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P63278 (AMELX_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amelogenin, X isoform
Alternative name(s):
Leucine-rich amelogenin peptide
Short name=LRAP
Gene names
Name:Amelx
Synonyms:Amel, Amgx
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Several forms are produced by C-terminal processing.

Sequence similarities

Belongs to the amelogenin family.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 4 (identifier: P63278-4)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: P63278-1)

The sequence of this isoform differs from the canonical sequence as follows:
     35-48: Missing.
Isoform 2 (identifier: P63278-2)

Also known as: LRAP;

The sequence of this isoform differs from the canonical sequence as follows:
     35-48: Missing.
     64-184: Missing.
Isoform 3 (identifier: P63278-3)

The sequence of this isoform differs from the canonical sequence as follows:
     35-48: Missing.
     64-87: Missing.
Isoform 5 (identifier: P63278-5)

The sequence of this isoform differs from the canonical sequence as follows:
     35-48: Missing.
     210-210: D → AFSPMKWYQGTARHPLNMETTTEK
Isoform 6 (identifier: P63278-6)

The sequence of this isoform differs from the canonical sequence as follows:
     35-48: Missing.
     64-87: Missing.
     210-210: D → AFSPMKWYQGTARHPLNMETTTEK

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 By similarity
Chain17 – 210194Amelogenin, X isoform
PRO_0000001202

Amino acid modifications

Modified residue321Phosphoserine By similarity

Natural variations

Alternative sequence35 – 4814Missing in isoform 1, isoform 2, isoform 3, isoform 5 and isoform 6.
VSP_011689
Alternative sequence64 – 184121Missing in isoform 2.
VSP_011690
Alternative sequence64 – 8724Missing in isoform 3 and isoform 6.
VSP_011691
Alternative sequence2101D → AFSPMKWYQGTARHPLNMET TTEK in isoform 5 and isoform 6.
VSP_011692

Experimental info

Sequence conflict641Y → H in AAB02691. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 4 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: EB6ED5D09AA83AFA

FASTA21023,483
        10         20         30         40         50         60 
MGTWILFACL LGAAFAMPLP PHPGSPGYIN LSYEKSHSQA INTDRTALVL TPLKWYQSMI 

        70         80         90        100        110        120 
RQPYPSYGYE PMGGWLHHQI IPVLSQQHPP SHTLQPHHHL PVVPAQQPVA PQQPMMPVPG 

       130        140        150        160        170        180 
HHSMTPTQHH QPNIPPSAQQ PFQQPFQPQA IPPQSHQPMQ PQSPLHPMQP LAPQPPLPPL 

       190        200        210 
FSMQPLSPIL PELPLEAWPA TDKTKREEVD 

« Hide

Isoform 1 [UniParc] [UniParc].

Checksum: 8E9DE372A13669F4
Show »

FASTA19621,959
Isoform 2 (LRAP) [UniParc] [UniParc].

Checksum: 14D8D8D2CA9DD235
Show »

FASTA758,406
Isoform 3 [UniParc] [UniParc].

Checksum: 0C571EDAFACC111C
Show »

FASTA17219,176
Isoform 5 [UniParc].

Checksum: BD42AF2E7EEC1955
Show »

FASTA21924,652
Isoform 6 [UniParc].

Checksum: FD1EC774937209A4
Show »

FASTA19521,868

References

[1]"Molecular cloning and DNA sequence of rat amelogenin and a comparative analysis of mammalian amelogenin protein sequence divergence."
Bonass W.A., Robinson P.A., Kirkham J., Shore R.C., Robinson C.
Biochem. Biophys. Res. Commun. 198:755-763(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Enamel organ.
[2]"Isolation and characterisation of an alternatively-spliced rat amelogenin cDNA: LRAP -- a highly conserved, functional alternatively-spliced amelogenin?"
Bonass W.A., Kirkham J., Brookes S.J., Shore R.C., Robinson C.
Biochim. Biophys. Acta 1219:690-692(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: Wistar.
Tissue: Enamel organ.
[3]"Rat amelogenin cDNA containing exon 4."
Bonass W.A.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[4]"Alternative splicing of amelogenin mRNA from rat incisor ameloblasts."
Li R., Li W., DenBesten P.K.
J. Dent. Res. 74:1880-1885(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6).
Tissue: Tooth enamel.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U01245 mRNA. Translation: AAA20491.1.
U07054 mRNA. Translation: AAA61964.1.
U67130 mRNA. Translation: AAB06753.1.
U51195 mRNA. Translation: AAB02691.1.
U60562 mRNA. Translation: AAB03481.1.
PIRJC2391.
RefSeqNP_001258002.1. NM_001271073.1.
NP_001258003.1. NM_001271074.1.
NP_001258004.1. NM_001271075.1.
NP_001258005.1. NM_001271076.1.
NP_001258006.1. NM_001271077.1.
NP_001258007.1. NM_001271078.1.
NP_062027.1. NM_019154.1.
XP_006256892.1. XM_006256830.1.
UniGeneRn.11368.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP63278.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005328; ENSRNOP00000005328; ENSRNOG00000003965. [P63278-4]
ENSRNOT00000052176; ENSRNOP00000048382; ENSRNOG00000003965. [P63278-5]
GeneID29160.
KEGGrno:29160.

Organism-specific databases

CTD265.
RGD2107. Amelx.

Phylogenomic databases

eggNOGNOG69988.
GeneTreeENSGT00390000009151.
HOGENOMHOG000231643.
HOVERGENHBG016835.
OMAHSMTPTQ.
OrthoDBEOG7JQBQ8.
PhylomeDBP63278.
TreeFamTF337092.

Gene expression databases

GenevestigatorP63278.

Family and domain databases

InterProIPR004116. Amelogenin.
[Graphical view]
PANTHERPTHR10039:SF2. PTHR10039:SF2. 1 hit.
PfamPF02948. Amelogenin. 1 hit.
[Graphical view]
PRINTSPR01757. AMELOGENIN.
SMARTSM00818. Amelogenin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608193.
PROP63278.

Entry information

Entry nameAMELX_RAT
AccessionPrimary (citable) accession number: P63278
Secondary accession number(s): P45559 expand/collapse secondary AC list , Q62945, Q63640, Q78E56
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families