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P63226

- GMHA_ECOL6

UniProt

P63226 - GMHA_ECOL6

Protein

Phosphoheptose isomerase

Gene

gmhA

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (27 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

    Catalytic activityi

    D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611ZincUniRule annotation
    Metal bindingi65 – 651ZincUniRule annotation
    Binding sitei65 – 651SubstrateUniRule annotation
    Binding sitei124 – 1241SubstrateUniRule annotation
    Metal bindingi172 – 1721ZincUniRule annotation
    Binding sitei172 – 1721SubstrateUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. lipopolysaccharide core region biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Lipopolysaccharide biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00041; UER00436.
    UPA00958.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
    Alternative name(s):
    Sedoheptulose 7-phosphate isomeraseUniRule annotation
    Gene namesi
    Name:gmhAUniRule annotation
    Ordered Locus Names:c0372
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192Phosphoheptose isomerasePRO_0000136528Add
    BLAST

    Proteomic databases

    PRIDEiP63226.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi199310.c0372.

    Structurei

    3D structure databases

    ProteinModelPortaliP63226.
    SMRiP63226. Positions 1-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 192156SISUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 543Substrate bindingUniRule annotation
    Regioni93 – 942Substrate bindingUniRule annotation
    Regioni119 – 1213Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the SIS family. GmhA subfamily.UniRule annotation
    Contains 1 SIS domain.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000237571.
    KOiK03271.
    OMAiHVFSRYV.
    OrthoDBiEOG6384PC.

    Family and domain databases

    HAMAPiMF_00067. GmhA.
    InterProiIPR004515. Phosphoheptose_Isoase.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF13580. SIS_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00441. gmhA. 1 hit.
    PROSITEiPS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63226-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYQDLIRNEL NEAAETLANF LKDDANIHAI QRAAVLLADS FKAGGKVLSC    50
    GNGGSHCDAM HFAEELTGRY RENRPGYPAI AISDVSHISC VGNDFGFNDI 100
    FSRYVEAVGR EGDVLLGIST SGNSANVIKA IAAAREKGMK VITLTGKDGG 150
    KMAGTADIEI RVPHFGYADR IQEIHIKVIH ILIQLIEKEM VK 192
    Length:192
    Mass (Da):20,815
    Last modified:September 27, 2004 - v1
    Checksum:i7A2C05E1079108B4
    GO

    Sequence cautioni

    The sequence AAN78853.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN78853.1. Different initiation.
    RefSeqiNP_752309.2. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN78853; AAN78853; c0372.
    GeneIDi1036332.
    KEGGiecc:c0372.
    PATRICi18278796. VBIEscCol75197_0345.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN78853.1 . Different initiation.
    RefSeqi NP_752309.2. NC_004431.1.

    3D structure databases

    ProteinModelPortali P63226.
    SMRi P63226. Positions 1-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c0372.

    Proteomic databases

    PRIDEi P63226.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN78853 ; AAN78853 ; c0372 .
    GeneIDi 1036332.
    KEGGi ecc:c0372.
    PATRICi 18278796. VBIEscCol75197_0345.

    Phylogenomic databases

    HOGENOMi HOG000237571.
    KOi K03271.
    OMAi HVFSRYV.
    OrthoDBi EOG6384PC.

    Enzyme and pathway databases

    UniPathwayi UPA00041 ; UER00436 .
    UPA00958 .

    Family and domain databases

    HAMAPi MF_00067. GmhA.
    InterProi IPR004515. Phosphoheptose_Isoase.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF13580. SIS_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00441. gmhA. 1 hit.
    PROSITEi PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiGMHA_ECOL6
    AccessioniPrimary (citable) accession number: P63226
    Secondary accession number(s): P51001
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3