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P63226

- GMHA_ECOL6

UniProt

P63226 - GMHA_ECOL6

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Protein

Phosphoheptose isomerase

Gene
gmhA, c0372
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Zinc By similarity
Metal bindingi65 – 651Zinc By similarity
Binding sitei65 – 651Substrate By similarity
Binding sitei124 – 1241Substrate By similarity
Metal bindingi172 – 1721Zinc By similarity
Binding sitei172 – 1721Substrate By similarity
Metal bindingi180 – 1801Zinc By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide core region biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Lipopolysaccharide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00041; UER00436.
UPA00958.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomerase (EC:5.3.1.28)
Alternative name(s):
Sedoheptulose 7-phosphate isomerase
Gene namesi
Name:gmhA
Ordered Locus Names:c0372
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Phosphoheptose isomeraseUniRule annotationPRO_0000136528Add
BLAST

Proteomic databases

PRIDEiP63226.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi199310.c0372.

Structurei

3D structure databases

ProteinModelPortaliP63226.
SMRiP63226. Positions 1-192.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 192156SISAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 543Substrate binding By similarity
Regioni93 – 942Substrate binding By similarity
Regioni119 – 1213Substrate binding By similarity

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.
Contains 1 SIS domain.

Phylogenomic databases

HOGENOMiHOG000237571.
KOiK03271.
OMAiHVFSRYV.
OrthoDBiEOG6384PC.

Family and domain databases

HAMAPiMF_00067. GmhA.
InterProiIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamiPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63226-1 [UniParc]FASTAAdd to Basket

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MYQDLIRNEL NEAAETLANF LKDDANIHAI QRAAVLLADS FKAGGKVLSC    50
GNGGSHCDAM HFAEELTGRY RENRPGYPAI AISDVSHISC VGNDFGFNDI 100
FSRYVEAVGR EGDVLLGIST SGNSANVIKA IAAAREKGMK VITLTGKDGG 150
KMAGTADIEI RVPHFGYADR IQEIHIKVIH ILIQLIEKEM VK 192
Length:192
Mass (Da):20,815
Last modified:September 27, 2004 - v1
Checksum:i7A2C05E1079108B4
GO

Sequence cautioni

The sequence AAN78853.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN78853.1. Different initiation.
RefSeqiNP_752309.2. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN78853; AAN78853; c0372.
GeneIDi1036332.
KEGGiecc:c0372.
PATRICi18278796. VBIEscCol75197_0345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN78853.1 . Different initiation.
RefSeqi NP_752309.2. NC_004431.1.

3D structure databases

ProteinModelPortali P63226.
SMRi P63226. Positions 1-192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 199310.c0372.

Proteomic databases

PRIDEi P63226.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN78853 ; AAN78853 ; c0372 .
GeneIDi 1036332.
KEGGi ecc:c0372.
PATRICi 18278796. VBIEscCol75197_0345.

Phylogenomic databases

HOGENOMi HOG000237571.
KOi K03271.
OMAi HVFSRYV.
OrthoDBi EOG6384PC.

Enzyme and pathway databases

UniPathwayi UPA00041 ; UER00436 .
UPA00958 .

Family and domain databases

HAMAPi MF_00067. GmhA.
InterProi IPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view ]
Pfami PF13580. SIS_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00441. gmhA. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiGMHA_ECOL6
AccessioniPrimary (citable) accession number: P63226
Secondary accession number(s): P51001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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