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P63213

- GBG2_MOUSE

UniProt

P63213 - GBG2_MOUSE

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

Gng2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. G-protein beta-subunit binding Source: UniProt
  2. GTPase activity Source: MGI
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. cell proliferation Source: MGI
  2. G-protein coupled receptor signaling pathway Source: MGI
  3. GTP catabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_198612. Presynaptic function of Kainate receptors.
REACT_204733. G alpha (12/13) signalling events.
REACT_205726. G-protein activation.
REACT_207651. G alpha (q) signalling events.
REACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).
REACT_221970. Ca2+ pathway.
REACT_223974. G beta:gamma signalling through PI3Kgamma.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
Gene namesi
Name:Gng2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:102705. Gng2.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. heterotrimeric G-protein complex Source: MGI
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 6867Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2PRO_0000012613Add
BLAST
Propeptidei69 – 713Removed in mature formPRO_0000012614

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei68 – 681Cysteine methyl esterBy similarity
Lipidationi68 – 681S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP63213.
PaxDbiP63213.
PRIDEiP63213.

PTM databases

PhosphoSiteiP63213.

Expressioni

Tissue specificityi

Adrenal gland and brain.

Gene expression databases

BgeeiP63213.
GenevestigatoriP63213.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus) By similarity.By similarity

Protein-protein interaction databases

BioGridi199986. 5 interactions.
IntActiP63213. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP63213.
SMRiP63213. Positions 8-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG298292.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63213.
KOiK07826.
OMAiYLLEMEQ.
OrthoDBiEOG7H1JP7.
PhylomeDBiP63213.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63213-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:January 23, 2007 - v2
Checksum:iEDB74E4135E7A37A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098489, AF098488 Genomic DNA. Translation: AAD16272.1.
AK003588 mRNA. Translation: BAB22878.1.
AK012405 mRNA. Translation: BAB28219.1.
AK036138 mRNA. Translation: BAC29316.1.
AK075698 mRNA. Translation: BAC35896.1.
AK158697 mRNA. Translation: BAE34615.1.
AK160396 mRNA. Translation: BAE35765.1.
BC021599 mRNA. Translation: AAH21599.1.
U38496 mRNA. Translation: AAB01727.1.
CCDSiCCDS26840.1.
PIRiD36204.
RefSeqiNP_001033726.1. NM_001038637.1.
NP_001272837.1. NM_001285908.1.
NP_001272838.1. NM_001285909.1.
NP_001272839.1. NM_001285910.1.
NP_001272840.1. NM_001285911.1.
NP_034445.1. NM_010315.4.
XP_006518625.1. XM_006518562.1.
UniGeneiMm.41737.

Genome annotation databases

EnsembliENSMUST00000055100; ENSMUSP00000055256; ENSMUSG00000043004.
ENSMUST00000159028; ENSMUSP00000125141; ENSMUSG00000043004.
ENSMUST00000159073; ENSMUSP00000125000; ENSMUSG00000043004.
ENSMUST00000160013; ENSMUSP00000125697; ENSMUSG00000043004.
ENSMUST00000161247; ENSMUSP00000124725; ENSMUSG00000043004.
ENSMUST00000162425; ENSMUSP00000124153; ENSMUSG00000043004.
GeneIDi14702.
KEGGimmu:14702.
UCSCiuc007siw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098489 , AF098488 Genomic DNA. Translation: AAD16272.1 .
AK003588 mRNA. Translation: BAB22878.1 .
AK012405 mRNA. Translation: BAB28219.1 .
AK036138 mRNA. Translation: BAC29316.1 .
AK075698 mRNA. Translation: BAC35896.1 .
AK158697 mRNA. Translation: BAE34615.1 .
AK160396 mRNA. Translation: BAE35765.1 .
BC021599 mRNA. Translation: AAH21599.1 .
U38496 mRNA. Translation: AAB01727.1 .
CCDSi CCDS26840.1.
PIRi D36204.
RefSeqi NP_001033726.1. NM_001038637.1.
NP_001272837.1. NM_001285908.1.
NP_001272838.1. NM_001285909.1.
NP_001272839.1. NM_001285910.1.
NP_001272840.1. NM_001285911.1.
NP_034445.1. NM_010315.4.
XP_006518625.1. XM_006518562.1.
UniGenei Mm.41737.

3D structure databases

ProteinModelPortali P63213.
SMRi P63213. Positions 8-64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199986. 5 interactions.
IntActi P63213. 1 interaction.

PTM databases

PhosphoSitei P63213.

Proteomic databases

MaxQBi P63213.
PaxDbi P63213.
PRIDEi P63213.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055100 ; ENSMUSP00000055256 ; ENSMUSG00000043004 .
ENSMUST00000159028 ; ENSMUSP00000125141 ; ENSMUSG00000043004 .
ENSMUST00000159073 ; ENSMUSP00000125000 ; ENSMUSG00000043004 .
ENSMUST00000160013 ; ENSMUSP00000125697 ; ENSMUSG00000043004 .
ENSMUST00000161247 ; ENSMUSP00000124725 ; ENSMUSG00000043004 .
ENSMUST00000162425 ; ENSMUSP00000124153 ; ENSMUSG00000043004 .
GeneIDi 14702.
KEGGi mmu:14702.
UCSCi uc007siw.1. mouse.

Organism-specific databases

CTDi 54331.
MGIi MGI:102705. Gng2.

Phylogenomic databases

eggNOGi NOG298292.
GeneTreei ENSGT00760000119218.
HOVERGENi HBG014983.
InParanoidi P63213.
KOi K07826.
OMAi YLLEMEQ.
OrthoDBi EOG7H1JP7.
PhylomeDBi P63213.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_198612. Presynaptic function of Kainate receptors.
REACT_204733. G alpha (12/13) signalling events.
REACT_205726. G-protein activation.
REACT_207651. G alpha (q) signalling events.
REACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).
REACT_221970. Ca2+ pathway.
REACT_223974. G beta:gamma signalling through PI3Kgamma.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

NextBioi 286671.
PROi P63213.
SOURCEi Search...

Gene expression databases

Bgeei P63213.
Genevestigatori P63213.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal mapping of five mouse G protein gamma subunits."
    Downes G.B., Gilbert D.J., Copeland N.G., Gautam N., Jenkins N.A.
    Genomics 57:173-176(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  4. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
    Williams C.J., Schultz R.M., Kopf G.S.
    Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-52.
    Strain: CF-1 / Harlan.
    Tissue: Embryo.

Entry informationi

Entry nameiGBG2_MOUSE
AccessioniPrimary (citable) accession number: P63213
Secondary accession number(s): P16874
, Q3TYE8, Q61013, Q9TS47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3