P63220 (RS21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S21

Gene names

Name:

RPS21

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	83 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S21e family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from Biological aspect of Ancestor. Source: RefGenome endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from Biological aspect of Ancestor. Source: RefGenome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic small ribosomal subunit Inferred from direct assay PubMed 15883184Ref.7. Source: UniProtKB
Molecular_function	structural constituent of ribosome Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 83	83	40S ribosomal protein S21		PRO_0000194730
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.6
	Modified residue	81	1	N6-acetyllysine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P63220 [UniParc]. Last modified September 27, 2004. Version 1. Checksum: 6794AC1292A06BD3	FASTA	83	9,111
	10 20 30 40 50 60 MQNDAGEFVD LYVPRKCSAS NRIIGAKDHA SIQMNVAEVD KVTGRFNGQF KTYAICGAIR 70 80 RMGESDDSIL RLAKADGIVS KNF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure of human ribosomal protein S21." Bhat K.S., Morrison S.G. Nucleic Acids Res. 21:2939-2939(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and characterization of the human ribosomal protein S21 gene." Smirnova E.V., Rakitina T.V., Evtodienko A.Y., Kostanian I.A., Lipkin V.M. Bioorg. Khim. 26:392-396(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N. Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"A map of 75 human ribosomal protein genes." Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C. Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-74.
[6]	Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M. Submitted (MAY-2006) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-15, ACETYLATION AT MET-1, MASS SPECTROMETRY. Tissue: T-cell.
[7]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 42-47. Tissue: Placenta.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-81, MASS SPECTROMETRY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L04483 mRNA. Translation: AAA99893.1. AJ250907 Genomic DNA. Translation: CAB83213.1. AB061843 Genomic DNA. Translation: BAB79481.1. AL121832 Genomic DNA. Translation: CAC21458.1. AB007157 Genomic DNA. Translation: BAA25821.1.
IPI	IPI00017448.
PIR	S34108.
RefSeq	NP_001015.1. NM_001024.3.
UniGene	Hs.190968.
3D structure databases
ProteinModelPortal	P63220.
ModBase	Search...
Protein-protein interaction databases
IntAct	P63220. 4 interactions.
STRING	9606.ENSP00000324438.
PTM databases
PhosphoSite	P63220.
Polymorphism databases
DMDM	52783792.
Proteomic databases
PaxDb	P63220.
PRIDE	P63220.
Protocols and materials databases
DNASU	6227.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343986; ENSP00000345957; ENSG00000171858.
GeneID	6227.
KEGG	hsa:6227.
UCSC	uc002ycr.3. human.
Organism-specific databases
CTD	6227.
GeneCards	GC20P060962.
HGNC	HGNC:10409. RPS21.
HPA	HPA003371.
MIM	180477. gene.
neXtProt	NX_P63220.
PharmGKB	PA34812.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG301320.
HOGENOM	HOG000183557.
KO	K02971.
OrthoDB	EOG43JC6C.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P63220.
Bgee	P63220.
CleanEx	HS_RPS21.
Genevestigator	P63220.
GermOnline	ENSG00000171858. Homo sapiens.
Family and domain databases
InterPro	IPR001931. Ribosomal_S21e. IPR018279. Ribosomal_S21e_CS. [Graphical view]
PANTHER	PTHR10442. PTHR10442. 1 hit.
Pfam	PF01249. Ribosomal_S21e. 1 hit. [Graphical view]
PIRSF	PIRSF002148. Ribosomal_S21e. 1 hit.
ProDom	PD006584. Ribosomal_S21e. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00996. RIBOSOMAL_S21E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RpS21. human.
GenomeRNAi	6227.
NextBio	24171.
PMAP-CutDB	P63220.
SOURCE	Search...

Entry information

Entry name

RS21_HUMAN

Accession

Primary (citable) accession number: P63220
Secondary accession number(s): P35265

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	September 27, 2004
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.