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Protein

Cysteine-rich protein 1

Gene

Crip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

GO - Molecular functioni

  • AT DNA binding Source: UniProtKB
  • DNA binding, bending Source: UniProtKB
  • peptide binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cellular response to antibiotic Source: UniProtKB
  • cellular response to UV-B Source: UniProtKB
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
  • response to zinc ion Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 1
Short name:
CRP-1
Alternative name(s):
Cysteine-rich intestinal protein
Short name:
CRIP
Gene namesi
Name:Crip1
Synonyms:Crip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1597237. Crip1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 7776Cysteine-rich protein 1PRO_0000075709Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91N6-acetyllysineBy similarity
Modified residuei22 – 221N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP63255.
PRIDEiP63255.

PTM databases

iPTMnetiP63255.
PhosphoSiteiP63255.

Expressioni

Developmental stagei

The concentration in intestinal tissues undergoes an abrupt increase during the animal's transition from suckling to weaning.

Gene expression databases

BgeeiENSRNOG00000027990.
GenevisibleiP63255. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006835.

Structurei

Secondary structure

1
77
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni5 – 73Combined sources
Beta strandi8 – 103Combined sources
Helixi13 – 153Combined sources
Beta strandi16 – 194Combined sources
Beta strandi22 – 254Combined sources
Turni26 – 283Combined sources
Turni32 – 343Combined sources
Beta strandi43 – 464Combined sources
Beta strandi49 – 524Combined sources
Turni53 – 553Combined sources
Helixi56 – 605Combined sources
Beta strandi71 – 733Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IMLNMR-A2-77[»]
ProteinModelPortaliP63255.
SMRiP63255. Positions 2-77.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63255.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 6362LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 709Gly-rich

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiENOG410ITI6. Eukaryota.
ENOG4111U5J. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000264233.
HOVERGENiHBG051118.
InParanoidiP63255.
OMAiCNKTLSA.
OrthoDBiEOG091G11RX.
PhylomeDBiP63255.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKCPKCDKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP
60 70
YCNHPCYSAM FGPKGFGRGG AESHTFK
Length:77
Mass (Da):8,550
Last modified:January 23, 2007 - v2
Checksum:iBBE8E17A19352EC1
GO

Sequence databases

PIRiA03270. GYRTI.
RefSeqiNP_001128405.1. NM_001134933.2.
NP_001231796.1. NM_001244867.1.
UniGeneiRn.8405.

Genome annotation databases

EnsembliENSRNOT00000006835; ENSRNOP00000006835; ENSRNOG00000027990.
GeneIDi691657.
KEGGirno:691657.

Cross-referencesi

Sequence databases

PIRiA03270. GYRTI.
RefSeqiNP_001128405.1. NM_001134933.2.
NP_001231796.1. NM_001244867.1.
UniGeneiRn.8405.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IMLNMR-A2-77[»]
ProteinModelPortaliP63255.
SMRiP63255. Positions 2-77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006835.

PTM databases

iPTMnetiP63255.
PhosphoSiteiP63255.

Proteomic databases

PaxDbiP63255.
PRIDEiP63255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006835; ENSRNOP00000006835; ENSRNOG00000027990.
GeneIDi691657.
KEGGirno:691657.

Organism-specific databases

CTDi1396.
RGDi1597237. Crip1.

Phylogenomic databases

eggNOGiENOG410ITI6. Eukaryota.
ENOG4111U5J. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000264233.
HOVERGENiHBG051118.
InParanoidiP63255.
OMAiCNKTLSA.
OrthoDBiEOG091G11RX.
PhylomeDBiP63255.

Miscellaneous databases

EvolutionaryTraceiP63255.
PROiP63255.

Gene expression databases

BgeeiENSRNOG00000027990.
GenevisibleiP63255. RN.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIP1_RAT
AccessioniPrimary (citable) accession number: P63255
Secondary accession number(s): P04006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.