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P63268

- ACTH_MOUSE

UniProt

P63268 - ACTH_MOUSE

Protein

Actin, gamma-enteric smooth muscle

Gene

Actg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin, gamma-enteric smooth muscle
    Alternative name(s):
    Alpha-actin-3
    Gamma-2-actin
    Smooth muscle gamma-actin
    Gene namesi
    Name:Actg2
    Synonyms:Acta3, Actsg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:104589. Actg2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell periphery Source: MGI
    2. cytoplasm Source: UniProtKB-KW
    3. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 22Removed in mature formBy similarityPRO_0000000750
    Chaini3 – 376374Actin, gamma-enteric smooth musclePRO_0000000751Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451Methionine (R)-sulfoxide1 Publication
    Modified residuei48 – 481Methionine (R)-sulfoxide1 Publication

    Post-translational modificationi

    Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.1 Publication
    Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration By similarity.By similarity

    Keywords - PTMi

    Oxidation

    Proteomic databases

    MaxQBiP63268.
    PaxDbiP63268.
    PRIDEiP63268.

    PTM databases

    PhosphoSiteiP63268.

    Expressioni

    Gene expression databases

    ArrayExpressiP63268.
    BgeeiP63268.
    CleanExiMM_ACTG2.
    GenevestigatoriP63268.

    Interactioni

    Subunit structurei

    Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

    Protein-protein interaction databases

    BioGridi197947. 1 interaction.
    IntActiP63268. 2 interactions.
    MINTiMINT-4086768.
    STRINGi10090.ENSMUSP00000113552.

    Structurei

    3D structure databases

    ProteinModelPortaliP63268.
    SMRiP63268. Positions 3-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family.Curated

    Phylogenomic databases

    eggNOGiCOG5277.
    HOGENOMiHOG000233340.
    HOVERGENiHBG003771.
    InParanoidiP63268.
    KOiK12315.
    OMAiASMESAN.
    OrthoDBiEOG72RMZ1.
    PhylomeDBiP63268.
    TreeFamiTF354237.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    PRINTSiPR00190. ACTIN.
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]
    PROSITEiPS00406. ACTINS_1. 1 hit.
    PS00432. ACTINS_2. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P63268-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCEEETTALV CDNGSGLCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ    50
    KDSYVGDEAQ SKRGILTLKY PIEHGIITNW DDMEKIWHHS FYNELRVAPE 100
    EHPTLLTEAP LNPKANREKM TQIMFETFNV PAMYVAIQAV LSLYASGRTT 150
    GIVLDSGDGV THNVPIYEGY ALPHAIMRLD LAGRDLTDYL MKILTERGYS 200
    FVTTAEREIV RDIKEKLCYV ALDFENEMAT AASSSSLEKS YELPDGQVIT 250
    IGNERFRCPE TLFQPSFIGM ESAGIHETTY NSIMKCDIDI RKDLYANNVL 300
    SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL 350
    STFQQMWISK PEYDEAGPSI VHRKCF 376
    Length:376
    Mass (Da):41,877
    Last modified:October 11, 2004 - v1
    Checksum:i6EC08CD5EEAD445E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26689 mRNA. Translation: AAA56841.1.
    BC002042 mRNA. Translation: AAH02042.1.
    CCDSiCCDS51822.1.
    PIRiA32788.
    RefSeqiNP_033740.2. NM_009610.2.
    UniGeneiMm.292865.

    Genome annotation databases

    EnsembliENSMUST00000075161; ENSMUSP00000074658; ENSMUSG00000059430.
    ENSMUST00000121731; ENSMUSP00000113552; ENSMUSG00000059430.
    GeneIDi11468.
    KEGGimmu:11468.
    UCSCiuc009cnr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26689 mRNA. Translation: AAA56841.1 .
    BC002042 mRNA. Translation: AAH02042.1 .
    CCDSi CCDS51822.1.
    PIRi A32788.
    RefSeqi NP_033740.2. NM_009610.2.
    UniGenei Mm.292865.

    3D structure databases

    ProteinModelPortali P63268.
    SMRi P63268. Positions 3-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 197947. 1 interaction.
    IntActi P63268. 2 interactions.
    MINTi MINT-4086768.
    STRINGi 10090.ENSMUSP00000113552.

    PTM databases

    PhosphoSitei P63268.

    Proteomic databases

    MaxQBi P63268.
    PaxDbi P63268.
    PRIDEi P63268.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075161 ; ENSMUSP00000074658 ; ENSMUSG00000059430 .
    ENSMUST00000121731 ; ENSMUSP00000113552 ; ENSMUSG00000059430 .
    GeneIDi 11468.
    KEGGi mmu:11468.
    UCSCi uc009cnr.1. mouse.

    Organism-specific databases

    CTDi 72.
    MGIi MGI:104589. Actg2.

    Phylogenomic databases

    eggNOGi COG5277.
    HOGENOMi HOG000233340.
    HOVERGENi HBG003771.
    InParanoidi P63268.
    KOi K12315.
    OMAi ASMESAN.
    OrthoDBi EOG72RMZ1.
    PhylomeDBi P63268.
    TreeFami TF354237.

    Miscellaneous databases

    ChiTaRSi ACTG2. mouse.
    NextBioi 278796.
    PROi P63268.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63268.
    Bgeei P63268.
    CleanExi MM_ACTG2.
    Genevestigatori P63268.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    PRINTSi PR00190. ACTIN.
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00406. ACTINS_1. 1 hit.
    PS00432. ACTINS_2. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice."
      Kim E., Waters S.H., Hake L.E., Hecht N.B.
      Mol. Cell. Biol. 9:1875-1881(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    3. "MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation."
      Lee B.C., Peterfi Z., Hoffmann F.W., Moore R.E., Kaya A., Avanesov A., Tarrago L., Zhou Y., Weerapana E., Fomenko D.E., Hoffmann P.R., Gladyshev V.N.
      Mol. Cell 51:397-404(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: OXIDATION AT MET-45 AND MET-48, DEOXIDATION AT MET-45 AND MET-48.

    Entry informationi

    Entry nameiACTH_MOUSE
    AccessioniPrimary (citable) accession number: P63268
    Secondary accession number(s): P12718
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3