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P63219 (GBG5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene names
Name:Gng5
Synonyms:Gngt5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the G protein gamma family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
PRO_0000012631
Propeptide66 – 683Removed in mature form By similarity
PRO_0000012632

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue21Phosphoserine By similarity
Modified residue651Cysteine methyl ester By similarity
Lipidation651S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P63219 [UniParc].

Last modified September 27, 2004. Version 1.
Checksum: 9AF7A16558863602

FASTA687,318
        10         20         30         40         50         60 
MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT GVSSSTNPFR 


PQKVCSFL 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)."
Fisher K.J., Aronson N.N. Jr.
Mol. Cell. Biol. 12:1585-1591(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95780 mRNA. Translation: AAA41188.1.
BC058469 mRNA. Translation: AAH58469.1.
RefSeqNP_077353.1. NM_024377.1.
UniGeneRn.2695.

3D structure databases

ProteinModelPortalP63219.
SMRP63219. Positions 6-59.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000054976.

Proteomic databases

PRIDEP63219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000021358; ENSRNOP00000021358; ENSRNOG00000015936.
ENSRNOT00000058172; ENSRNOP00000054976; ENSRNOG00000038205.
GeneID79218.
KEGGrno:100360499.
rno:79218.

Organism-specific databases

CTD2787.
RGD620807. Gng5.

Phylogenomic databases

eggNOGNOG262845.
GeneTreeENSGT00740000115214.
HOVERGENHBG014983.
InParanoidP63219.
KOK04542.
OMAADLQQFC.
OrthoDBEOG7H1JP7.
PhylomeDBP63219.
TreeFamTF319909.

Gene expression databases

GenevestigatorP63219.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614632.
PROP63219.

Entry information

Entry nameGBG5_RAT
AccessionPrimary (citable) accession number: P63219
Secondary accession number(s): P30670, Q61015
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families