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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene

Gng5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-RNO-1296041 Activation of G protein gated Potassium channels
R-RNO-202040 G-protein activation
R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-392170 ADP signalling through P2Y purinoceptor 12
R-RNO-392451 G beta:gamma signalling through PI3Kgamma
R-RNO-392851 Prostacyclin signalling through prostacyclin receptor
R-RNO-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-RNO-4086398 Ca2+ pathway
R-RNO-416476 G alpha (q) signalling events
R-RNO-416482 G alpha (12/13) signalling events
R-RNO-418217 G beta:gamma signalling through PLC beta
R-RNO-418555 G alpha (s) signalling events
R-RNO-418592 ADP signalling through P2Y purinoceptor 1
R-RNO-418594 G alpha (i) signalling events
R-RNO-418597 G alpha (z) signalling events
R-RNO-420092 Glucagon-type ligand receptors
R-RNO-428930 Thromboxane signalling through TP receptor
R-RNO-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-RNO-500657 Presynaptic function of Kainate receptors
R-RNO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-RNO-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene namesi
Name:Gng5
Synonyms:Gngt5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 1, Chromosome 2

Organism-specific databases

RGDi620807 Gng5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000126312 – 65Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5Add BLAST64
PropeptideiPRO_000001263266 – 68Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei65Cysteine methyl esterBy similarity1
Lipidationi65S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP63219
PRIDEiP63219

Expressioni

Gene expression databases

BgeeiENSRNOG00000015936
GenevisibleiP63219 RN

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054976

Structurei

3D structure databases

ProteinModelPortaliP63219
SMRiP63219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP63219
KOiK04542
OMAiQFCIQNA
OrthoDBiEOG091G17J0
PhylomeDBiP63219
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT
60
GVSSSTNPFR PQKVCSFL
Length:68
Mass (Da):7,318
Last modified:September 27, 2004 - v1
Checksum:i9AF7A16558863602
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95780 mRNA Translation: AAA41188.1
BC058469 mRNA Translation: AAH58469.1
RefSeqiNP_077353.1, NM_024377.1
XP_017445483.1, XM_017589994.1
XP_017460456.1, XM_017604967.1
UniGeneiRn.2695

Genome annotation databases

EnsembliENSRNOT00000021358; ENSRNOP00000021358; ENSRNOG00000015936
ENSRNOT00000058172; ENSRNOP00000054976; ENSRNOG00000038205
GeneIDi108349548
79218
KEGGirno:108349548
rno:79218

Similar proteinsi

Entry informationi

Entry nameiGBG5_RAT
AccessioniPrimary (citable) accession number: P63219
Secondary accession number(s): P30670, Q61015
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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