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P63213 (GBG2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
Gene names
Name:Gng2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length71 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus) By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Adrenal gland and brain.

Sequence similarities

Belongs to the G protein gamma family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 6867Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
PRO_0000012613
Propeptide69 – 713Removed in mature form
PRO_0000012614

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue681Cysteine methyl ester By similarity
Lipidation681S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P63213 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: EDB74E4135E7A37A

FASTA717,850
        10         20         30         40         50         60 
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL LTPVPASENP 

        70 
FREKKFFCAI L 

« Hide

References

« Hide 'large scale' references
[1]"Chromosomal mapping of five mouse G protein gamma subunits."
Downes G.B., Gilbert D.J., Copeland N.G., Gautam N., Jenkins N.A.
Genomics 57:173-176(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum and Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[4]"G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
Williams C.J., Schultz R.M., Kopf G.S.
Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-52.
Strain: CF-1 / Harlan.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF098489, AF098488 Genomic DNA. Translation: AAD16272.1.
AK003588 mRNA. Translation: BAB22878.1.
AK012405 mRNA. Translation: BAB28219.1.
AK036138 mRNA. Translation: BAC29316.1.
AK075698 mRNA. Translation: BAC35896.1.
AK158697 mRNA. Translation: BAE34615.1.
AK160396 mRNA. Translation: BAE35765.1.
BC021599 mRNA. Translation: AAH21599.1.
U38496 mRNA. Translation: AAB01727.1.
CCDSCCDS26840.1.
PIRD36204.
RefSeqNP_001033726.1. NM_001038637.1.
NP_001272837.1. NM_001285908.1.
NP_001272838.1. NM_001285909.1.
NP_001272839.1. NM_001285910.1.
NP_001272840.1. NM_001285911.1.
NP_034445.1. NM_010315.4.
XP_006518625.1. XM_006518562.1.
UniGeneMm.41737.

3D structure databases

ProteinModelPortalP63213.
SMRP63213. Positions 8-64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199986. 5 interactions.
IntActP63213. 1 interaction.

PTM databases

PhosphoSiteP63213.

Proteomic databases

MaxQBP63213.
PaxDbP63213.
PRIDEP63213.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055100; ENSMUSP00000055256; ENSMUSG00000043004.
ENSMUST00000159028; ENSMUSP00000125141; ENSMUSG00000043004.
ENSMUST00000159073; ENSMUSP00000125000; ENSMUSG00000043004.
ENSMUST00000160013; ENSMUSP00000125697; ENSMUSG00000043004.
ENSMUST00000161247; ENSMUSP00000124725; ENSMUSG00000043004.
ENSMUST00000162425; ENSMUSP00000124153; ENSMUSG00000043004.
GeneID14702.
KEGGmmu:14702.
UCSCuc007siw.1. mouse.

Organism-specific databases

CTD54331.
MGIMGI:102705. Gng2.

Phylogenomic databases

eggNOGNOG298292.
GeneTreeENSGT00740000115378.
HOVERGENHBG014983.
InParanoidP63213.
KOK07826.
OMAYLLEMEQ.
OrthoDBEOG7H1JP7.
PhylomeDBP63213.
TreeFamTF319909.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

BgeeP63213.
GenevestigatorP63213.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286671.
PROP63213.
SOURCESearch...

Entry information

Entry nameGBG2_MOUSE
AccessionPrimary (citable) accession number: P63213
Secondary accession number(s): P16874 expand/collapse secondary AC list , Q3TYE8, Q61013, Q9TS47
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot