P63219 (GBG5_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene names

Name:	Gng5
Synonyms:	Gngt5

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Acetylation Lipoprotein Methylation Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 65	64	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5		PRO_0000012631
	Propeptide	66 – 68	3	Removed in mature form By similarity		PRO_0000012632
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	2	1	Phosphoserine By similarity
	Modified residue	65	1	Cysteine methyl ester By similarity
	Lipidation	65	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63219 [UniParc]. Last modified September 27, 2004. Version 1. Checksum: 9AF7A16558863602	FASTA	68	7,318
	10 20 30 40 50 60 MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT GVSSSTNPFR PQKVCSFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)." Fisher K.J., Aronson N.N. Jr. Mol. Cell. Biol. 12:1585-1591(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M95780 mRNA. Translation: AAA41188.1. BC058469 mRNA. Translation: AAH58469.1.
IPI	IPI00211098.
RefSeq	NP_077353.1. NM_024377.1. XP_002725580.1. XM_002725534.1. XP_002728742.1. XM_002728696.1.
UniGene	Rn.2695.
3D structure databases
ProteinModelPortal	P63219.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000054976.
Proteomic databases
PRIDE	P63219.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000021358; ENSRNOP00000021358; ENSRNOG00000015936. ENSRNOT00000058172; ENSRNOP00000054976; ENSRNOG00000038205.
GeneID	100360499. 79218.
KEGG	rno:100360499. rno:79218.
Organism-specific databases
CTD	2787.
RGD	620807. Gng5.
Phylogenomic databases
eggNOG	NOG262845.
GeneTree	ENSGT00550000074352.
HOVERGEN	HBG014983.
InParanoid	P63219.
KO	K04542.
OMA	QLRFEAS.
OrthoDB	EOG43FGZM.
Gene expression databases
ArrayExpress	P63219.
Genevestigator	P63219.
GermOnline	ENSRNOG00000015936. Rattus norvegicus. ENSRNOG00000038205. Rattus norvegicus.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	614632.

Entry information

Entry name

GBG5_RAT

Accession

Primary (citable) accession number: P63219
Secondary accession number(s): P30670, Q61015

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	September 27, 2004
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program