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Protein

Vasoactive intestinal peptide

Gene

VIP

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Vasoactive intestinal peptide
Short name:
VIP
Alternative name(s):
Vasoactive intestinal polypeptide
Gene namesi
Name:VIP
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000439431 – 28Vasoactive intestinal peptideAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28Asparagine amide1 Publication1

Keywords - PTMi

Amidation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP63291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Phylogenomic databases

HOVERGENiHBG008141.

Family and domain databases

InterProiView protein in InterPro
IPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
PANTHERiPTHR11213:SF10. PTHR11213:SF10. 1 hit.
PfamiView protein in Pfam
PF00123. Hormone_2. 1 hit.
SMARTiView protein in SMART
SM00070. GLUCA. 1 hit.
PROSITEiView protein in PROSITE
PS00260. GLUCAGON. 1 hit.

Sequencei

Sequence statusi: Complete.

P63291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
HSDAVFTDNY TRLRKQMAVK KYLNSILN
Length:28
Mass (Da):3,327
Last modified:August 13, 1987 - v1
Checksum:iEF313FB573FF6F3F
GO

Sequence databases

PIRiB60072. VRSH.
UniGeneiOar.17401.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVIP_SHEEP
AccessioniPrimary (citable) accession number: P63291
Secondary accession number(s): P04565
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 10, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families