ID   ACTH_HUMAN              Reviewed;         376 AA.
AC   P63267; B2R7E7; P12718; Q504R1; Q6FI22;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-NOV-2009, entry version 57.
DE   RecName: Full=Actin, gamma-enteric smooth muscle;
DE   AltName: Full=Smooth muscle gamma-actin;
DE   AltName: Full=Gamma-2-actin;
DE   AltName: Full=Alpha-actin-3;
GN   Name=ACTG2; Synonyms=ACTA3, ACTL3, ACTSG;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Stomach;
RX   MEDLINE=90332437; PubMed=2377475; DOI=10.1093/nar/18.14.4263;
RA   Miwa T., Kamada S., Kakunaga T.;
RT   "The nucleotide sequence of a human smooth muscle (enteric type)
RT   gamma-actin cDNA.";
RL   Nucleic Acids Res. 18:4263-4263(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=91246198; PubMed=1710027;
RA   Miwa T., Manabe Y., Kurokawa K., Kamada S., Kanda N., Bruns G.,
RA   Ueyama H., Kakunaga T.;
RT   "Structure, chromosome location, and expression of the human smooth
RT   muscle (enteric type) gamma-actin gene: evolution of six human actin
RT   genes.";
RL   Mol. Cell. Biol. 11:3296-3306(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland, and Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved
CC       in various types of cell motility and are ubiquitously expressed
CC       in all eukaryotic cells.
CC   -!- SUBUNIT: Polymerization of globular actin (G-actin) leads to a
CC       structural filament (F-actin) in the form of a two-stranded helix.
CC       Each actin can bind to 4 others.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- MISCELLANEOUS: In vertebrates 3 main groups of actin isoforms,
CC       alpha, beta and gamma have been identified. The alpha actins are
CC       found in muscle tissues and are a major constituent of the
CC       contractile apparatus. The beta and gamma actins coexist in most
CC       cell types as components of the cytoskeleton and as mediators of
CC       internal cell motility.
CC   -!- SIMILARITY: Belongs to the actin family.
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DR   EMBL; X16940; CAA34814.1; -; mRNA.
DR   EMBL; D00654; BAA00546.1; -; Genomic_DNA.
DR   EMBL; AK312955; BAG35794.1; -; mRNA.
DR   EMBL; CR536515; CAG38753.1; -; mRNA.
DR   EMBL; CR541794; CAG46593.1; -; mRNA.
DR   EMBL; AC073046; AAX88909.1; -; Genomic_DNA.
DR   EMBL; BC012617; AAH12617.1; -; mRNA.
DR   EMBL; BC094877; AAH94877.1; -; mRNA.
DR   IPI; IPI00025416; -.
DR   PIR; A40261; A40261.
DR   RefSeq; NP_001606.1; -.
DR   UniGene; Hs.516105; -.
DR   HSSP; P02568; 1IJJ.
DR   SMR; P63267; 5-372.
DR   STRING; P63267; -.
DR   PhosphoSite; P63267; -.
DR   HSC-2DPAGE; P63267; -.
DR   OGP; P12718; -.
DR   PRIDE; P63267; -.
DR   Ensembl; ENST00000345517; ENSP00000295137; ENSG00000163017; Homo sapiens.
DR   Ensembl; ENST00000409624; ENSP00000386857; ENSG00000163017; Homo sapiens.
DR   Ensembl; ENST00000409731; ENSP00000386929; ENSG00000163017; Homo sapiens.
DR   Ensembl; ENST00000409918; ENSP00000387182; ENSG00000163017; Homo sapiens.
DR   Ensembl; ENST00000429756; ENSP00000392894; ENSG00000163017; Homo sapiens.
DR   Ensembl; ENST00000438902; ENSP00000410706; ENSG00000163017; Homo sapiens.
DR   Ensembl; ENST00000442912; ENSP00000410020; ENSG00000163017; Homo sapiens.
DR   GeneID; 72; -.
DR   KEGG; hsa:72; -.
DR   UCSC; uc002sjw.1; human.
DR   CTD; 72; -.
DR   GeneCards; GC02P074031; -.
DR   H-InvDB; HIX0002173; -.
DR   HGNC; HGNC:145; ACTG2.
DR   HPA; CAB003761; -.
DR   MIM; 102545; gene.
DR   PharmGKB; PA24469; -.
DR   HOGENOM; P63267; -.
DR   HOVERGEN; P63267; -.
DR   OMA; MEITALA; -.
DR   NextBio; 283; -.
DR   PMAP-CutDB; P63267; -.
DR   ArrayExpress; P63267; -.
DR   Bgee; P63267; -.
DR   CleanEx; HS_ACTG2; -.
DR   Genevestigator; P63267; -.
DR   GermOnline; ENSG00000163017; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IEA:InterPro.
DR   InterPro; IPR004000; Actin-like.
DR   InterPro; IPR004001; Actin_CS.
DR   PANTHER; PTHR11937; Actin_like; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   1: Evidence at protein level;
KW   Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton;
KW   Muscle protein; Nucleotide-binding.
FT   PROPEP        1      2       Removed in mature form (By similarity).
FT                                /FTId=PRO_0000000748.
FT   CHAIN         3    376       Actin, gamma-enteric smooth muscle.
FT                                /FTId=PRO_0000000749.
FT   MOD_RES       3      3       N-acetylglutamate (By similarity).
FT   CONFLICT    130    130       V -> F (in Ref. 4; CAG38753).
SQ   SEQUENCE   376 AA;  41877 MW;  6EC08CD5EEAD445E CRC64;
     MCEEETTALV CDNGSGLCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ
     SKRGILTLKY PIEHGIITNW DDMEKIWHHS FYNELRVAPE EHPTLLTEAP LNPKANREKM
     TQIMFETFNV PAMYVAIQAV LSLYASGRTT GIVLDSGDGV THNVPIYEGY ALPHAIMRLD
     LAGRDLTDYL MKILTERGYS FVTTAEREIV RDIKEKLCYV ALDFENEMAT AASSSSLEKS
     YELPDGQVIT IGNERFRCPE TLFQPSFIGM ESAGIHETTY NSIMKCDIDI RKDLYANNVL
     SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK
     PEYDEAGPSI VHRKCF
//