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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

Gng2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-163359 Glucagon signaling in metabolic regulation
R-MMU-202040 G-protein activation
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
Gene namesi
Name:Gng2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:102705 Gng2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000126132 – 68Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Add BLAST67
PropeptideiPRO_000001261469 – 71Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei68Cysteine methyl esterBy similarity1
Lipidationi68S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP63213
MaxQBiP63213
PaxDbiP63213
PeptideAtlasiP63213
PRIDEiP63213
TopDownProteomicsiP63213

PTM databases

iPTMnetiP63213
PhosphoSitePlusiP63213

Expressioni

Tissue specificityi

Adrenal gland and brain.

Gene expression databases

BgeeiENSMUSG00000043004
GenevisibleiP63213 MM

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1999865 interactors.
CORUMiP63213
IntActiP63213 1 interactor.
STRINGi10090.ENSMUSP00000055256

Structurei

3D structure databases

ProteinModelPortaliP63213
SMRiP63213
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP63213
KOiK07826
OMAiETSEMAS
OrthoDBiEOG091G17J0
PhylomeDBiP63213
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.101 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:January 23, 2007 - v2
Checksum:iEDB74E4135E7A37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098489, AF098488 Genomic DNA Translation: AAD16272.1
AK003588 mRNA Translation: BAB22878.1
AK012405 mRNA Translation: BAB28219.1
AK036138 mRNA Translation: BAC29316.1
AK075698 mRNA Translation: BAC35896.1
AK158697 mRNA Translation: BAE34615.1
AK160396 mRNA Translation: BAE35765.1
BC021599 mRNA Translation: AAH21599.1
U38496 mRNA Translation: AAB01727.1
CCDSiCCDS26840.1
PIRiD36204
RefSeqiNP_001033726.1, NM_001038637.1
NP_001272837.1, NM_001285908.1
NP_001272838.1, NM_001285909.1
NP_001272839.1, NM_001285910.1
NP_001272840.1, NM_001285911.1
NP_034445.1, NM_010315.4
UniGeneiMm.41737

Genome annotation databases

EnsembliENSMUST00000055100; ENSMUSP00000055256; ENSMUSG00000043004
ENSMUST00000159028; ENSMUSP00000125141; ENSMUSG00000043004
ENSMUST00000159073; ENSMUSP00000125000; ENSMUSG00000043004
ENSMUST00000160013; ENSMUSP00000125697; ENSMUSG00000043004
ENSMUST00000161247; ENSMUSP00000124725; ENSMUSG00000043004
ENSMUST00000162425; ENSMUSP00000124153; ENSMUSG00000043004
GeneIDi14702
KEGGimmu:14702
UCSCiuc007siw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGBG2_MOUSE
AccessioniPrimary (citable) accession number: P63213
Secondary accession number(s): P16874
, Q3TYE8, Q61013, Q9TS47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome