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Protein

Somatoliberin

Gene

GHRH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

GO - Molecular functioni

  • growth hormone-releasing hormone activity Source: CAFA
  • growth hormone-releasing hormone receptor binding Source: Ensembl

GO - Biological processi

  • adenohypophysis development Source: Ensembl
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  • cAMP-mediated signaling Source: Ensembl
  • cellular response to calcium ion Source: CAFA
  • growth hormone secretion Source: Ensembl
  • positive regulation of cAMP biosynthetic process Source: CAFA
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of growth hormone secretion Source: AgBase
  • positive regulation of insulin secretion Source: AgBase
  • positive regulation of lactation Source: AgBase
  • positive regulation of multicellular organism growth Source: Ensembl
  • response to food Source: Ensembl

Enzyme and pathway databases

ReactomeiR-BTA-418555. G alpha (s) signalling events.
R-BTA-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatoliberin
Alternative name(s):
Growth hormone-releasing factor
Short name:
GRF
Growth hormone-releasing hormone
Short name:
GHRH
Gene namesi
Name:GHRH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000001143520 – 301 PublicationAdd BLAST11
PeptideiPRO_000001143631 – 74SomatoliberinAdd BLAST44
PropeptideiPRO_000001143777 – 106Add BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74Leucine amide1 Publication1

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiP63292.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012710.

Interactioni

GO - Molecular functioni

  • growth hormone-releasing hormone activity Source: CAFA
  • growth hormone-releasing hormone receptor binding Source: Ensembl

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016891.

Structurei

3D structure databases

DisProtiDP00125.
SMRiP63292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
GeneTreeiENSGT00390000008103.
HOGENOMiHOG000115417.
HOVERGENiHBG004478.
InParanoidiP63292.
KOiK05260.
OMAiPLWVFFF.
OrthoDBiEOG091G11MO.
TreeFamiTF353187.

Family and domain databases

InterProiView protein in InterPro
IPR000532. Glucagon_GIP_secretin_VIP.
PfamiView protein in Pfam
PF00123. Hormone_2. 1 hit.
SMARTiView protein in SMART
SM00070. GLUCA. 1 hit.
PROSITEiView protein in PROSITE
PS00260. GLUCAGON. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLWVFFLVT LTLSSGSHGS LPSQPLRIPR YADAIFTNSY RKVLGQLSAR
60 70 80 90 100
KLLQDIMNRQ QGERNQEQGA KVRLGRQVDG VWTDQQQMAL ESTLVSLLQE

RRNSQG
Length:106
Mass (Da):12,058
Last modified:October 11, 2004 - v1
Checksum:i6584F4F25ABEF178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242855 Genomic DNA. Translation: AAF89171.1.
PIRiA01554. RHBOS.
RefSeqiNP_847895.1. NM_178325.1.
UniGeneiBt.45045.

Genome annotation databases

EnsembliENSBTAT00000016891; ENSBTAP00000016891; ENSBTAG00000012710.
GeneIDi281191.
KEGGibta:281191.

Similar proteinsi

Entry informationi

Entry nameiSLIB_BOVIN
AccessioniPrimary (citable) accession number: P63292
Secondary accession number(s): P01288, Q9MZD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 11, 2004
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families