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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene

GNG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • PDZ domain binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene namesi
Name:GNG5
Synonyms:GNGT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174021.10
HGNCiHGNC:4408 GNG5
MIMi600874 gene
neXtProtiNX_P63218

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2787
OpenTargetsiENSG00000174021
PharmGKBiPA28787

Polymorphism and mutation databases

BioMutaiGNG5
DMDMi52783599

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000126272 – 65Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5Add BLAST64
PropeptideiPRO_000001262866 – 68Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei2PhosphoserineCombined sources1
Modified residuei65Cysteine methyl esterBy similarity1
Lipidationi65S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP63218
MaxQBiP63218
PaxDbiP63218
PeptideAtlasiP63218
PRIDEiP63218
ProteomicsDBi57508

PTM databases

iPTMnetiP63218
PhosphoSitePlusiP63218

Expressioni

Gene expression databases

BgeeiENSG00000174021
CleanExiHS_GNG5
GenevisibleiP63218 HS

Organism-specific databases

HPAiCAB032623
HPA043651

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

Show more details

GO - Molecular functioni

  • PDZ domain binding Source: MGI

Protein-protein interaction databases

BioGridi109049, 42 interactors
IntActiP63218, 8 interactors
STRINGi9606.ENSP00000359675

Structurei

3D structure databases

ProteinModelPortaliP63218
SMRiP63218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP63218
KOiK04542
OMAiQFCIQNA
OrthoDBiEOG091G17J0
PhylomeDBiP63218
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT
60
GVSSSTNPFR PQKVCSFL
Length:68
Mass (Da):7,318
Last modified:January 23, 2007 - v3
Checksum:i9AF7A16558863602
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085709, AF085708 Genomic DNA Translation: AAC72203.1
AF038955 mRNA Translation: AAC39869.1
AF493873 mRNA Translation: AAM12587.1
BT006823 mRNA Translation: AAP35469.1
AK312111 mRNA Translation: BAG35047.1
AL359762 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73236.1
BC003563 mRNA Translation: AAH03563.1
CCDSiCCDS696.1
RefSeqiNP_005265.1, NM_005274.2
UniGeneiHs.645427

Genome annotation databases

EnsembliENST00000370641; ENSP00000359675; ENSG00000174021
ENST00000370645; ENSP00000359679; ENSG00000174021
GeneIDi2787
KEGGihsa:2787
UCSCiuc001djw.5 human

Similar proteinsi

Entry informationi

Entry nameiGBG5_HUMAN
AccessioniPrimary (citable) accession number: P63218
Secondary accession number(s): B2R5A0
, P30670, Q5VX54, Q61015
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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