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Reviewed, UniProtKB/Swiss-Prot P63244 (GBLP_HUMAN)

Last modified November 4, 2008. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Guanine nucleotide-binding protein subunit beta-2-like 1
Alternative name(s):
    Guanine nucleotide-binding protein subunit beta-like protein 12.3
    Receptor of activated protein kinase C 1
      Short name=RACK1
    Receptor for activated C kinase
Gene names
Name: GNB2L1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton By similarity.

Subunit structure

Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4.

Domain

The WD repeats domain 5 mediates interaction with TRIM63.

Sequence similarities

Belongs to the WD repeat G protein beta family.

Contains 7 WD repeats.

Ontologies

Keywords

   DomainRepeat
WD repeat
   PTMAcetylation
Phosphoprotein
   Technical termDirect protein sequencing

Gene Ontology (GO)

   Molecular functionreceptor binding

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

IFNAR2P485514EBI-296739,EBI-958408
LRP12Q9Y5611EBI-296739,EBI-296693

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 317316Guanine nucleotide-binding protein subunit beta-2-like 1
PRO_0000127731

Regions

Repeat13 – 4432WD 1
Repeat61 – 9131WD 2
Repeat103 – 13331WD 3
Repeat146 – 17833WD 4
Repeat190 – 22031WD 5
Repeat231 – 26030WD 6
Repeat281 – 31131WD 7

Amino acid modifications

Modified residue21N-acetylthreonine
Modified residue2281Phosphotyrosine

Sequences

Sequence LengthMass (Da)Tools
P63244-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 257F91E369ED2044

FASTA31735,077
        10         20         30         40         50         60 
MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR 

        70         80         90        100        110        120 
GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI 

       130        140        150        160        170        180 
VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA 

       190        200        210        220        230        240 
NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC 

       250        260        270        280        290        300 
FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA 

       310 
GYTDNLVRVW QVTIGTR 

« Hide

References

« Hide 'large scale' references
[1]"Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex."
Guillemot F., Billault A., Auffray C.
Proc. Natl. Acad. Sci. U.S.A. 86:4594-4598(1989) [PubMed: 2499885] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell, Brain, Cervix, Lung, Lymph, Ovary and Skin.
[4]Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M.
Submitted (MAY-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-11; 48-57; 107-118; 258-280 AND 309-317, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, MASS SPECTROMETRY.
Tissue: B-cell lymphoma and T-cell.
[5]Lubec G., Afjehi-Sadat L.
Submitted (MAR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 48-57; 107-118; 140-155 AND 226-245, MASS SPECTROMETRY.
Tissue: Brain and Cajal-Retzius cell.
[6]"Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor."
Liedtke C.M., Yun C.H.C., Kyle N., Wang D.
J. Biol. Chem. 277:22925-22933(2002) [PubMed: 11956211] [Abstract]
Cited for: INTERACTION WITH SLC9A3R1.
[7]"Muscle ring finger protein-1 inhibits PKC-epsilon activation and prevents cardiomyocyte hypertrophy."
Arya R., Kedar V., Hwang J.R., McDonough H., Li H.-H., Taylor J., Patterson C.
J. Cell Biol. 167:1147-1159(2004) [PubMed: 15596539] [Abstract]
Cited for: INTERACTION WITH TRIM63 AND PRKCE.
[8]"Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C."
Nery F.C., Passos D.O., Garcia V.S., Kobarg J.
J. Biol. Chem. 279:11444-11455(2004) [PubMed: 14699138] [Abstract]
Cited for: INTERACTION WITH HABP4.
[9]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-228, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

M24194 mRNA. Translation: AAA59626.1.
CR456978 mRNA. Translation: CAG33259.1.
BC000214 mRNA. Translation: AAH00214.1.
BC000366 mRNA. Translation: AAH00366.1.
BC010119 mRNA. Translation: AAH10119.1.
BC014256 mRNA. Translation: AAH14256.1.
BC014788 mRNA. Translation: AAH14788.1.
BC017287 mRNA. Translation: AAH17287.1.
BC019093 mRNA. Translation: AAH19093.1.
BC019362 mRNA. Translation: AAH19362.1.
BC021993 mRNA. Translation: AAH21993.1.
BC032006 mRNA. Translation: AAH32006.1.
PIRB33928.
RefSeqNP_006089.1.
UniGeneHs.5662

3D structure databases

HSSPHSSP built from PDB template 1ERJ based on UniProtKB P16649.
ModBaseSearch...

Protein-protein interaction databases

IntActP63244.

PTM databases

PhosphoSiteP63244.

2-D gel databases

REPRODUCTION-2DPAGEIPI00848226.
P63244.

Genome annotation databases

EnsemblENSG00000204628. Homo sapiens. [Contig view]
GeneID10399.
KEGGhsa:10399.

Organism-specific databases

H-InvDBHIX0005509.
HIX0080673.
HGNCHGNC:4399. GNB2L1.
HPACAB004288.
MIM176981. gene.
PharmGKBPA28779.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENP63244.

Gene expression databases

ArrayExpressP63244.
CleanExHS_GNB2L1.
GermOnlineENSG00000204628. Homo sapiens.

Family and domain databases

InterProIPR015943. WD40/YVTN_repeat-like.
IPR001680. WD40_repeat.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PfamPF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
ProDomPD000018. WD40. 5 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00320. WD40. 7 hits.
[Graphical view]
PROSITEPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubP63244.
NextBio39404.
SOURCESearch...

Entry information

Entry nameGBLP_HUMAN
AccessionPrimary (citable) accession number: P63244
Secondary accession number(s): P25388, P99049
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: November 4, 2008
This is version 45 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents