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P63216

- GBG3_MOUSE

UniProt

P63216 - GBG3_MOUSE

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Protein
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene
Gng3, Gngt3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. GTPase activity Source: MGI
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
  2. GTP catabolic process Source: GOC
  3. positive regulation of cytosolic calcium ion concentration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene namesi
Name:Gng3
Synonyms:Gngt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:102704. Gng3.

Subcellular locationi

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
PRO_0000012619Add
BLAST
Propeptidei73 – 753Removed in mature form By similarity
PRO_0000012620

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721Cysteine methyl ester By similarity
Lipidationi72 – 721S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP63216.
PRIDEiP63216.

PTM databases

PhosphoSiteiP63216.

Expressioni

Tissue specificityi

Abundantly expressed in brain. Low levels in testis.

Gene expression databases

BgeeiP63216.
GenevestigatoriP63216.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

IntActiP63216. 1 interaction.
STRINGi10090.ENSMUSP00000093978.

Structurei

3D structure databases

ProteinModelPortaliP63216.
SMRiP63216. Positions 12-71.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.

Phylogenomic databases

eggNOGiNOG279844.
GeneTreeiENSGT00740000115378.
HOVERGENiHBG014983.
InParanoidiP63216.
KOiK04540.
OMAiTINNENT.
OrthoDBiEOG7H1JP7.
PhylomeDBiP63216.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63216-1 [UniParc]FASTAAdd to Basket

« Hide

MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC   50
EDPLITPVPT SENPFREKKF FCALL 75
Length:75
Mass (Da):8,305
Last modified:September 27, 2004 - v1
Checksum:i35CC03965FE69A9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF069953 Genomic DNA. Translation: AAC83941.1.
AK004459 mRNA. Translation: BAB23313.1.
AK032646 mRNA. Translation: BAC27969.1.
BC029680 mRNA. Translation: AAH29680.1.
U38497 mRNA. Translation: AAB01728.1.
CCDSiCCDS29550.1.
PIRiJC4340.
RefSeqiNP_034446.1. NM_010316.3.
UniGeneiMm.329700.

Genome annotation databases

EnsembliENSMUST00000096259; ENSMUSP00000093978; ENSMUSG00000071658.
GeneIDi14704.
KEGGimmu:14704.
UCSCiuc008gnh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF069953 Genomic DNA. Translation: AAC83941.1 .
AK004459 mRNA. Translation: BAB23313.1 .
AK032646 mRNA. Translation: BAC27969.1 .
BC029680 mRNA. Translation: AAH29680.1 .
U38497 mRNA. Translation: AAB01728.1 .
CCDSi CCDS29550.1.
PIRi JC4340.
RefSeqi NP_034446.1. NM_010316.3.
UniGenei Mm.329700.

3D structure databases

ProteinModelPortali P63216.
SMRi P63216. Positions 12-71.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P63216. 1 interaction.
STRINGi 10090.ENSMUSP00000093978.

PTM databases

PhosphoSitei P63216.

Proteomic databases

PaxDbi P63216.
PRIDEi P63216.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000096259 ; ENSMUSP00000093978 ; ENSMUSG00000071658 .
GeneIDi 14704.
KEGGi mmu:14704.
UCSCi uc008gnh.1. mouse.

Organism-specific databases

CTDi 2785.
MGIi MGI:102704. Gng3.

Phylogenomic databases

eggNOGi NOG279844.
GeneTreei ENSGT00740000115378.
HOVERGENi HBG014983.
InParanoidi P63216.
KOi K04540.
OMAi TINNENT.
OrthoDBi EOG7H1JP7.
PhylomeDBi P63216.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

NextBioi 286679.
PROi P63216.
SOURCEi Search...

Gene expression databases

Bgeei P63216.
Genevestigatori P63216.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain.
  2. "Structure and mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, Gng3lg."
    Downes G.B., Copeland N.G., Jenkins N.A., Gautam N.
    Genomics 53:220-230(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-17 AND 25-31, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  6. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
    Williams C.J., Schultz R.M., Kopf G.S.
    Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-68.
    Strain: CF-1 / Harlan.
  7. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiGBG3_MOUSE
AccessioniPrimary (citable) accession number: P63216
Secondary accession number(s): P29798, Q61014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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