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P63267

- ACTH_HUMAN

UniProt

P63267 - ACTH_HUMAN

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Protein
Actin, gamma-enteric smooth muscle
Gene
ACTG2, ACTA3, ACTL3, ACTSG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. muscle contraction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_20558. Smooth Muscle Contraction.
SignaLinkiP63267.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin, gamma-enteric smooth muscle
Alternative name(s):
Alpha-actin-3
Gamma-2-actin
Smooth muscle gamma-actin
Gene namesi
Name:ACTG2
Synonyms:ACTA3, ACTL3, ACTSG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:145. ACTG2.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. cell periphery Source: Ensembl
  3. cytoskeleton Source: UniProtKB-SubCell
  4. cytosol Source: Reactome
  5. extracellular space Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

Orphaneti2604. Familial visceral myopathy.
PharmGKBiPA24469.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 22Removed in mature form By similarity
PRO_0000000748
Chaini3 – 376374Actin, gamma-enteric smooth muscle
PRO_0000000749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Methionine (R)-sulfoxide By similarity
Modified residuei48 – 481Methionine (R)-sulfoxide By similarity

Post-translational modificationi

Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization By similarity.
Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration By similarity.

Keywords - PTMi

Oxidation

Proteomic databases

MaxQBiP63267.
PRIDEiP63267.

2D gel databases

OGPiP12718.

PTM databases

PhosphoSiteiP63267.

Miscellaneous databases

PMAP-CutDBP63267.

Expressioni

Gene expression databases

ArrayExpressiP63267.
BgeeiP63267.
CleanExiHS_ACTG2.
GenevestigatoriP63267.

Organism-specific databases

HPAiCAB003761.
HPA041271.

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Protein-protein interaction databases

BioGridi106587. 12 interactions.
IntActiP63267. 9 interactions.
MINTiMINT-256943.
STRINGi9606.ENSP00000295137.

Structurei

3D structure databases

ProteinModelPortaliP63267.
SMRiP63267. Positions 3-376.

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.

Phylogenomic databases

HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiP63267.
KOiK12315.
OMAiASMESAN.
PhylomeDBiP63267.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P63267-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MCEEETTALV CDNGSGLCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ    50
KDSYVGDEAQ SKRGILTLKY PIEHGIITNW DDMEKIWHHS FYNELRVAPE 100
EHPTLLTEAP LNPKANREKM TQIMFETFNV PAMYVAIQAV LSLYASGRTT 150
GIVLDSGDGV THNVPIYEGY ALPHAIMRLD LAGRDLTDYL MKILTERGYS 200
FVTTAEREIV RDIKEKLCYV ALDFENEMAT AASSSSLEKS YELPDGQVIT 250
IGNERFRCPE TLFQPSFIGM ESAGIHETTY NSIMKCDIDI RKDLYANNVL 300
SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL 350
STFQQMWISK PEYDEAGPSI VHRKCF 376
Length:376
Mass (Da):41,877
Last modified:October 11, 2004 - v1
Checksum:i6EC08CD5EEAD445E
GO
Isoform 2 (identifier: P63267-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-85: Missing.

Note: No experimental confirmation available.

Show »
Length:333
Mass (Da):37,083
Checksum:i1D423B1372E4BFCD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei43 – 8543Missing in isoform 2.
VSP_045861Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301V → F in CAG38753. 1 Publication
Sequence conflicti157 – 1571G → C in BAG65327. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16940 mRNA. Translation: CAA34814.1.
D00654 Genomic DNA. Translation: BAA00546.1.
AK304523 mRNA. Translation: BAG65327.1.
AK312955 mRNA. Translation: BAG35794.1.
CR536515 mRNA. Translation: CAG38753.1.
CR541794 mRNA. Translation: CAG46593.1.
AC073046 Genomic DNA. Translation: AAX88909.1.
CH471053 Genomic DNA. Translation: EAW99713.1.
BC012617 mRNA. Translation: AAH12617.1.
BC094877 mRNA. Translation: AAH94877.1.
CCDSiCCDS1930.1. [P63267-1]
CCDS56124.1. [P63267-2]
PIRiA40261.
RefSeqiNP_001186822.1. NM_001199893.1. [P63267-2]
NP_001606.1. NM_001615.3. [P63267-1]
UniGeneiHs.516105.

Genome annotation databases

EnsembliENST00000345517; ENSP00000295137; ENSG00000163017. [P63267-1]
ENST00000409624; ENSP00000386857; ENSG00000163017. [P63267-1]
ENST00000409731; ENSP00000386929; ENSG00000163017. [P63267-2]
GeneIDi72.
KEGGihsa:72.
UCSCiuc002sjw.3. human. [P63267-1]

Polymorphism databases

DMDMi54036679.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16940 mRNA. Translation: CAA34814.1 .
D00654 Genomic DNA. Translation: BAA00546.1 .
AK304523 mRNA. Translation: BAG65327.1 .
AK312955 mRNA. Translation: BAG35794.1 .
CR536515 mRNA. Translation: CAG38753.1 .
CR541794 mRNA. Translation: CAG46593.1 .
AC073046 Genomic DNA. Translation: AAX88909.1 .
CH471053 Genomic DNA. Translation: EAW99713.1 .
BC012617 mRNA. Translation: AAH12617.1 .
BC094877 mRNA. Translation: AAH94877.1 .
CCDSi CCDS1930.1. [P63267-1 ]
CCDS56124.1. [P63267-2 ]
PIRi A40261.
RefSeqi NP_001186822.1. NM_001199893.1. [P63267-2 ]
NP_001606.1. NM_001615.3. [P63267-1 ]
UniGenei Hs.516105.

3D structure databases

ProteinModelPortali P63267.
SMRi P63267. Positions 3-376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106587. 12 interactions.
IntActi P63267. 9 interactions.
MINTi MINT-256943.
STRINGi 9606.ENSP00000295137.

PTM databases

PhosphoSitei P63267.

Polymorphism databases

DMDMi 54036679.

2D gel databases

OGPi P12718.

Proteomic databases

MaxQBi P63267.
PRIDEi P63267.

Protocols and materials databases

DNASUi 72.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345517 ; ENSP00000295137 ; ENSG00000163017 . [P63267-1 ]
ENST00000409624 ; ENSP00000386857 ; ENSG00000163017 . [P63267-1 ]
ENST00000409731 ; ENSP00000386929 ; ENSG00000163017 . [P63267-2 ]
GeneIDi 72.
KEGGi hsa:72.
UCSCi uc002sjw.3. human. [P63267-1 ]

Organism-specific databases

CTDi 72.
GeneCardsi GC02P074119.
HGNCi HGNC:145. ACTG2.
HPAi CAB003761.
HPA041271.
MIMi 102545. gene.
neXtProti NX_P63267.
Orphaneti 2604. Familial visceral myopathy.
PharmGKBi PA24469.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000233340.
HOVERGENi HBG003771.
InParanoidi P63267.
KOi K12315.
OMAi ASMESAN.
PhylomeDBi P63267.
TreeFami TF354237.

Enzyme and pathway databases

Reactomei REACT_20558. Smooth Muscle Contraction.
SignaLinki P63267.

Miscellaneous databases

ChiTaRSi ACTG2. human.
GeneWikii ACTG2.
GenomeRNAii 72.
NextBioi 283.
PMAP-CutDB P63267.
PROi P63267.
SOURCEi Search...

Gene expression databases

ArrayExpressi P63267.
Bgeei P63267.
CleanExi HS_ACTG2.
Genevestigatori P63267.

Family and domain databases

InterProi IPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view ]
PANTHERi PTHR11937. PTHR11937. 1 hit.
Pfami PF00022. Actin. 1 hit.
[Graphical view ]
PRINTSi PR00190. ACTIN.
SMARTi SM00268. ACTIN. 1 hit.
[Graphical view ]
PROSITEi PS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of a human smooth muscle (enteric type) gamma-actin cDNA."
    Miwa T., Kamada S., Kakunaga T.
    Nucleic Acids Res. 18:4263-4263(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Stomach.
  2. "Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes."
    Miwa T., Manabe Y., Kurokawa K., Kamada S., Kanda N., Bruns G., Ueyama H., Kakunaga T.
    Mol. Cell. Biol. 11:3296-3306(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Uterus.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland and Prostate.

Entry informationi

Entry nameiACTH_HUMAN
AccessioniPrimary (citable) accession number: P63267
Secondary accession number(s): B2R7E7
, B4E315, D6W5H8, E9PG30, P12718, Q504R1, Q6FI22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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