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Protein

Somatoliberin

Gene

GHRH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-418555. G alpha (s) signalling events.
R-BTA-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatoliberin
Alternative name(s):
Growth hormone-releasing factor
Short name:
GRF
Growth hormone-releasing hormone
Short name:
GHRH
Gene namesi
Name:GHRH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 30111 PublicationPRO_0000011435Add
BLAST
Peptidei31 – 7444SomatoliberinPRO_0000011436Add
BLAST
Propeptidei77 – 10630PRO_0000011437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei74 – 741Leucine amide

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiP63292.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016891.

Structurei

3D structure databases

DisProtiDP00125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
GeneTreeiENSGT00390000008103.
HOGENOMiHOG000115417.
HOVERGENiHBG004478.
InParanoidiP63292.
KOiK05260.
OMAiIMSRQQG.
OrthoDBiEOG091G11MO.
TreeFamiTF353187.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLWVFFLVT LTLSSGSHGS LPSQPLRIPR YADAIFTNSY RKVLGQLSAR
60 70 80 90 100
KLLQDIMNRQ QGERNQEQGA KVRLGRQVDG VWTDQQQMAL ESTLVSLLQE

RRNSQG
Length:106
Mass (Da):12,058
Last modified:October 11, 2004 - v1
Checksum:i6584F4F25ABEF178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242855 Genomic DNA. Translation: AAF89171.1.
PIRiA01554. RHBOS.
RefSeqiNP_847895.1. NM_178325.1.
UniGeneiBt.45045.

Genome annotation databases

EnsembliENSBTAT00000016891; ENSBTAP00000016891; ENSBTAG00000012710.
GeneIDi281191.
KEGGibta:281191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242855 Genomic DNA. Translation: AAF89171.1.
PIRiA01554. RHBOS.
RefSeqiNP_847895.1. NM_178325.1.
UniGeneiBt.45045.

3D structure databases

DisProtiDP00125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016891.

Proteomic databases

PaxDbiP63292.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016891; ENSBTAP00000016891; ENSBTAG00000012710.
GeneIDi281191.
KEGGibta:281191.

Organism-specific databases

CTDi2691.

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
GeneTreeiENSGT00390000008103.
HOGENOMiHOG000115417.
HOVERGENiHBG004478.
InParanoidiP63292.
KOiK05260.
OMAiIMSRQQG.
OrthoDBiEOG091G11MO.
TreeFamiTF353187.

Enzyme and pathway databases

ReactomeiR-BTA-418555. G alpha (s) signalling events.
R-BTA-420092. Glucagon-type ligand receptors.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
[Graphical view]
PfamiPF00123. Hormone_2. 1 hit.
[Graphical view]
SMARTiSM00070. GLUCA. 1 hit.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLIB_BOVIN
AccessioniPrimary (citable) accession number: P63292
Secondary accession number(s): P01288, Q9MZD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.