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Protein

G protein-activated inward rectifier potassium channel 1

Gene

Kcnj3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei173Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

  • G-protein activated inward rectifier potassium channel activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-activated inward rectifier potassium channel 1
Short name:
GIRK-1
Alternative name(s):
Inward rectifier K(+) channel Kir3.1
Potassium channel, inwardly rectifying subfamily J member 3
Gene namesi
Name:Kcnj3
Synonyms:Girk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104742 Kcnj3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 80CytoplasmicAdd BLAST80
Transmembranei81 – 105Helical; Name=M1By similarityAdd BLAST25
Topological domaini106 – 129ExtracellularBy similarityAdd BLAST24
Intramembranei130 – 141Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei142 – 148Pore-formingBy similarity7
Topological domaini149 – 157ExtracellularBy similarity9
Transmembranei158 – 179Helical; Name=M2By similarityAdd BLAST22
Topological domaini180 – 501CytoplasmicAdd BLAST322

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi434

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549391 – 501G protein-activated inward rectifier potassium channel 1Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei385PhosphoserineCombined sources1
Modified residuei424PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP63250
PeptideAtlasiP63250
PRIDEiP63250

PTM databases

iPTMnetiP63250
PhosphoSitePlusiP63250

Expressioni

Gene expression databases

BgeeiENSMUSG00000026824
ExpressionAtlasiP63250 baseline and differential
GenevisibleiP63250 MM

Interactioni

Subunit structurei

Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger (By similarity).By similarity

Protein-protein interaction databases

CORUMiP63250
DIPiDIP-48585N
STRINGi10090.ENSMUSP00000063329

Structurei

Secondary structure

1501
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi69 – 77Combined sources9
Helixi179 – 185Combined sources7
Helixi190 – 192Combined sources3
Beta strandi194 – 196Combined sources3
Beta strandi200 – 205Combined sources6
Beta strandi208 – 215Combined sources8
Beta strandi219 – 221Combined sources3
Beta strandi223 – 237Combined sources15
Beta strandi243 – 250Combined sources8
Turni255 – 257Combined sources3
Turni258 – 260Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi268 – 273Combined sources6
Turni279 – 282Combined sources4
Helixi287 – 289Combined sources3
Beta strandi294 – 303Combined sources10
Turni304 – 306Combined sources3
Beta strandi312 – 317Combined sources6
Helixi318 – 320Combined sources3
Beta strandi321 – 323Combined sources3
Beta strandi325 – 327Combined sources3
Beta strandi331 – 336Combined sources6
Beta strandi338 – 340Combined sources3
Helixi342 – 344Combined sources3
Beta strandi348 – 350Combined sources3
Helixi358 – 368Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N9PX-ray1.80A41-371[»]
1U4EX-ray2.09A41-63[»]
A189-371[»]
2QKSX-ray2.20A/B41-82[»]
A/B178-371[»]
3K6NX-ray2.00A41-63[»]
A190-371[»]
5UM4X-ray2.50A201-370[»]
ProteinModelPortaliP63250
SMRiP63250
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63250

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi143 – 148Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOGENOMiHOG000237325
HOVERGENiHBG006178
InParanoidiP63250
KOiK04997
OMAiCHVIDTK
OrthoDBiEOG091G08HC
PhylomeDBiP63250
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003274 K_chnl_inward-rec_Kir3.1
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PRINTSiPR01327 KIR31CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

P63250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALRRKFGD DYQVVTTSSS GSGLQPQGPG QGPQQQLVPK KKRQRFVDKN
60 70 80 90 100
GRCNVQHGNL GSETSRYLSD LFTTLVDLKW RWNLFIFILT YTVAWLFMAS
110 120 130 140 150
MWWVIAYTRG DLNKAHVGNY TPCVANVYNF PSAFLFFIET EATIGYGYRY
160 170 180 190 200
ITDKCPEGII LFLFQSILGS IVDAFLIGCM FIKMSQPKKR AETLMFSEHA
210 220 230 240 250
VISMRDGKLT LMFRVGNLRN SHMVSAQIRC KLLKSRQTPE GEFLPLDQLE
260 270 280 290 300
LDVGFSTGAD QLFLVSPLTI CHVIDAKSPF YDLSQRSMQT EQFEVVVILE
310 320 330 340 350
GIVETTGMTC QARTSYTEDE VLWGHRFFPV ISLEEGFFKV DYSQFHATFE
360 370 380 390 400
VPTPPYSVKE QEEMLLMSSP LIAPAITNSK ERHNSVECLD GLDDISTKLP
410 420 430 440 450
SKLQKITGRE DFPKKLLRMS STTSEKAYSL GDLPMKLQRI SSVPGNSEEK
460 470 480 490 500
LVSKTTKMLS DPMSQSVADL PPKLQKMAGG PTRMEGNLPA KLRKMNSDRF

T
Length:501
Mass (Da):56,573
Last modified:October 11, 2004 - v1
Checksum:iAB8910E9CC08FFEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45022 mRNA Translation: BAA08079.1
CCDSiCCDS16042.1
PIRiJC4139
RefSeqiNP_032452.1, NM_008426.2
XP_006497793.1, XM_006497730.3
UniGeneiMm.418451
Mm.5127

Genome annotation databases

EnsembliENSMUST00000067101; ENSMUSP00000063329; ENSMUSG00000026824
ENSMUST00000112633; ENSMUSP00000108252; ENSMUSG00000026824
GeneIDi16519
KEGGimmu:16519
UCSCiuc008jru.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKCNJ3_MOUSE
AccessioniPrimary (citable) accession number: P63250
Secondary accession number(s): P35562
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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