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P63216 (GBG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene names
Name:Gng3
Synonyms:Gngt3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length75 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Abundantly expressed in brain. Low levels in testis.

Sequence similarities

Belongs to the G protein gamma family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
PRO_0000012619
Propeptide73 – 753Removed in mature form By similarity
PRO_0000012620

Amino acid modifications

Modified residue721Cysteine methyl ester By similarity
Lipidation721S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P63216 [UniParc].

Last modified September 27, 2004. Version 1.
Checksum: 35CC03965FE69A9D

FASTA758,305
        10         20         30         40         50         60 
MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC EDPLITPVPT 

        70 
SENPFREKKF FCALL 

« Hide

References

« Hide 'large scale' references
[1]"A brain-specific G protein gamma subunit."
Kalyanaraman S., Kalyanaraman V., Gautam N.
Biochem. Biophys. Res. Commun. 216:126-132(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain.
[2]"Structure and mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, Gng3lg."
Downes G.B., Copeland N.G., Jenkins N.A., Gautam N.
Genomics 53:220-230(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[5]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-17 AND 25-31, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[6]"G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
Williams C.J., Schultz R.M., Kopf G.S.
Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-68.
Strain: CF-1 / Harlan.
[7]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF069953 Genomic DNA. Translation: AAC83941.1.
AK004459 mRNA. Translation: BAB23313.1.
AK032646 mRNA. Translation: BAC27969.1.
BC029680 mRNA. Translation: AAH29680.1.
U38497 mRNA. Translation: AAB01728.1.
PIRJC4340.
RefSeqNP_034446.1. NM_010316.3.
UniGeneMm.329700.

3D structure databases

ProteinModelPortalP63216.
SMRP63216. Positions 12-71.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP63216. 1 interaction.
STRING10090.ENSMUSP00000093978.

PTM databases

PhosphoSiteP63216.

Proteomic databases

PaxDbP63216.
PRIDEP63216.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000096259; ENSMUSP00000093978; ENSMUSG00000071658.
GeneID14704.
KEGGmmu:14704.
UCSCuc008gnh.1. mouse.

Organism-specific databases

CTD2785.
MGIMGI:102704. Gng3.

Phylogenomic databases

eggNOGNOG279844.
GeneTreeENSGT00740000115378.
HOVERGENHBG014983.
InParanoidP63216.
KOK04540.
OMAEASMCRI.
OrthoDBEOG7H1JP7.
PhylomeDBP63216.
TreeFamTF319909.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

BgeeP63216.
GenevestigatorP63216.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286679.
PROP63216.
SOURCESearch...

Entry information

Entry nameGBG3_MOUSE
AccessionPrimary (citable) accession number: P63216
Secondary accession number(s): P29798, Q61014
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot