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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene

GNG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • PDZ domain binding Source: MGI
  • signal transducer activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene namesi
Name:GNG5
Synonyms:GNGT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174021.10.
HGNCiHGNC:4408. GNG5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2787.
OpenTargetsiENSG00000174021.
PharmGKBiPA28787.

Polymorphism and mutation databases

BioMutaiGNG5.
DMDMi52783599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000126272 – 65Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5Add BLAST64
PropeptideiPRO_000001262866 – 68Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei2PhosphoserineCombined sources1
Modified residuei65Cysteine methyl esterBy similarity1
Lipidationi65S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP63218.
MaxQBiP63218.
PaxDbiP63218.
PeptideAtlasiP63218.
PRIDEiP63218.

PTM databases

iPTMnetiP63218.
PhosphoSitePlusiP63218.

Expressioni

Gene expression databases

BgeeiENSG00000174021.
CleanExiHS_GNG5.
GenevisibleiP63218. HS.

Organism-specific databases

HPAiCAB032623.
HPA043651.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

Show more details

GO - Molecular functioni

  • PDZ domain binding Source: MGI

Protein-protein interaction databases

BioGridi109049. 42 interactors.
IntActiP63218. 8 interactors.
STRINGi9606.ENSP00000359675.

Structurei

3D structure databases

ProteinModelPortaliP63218.
SMRiP63218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63218.
KOiK04542.
OMAiQFCIQNA.
OrthoDBiEOG091G17J0.
PhylomeDBiP63218.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
InterProiView protein in InterPro
IPR015898. G-protein_gamma-like_dom.
IPR036284. GGL_sf.
IPR001770. Gprotein-gamma.
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiView protein in Pfam
PF00631. G-gamma. 1 hit.
PRINTSiPR00321. GPROTEING.
SMARTiView protein in SMART
SM00224. GGL. 1 hit.
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiView protein in PROSITE
PS50058. G_PROTEIN_GAMMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT
60
GVSSSTNPFR PQKVCSFL
Length:68
Mass (Da):7,318
Last modified:January 23, 2007 - v3
Checksum:i9AF7A16558863602
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085709, AF085708 Genomic DNA. Translation: AAC72203.1.
AF038955 mRNA. Translation: AAC39869.1.
AF493873 mRNA. Translation: AAM12587.1.
BT006823 mRNA. Translation: AAP35469.1.
AK312111 mRNA. Translation: BAG35047.1.
AL359762 Genomic DNA. No translation available.
CH471097 Genomic DNA. Translation: EAW73236.1.
BC003563 mRNA. Translation: AAH03563.1.
CCDSiCCDS696.1.
RefSeqiNP_005265.1. NM_005274.2.
UniGeneiHs.645427.

Genome annotation databases

EnsembliENST00000370641; ENSP00000359675; ENSG00000174021.
ENST00000370645; ENSP00000359679; ENSG00000174021.
GeneIDi2787.
KEGGihsa:2787.
UCSCiuc001djw.5. human.

Similar proteinsi

Entry informationi

Entry nameiGBG5_HUMAN
AccessioniPrimary (citable) accession number: P63218
Secondary accession number(s): B2R5A0
, P30670, Q5VX54, Q61015
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families