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P63300

- SELW_MOUSE

UniProt

P63300 - SELW_MOUSE

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Protein

Selenoprotein W

Gene
Sepw1, Selw
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.3 Publications

GO - Molecular functioni

  1. antioxidant activity Source: UniProtKB-KW
  2. oxidoreductase activity Source: UniProtKB
  3. selenium binding Source: InterPro

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. oxidation-reduction process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein W
Short name:
SelW
Gene namesi
Name:Sepw1
Synonyms:Selw
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1100878. Sepw1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi10 – 101C → S: Disrupts redox reaction.
Mutagenesisi13 – 131U → C: Increased sensitivity to hydrogen peroxide-induced toxicity. 1 Publication
Mutagenesisi13 – 131U → S: Impairs protection against hydrogen peroxide-induced toxicity. 1 Publication
Mutagenesisi37 – 371C → S: Impairs protection against hydrogen peroxide-induced toxicity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 8887Selenoprotein WPRO_0000097680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki10 ↔ 13Cysteinyl-selenocysteine (Cys-Sec); redox-active By similarity
Modified residuei37 – 371S-glutathionyl cysteine By similarity

Keywords - PTMi

Glutathionylation

Proteomic databases

PaxDbiP63300.
PRIDEiP63300.

PTM databases

PhosphoSiteiP63300.

Expressioni

Tissue specificityi

In the embryo, expressed in the developing nervous system and in mesoderm-derived tissues such as heart and limbs. In the adult, predominantly expressed in brain, skeletal muscle and heart.2 Publications

Developmental stagei

Expression is first detected in the newly implanted embryo. Levels increase gradually during embryonic development with a steady increase during the second week and a dramatic increase by the end of gestation. Expression increases gradually in proliferating myotubes but is low in terminally differentiated myobutubes.1 Publication

Inductioni

Down-regulated by hydrogen peroxide. Increased levels are detected after treatment with L-buthionine sulfoxide (BSO) before exposure to hydrogen peroxide.1 Publication

Gene expression databases

BgeeiP63300.
CleanExiMM_SEPW1.
GenevestigatoriP63300.

Interactioni

Subunit structurei

Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038943.

Structurei

Secondary structure

1
88
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86
Helixi15 – 2915
Beta strandi34 – 385
Beta strandi49 – 524
Beta strandi55 – 595
Turni60 – 634
Helixi70 – 8718

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NPBNMR-A1-88[»]
ProteinModelPortaliP63300.
SMRiP63300. Positions 1-88.

Miscellaneous databases

EvolutionaryTraceiP63300.

Family & Domainsi

Sequence similaritiesi

Belongs to the SelWTH family. SELW subfamily.

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiNOG84296.
GeneTreeiENSGT00530000064138.
HOGENOMiHOG000286957.
HOVERGENiHBG059755.
InParanoidiP63300.
OMAiKKRGDGY.
OrthoDBiEOG7QRQXF.
PhylomeDBiP63300.
TreeFamiTF326627.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63300-1 [UniParc]FASTAAdd to Basket

« Hide

MALAVRVVYC GAUGYKPKYL QLKEKLEHEF PGCLDICGEG TPQVTGFFEV   50
TVAGKLVHSK KRGDGYVDTE SKFRKLVTAI KAALAQCQ 88
Length:88
Mass (Da):9,687
Last modified:February 26, 2008 - v3
Checksum:i03E297B668D3D7E0
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei13 – 131Selenocysteine

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67890 mRNA. Translation: AAC53317.1.
AF241527 mRNA. Translation: AAF64481.1.
AF015284 mRNA. Translation: AAB69860.1.
AK002870 mRNA. Translation: BAC55247.1.
AK028124 mRNA. Translation: BAC55256.1.
BC052719 mRNA. Translation: AAH52719.2.
CCDSiCCDS39778.1.
RefSeqiNP_033182.1. NM_009156.2.
UniGeneiMm.42829.

Genome annotation databases

EnsembliENSMUST00000044355; ENSMUSP00000038943; ENSMUSG00000041571.
GeneIDi20364.
KEGGimmu:20364.
UCSCiuc009fgp.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67890 mRNA. Translation: AAC53317.1 .
AF241527 mRNA. Translation: AAF64481.1 .
AF015284 mRNA. Translation: AAB69860.1 .
AK002870 mRNA. Translation: BAC55247.1 .
AK028124 mRNA. Translation: BAC55256.1 .
BC052719 mRNA. Translation: AAH52719.2 .
CCDSi CCDS39778.1.
RefSeqi NP_033182.1. NM_009156.2.
UniGenei Mm.42829.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2NPB NMR - A 1-88 [» ]
ProteinModelPortali P63300.
SMRi P63300. Positions 1-88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000038943.

PTM databases

PhosphoSitei P63300.

Proteomic databases

PaxDbi P63300.
PRIDEi P63300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044355 ; ENSMUSP00000038943 ; ENSMUSG00000041571 .
GeneIDi 20364.
KEGGi mmu:20364.
UCSCi uc009fgp.1. mouse.

Organism-specific databases

CTDi 6415.
MGIi MGI:1100878. Sepw1.

Phylogenomic databases

eggNOGi NOG84296.
GeneTreei ENSGT00530000064138.
HOGENOMi HOG000286957.
HOVERGENi HBG059755.
InParanoidi P63300.
OMAi KKRGDGY.
OrthoDBi EOG7QRQXF.
PhylomeDBi P63300.
TreeFami TF326627.

Miscellaneous databases

EvolutionaryTracei P63300.
NextBioi 298265.
PROi P63300.
SOURCEi Search...

Gene expression databases

Bgeei P63300.
CleanExi MM_SEPW1.
Genevestigatori P63300.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF10262. Rdx. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR02174. CXXU_selWTH. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species."
    Gu Q.-P., Beilstein M.A., Vendeland S.C., Lugade A., Ream W., Whanger P.D.
    Gene 193:187-196(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Selenoprotein W is a glutathione-dependent antioxidant in vivo."
    Jeong D., Kim T.S., Chung Y.W., Lee B.J., Kim I.Y.
    FEBS Lett. 517:225-228(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF SEC-13 AND CYS-37.
    Tissue: Brain.
  3. "SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family."
    Dikiy A., Novoselov S.V., Fomenko D.E., Sengupta A., Carlson B.A., Cerny R.L., Ginalski K., Grishin N.V., Hatfield D.L., Gladyshev V.N.
    Biochemistry 46:6871-6882(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH YWHAB; YWHAG; DPYSL2; PRDX1; HSP70 AND HSP90, TISSUE SPECIFICITY.
    Tissue: Brain.
  4. Bellingham J., Gregory-Evans C.Y.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Fetus.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Stomach.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  7. "Selenoprotein W during development and oxidative stress."
    Loflin J., Lopez N., Whanger P.D., Kioussi C.
    J. Inorg. Biochem. 100:1679-1684(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, INDUCTION.
  8. "Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins."
    Aachmann F.L., Fomenko D.E., Soragni A., Gladyshev V.N., Dikiy A.
    J. Biol. Chem. 282:37036-37044(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF MUTANT SER-10/CYS-13, INTERACTION WITH YWHAB AND YWHAG.

Entry informationi

Entry nameiSELW_MOUSE
AccessioniPrimary (citable) accession number: P63300
Secondary accession number(s): O35965, P49904, Q9JIC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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