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P63219

- GBG5_RAT

UniProt

P63219 - GBG5_RAT

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene
Gng5, Gngt5
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene namesi
Name:Gng5
Synonyms:Gngt5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1, UP000002494: Chromosome 2

Organism-specific databases

RGDi620807. Gng5.

Subcellular locationi

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5PRO_0000012631Add
BLAST
Propeptidei66 – 683Removed in mature form By similarityPRO_0000012632

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei2 – 21Phosphoserine By similarity
Modified residuei65 – 651Cysteine methyl ester By similarity
Lipidationi65 – 651S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PRIDEiP63219.

Expressioni

Gene expression databases

GenevestigatoriP63219.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054976.

Structurei

3D structure databases

ProteinModelPortaliP63219.
SMRiP63219. Positions 6-59.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.

Phylogenomic databases

eggNOGiNOG262845.
GeneTreeiENSGT00740000115214.
HOVERGENiHBG014983.
InParanoidiP63219.
KOiK04542.
OMAiRFEAGIN.
OrthoDBiEOG7H1JP7.
PhylomeDBiP63219.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63219-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT   50
GVSSSTNPFR PQKVCSFL 68
Length:68
Mass (Da):7,318
Last modified:September 27, 2004 - v1
Checksum:i9AF7A16558863602
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95780 mRNA. Translation: AAA41188.1.
BC058469 mRNA. Translation: AAH58469.1.
RefSeqiNP_077353.1. NM_024377.1.
UniGeneiRn.2695.

Genome annotation databases

EnsembliENSRNOT00000021358; ENSRNOP00000021358; ENSRNOG00000015936.
ENSRNOT00000058172; ENSRNOP00000054976; ENSRNOG00000038205.
GeneIDi79218.
KEGGirno:79218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95780 mRNA. Translation: AAA41188.1 .
BC058469 mRNA. Translation: AAH58469.1 .
RefSeqi NP_077353.1. NM_024377.1.
UniGenei Rn.2695.

3D structure databases

ProteinModelPortali P63219.
SMRi P63219. Positions 6-59.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000054976.

Proteomic databases

PRIDEi P63219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021358 ; ENSRNOP00000021358 ; ENSRNOG00000015936 .
ENSRNOT00000058172 ; ENSRNOP00000054976 ; ENSRNOG00000038205 .
GeneIDi 79218.
KEGGi rno:79218.

Organism-specific databases

CTDi 2787.
RGDi 620807. Gng5.

Phylogenomic databases

eggNOGi NOG262845.
GeneTreei ENSGT00740000115214.
HOVERGENi HBG014983.
InParanoidi P63219.
KOi K04542.
OMAi RFEAGIN.
OrthoDBi EOG7H1JP7.
PhylomeDBi P63219.
TreeFami TF319909.

Miscellaneous databases

NextBioi 614632.
PROi P63219.

Gene expression databases

Genevestigatori P63219.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)."
    Fisher K.J., Aronson N.N. Jr.
    Mol. Cell. Biol. 12:1585-1591(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiGBG5_RAT
AccessioniPrimary (citable) accession number: P63219
Secondary accession number(s): P30670, Q61015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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