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Protein

Actin, cytoplasmic 2

Gene

Actg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

GO - Molecular functioni

GO - Biological processi

  • cellular response to interferon-gamma Source: MGI
  • response to calcium ion Source: Ensembl
  • response to mechanical stimulus Source: Ensembl
  • sarcomere organization Source: MGI

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-190873 Gap junction degradation
R-MMU-196025 Formation of annular gap junctions
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-418990 Adherens junctions interactions
R-MMU-437239 Recycling pathway of L1
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-446353 Cell-extracellular matrix interactions
R-MMU-5626467 RHO GTPases activate IQGAPs
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin, cytoplasmic 2
Alternative name(s):
Gamma-actin
Cleaved into the following chain:
Gene namesi
Name:Actg1
Synonyms:Actg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:87906 Actg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003671011 – 375Actin, cytoplasmic 2Add BLAST375
Initiator methionineiRemoved; alternate1 Publication
ChainiPRO_00000008332 – 375Actin, cytoplasmic 2, N-terminally processedAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylglutamate; in Actin, cytoplasmic 2, N-terminally processed1 Publication1
Modified residuei44Methionine (R)-sulfoxide1 Publication1
Modified residuei47Methionine (R)-sulfoxide1 Publication1
Modified residuei73Tele-methylhistidine1 Publication1
Modified residuei84N6-methyllysineBy similarity1

Post-translational modificationi

Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.1 Publication
Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Oxidation

Proteomic databases

EPDiP63260
PaxDbiP63260
PeptideAtlasiP63260
PRIDEiP63260

2D gel databases

COMPLUYEAST-2DPAGEP63260
REPRODUCTION-2DPAGEP63260
UCD-2DPAGEP63260

PTM databases

CarbonylDBiP63260
iPTMnetiP63260
PhosphoSitePlusiP63260
SwissPalmiP63260

Miscellaneous databases

PMAP-CutDBP63260

Expressioni

Gene expression databases

BgeeiENSMUSG00000062825
CleanExiMM_ACTG1
ExpressionAtlasiP63260 baseline and differential
GenevisibleiP63260 MM

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TWF1, CAPZB, cofilin and profilin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084604EBI-351301,EBI-1633915

GO - Molecular functioni

Protein-protein interaction databases

BioGridi197946, 21 interactors
CORUMiP63260
IntActiP63260, 25 interactors
MINTiP63260
STRINGi10090.ENSMUSP00000071486

Structurei

3D structure databases

ProteinModelPortaliP63260
SMRiP63260
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP63260
KOiK05692
OMAiMIGRECS
OrthoDBiEOG091G08LD
PhylomeDBiP63260
TreeFamiTF354237

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK
60 70 80 90 100
DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG
160 170 180 190 200
IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF
210 220 230 240 250
TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
310 320 330 340 350
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Length:375
Mass (Da):41,793
Last modified:July 21, 1986 - v1
Checksum:i54D08F986964EFD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13055 mRNA Translation: CAA31455.1
AK076081 mRNA Translation: BAC36167.1
AK087983 mRNA Translation: BAC40075.1
BC003337 mRNA Translation: AAH03337.1
BC021796 mRNA Translation: AAH21796.1
BC023248 mRNA Translation: AAH23248.1
M21495 mRNA Translation: AAA37168.1
CCDSiCCDS25730.1
PIRiA30243 ATMSG
RefSeqiNP_033739.1, NM_009609.3
UniGeneiMm.196173
Mm.426706
Mm.470166

Genome annotation databases

EnsembliENSMUST00000071555; ENSMUSP00000071486; ENSMUSG00000062825
ENSMUST00000106215; ENSMUSP00000101822; ENSMUSG00000062825
GeneIDi11465
KEGGimmu:11465
UCSCiuc007msi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiACTG_MOUSE
AccessioniPrimary (citable) accession number: P63260
Secondary accession number(s): P02571, P14104, P99022
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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