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Protein

Amelogenin, X isoform

Gene

Amelx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.

GO - Molecular functioni

  • calcium ion binding Source: CAFA
  • growth factor activity Source: BHF-UCL
  • hydroxyapatite binding Source: BHF-UCL
  • identical protein binding Source: MGI
  • protein homodimerization activity Source: CAFA
  • sodium ion binding Source: CAFA
  • structural constituent of tooth enamel Source: MGI

GO - Biological processi

  • cell adhesion Source: BHF-UCL
  • odontogenesis of dentin-containing tooth Source: BHF-UCL
  • protein homooligomerization Source: CAFA
  • regulation of cell proliferation Source: BHF-UCL
  • signal transduction Source: BHF-UCL
  • tooth mineralization Source: BHF-UCL

Keywordsi

Biological processBiomineralization

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Amelogenin, X isoform
Alternative name(s):
Leucine-rich amelogenin peptide
Short name:
LRAP
Gene namesi
Name:Amelx
Synonyms:Amel
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:88005 Amelx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
ChainiPRO_000000120117 – 210Amelogenin, X isoformAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1

Post-translational modificationi

Several forms are produced by C-terminal processing.
Phosphorylated by FAM20C in vitro.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP63277

PTM databases

iPTMnetiP63277

Expressioni

Gene expression databases

BgeeiENSMUSG00000031354
CleanExiMM_AMELX
ExpressionAtlasiP63277 baseline and differential
GenevisibleiP63277 MM

Interactioni

GO - Molecular functioni

  • growth factor activity Source: BHF-UCL
  • identical protein binding Source: MGI
  • protein homodimerization activity Source: CAFA

Protein-protein interaction databases

DIPiDIP-59703N

Structurei

3D structure databases

ProteinModelPortaliP63277
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amelogenin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00390000009151
HOGENOMiHOG000231643
HOVERGENiHBG016835
InParanoidiP63277

Family and domain databases

InterProiView protein in InterPro
IPR004116 Amelogenin
PfamiView protein in Pfam
PF02948 Amelogenin, 1 hit
PRINTSiPR01757 AMELOGENIN
SMARTiView protein in SMART
SM00818 Amelogenin, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 4 (identifier: P63277-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTWILFACL LGAAFAMPLP PHPGSPGYIN LSYEKSHSQA INTDRTALVL
60 70 80 90 100
TPLKWYQSMI RQPYPSYGYE PMGGWLHHQI IPVLSQQHPP SHTLQPHHHL
110 120 130 140 150
PVVPAQQPVA PQQPMMPVPG HHSMTPTQHH QPNIPPSAQQ PFQQPFQPQA
160 170 180 190 200
IPPQSHQPMQ PQSPLHPMQP LAPQPPLPPL FSMQPLSPIL PELPLEAWPA
210
TDKTKREEVD
Length:210
Mass (Da):23,483
Last modified:October 11, 2004 - v1
Checksum:iEB6ED5D09AA83AFA
GO
Isoform 1 (identifier: P63277-1) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-48: Missing.

Show »
Length:196
Mass (Da):21,959
Checksum:i8E9DE372A13669F4
GO
Isoform 2 (identifier: P63277-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: LRAP

The sequence of this isoform differs from the canonical sequence as follows:
     35-48: Missing.
     64-184: Missing.

Show »
Length:75
Mass (Da):8,406
Checksum:i14D8D8D2CA9DD235
GO
Isoform 3 (identifier: P63277-3) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-48: Missing.
     64-87: Missing.

Show »
Length:172
Mass (Da):19,176
Checksum:i0C571EDAFACC111C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111P → A in AAA37218 (PubMed:4015654).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01168835 – 48Missing in isoform 1, isoform 2 and isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_00023064 – 184Missing in isoform 2. CuratedAdd BLAST121
Alternative sequenceiVSP_00023164 – 87Missing in isoform 3. CuratedAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31768 mRNA Translation: BAA06546.1
D31769 mRNA Translation: BAA06547.1
D83067 Genomic DNA Translation: BAA23665.1
AK029358 mRNA Translation: BAC26415.1
AL805974 Genomic DNA Translation: CAM21303.1
AL805974 Genomic DNA Translation: CAM21304.1
M10095 mRNA Translation: AAA37218.1
CCDSiCCDS41214.1 [P63277-1]
CCDS81197.1 [P63277-3]
PIRiI49486
PC1148
RefSeqiNP_001075447.1, NM_001081978.2
NP_001277300.1, NM_001290371.1 [P63277-3]
NP_033796.1, NM_009666.4 [P63277-1]
UniGeneiMm.391342

Genome annotation databases

EnsembliENSMUST00000112118; ENSMUSP00000107746; ENSMUSG00000031354 [P63277-1]
ENSMUST00000112119; ENSMUSP00000107747; ENSMUSG00000031354 [P63277-4]
ENSMUST00000112120; ENSMUSP00000107748; ENSMUSG00000031354 [P63277-3]
GeneIDi11704
KEGGimmu:11704
UCSCiuc009uxs.2 mouse [P63277-1]
uc009uxu.1 mouse [P63277-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAMELX_MOUSE
AccessioniPrimary (citable) accession number: P63277
Secondary accession number(s): A2ALX2
, A2ALX3, P45559, P70592, Q61293
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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