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P63268

- ACTH_MOUSE

UniProt

P63268 - ACTH_MOUSE

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Protein

Actin, gamma-enteric smooth muscle

Gene

Actg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_235059. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin, gamma-enteric smooth muscle
Alternative name(s):
Alpha-actin-3
Gamma-2-actin
Smooth muscle gamma-actin
Gene namesi
Name:Actg2
Synonyms:Acta3, Actsg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:104589. Actg2.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
  2. cell periphery Source: MGI
  3. cytoplasm Source: UniProtKB-KW
  4. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 22Removed in mature formBy similarityPRO_0000000750
Chaini3 – 376374Actin, gamma-enteric smooth musclePRO_0000000751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Methionine (R)-sulfoxide1 Publication
Modified residuei48 – 481Methionine (R)-sulfoxide1 Publication

Post-translational modificationi

Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.1 Publication
Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity).By similarity

Keywords - PTMi

Oxidation

Proteomic databases

MaxQBiP63268.
PaxDbiP63268.
PRIDEiP63268.

PTM databases

PhosphoSiteiP63268.

Expressioni

Tissue specificityi

Expressed in tissues containing smooth muscle particularly the intestines and bladder.1 Publication

Gene expression databases

BgeeiP63268.
CleanExiMM_ACTG2.
ExpressionAtlasiP63268. baseline and differential.
GenevestigatoriP63268.

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Protein-protein interaction databases

BioGridi197947. 1 interaction.
IntActiP63268. 2 interactions.
MINTiMINT-4086768.
STRINGi10090.ENSMUSP00000113552.

Structurei

3D structure databases

ProteinModelPortaliP63268.
SMRiP63268. Positions 3-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiCOG5277.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiP63268.
KOiK12315.
OMAiASMESAN.
OrthoDBiEOG72RMZ1.
PhylomeDBiP63268.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63268-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCEEETTALV CDNGSGLCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIITNW DDMEKIWHHS FYNELRVAPE
110 120 130 140 150
EHPTLLTEAP LNPKANREKM TQIMFETFNV PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVLDSGDGV THNVPIYEGY ALPHAIMRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FVTTAEREIV RDIKEKLCYV ALDFENEMAT AASSSSLEKS YELPDGQVIT
260 270 280 290 300
IGNERFRCPE TLFQPSFIGM ESAGIHETTY NSIMKCDIDI RKDLYANNVL
310 320 330 340 350
SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK PEYDEAGPSI VHRKCF
Length:376
Mass (Da):41,877
Last modified:October 11, 2004 - v1
Checksum:i6EC08CD5EEAD445E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26689 mRNA. Translation: AAA56841.1.
BC002042 mRNA. Translation: AAH02042.1.
CCDSiCCDS51822.1.
PIRiA32788.
RefSeqiNP_033740.2. NM_009610.2.
UniGeneiMm.292865.

Genome annotation databases

EnsembliENSMUST00000075161; ENSMUSP00000074658; ENSMUSG00000059430.
ENSMUST00000121731; ENSMUSP00000113552; ENSMUSG00000059430.
GeneIDi11468.
KEGGimmu:11468.
UCSCiuc009cnr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26689 mRNA. Translation: AAA56841.1 .
BC002042 mRNA. Translation: AAH02042.1 .
CCDSi CCDS51822.1.
PIRi A32788.
RefSeqi NP_033740.2. NM_009610.2.
UniGenei Mm.292865.

3D structure databases

ProteinModelPortali P63268.
SMRi P63268. Positions 3-376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 197947. 1 interaction.
IntActi P63268. 2 interactions.
MINTi MINT-4086768.
STRINGi 10090.ENSMUSP00000113552.

PTM databases

PhosphoSitei P63268.

Proteomic databases

MaxQBi P63268.
PaxDbi P63268.
PRIDEi P63268.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075161 ; ENSMUSP00000074658 ; ENSMUSG00000059430 .
ENSMUST00000121731 ; ENSMUSP00000113552 ; ENSMUSG00000059430 .
GeneIDi 11468.
KEGGi mmu:11468.
UCSCi uc009cnr.1. mouse.

Organism-specific databases

CTDi 72.
MGIi MGI:104589. Actg2.

Phylogenomic databases

eggNOGi COG5277.
HOGENOMi HOG000233340.
HOVERGENi HBG003771.
InParanoidi P63268.
KOi K12315.
OMAi ASMESAN.
OrthoDBi EOG72RMZ1.
PhylomeDBi P63268.
TreeFami TF354237.

Enzyme and pathway databases

Reactomei REACT_235059. Smooth Muscle Contraction.

Miscellaneous databases

NextBioi 278796.
PROi P63268.
SOURCEi Search...

Gene expression databases

Bgeei P63268.
CleanExi MM_ACTG2.
ExpressionAtlasi P63268. baseline and differential.
Genevestigatori P63268.

Family and domain databases

InterProi IPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view ]
PANTHERi PTHR11937. PTHR11937. 1 hit.
Pfami PF00022. Actin. 1 hit.
[Graphical view ]
PRINTSi PR00190. ACTIN.
SMARTi SM00268. ACTIN. 1 hit.
[Graphical view ]
PROSITEi PS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice."
    Kim E., Waters S.H., Hake L.E., Hecht N.B.
    Mol. Cell. Biol. 9:1875-1881(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. "MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation."
    Lee B.C., Peterfi Z., Hoffmann F.W., Moore R.E., Kaya A., Avanesov A., Tarrago L., Zhou Y., Weerapana E., Fomenko D.E., Hoffmann P.R., Gladyshev V.N.
    Mol. Cell 51:397-404(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: OXIDATION AT MET-45 AND MET-48, DEOXIDATION AT MET-45 AND MET-48.
  4. "De novo ACTG2 mutations cause congenital distended bladder, microcolon, and intestinal hypoperistalsis."
    Thorson W., Diaz-Horta O., Foster J. II, Spiliopoulos M., Quintero R., Farooq A., Blanton S., Tekin M.
    Hum. Genet. 133:737-742(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiACTH_MOUSE
AccessioniPrimary (citable) accession number: P63268
Secondary accession number(s): P12718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3