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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

Gng2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-202040. G-protein activation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-392170. ADP signalling through P2Y purinoceptor 12.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-392851. Prostacyclin signalling through prostacyclin receptor.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-4086398. Ca2+ pathway.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-418217. G beta:gamma signalling through PLC beta.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-418592. ADP signalling through P2Y purinoceptor 1.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-418597. G alpha (z) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-428930. Thromboxane signalling through TP receptor.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-MMU-500657. Presynaptic function of Kainate receptors.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
Gene namesi
Name:Gng2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:102705. Gng2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000126132 – 68Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Add BLAST67
PropeptideiPRO_000001261469 – 71Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei68Cysteine methyl esterBy similarity1
Lipidationi68S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP63213.
MaxQBiP63213.
PaxDbiP63213.
PeptideAtlasiP63213.
PRIDEiP63213.
TopDownProteomicsiP63213.

PTM databases

iPTMnetiP63213.
PhosphoSitePlusiP63213.

Expressioni

Tissue specificityi

Adrenal gland and brain.

Gene expression databases

BgeeiENSMUSG00000043004.
GenevisibleiP63213. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199986. 5 interactors.
CORUMiP63213.
IntActiP63213. 1 interactor.
STRINGi10090.ENSMUSP00000055256.

Structurei

3D structure databases

ProteinModelPortaliP63213.
SMRiP63213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63213.
KOiK07826.
OMAiETSEMAS.
OrthoDBiEOG091G17J0.
PhylomeDBiP63213.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
InterProiView protein in InterPro
IPR015898. G-protein_gamma-like_dom.
IPR036284. GGL_sf.
IPR001770. Gprotein-gamma.
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiView protein in Pfam
PF00631. G-gamma. 1 hit.
PRINTSiPR00321. GPROTEING.
SMARTiView protein in SMART
SM00224. GGL. 1 hit.
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiView protein in PROSITE
PS50058. G_PROTEIN_GAMMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:January 23, 2007 - v2
Checksum:iEDB74E4135E7A37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098489, AF098488 Genomic DNA. Translation: AAD16272.1.
AK003588 mRNA. Translation: BAB22878.1.
AK012405 mRNA. Translation: BAB28219.1.
AK036138 mRNA. Translation: BAC29316.1.
AK075698 mRNA. Translation: BAC35896.1.
AK158697 mRNA. Translation: BAE34615.1.
AK160396 mRNA. Translation: BAE35765.1.
BC021599 mRNA. Translation: AAH21599.1.
U38496 mRNA. Translation: AAB01727.1.
CCDSiCCDS26840.1.
PIRiD36204.
RefSeqiNP_001033726.1. NM_001038637.1.
NP_001272837.1. NM_001285908.1.
NP_001272838.1. NM_001285909.1.
NP_001272839.1. NM_001285910.1.
NP_001272840.1. NM_001285911.1.
NP_034445.1. NM_010315.4.
UniGeneiMm.41737.

Genome annotation databases

EnsembliENSMUST00000055100; ENSMUSP00000055256; ENSMUSG00000043004.
ENSMUST00000159028; ENSMUSP00000125141; ENSMUSG00000043004.
ENSMUST00000159073; ENSMUSP00000125000; ENSMUSG00000043004.
ENSMUST00000160013; ENSMUSP00000125697; ENSMUSG00000043004.
ENSMUST00000161247; ENSMUSP00000124725; ENSMUSG00000043004.
ENSMUST00000162425; ENSMUSP00000124153; ENSMUSG00000043004.
GeneIDi14702.
KEGGimmu:14702.
UCSCiuc007siw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiGBG2_MOUSE
AccessioniPrimary (citable) accession number: P63213
Secondary accession number(s): P16874
, Q3TYE8, Q61013, Q9TS47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families