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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

Gng2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-202040. G-protein activation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-392170. ADP signalling through P2Y purinoceptor 12.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-392851. Prostacyclin signalling through prostacyclin receptor.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-4086398. Ca2+ pathway.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-418217. G beta:gamma signalling through PLC beta.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-418592. ADP signalling through P2Y purinoceptor 1.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-418597. G alpha (z) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-428930. Thromboxane signalling through TP receptor.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-MMU-500657. Presynaptic function of Kainate receptors.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
Gene namesi
Name:Gng2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:102705. Gng2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 6867Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2PRO_0000012613Add
BLAST
Propeptidei69 – 713Removed in mature formPRO_0000012614

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei68 – 681Cysteine methyl esterBy similarity
Lipidationi68 – 681S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP63213.
MaxQBiP63213.
PaxDbiP63213.
PeptideAtlasiP63213.
PRIDEiP63213.
TopDownProteomicsiP63213.

PTM databases

iPTMnetiP63213.
PhosphoSiteiP63213.

Expressioni

Tissue specificityi

Adrenal gland and brain.

Gene expression databases

BgeeiENSMUSG00000043004.
GenevisibleiP63213. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199986. 5 interactions.
IntActiP63213. 1 interaction.
STRINGi10090.ENSMUSP00000055256.

Structurei

3D structure databases

ProteinModelPortaliP63213.
SMRiP63213. Positions 8-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63213.
KOiK07826.
OMAiAPMASNN.
OrthoDBiEOG091G17J0.
PhylomeDBiP63213.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:January 23, 2007 - v2
Checksum:iEDB74E4135E7A37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098489, AF098488 Genomic DNA. Translation: AAD16272.1.
AK003588 mRNA. Translation: BAB22878.1.
AK012405 mRNA. Translation: BAB28219.1.
AK036138 mRNA. Translation: BAC29316.1.
AK075698 mRNA. Translation: BAC35896.1.
AK158697 mRNA. Translation: BAE34615.1.
AK160396 mRNA. Translation: BAE35765.1.
BC021599 mRNA. Translation: AAH21599.1.
U38496 mRNA. Translation: AAB01727.1.
CCDSiCCDS26840.1.
PIRiD36204.
RefSeqiNP_001033726.1. NM_001038637.1.
NP_001272837.1. NM_001285908.1.
NP_001272838.1. NM_001285909.1.
NP_001272839.1. NM_001285910.1.
NP_001272840.1. NM_001285911.1.
NP_034445.1. NM_010315.4.
XP_011243263.1. XM_011244961.1.
UniGeneiMm.41737.

Genome annotation databases

EnsembliENSMUST00000055100; ENSMUSP00000055256; ENSMUSG00000043004.
ENSMUST00000159028; ENSMUSP00000125141; ENSMUSG00000043004.
ENSMUST00000159073; ENSMUSP00000125000; ENSMUSG00000043004.
ENSMUST00000160013; ENSMUSP00000125697; ENSMUSG00000043004.
ENSMUST00000161247; ENSMUSP00000124725; ENSMUSG00000043004.
ENSMUST00000162425; ENSMUSP00000124153; ENSMUSG00000043004.
GeneIDi14702.
KEGGimmu:14702.
UCSCiuc007siw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098489, AF098488 Genomic DNA. Translation: AAD16272.1.
AK003588 mRNA. Translation: BAB22878.1.
AK012405 mRNA. Translation: BAB28219.1.
AK036138 mRNA. Translation: BAC29316.1.
AK075698 mRNA. Translation: BAC35896.1.
AK158697 mRNA. Translation: BAE34615.1.
AK160396 mRNA. Translation: BAE35765.1.
BC021599 mRNA. Translation: AAH21599.1.
U38496 mRNA. Translation: AAB01727.1.
CCDSiCCDS26840.1.
PIRiD36204.
RefSeqiNP_001033726.1. NM_001038637.1.
NP_001272837.1. NM_001285908.1.
NP_001272838.1. NM_001285909.1.
NP_001272839.1. NM_001285910.1.
NP_001272840.1. NM_001285911.1.
NP_034445.1. NM_010315.4.
XP_011243263.1. XM_011244961.1.
UniGeneiMm.41737.

3D structure databases

ProteinModelPortaliP63213.
SMRiP63213. Positions 8-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199986. 5 interactions.
IntActiP63213. 1 interaction.
STRINGi10090.ENSMUSP00000055256.

PTM databases

iPTMnetiP63213.
PhosphoSiteiP63213.

Proteomic databases

EPDiP63213.
MaxQBiP63213.
PaxDbiP63213.
PeptideAtlasiP63213.
PRIDEiP63213.
TopDownProteomicsiP63213.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055100; ENSMUSP00000055256; ENSMUSG00000043004.
ENSMUST00000159028; ENSMUSP00000125141; ENSMUSG00000043004.
ENSMUST00000159073; ENSMUSP00000125000; ENSMUSG00000043004.
ENSMUST00000160013; ENSMUSP00000125697; ENSMUSG00000043004.
ENSMUST00000161247; ENSMUSP00000124725; ENSMUSG00000043004.
ENSMUST00000162425; ENSMUSP00000124153; ENSMUSG00000043004.
GeneIDi14702.
KEGGimmu:14702.
UCSCiuc007siw.1. mouse.

Organism-specific databases

CTDi54331.
MGIiMGI:102705. Gng2.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63213.
KOiK07826.
OMAiAPMASNN.
OrthoDBiEOG091G17J0.
PhylomeDBiP63213.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-202040. G-protein activation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-392170. ADP signalling through P2Y purinoceptor 12.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-392851. Prostacyclin signalling through prostacyclin receptor.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-4086398. Ca2+ pathway.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-418217. G beta:gamma signalling through PLC beta.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-418592. ADP signalling through P2Y purinoceptor 1.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-418597. G alpha (z) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-428930. Thromboxane signalling through TP receptor.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-MMU-500657. Presynaptic function of Kainate receptors.
R-MMU-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

PROiP63213.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043004.
GenevisibleiP63213. MM.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG2_MOUSE
AccessioniPrimary (citable) accession number: P63213
Secondary accession number(s): P16874
, Q3TYE8, Q61013, Q9TS47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.