Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene

Gng5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_278318. Activation of G protein gated Potassium channels.
REACT_287906. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_295737. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_297045. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_311068. Glucagon signaling in metabolic regulation.
REACT_326473. Glucagon-type ligand receptors.
REACT_351378. Adrenaline,noradrenaline inhibits insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene namesi
Name:Gng5
Synonyms:Gngt5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componentsi: Chromosome 1, Chromosome 2

Organism-specific databases

RGDi620807. Gng5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5PRO_0000012631Add
BLAST
Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012632

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei65 – 651Cysteine methyl esterBy similarity
Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PRIDEiP63219.

Expressioni

Gene expression databases

ExpressionAtlasiP63219. baseline and differential.
GenevestigatoriP63219.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054976.

Structurei

3D structure databases

ProteinModelPortaliP63219.
SMRiP63219. Positions 6-59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG262845.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63219.
KOiK04542.
OMAiADLQQFC.
OrthoDBiEOG7H1JP7.
PhylomeDBiP63219.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT
60
GVSSSTNPFR PQKVCSFL
Length:68
Mass (Da):7,318
Last modified:September 27, 2004 - v1
Checksum:i9AF7A16558863602
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95780 mRNA. Translation: AAA41188.1.
BC058469 mRNA. Translation: AAH58469.1.
RefSeqiNP_077353.1. NM_024377.1.
UniGeneiRn.2695.

Genome annotation databases

EnsembliENSRNOT00000021358; ENSRNOP00000021358; ENSRNOG00000015936.
ENSRNOT00000058172; ENSRNOP00000054976; ENSRNOG00000038205.
GeneIDi79218.
KEGGirno:79218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95780 mRNA. Translation: AAA41188.1.
BC058469 mRNA. Translation: AAH58469.1.
RefSeqiNP_077353.1. NM_024377.1.
UniGeneiRn.2695.

3D structure databases

ProteinModelPortaliP63219.
SMRiP63219. Positions 6-59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054976.

Proteomic databases

PRIDEiP63219.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021358; ENSRNOP00000021358; ENSRNOG00000015936.
ENSRNOT00000058172; ENSRNOP00000054976; ENSRNOG00000038205.
GeneIDi79218.
KEGGirno:79218.

Organism-specific databases

CTDi2787.
RGDi620807. Gng5.

Phylogenomic databases

eggNOGiNOG262845.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63219.
KOiK04542.
OMAiADLQQFC.
OrthoDBiEOG7H1JP7.
PhylomeDBiP63219.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_278318. Activation of G protein gated Potassium channels.
REACT_287906. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_295737. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_297045. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_311068. Glucagon signaling in metabolic regulation.
REACT_326473. Glucagon-type ligand receptors.
REACT_351378. Adrenaline,noradrenaline inhibits insulin secretion.

Miscellaneous databases

NextBioi614632.
PROiP63219.

Gene expression databases

ExpressionAtlasiP63219. baseline and differential.
GenevestigatoriP63219.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)."
    Fisher K.J., Aronson N.N. Jr.
    Mol. Cell. Biol. 12:1585-1591(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiGBG5_RAT
AccessioniPrimary (citable) accession number: P63219
Secondary accession number(s): P30670, Q61015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: May 27, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.