Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene

GNG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • PDZ domain binding Source: MGI
  • signal transducer activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene namesi
Name:GNG5
Synonyms:GNGT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4408. GNG5.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • heterotrimeric G-protein complex Source: UniProtKB
  • membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28787.

Polymorphism and mutation databases

BioMutaiGNG5.
DMDMi52783599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5PRO_0000012627Add
BLAST
Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012628

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources1 Publication
Modified residuei2 – 21PhosphoserineCombined sources
Modified residuei65 – 651Cysteine methyl esterBy similarity
Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP63218.
MaxQBiP63218.
PaxDbiP63218.
PeptideAtlasiP63218.
PRIDEiP63218.

PTM databases

iPTMnetiP63218.
PhosphoSiteiP63218.

Expressioni

Gene expression databases

BgeeiENSG00000174021.
CleanExiHS_GNG5.
GenevisibleiP63218. HS.

Organism-specific databases

HPAiCAB032623.
HPA043651.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
AMOTL2Q9Y2J4-43EBI-10220734,EBI-10187270
EPS15L1Q9UBC23EBI-10220734,EBI-2556746
GOLGA2Q083793EBI-10220734,EBI-618309
KRT31Q153233EBI-10220734,EBI-948001
KRT40Q6A1623EBI-10220734,EBI-10171697
MDFIQ997503EBI-10220734,EBI-724076
TRAF1Q130773EBI-10220734,EBI-359224

GO - Molecular functioni

  • PDZ domain binding Source: MGI

Protein-protein interaction databases

BioGridi109049. 29 interactions.
IntActiP63218. 8 interactions.
STRINGi9606.ENSP00000359675.

Structurei

3D structure databases

ProteinModelPortaliP63218.
SMRiP63218. Positions 6-59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63218.
KOiK04542.
OMAiADLQQFC.
OrthoDBiEOG091G17J0.
PhylomeDBiP63218.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT
60
GVSSSTNPFR PQKVCSFL
Length:68
Mass (Da):7,318
Last modified:January 23, 2007 - v3
Checksum:i9AF7A16558863602
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085709, AF085708 Genomic DNA. Translation: AAC72203.1.
AF038955 mRNA. Translation: AAC39869.1.
AF493873 mRNA. Translation: AAM12587.1.
BT006823 mRNA. Translation: AAP35469.1.
AK312111 mRNA. Translation: BAG35047.1.
AL359762 Genomic DNA. Translation: CAH70203.1.
CH471097 Genomic DNA. Translation: EAW73236.1.
BC003563 mRNA. Translation: AAH03563.1.
CCDSiCCDS696.1.
RefSeqiNP_005265.1. NM_005274.2.
UniGeneiHs.645427.

Genome annotation databases

EnsembliENST00000370641; ENSP00000359675; ENSG00000174021.
ENST00000370645; ENSP00000359679; ENSG00000174021.
GeneIDi2787.
KEGGihsa:2787.
UCSCiuc001djw.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085709, AF085708 Genomic DNA. Translation: AAC72203.1.
AF038955 mRNA. Translation: AAC39869.1.
AF493873 mRNA. Translation: AAM12587.1.
BT006823 mRNA. Translation: AAP35469.1.
AK312111 mRNA. Translation: BAG35047.1.
AL359762 Genomic DNA. Translation: CAH70203.1.
CH471097 Genomic DNA. Translation: EAW73236.1.
BC003563 mRNA. Translation: AAH03563.1.
CCDSiCCDS696.1.
RefSeqiNP_005265.1. NM_005274.2.
UniGeneiHs.645427.

3D structure databases

ProteinModelPortaliP63218.
SMRiP63218. Positions 6-59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109049. 29 interactions.
IntActiP63218. 8 interactions.
STRINGi9606.ENSP00000359675.

PTM databases

iPTMnetiP63218.
PhosphoSiteiP63218.

Polymorphism and mutation databases

BioMutaiGNG5.
DMDMi52783599.

Proteomic databases

EPDiP63218.
MaxQBiP63218.
PaxDbiP63218.
PeptideAtlasiP63218.
PRIDEiP63218.

Protocols and materials databases

DNASUi2787.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370641; ENSP00000359675; ENSG00000174021.
ENST00000370645; ENSP00000359679; ENSG00000174021.
GeneIDi2787.
KEGGihsa:2787.
UCSCiuc001djw.5. human.

Organism-specific databases

CTDi2787.
GeneCardsiGNG5.
HGNCiHGNC:4408. GNG5.
HPAiCAB032623.
HPA043651.
MIMi600874. gene.
neXtProtiNX_P63218.
PharmGKBiPA28787.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63218.
KOiK04542.
OMAiADLQQFC.
OrthoDBiEOG091G17J0.
PhylomeDBiP63218.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

GeneWikiiGNG5.
GenomeRNAii2787.
PROiP63218.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174021.
CleanExiHS_GNG5.
GenevisibleiP63218. HS.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG5_HUMAN
AccessioniPrimary (citable) accession number: P63218
Secondary accession number(s): B2R5A0
, P30670, Q5VX54, Q61015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.