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P63213

- GBG2_MOUSE

UniProt

P63213 - GBG2_MOUSE

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

Gng2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. G-protein beta-subunit binding Source: UniProt
    2. GTPase activity Source: MGI
    3. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. cell proliferation Source: MGI
    2. G-protein coupled receptor signaling pathway Source: MGI
    3. GTP catabolic process Source: GOC

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_198612. Presynaptic function of Kainate receptors.
    REACT_204733. G alpha (12/13) signalling events.
    REACT_205726. G-protein activation.
    REACT_207651. G alpha (q) signalling events.
    REACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_221970. Ca2+ pathway.
    REACT_223974. G beta:gamma signalling through PI3Kgamma.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Alternative name(s):
    G gamma-I
    Gene namesi
    Name:Gng2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:102705. Gng2.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: MGI
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 6867Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2PRO_0000012613Add
    BLAST
    Propeptidei69 – 713Removed in mature formPRO_0000012614

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei68 – 681Cysteine methyl esterBy similarity
    Lipidationi68 – 681S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiP63213.
    PaxDbiP63213.
    PRIDEiP63213.

    PTM databases

    PhosphoSiteiP63213.

    Expressioni

    Tissue specificityi

    Adrenal gland and brain.

    Gene expression databases

    BgeeiP63213.
    GenevestigatoriP63213.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus) By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199986. 5 interactions.
    IntActiP63213. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP63213.
    SMRiP63213. Positions 8-64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG298292.
    GeneTreeiENSGT00740000115378.
    HOVERGENiHBG014983.
    InParanoidiP63213.
    KOiK07826.
    OMAiYLLEMEQ.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiP63213.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P63213-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL   50
    LTPVPASENP FREKKFFCAI L 71
    Length:71
    Mass (Da):7,850
    Last modified:January 23, 2007 - v2
    Checksum:iEDB74E4135E7A37A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098489, AF098488 Genomic DNA. Translation: AAD16272.1.
    AK003588 mRNA. Translation: BAB22878.1.
    AK012405 mRNA. Translation: BAB28219.1.
    AK036138 mRNA. Translation: BAC29316.1.
    AK075698 mRNA. Translation: BAC35896.1.
    AK158697 mRNA. Translation: BAE34615.1.
    AK160396 mRNA. Translation: BAE35765.1.
    BC021599 mRNA. Translation: AAH21599.1.
    U38496 mRNA. Translation: AAB01727.1.
    CCDSiCCDS26840.1.
    PIRiD36204.
    RefSeqiNP_001033726.1. NM_001038637.1.
    NP_001272837.1. NM_001285908.1.
    NP_001272838.1. NM_001285909.1.
    NP_001272839.1. NM_001285910.1.
    NP_001272840.1. NM_001285911.1.
    NP_034445.1. NM_010315.4.
    XP_006518625.1. XM_006518562.1.
    UniGeneiMm.41737.

    Genome annotation databases

    EnsembliENSMUST00000055100; ENSMUSP00000055256; ENSMUSG00000043004.
    ENSMUST00000159028; ENSMUSP00000125141; ENSMUSG00000043004.
    ENSMUST00000159073; ENSMUSP00000125000; ENSMUSG00000043004.
    ENSMUST00000160013; ENSMUSP00000125697; ENSMUSG00000043004.
    ENSMUST00000161247; ENSMUSP00000124725; ENSMUSG00000043004.
    ENSMUST00000162425; ENSMUSP00000124153; ENSMUSG00000043004.
    GeneIDi14702.
    KEGGimmu:14702.
    UCSCiuc007siw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098489 , AF098488 Genomic DNA. Translation: AAD16272.1 .
    AK003588 mRNA. Translation: BAB22878.1 .
    AK012405 mRNA. Translation: BAB28219.1 .
    AK036138 mRNA. Translation: BAC29316.1 .
    AK075698 mRNA. Translation: BAC35896.1 .
    AK158697 mRNA. Translation: BAE34615.1 .
    AK160396 mRNA. Translation: BAE35765.1 .
    BC021599 mRNA. Translation: AAH21599.1 .
    U38496 mRNA. Translation: AAB01727.1 .
    CCDSi CCDS26840.1.
    PIRi D36204.
    RefSeqi NP_001033726.1. NM_001038637.1.
    NP_001272837.1. NM_001285908.1.
    NP_001272838.1. NM_001285909.1.
    NP_001272839.1. NM_001285910.1.
    NP_001272840.1. NM_001285911.1.
    NP_034445.1. NM_010315.4.
    XP_006518625.1. XM_006518562.1.
    UniGenei Mm.41737.

    3D structure databases

    ProteinModelPortali P63213.
    SMRi P63213. Positions 8-64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199986. 5 interactions.
    IntActi P63213. 1 interaction.

    PTM databases

    PhosphoSitei P63213.

    Proteomic databases

    MaxQBi P63213.
    PaxDbi P63213.
    PRIDEi P63213.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055100 ; ENSMUSP00000055256 ; ENSMUSG00000043004 .
    ENSMUST00000159028 ; ENSMUSP00000125141 ; ENSMUSG00000043004 .
    ENSMUST00000159073 ; ENSMUSP00000125000 ; ENSMUSG00000043004 .
    ENSMUST00000160013 ; ENSMUSP00000125697 ; ENSMUSG00000043004 .
    ENSMUST00000161247 ; ENSMUSP00000124725 ; ENSMUSG00000043004 .
    ENSMUST00000162425 ; ENSMUSP00000124153 ; ENSMUSG00000043004 .
    GeneIDi 14702.
    KEGGi mmu:14702.
    UCSCi uc007siw.1. mouse.

    Organism-specific databases

    CTDi 54331.
    MGIi MGI:102705. Gng2.

    Phylogenomic databases

    eggNOGi NOG298292.
    GeneTreei ENSGT00740000115378.
    HOVERGENi HBG014983.
    InParanoidi P63213.
    KOi K07826.
    OMAi YLLEMEQ.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi P63213.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_198612. Presynaptic function of Kainate receptors.
    REACT_204733. G alpha (12/13) signalling events.
    REACT_205726. G-protein activation.
    REACT_207651. G alpha (q) signalling events.
    REACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_221970. Ca2+ pathway.
    REACT_223974. G beta:gamma signalling through PI3Kgamma.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Miscellaneous databases

    NextBioi 286671.
    PROi P63213.
    SOURCEi Search...

    Gene expression databases

    Bgeei P63213.
    Genevestigatori P63213.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal mapping of five mouse G protein gamma subunits."
      Downes G.B., Gilbert D.J., Copeland N.G., Gautam N., Jenkins N.A.
      Genomics 57:173-176(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    4. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
      Williams C.J., Schultz R.M., Kopf G.S.
      Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-52.
      Strain: CF-1 / Harlan.
      Tissue: Embryo.

    Entry informationi

    Entry nameiGBG2_MOUSE
    AccessioniPrimary (citable) accession number: P63213
    Secondary accession number(s): P16874
    , Q3TYE8, Q61013, Q9TS47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3