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P63219

- GBG5_RAT

UniProt

P63219 - GBG5_RAT

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene

Gng5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
    Gene namesi
    Name:Gng5
    Synonyms:Gngt5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1, UP000002494: Chromosome 2

    Organism-specific databases

    RGDi620807. Gng5.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5PRO_0000012631Add
    BLAST
    Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012632

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei2 – 21PhosphoserineBy similarity
    Modified residuei65 – 651Cysteine methyl esterBy similarity
    Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PRIDEiP63219.

    Expressioni

    Gene expression databases

    GenevestigatoriP63219.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000054976.

    Structurei

    3D structure databases

    ProteinModelPortaliP63219.
    SMRiP63219. Positions 6-59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG262845.
    GeneTreeiENSGT00740000115214.
    HOVERGENiHBG014983.
    InParanoidiP63219.
    KOiK04542.
    OMAiRFEAGIN.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiP63219.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P63219-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT   50
    GVSSSTNPFR PQKVCSFL 68
    Length:68
    Mass (Da):7,318
    Last modified:September 27, 2004 - v1
    Checksum:i9AF7A16558863602
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95780 mRNA. Translation: AAA41188.1.
    BC058469 mRNA. Translation: AAH58469.1.
    RefSeqiNP_077353.1. NM_024377.1.
    UniGeneiRn.2695.

    Genome annotation databases

    EnsembliENSRNOT00000021358; ENSRNOP00000021358; ENSRNOG00000015936.
    ENSRNOT00000058172; ENSRNOP00000054976; ENSRNOG00000038205.
    GeneIDi79218.
    KEGGirno:79218.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95780 mRNA. Translation: AAA41188.1 .
    BC058469 mRNA. Translation: AAH58469.1 .
    RefSeqi NP_077353.1. NM_024377.1.
    UniGenei Rn.2695.

    3D structure databases

    ProteinModelPortali P63219.
    SMRi P63219. Positions 6-59.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000054976.

    Proteomic databases

    PRIDEi P63219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021358 ; ENSRNOP00000021358 ; ENSRNOG00000015936 .
    ENSRNOT00000058172 ; ENSRNOP00000054976 ; ENSRNOG00000038205 .
    GeneIDi 79218.
    KEGGi rno:79218.

    Organism-specific databases

    CTDi 2787.
    RGDi 620807. Gng5.

    Phylogenomic databases

    eggNOGi NOG262845.
    GeneTreei ENSGT00740000115214.
    HOVERGENi HBG014983.
    InParanoidi P63219.
    KOi K04542.
    OMAi RFEAGIN.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi P63219.
    TreeFami TF319909.

    Miscellaneous databases

    NextBioi 614632.
    PROi P63219.

    Gene expression databases

    Genevestigatori P63219.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)."
      Fisher K.J., Aronson N.N. Jr.
      Mol. Cell. Biol. 12:1585-1591(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.

    Entry informationi

    Entry nameiGBG5_RAT
    AccessioniPrimary (citable) accession number: P63219
    Secondary accession number(s): P30670, Q61015
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3