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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Gene

Gng3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene namesi
Name:Gng3
Synonyms:Gngt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:102704. Gng3.

Subcellular locationi

GO - Cellular componenti

  • cell body Source: MGI
  • dendrite Source: MGI
  • heterotrimeric G-protein complex Source: MGI
  • postsynaptic density Source: MGI

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126191 – 72Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3Add BLAST72
PropeptideiPRO_000001262073 – 75Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphothreonineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei10PhosphothreonineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei72Cysteine methyl esterBy similarity1
Lipidationi72S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiP63216.
PaxDbiP63216.
PeptideAtlasiP63216.
PRIDEiP63216.

PTM databases

iPTMnetiP63216.
PhosphoSitePlusiP63216.

Expressioni

Tissue specificityi

Abundantly expressed in brain. Low levels in testis.

Gene expression databases

BgeeiENSMUSG00000071658.
GenevisibleiP63216. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with SCN8A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP63216. 1 interactor.
STRINGi10090.ENSMUSP00000093978.

Structurei

3D structure databases

ProteinModelPortaliP63216.
SMRiP63216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63216.
KOiK04540.
OMAiEASMCRI.
OrthoDBiEOG091G17J0.
PhylomeDBiP63216.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
InterProiView protein in InterPro
IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiView protein in Pfam
PF00631. G-gamma. 1 hit.
PRINTSiPR00321. GPROTEING.
SMARTiView protein in SMART
SM00224. GGL. 1 hit.
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiView protein in PROSITE
PS50058. G_PROTEIN_GAMMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC
60 70
EDPLITPVPT SENPFREKKF FCALL
Length:75
Mass (Da):8,305
Last modified:September 27, 2004 - v1
Checksum:i35CC03965FE69A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069953 Genomic DNA. Translation: AAC83941.1.
AK004459 mRNA. Translation: BAB23313.1.
AK032646 mRNA. Translation: BAC27969.1.
BC029680 mRNA. Translation: AAH29680.1.
U38497 mRNA. Translation: AAB01728.1.
CCDSiCCDS29550.1.
PIRiJC4340.
RefSeqiNP_034446.1. NM_010316.3.
UniGeneiMm.329700.

Genome annotation databases

EnsembliENSMUST00000096259; ENSMUSP00000093978; ENSMUSG00000071658.
GeneIDi14704.
KEGGimmu:14704.
UCSCiuc008gnh.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGBG3_MOUSE
AccessioniPrimary (citable) accession number: P63216
Secondary accession number(s): P29798, Q61014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: June 7, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families