENSP00000422644.

PTM databases

iPTMnetiP63302.
PhosphoSiteiP63302.

Polymorphism and mutation databases

BioMutaiSEPW1.
DMDMi190358772.

Proteomic databases

EPDiP63302.
PaxDbiP63302.
PeptideAtlasiP63302.
PRIDEiP63302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000593892; ENSP00000471149; ENSG00000178980.
ENST00000595615; ENSP00000470941; ENSG00000178980.
ENST00000601048; ENSP00000473185; ENSG00000178980.
GeneIDi6415.
KEGGihsa:6415.
UCSCiuc021uwp.2. human.

Organism-specific databases

CTDi6415.
GeneCardsiSEPW1.
H-InvDBHIX0202735.
HGNCiHGNC:10752. SEPW1.
MIMi603235. gene.
neXtProtiNX_P63302.
PharmGKBiPA35673.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J485. Eukaryota.
ENOG41127WK. LUCA.
GeneTreeiENSGT00530000064138.
HOGENOMiHOG000286957.
HOVERGENiHBG059755.
InParanoidiP63302.
OrthoDBiEOG7QRQXF.
PhylomeDBiP63302.

Miscellaneous databases

ChiTaRSiSEPW1. human.
GeneWikiiSEPW1.
GenomeRNAii6415.
PROiP63302.
SOURCEiSearch...

Gene expression databases

CleanExiHS_SEPW1.
ExpressionAtlasiP63302. baseline and differential.
GenevisibleiP63302. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species."
    Gu Q.-P., Beilstein M.A., Vendeland S.C., Lugade A., Ream W., Whanger P.D.
    Gene 193:187-196(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P."
    Bellingham J., Gregory-Evans K., Fox M.F., Gregory-Evans C.Y.
    Biochim. Biophys. Acta 1627:140-146(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Tissue: Placenta.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, PNS, Testis and Uterus.
  5. "Selenoprotein W accumulates primarily in primate skeletal muscle, heart, brain and tongue."
    Gu Q.P., Sun Y., Ream L.W., Whanger P.D.
    Mol. Cell. Biochem. 204:49-56(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSELW_HUMAN
AccessioniPrimary (citable) accession number: P63302
Secondary accession number(s): A8MRR7
, O15532, O19096, Q86TI9, Q96KM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 26, 2008
Last modified: July 6, 2016
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.