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Protein

Receptor of activated protein C kinase 1

Gene

RACK1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-5626978. TNFR1-mediated ceramide production.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor of activated protein C kinase 1
Alternative name(s):
Guanine nucleotide-binding protein subunit beta-like protein 12.3
Receptor for activated C kinase
Receptor of activated protein kinase C 1
Short name:
RACK1
Gene namesi
Name:RACK1
Synonyms:GNB2L1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 16

Subcellular locationi

  • Cell membrane By similarity; Peripheral membrane protein By similarity
  • Cytoplasm By similarity
  • Cytoplasmperinuclear region By similarity
  • Nucleus By similarity
  • Perikaryon By similarity
  • Cell projectiondendrite By similarity

  • Note: Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery (By similarity). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 317316Receptor of activated protein C kinase 1PRO_0000127735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei228 – 2281PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP63247.
PRIDEiP63247.

Interactioni

Protein-protein interaction databases

BioGridi678470. 1 interaction.
MINTiMINT-92357.
STRINGi9031.ENSGALP00000000170.

Structurei

3D structure databases

ProteinModelPortaliP63247.
SMRiP63247. Positions 2-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 4432WD 1Add
BLAST
Repeati61 – 9131WD 2Add
BLAST
Repeati103 – 13331WD 3Add
BLAST
Repeati146 – 17833WD 4Add
BLAST
Repeati190 – 22031WD 5Add
BLAST
Repeati231 – 26030WD 6Add
BLAST
Repeati281 – 31131WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
GeneTreeiENSGT00840000129847.
HOGENOMiHOG000091643.
HOVERGENiHBG000277.
InParanoidiP63247.
KOiK14753.
OMAiATSMENP.
PhylomeDBiP63247.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET
60 70 80 90 100
NYGIPQRALR GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR
110 120 130 140 150
FVGHTKDVLS VAFSSDNRQI VSGSRDKTIK LWNTLGVCKY TVQDESHSEW
160 170 180 190 200
VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA NCKLKTNHIG HTGYLNTVTV
210 220 230 240 250
SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC FSPNRYWLCA
260 270 280 290 300
ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA
310
GYTDNLVRVW QVTIGTR
Length:317
Mass (Da):35,077
Last modified:October 11, 2004 - v1
Checksum:i257F91E369ED2044
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24193 mRNA. Translation: AAA50559.1.
AY393848 mRNA. Translation: AAS49613.1.
AY694127 Genomic DNA. Translation: AAW82329.1.
AB268588 Genomic DNA. Translation: BAF62990.1.
PIRiA33928.
RefSeqiNP_001004378.1. NM_001004378.2.
UniGeneiGga.7066.

Genome annotation databases

EnsembliENSGALT00000000171; ENSGALP00000000170; ENSGALG00000000122.
GeneIDi417044.
KEGGigga:417044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24193 mRNA. Translation: AAA50559.1.
AY393848 mRNA. Translation: AAS49613.1.
AY694127 Genomic DNA. Translation: AAW82329.1.
AB268588 Genomic DNA. Translation: BAF62990.1.
PIRiA33928.
RefSeqiNP_001004378.1. NM_001004378.2.
UniGeneiGga.7066.

3D structure databases

ProteinModelPortaliP63247.
SMRiP63247. Positions 2-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi678470. 1 interaction.
MINTiMINT-92357.
STRINGi9031.ENSGALP00000000170.

Proteomic databases

PaxDbiP63247.
PRIDEiP63247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000000171; ENSGALP00000000170; ENSGALG00000000122.
GeneIDi417044.
KEGGigga:417044.

Organism-specific databases

CTDi10399.

Phylogenomic databases

eggNOGiKOG0279. Eukaryota.
ENOG410XQGZ. LUCA.
GeneTreeiENSGT00840000129847.
HOGENOMiHOG000091643.
HOVERGENiHBG000277.
InParanoidiP63247.
KOiK14753.
OMAiATSMENP.
PhylomeDBiP63247.

Enzyme and pathway databases

ReactomeiR-GGA-5626978. TNFR1-mediated ceramide production.

Miscellaneous databases

PROiP63247.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex."
    Guillemot F., Billault A., Auffray C.
    Proc. Natl. Acad. Sci. U.S.A. 86:4594-4598(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The phylogenetic relationship of tetrapod, coelacanth, and lungfish revealed by the sequences of forty-four nuclear genes."
    Takezaki N., Figueroa F., Zaleska-Rutczynska Z., Takahata N., Klein J.
    Mol. Biol. Evol. 21:1512-1524(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Characterisation of a cluster of TRIM-B30.2 genes in the chicken MHC B locus."
    Ruby T., Bed'Hom B., Wittzell H., Morin V., Oudin A., Zoorob R.
    Immunogenetics 57:116-128(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Extended gene map reveals tripartite motif, C-type lectin, and Ig superfamily type genes within a subregion of the chicken MHC-B affecting infectious disease."
    Shiina T., Briles W.E., Goto R.M., Hosomichi K., Yanagiya K., Shimizu S., Inoko H., Miller M.M.
    J. Immunol. 178:7162-7172(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiRACK1_CHICK
AccessioniPrimary (citable) accession number: P63247
Secondary accession number(s): A5HUK6
, P25388, P99049, Q5EVY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.