P63268 (ACTH_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin, gamma-enteric smooth muscle

Alternative name(s):
Alpha-actin-3
Gamma-2-actin
Smooth muscle gamma-actin

Gene names

Name:	Actg2
Synonyms:	Acta3, Actsg

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subunit structure	Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
Subcellular location	Cytoplasm › cytoskeleton.
Post-translational modification	Oxidation of Met-45 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced By similarity.
Miscellaneous	In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
Molecular function	Muscle protein
PTM	Oxidation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell periphery Inferred from direct assay PubMed 12040017. Source: MGI cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 2	2	Removed in mature form By similarity		PRO_0000000750
	Chain	3 – 376	374	Actin, gamma-enteric smooth muscle		PRO_0000000751
Amino acid modifications
	Modified residue	45	1	Methionine sulfoxide By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63268 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 6EC08CD5EEAD445E	FASTA	376	41,877
	10 20 30 40 50 60 MCEEETTALV CDNGSGLCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ 70 80 90 100 110 120 SKRGILTLKY PIEHGIITNW DDMEKIWHHS FYNELRVAPE EHPTLLTEAP LNPKANREKM 130 140 150 160 170 180 TQIMFETFNV PAMYVAIQAV LSLYASGRTT GIVLDSGDGV THNVPIYEGY ALPHAIMRLD 190 200 210 220 230 240 LAGRDLTDYL MKILTERGYS FVTTAEREIV RDIKEKLCYV ALDFENEMAT AASSSSLEKS 250 260 270 280 290 300 YELPDGQVIT IGNERFRCPE TLFQPSFIGM ESAGIHETTY NSIMKCDIDI RKDLYANNVL 310 320 330 340 350 360 SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK 370 PEYDEAGPSI VHRKCF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice." Kim E., Waters S.H., Hake L.E., Hecht N.B. Mol. Cell. Biol. 9:1875-1881(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M26689 mRNA. Translation: AAA56841.1. BC002042 mRNA. Translation: AAH02042.1.
IPI	IPI00404804.
PIR	A32788.
RefSeq	NP_033740.2. NM_009610.2.
UniGene	Mm.292865.
3D structure databases
ProteinModelPortal	P63268.
ModBase	Search...
Protein-protein interaction databases
IntAct	P63268. 1 interaction.
STRING	10090.ENSMUSP00000113552.
PTM databases
PhosphoSite	P63268.
Proteomic databases
PaxDb	P63268.
PRIDE	P63268.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000075161; ENSMUSP00000074658; ENSMUSG00000059430. ENSMUST00000121731; ENSMUSP00000113552; ENSMUSG00000059430.
GeneID	11468.
KEGG	mmu:11468.
Organism-specific databases
CTD	72.
MGI	MGI:104589. Actg2.
Phylogenomic databases
eggNOG	COG5277.
HOGENOM	HOG000233340.
HOVERGEN	HBG003771.
InParanoid	P63268.
KO	K12315.
OMA	MEITALA.
OrthoDB	EOG4W9J40.
Gene expression databases
ArrayExpress	P63268.
Bgee	P63268.
CleanEx	MM_ACTG2.
Genevestigator	P63268.
GermOnline	ENSMUSG00000059430. Mus musculus.
Family and domain databases
InterPro	IPR004000. Actin-related. IPR020902. Actin/actin-like_CS. IPR004001. Actin_CS. [Graphical view]
PANTHER	PTHR11937. PTHR11937. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ACTG2. mouse.
NextBio	278796.
SOURCE	Search...

Entry information

Entry name

ACTH_MOUSE

Accession

Primary (citable) accession number: P63268
Secondary accession number(s): P12718

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program