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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Gene

Gng3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene namesi
Name:Gng3
Synonyms:Gngt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:102704. Gng3.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: MGI
  • cytosol Source: Ensembl
  • dendrite Source: MGI
  • heterotrimeric G-protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3PRO_0000012619Add
BLAST
Propeptidei73 – 753Removed in mature formBy similarityPRO_0000012620

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51PhosphothreonineCombined sources
Modified residuei9 – 91PhosphoserineCombined sources
Modified residuei10 – 101PhosphothreonineCombined sources
Modified residuei12 – 121PhosphoserineCombined sources
Modified residuei72 – 721Cysteine methyl esterBy similarity
Lipidationi72 – 721S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiP63216.
PaxDbiP63216.
PeptideAtlasiP63216.
PRIDEiP63216.

PTM databases

iPTMnetiP63216.
PhosphoSiteiP63216.

Expressioni

Tissue specificityi

Abundantly expressed in brain. Low levels in testis.

Gene expression databases

BgeeiENSMUSG00000071658.
GenevisibleiP63216. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with SCN8A.By similarity

Protein-protein interaction databases

IntActiP63216. 1 interaction.
STRINGi10090.ENSMUSP00000093978.

Structurei

3D structure databases

ProteinModelPortaliP63216.
SMRiP63216. Positions 12-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63216.
KOiK04540.
OMAiEASMCRI.
OrthoDBiEOG091G17J0.
PhylomeDBiP63216.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC
60 70
EDPLITPVPT SENPFREKKF FCALL
Length:75
Mass (Da):8,305
Last modified:September 27, 2004 - v1
Checksum:i35CC03965FE69A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069953 Genomic DNA. Translation: AAC83941.1.
AK004459 mRNA. Translation: BAB23313.1.
AK032646 mRNA. Translation: BAC27969.1.
BC029680 mRNA. Translation: AAH29680.1.
U38497 mRNA. Translation: AAB01728.1.
CCDSiCCDS29550.1.
PIRiJC4340.
RefSeqiNP_034446.1. NM_010316.3.
UniGeneiMm.329700.

Genome annotation databases

EnsembliENSMUST00000096259; ENSMUSP00000093978; ENSMUSG00000071658.
GeneIDi14704.
KEGGimmu:14704.
UCSCiuc008gnh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069953 Genomic DNA. Translation: AAC83941.1.
AK004459 mRNA. Translation: BAB23313.1.
AK032646 mRNA. Translation: BAC27969.1.
BC029680 mRNA. Translation: AAH29680.1.
U38497 mRNA. Translation: AAB01728.1.
CCDSiCCDS29550.1.
PIRiJC4340.
RefSeqiNP_034446.1. NM_010316.3.
UniGeneiMm.329700.

3D structure databases

ProteinModelPortaliP63216.
SMRiP63216. Positions 12-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP63216. 1 interaction.
STRINGi10090.ENSMUSP00000093978.

PTM databases

iPTMnetiP63216.
PhosphoSiteiP63216.

Proteomic databases

MaxQBiP63216.
PaxDbiP63216.
PeptideAtlasiP63216.
PRIDEiP63216.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096259; ENSMUSP00000093978; ENSMUSG00000071658.
GeneIDi14704.
KEGGimmu:14704.
UCSCiuc008gnh.1. mouse.

Organism-specific databases

CTDi2785.
MGIiMGI:102704. Gng3.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63216.
KOiK04540.
OMAiEASMCRI.
OrthoDBiEOG091G17J0.
PhylomeDBiP63216.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

PROiP63216.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071658.
GenevisibleiP63216. MM.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG3_MOUSE
AccessioniPrimary (citable) accession number: P63216
Secondary accession number(s): P29798, Q61014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.