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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Gene

GNG3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-BTA-1296041 Activation of G protein gated Potassium channels
R-BTA-163359 Glucagon signaling in metabolic regulation
R-BTA-202040 G-protein activation
R-BTA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-BTA-392170 ADP signalling through P2Y purinoceptor 12
R-BTA-392451 G beta:gamma signalling through PI3Kgamma
R-BTA-392851 Prostacyclin signalling through prostacyclin receptor
R-BTA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-BTA-4086398 Ca2+ pathway
R-BTA-416476 G alpha (q) signalling events
R-BTA-416482 G alpha (12/13) signalling events
R-BTA-418217 G beta:gamma signalling through PLC beta
R-BTA-418555 G alpha (s) signalling events
R-BTA-418592 ADP signalling through P2Y purinoceptor 1
R-BTA-418594 G alpha (i) signalling events
R-BTA-418597 G alpha (z) signalling events
R-BTA-420092 Glucagon-type ligand receptors
R-BTA-428930 Thromboxane signalling through TP receptor
R-BTA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-BTA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-BTA-500657 Presynaptic function of Kainate receptors
R-BTA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-BTA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene namesi
Name:GNG3
Synonyms:GNGT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Organism-specific databases

VGNCiVGNC:29466 GNG3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126151 – 72Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3Add BLAST72
PropeptideiPRO_000001261673 – 75Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphothreonineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei10PhosphothreonineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei72Cysteine methyl esterBy similarity1
Lipidationi72S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP63214
PRIDEiP63214

Expressioni

Tissue specificityi

Abundantly expressed in brain. Low levels in testis.1 Publication

Gene expression databases

BgeeiENSBTAG00000002508

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with SCN8A.By similarity

Protein-protein interaction databases

DIPiDIP-587N
STRINGi9913.ENSBTAP00000003257

Structurei

3D structure databases

ProteinModelPortaliP63214
SMRiP63214
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP63214
KOiK04540
OMAiEASMCRI
OrthoDBiEOG091G17J0
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC
60 70
EDPLITPVPT SENPFREKKF FCALL
Length:75
Mass (Da):8,305
Last modified:September 27, 2004 - v1
Checksum:i35CC03965FE69A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58349 mRNA Translation: AAA30539.1
BC109874 mRNA Translation: AAI09875.1
PIRiA36204 RGBOG3
RefSeqiNP_776498.1, NM_174073.2
UniGeneiBt.5464

Genome annotation databases

EnsembliENSBTAT00000003257; ENSBTAP00000003257; ENSBTAG00000002508
GeneIDi281204
KEGGibta:281204

Similar proteinsi

Entry informationi

Entry nameiGBG3_BOVIN
AccessioniPrimary (citable) accession number: P63214
Secondary accession number(s): P29798, Q32KX4, Q61014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health