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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Gene

GNG3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-BTA-1296041. Activation of G protein gated Potassium channels.
R-BTA-163359. Glucagon signaling in metabolic regulation.
R-BTA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-BTA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-BTA-420092. Glucagon-type ligand receptors.
R-BTA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-BTA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene namesi
Name:GNG3
Synonyms:GNGT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3PRO_0000012615Add
BLAST
Propeptidei73 – 753Removed in mature formBy similarityPRO_0000012616

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51PhosphothreonineBy similarity
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei10 – 101PhosphothreonineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei72 – 721Cysteine methyl esterBy similarity
Lipidationi72 – 721S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP63214.

Expressioni

Tissue specificityi

Abundantly expressed in brain. Low levels in testis.1 Publication

Gene expression databases

BgeeiENSBTAG00000002508.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with SCN8A.By similarity

Protein-protein interaction databases

DIPiDIP-587N.
MINTiMINT-87181.
STRINGi9913.ENSBTAP00000003257.

Structurei

3D structure databases

ProteinModelPortaliP63214.
SMRiP63214. Positions 12-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63214.
KOiK04540.
OMAiEASMCRI.
OrthoDBiEOG091G17J0.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC
60 70
EDPLITPVPT SENPFREKKF FCALL
Length:75
Mass (Da):8,305
Last modified:September 27, 2004 - v1
Checksum:i35CC03965FE69A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58349 mRNA. Translation: AAA30539.1.
BC109874 mRNA. Translation: AAI09875.1.
PIRiA36204. RGBOG3.
RefSeqiNP_776498.1. NM_174073.2.
UniGeneiBt.5464.

Genome annotation databases

EnsembliENSBTAT00000003257; ENSBTAP00000003257; ENSBTAG00000002508.
GeneIDi281204.
KEGGibta:281204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58349 mRNA. Translation: AAA30539.1.
BC109874 mRNA. Translation: AAI09875.1.
PIRiA36204. RGBOG3.
RefSeqiNP_776498.1. NM_174073.2.
UniGeneiBt.5464.

3D structure databases

ProteinModelPortaliP63214.
SMRiP63214. Positions 12-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-587N.
MINTiMINT-87181.
STRINGi9913.ENSBTAP00000003257.

Proteomic databases

PaxDbiP63214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003257; ENSBTAP00000003257; ENSBTAG00000002508.
GeneIDi281204.
KEGGibta:281204.

Organism-specific databases

CTDi2785.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63214.
KOiK04540.
OMAiEASMCRI.
OrthoDBiEOG091G17J0.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-BTA-1296041. Activation of G protein gated Potassium channels.
R-BTA-163359. Glucagon signaling in metabolic regulation.
R-BTA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-BTA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-BTA-420092. Glucagon-type ligand receptors.
R-BTA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-BTA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Gene expression databases

BgeeiENSBTAG00000002508.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG3_BOVIN
AccessioniPrimary (citable) accession number: P63214
Secondary accession number(s): P29798, Q32KX4, Q61014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.