ID GBG2_BOVIN Reviewed; 71 AA. AC P63212; P16874; Q2KI31; Q61013; Q9TS47; DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 27-MAR-2024, entry version 156. DE RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; DE AltName: Full=G gamma-I; DE Flags: Precursor; GN Name=GNG2; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 14-62. RC TISSUE=Adrenal gland, and Brain; RX PubMed=2506169; DOI=10.1016/s0021-9258(18)71540-8; RA Robishaw J.D., Kalman V.K., Moomaw C.R., Slaughter C.A.; RT "Existence of two gamma subunits of the G proteins in brain."; RL J. Biol. Chem. 264:15758-15761(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2499046; DOI=10.1126/science.2499046; RA Gautam N., Baetscher M., Aebersold R., Simon M.I.; RT "A G protein gamma subunit shares homology with ras proteins."; RL Science 244:971-974(1989). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Kidney; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. RN [4] RP PROTEIN SEQUENCE OF 2-68, ACETYLATION AT ALA-2, AND ISOPRENYLATION AT RP CYS-68. RC TISSUE=Brain; RX PubMed=7626050; DOI=10.1006/bbrc.1995.1979; RA Wilcox M.D., Schey K.L., Busman M., Hildebrandt J.D.; RT "Determination of the complete covalent structure of the gamma 2 subunit of RT bovine brain G proteins by mass spectrometry."; RL Biochem. Biophys. Res. Commun. 212:367-374(1995). RN [5] RP PROTEIN SEQUENCE OF 2-64. RC TISSUE=Brain; RX PubMed=8439334; DOI=10.1006/bbrc.1993.1126; RA Sohma H., Hashimoto H., Hiraike N., Ohguro H., Akino T.; RT "Identification of a novel gamma-subunit from bovine brain GTP binding RT regulatory proteins (Gi/o)."; RL Biochem. Biophys. Res. Commun. 190:849-856(1993). RN [6] RP ISOPRENYLATION AT CYS-68, AND METHYLATION AT CYS-68. RX PubMed=1903391; DOI=10.1016/s0021-9258(18)92858-9; RA Sanford J., Codina J., Birnbaumer L.; RT "Gamma-subunits of G proteins, but not their alpha- or beta-subunits, are RT polyisoprenylated. Studies on post-translational modifications using in RT vitro translation with rabbit reticulocyte lysates."; RL J. Biol. Chem. 266:9570-9579(1991). RN [7] RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF HETEROTRIMER. RX PubMed=8521505; DOI=10.1016/0092-8674(95)90220-1; RA Wall M.A., Coleman D.E., Lee E., Iniguez-Lluhi J.A., Posner B.A., RA Gilman A.G., Sprang S.R.; RT "The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2."; RL Cell 83:1047-1058(1995). RN [8] RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-68 IN COMPLEX WITH GNB1 AND RP GRK2, SUBCELLULAR LOCATION, AND ISOPRENYLATION AT CYS-68. RX PubMed=12764189; DOI=10.1126/science.1082348; RA Lodowski D.T., Pitcher J.A., Capel W.D., Lefkowitz R.J., Tesmer J.J.; RT "Keeping G proteins at bay: a complex between G protein-coupled receptor RT kinase 2 and Gbetagamma."; RL Science 300:1256-1262(2003). CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved CC as a modulator or transducer in various transmembrane signaling CC systems. The beta and gamma chains are required for the GTPase CC activity, for replacement of GDP by GTP, and for G protein-effector CC interaction. CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma CC (PubMed:8521505). In this context, interacts with GNB2 (By similarity). CC The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By CC similarity). The heterodimer formed by GNB1 and GNG2 interacts with CC GRK2 (PubMed:12764189). {ECO:0000250|UniProtKB:P59768, CC ECO:0000269|PubMed:12764189, ECO:0000269|PubMed:8521505}. CC -!- INTERACTION: CC P63212; P62871: GNB1; NbExp=6; IntAct=EBI-1036424, EBI-357141; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12764189}; CC Lipid-anchor {ECO:0000305}; Cytoplasmic side CC {ECO:0000269|PubMed:12764189}. CC -!- TISSUE SPECIFICITY: Adrenal gland and brain. CC -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J05071; AAA30541.1; -; mRNA. DR EMBL; M37183; AAA30555.1; -; mRNA. DR EMBL; BC112789; AAI12790.1; -; mRNA. DR PIR; B34228; RGBOG2. DR RefSeq; NP_776497.1; NM_174072.4. DR RefSeq; XP_005211711.1; XM_005211654.3. DR RefSeq; XP_010807541.1; XM_010809239.2. DR PDB; 1GG2; X-ray; 2.40 A; G=1-71. DR PDB; 1GP2; X-ray; 2.30 A; G=1-71. DR PDB; 1OMW; X-ray; 2.50 A; G=1-68. DR PDB; 1XHM; X-ray; 2.70 A; B=1-71. DR PDB; 2BCJ; X-ray; 3.06 A; G=1-71. DR PDB; 3AH8; X-ray; 2.90 A; G=1-71. DR PDB; 3CIK; X-ray; 2.75 A; G=1-68. DR PDB; 3KRW; X-ray; 2.90 A; G=1-68. DR PDB; 3KRX; X-ray; 3.10 A; G=1-68. DR PDB; 3PSC; X-ray; 2.67 A; G=1-68. DR PDB; 3PVU; X-ray; 2.48 A; G=1-68. DR PDB; 3PVW; X-ray; 2.49 A; G=1-68. DR PDB; 3SN6; X-ray; 3.20 A; G=1-68. DR PDB; 3UZS; X-ray; 4.52 A; G=1-67. DR PDB; 3V5W; X-ray; 2.07 A; G=1-71. DR PDB; 4MK0; X-ray; 2.40 A; G=6-64. DR PDB; 4PNK; X-ray; 2.56 A; G=1-71. DR PDB; 5TDH; X-ray; 3.00 A; G/K=1-68. DR PDB; 5VAI; EM; 4.10 A; G=1-68. DR PDB; 5WG3; X-ray; 2.90 A; G=1-71. DR PDB; 5WG4; X-ray; 2.31 A; G=1-71. DR PDB; 5WG5; X-ray; 3.10 A; G=1-71. DR PDB; 6C2Y; X-ray; 2.74 A; G=1-71. DR PDB; 6CMO; EM; 4.50 A; G=1-68. DR PDB; 6LPB; EM; 3.90 A; G=1-67. DR PDB; 6NBF; EM; 3.00 A; G=1-71. DR PDB; 6NBH; EM; 3.50 A; G=1-71. DR PDB; 6NBI; EM; 4.00 A; G=1-71. DR PDB; 6PCV; EM; 3.20 A; G=1-71. DR PDB; 6U7C; X-ray; 2.44 A; G=1-71. DR PDB; 7BW0; EM; 3.90 A; G=1-71. DR PDB; 7BZ2; EM; 3.82 A; G=1-71. DR PDB; 7CZ5; EM; 2.60 A; G=1-71. DR PDB; 7D3S; EM; 2.90 A; G=1-67. DR PDB; 7D68; EM; 3.00 A; G=1-71. DR PDB; 7DB6; EM; 3.30 A; C=1-67. DR PDB; 7DH5; EM; 3.16 A; G=1-67. DR PDB; 7DHI; EM; 3.26 A; G=1-71. DR PDB; 7DHR; EM; 3.80 A; G=1-71. DR PDB; 7DTY; EM; 2.98 A; G=1-71. DR PDB; 7DUQ; EM; 2.50 A; G=2-71. DR PDB; 7DUR; EM; 3.30 A; G=2-71. DR PDB; 7DW9; EM; 2.60 A; Y=1-71. DR PDB; 7EIB; EM; 3.00 A; E=1-71. DR PDB; 7EQ1; EM; 3.30 A; Y=1-71. DR PDB; 7EVM; EM; 2.50 A; G=2-71. DR PDB; 7F16; EM; 2.80 A; G=1-71. DR PDB; 7F2O; EM; 2.90 A; Y=1-71. DR PDB; 7FIG; EM; 3.90 A; G=1-71. DR PDB; 7FIH; EM; 3.20 A; G=1-71. DR PDB; 7FII; EM; 4.30 A; G=1-71. DR PDB; 7FIM; EM; 3.40 A; G=1-71. DR PDB; 7FIN; EM; 3.10 A; G=1-71. DR PDB; 7FIY; EM; 3.40 A; G=1-71. DR PDB; 7JJO; EM; 2.60 A; G=1-71. DR PDB; 7LJC; EM; 3.00 A; G=2-68. DR PDB; 7LJD; EM; 3.20 A; G=2-68. DR PDB; 7PIU; EM; 2.58 A; G=1-71. DR PDB; 7PWD; X-ray; 2.60 A; G=1-71. DR PDB; 7S0F; EM; 2.96 A; G=1-71. DR PDB; 7S0G; EM; 3.86 A; G=1-71. DR PDB; 7SQO; EM; 3.17 A; G=1-68. DR PDB; 7T6S; EM; 3.00 A; C=2-68. DR PDB; 7T6T; EM; 3.20 A; C=2-68. DR PDB; 7T6U; EM; 2.90 A; C=2-68. DR PDB; 7T6V; EM; 3.10 A; C=2-68. DR PDB; 7TD0; EM; 2.83 A; G=1-71. DR PDB; 7TD1; EM; 3.08 A; G=1-71. DR PDB; 7TD2; EM; 3.11 A; G=1-71. DR PDB; 7TD3; EM; 3.00 A; G=1-71. DR PDB; 7TD4; EM; 2.60 A; G=1-71. DR PDB; 7V35; EM; 3.40 A; C=1-71. DR PDB; 7V9L; EM; 2.60 A; Y=1-71. DR PDB; 7V9M; EM; 3.29 A; Y=1-71. DR PDB; 7VAB; EM; 3.20 A; G=1-64. DR PDB; 7VBH; EM; 3.00 A; G=2-71. DR PDB; 7VBI; EM; 3.00 A; G=2-71. DR PDB; 7VGY; EM; 3.10 A; D=2-68. DR PDB; 7VGZ; EM; 3.30 A; E=2-68. DR PDB; 7VQX; EM; 2.74 A; G=1-71. DR PDB; 7VVJ; EM; 3.20 A; G=1-67. DR PDB; 7VVK; EM; 3.30 A; G=1-67. DR PDB; 7VVL; EM; 2.80 A; G=1-67. DR PDB; 7VVM; EM; 3.20 A; G=1-67. DR PDB; 7VVN; EM; 3.80 A; G=1-67. DR PDB; 7VVO; EM; 4.10 A; G=1-67. DR PDB; 7WBJ; EM; 3.42 A; G=1-71. DR PDB; 7WIC; EM; 2.80 A; G=2-71. DR PDB; 7WIG; EM; 2.70 A; G=2-71. DR PDB; 7WQ3; EM; 2.70 A; G=1-71. DR PDB; 7WQ4; EM; 2.60 A; G=1-71. DR PDB; 7X1T; EM; 3.26 A; F=1-71. DR PDB; 7X1U; EM; 3.19 A; F=1-71. DR PDB; 7XAT; EM; 2.85 A; D=1-71. DR PDB; 7XAU; EM; 2.97 A; D=1-71. DR PDB; 7XAV; EM; 2.87 A; D=1-71. DR PDB; 7XJH; EM; 3.30 A; G=1-67. DR PDB; 7XJI; EM; 3.90 A; G=1-67. DR PDB; 7XW9; EM; 2.70 A; G=2-71. DR PDB; 7XWO; EM; 2.70 A; G=1-71. DR PDB; 7Y35; EM; 2.90 A; G=2-71. DR PDB; 7Y36; EM; 2.80 A; G=2-71. DR PDB; 7YJ4; EM; 3.19 A; G=1-71. DR PDB; 7YK6; EM; 3.03 A; G=1-71. DR PDB; 7YK7; EM; 2.75 A; G=1-71. DR PDB; 7YU3; EM; 3.40 A; G=1-67. DR PDB; 7YU5; EM; 3.30 A; G=1-67. DR PDB; 7YU6; EM; 3.50 A; G=1-67. DR PDB; 7YU7; EM; 3.80 A; G=1-67. DR PDB; 7YU8; EM; 4.50 A; G=1-67. DR PDB; 8DCR; EM; 2.60 A; G=1-71. DR PDB; 8DCS; EM; 2.50 A; G=1-71. DR PDB; 8EF5; EM; 3.30 A; C=1-68. DR PDB; 8EF6; EM; 3.20 A; C=1-68. DR PDB; 8EFB; EM; 3.20 A; C=1-68. DR PDB; 8EFO; EM; 2.80 A; C=1-68. DR PDB; 8EFQ; EM; 3.30 A; G=1-68. DR PDB; 8F7Q; EM; 3.22 A; C=1-68. DR PDB; 8F7R; EM; 3.28 A; C=1-68. DR PDB; 8F7S; EM; 3.00 A; C=1-68. DR PDB; 8F7W; EM; 3.19 A; C=1-68. DR PDB; 8F7X; EM; 3.28 A; C=1-68. DR PDB; 8GW8; EM; 2.90 A; G=1-67. DR PDB; 8HA0; EM; 2.62 A; G=1-71. DR PDB; 8HAF; EM; 3.25 A; G=1-71. DR PDB; 8HAO; EM; 3.76 A; E/G=1-71. DR PDB; 8HK2; EM; 2.90 A; G=2-68. DR PDB; 8HK3; EM; 3.20 A; G=2-68. DR PDB; 8INR; EM; 2.73 A; G=1-71. DR PDB; 8IOC; EM; 2.86 A; G=1-71. DR PDB; 8IOD; EM; 2.59 A; G=1-71. DR PDB; 8ITL; EM; 3.23 A; G=1-71. DR PDB; 8ITM; EM; 3.13 A; G=1-71. DR PDB; 8IY5; EM; 2.80 A; C=1-68. DR PDB; 8JIP; EM; 2.85 A; G=2-71. DR PDB; 8JIQ; EM; 3.40 A; C=2-71. DR PDB; 8JIR; EM; 2.57 A; G=2-71. DR PDB; 8JIS; EM; 2.46 A; G=6-62. DR PDB; 8JIT; EM; 2.91 A; C=2-71. DR PDB; 8JIU; EM; 2.76 A; C=2-71. DR PDBsum; 1GG2; -. DR PDBsum; 1GP2; -. DR PDBsum; 1OMW; -. DR PDBsum; 1XHM; -. DR PDBsum; 2BCJ; -. DR PDBsum; 3AH8; -. DR PDBsum; 3CIK; -. DR PDBsum; 3KRW; -. DR PDBsum; 3KRX; -. DR PDBsum; 3PSC; -. DR PDBsum; 3PVU; -. DR PDBsum; 3PVW; -. DR PDBsum; 3SN6; -. DR PDBsum; 3UZS; -. DR PDBsum; 3V5W; -. DR PDBsum; 4MK0; -. DR PDBsum; 4PNK; -. DR PDBsum; 5TDH; -. DR PDBsum; 5VAI; -. DR PDBsum; 5WG3; -. DR PDBsum; 5WG4; -. DR PDBsum; 5WG5; -. DR PDBsum; 6C2Y; -. DR PDBsum; 6CMO; -. DR PDBsum; 6LPB; -. DR PDBsum; 6NBF; -. DR PDBsum; 6NBH; -. DR PDBsum; 6NBI; -. DR PDBsum; 6PCV; -. DR PDBsum; 6U7C; -. DR PDBsum; 7BW0; -. DR PDBsum; 7BZ2; -. DR PDBsum; 7CZ5; -. DR PDBsum; 7D3S; -. DR PDBsum; 7D68; -. DR PDBsum; 7DB6; -. DR PDBsum; 7DH5; -. DR PDBsum; 7DHI; -. DR PDBsum; 7DHR; -. DR PDBsum; 7DTY; -. DR PDBsum; 7DUQ; -. DR PDBsum; 7DUR; -. DR PDBsum; 7DW9; -. DR PDBsum; 7EIB; -. DR PDBsum; 7EQ1; -. DR PDBsum; 7EVM; -. DR PDBsum; 7F16; -. DR PDBsum; 7F2O; -. DR PDBsum; 7FIG; -. DR PDBsum; 7FIH; -. DR PDBsum; 7FII; -. DR PDBsum; 7FIM; -. DR PDBsum; 7FIN; -. DR PDBsum; 7FIY; -. DR PDBsum; 7JJO; -. DR PDBsum; 7LJC; -. DR PDBsum; 7LJD; -. DR PDBsum; 7PIU; -. DR PDBsum; 7PWD; -. DR PDBsum; 7S0F; -. DR PDBsum; 7S0G; -. DR PDBsum; 7SQO; -. DR PDBsum; 7T6S; -. DR PDBsum; 7T6T; -. DR PDBsum; 7T6U; -. DR PDBsum; 7T6V; -. DR PDBsum; 7TD0; -. DR PDBsum; 7TD1; -. DR PDBsum; 7TD2; -. DR PDBsum; 7TD3; -. DR PDBsum; 7TD4; -. DR PDBsum; 7V35; -. DR PDBsum; 7V9L; -. DR PDBsum; 7V9M; -. DR PDBsum; 7VAB; -. DR PDBsum; 7VBH; -. DR PDBsum; 7VBI; -. DR PDBsum; 7VGY; -. DR PDBsum; 7VGZ; -. DR PDBsum; 7VQX; -. DR PDBsum; 7VVJ; -. DR PDBsum; 7VVK; -. DR PDBsum; 7VVL; -. DR PDBsum; 7VVM; -. DR PDBsum; 7VVN; -. DR PDBsum; 7VVO; -. DR PDBsum; 7WBJ; -. DR PDBsum; 7WIC; -. DR PDBsum; 7WIG; -. DR PDBsum; 7WQ3; -. DR PDBsum; 7WQ4; -. DR PDBsum; 7X1T; -. DR PDBsum; 7X1U; -. DR PDBsum; 7XAT; -. DR PDBsum; 7XAU; -. DR PDBsum; 7XAV; -. DR PDBsum; 7XJH; -. DR PDBsum; 7XJI; -. DR PDBsum; 7XW9; -. DR PDBsum; 7XWO; -. DR PDBsum; 7Y35; -. DR PDBsum; 7Y36; -. DR PDBsum; 7YJ4; -. DR PDBsum; 7YK6; -. DR PDBsum; 7YK7; -. DR PDBsum; 7YU3; -. DR PDBsum; 7YU5; -. DR PDBsum; 7YU6; -. DR PDBsum; 7YU7; -. DR PDBsum; 7YU8; -. DR PDBsum; 8DCR; -. DR PDBsum; 8DCS; -. DR PDBsum; 8EF5; -. DR PDBsum; 8EF6; -. DR PDBsum; 8EFB; -. DR PDBsum; 8EFO; -. DR PDBsum; 8EFQ; -. DR PDBsum; 8F7Q; -. DR PDBsum; 8F7R; -. DR PDBsum; 8F7S; -. DR PDBsum; 8F7W; -. DR PDBsum; 8F7X; -. DR PDBsum; 8GW8; -. DR PDBsum; 8HA0; -. DR PDBsum; 8HAF; -. DR PDBsum; 8HAO; -. DR PDBsum; 8HK2; -. DR PDBsum; 8HK3; -. DR PDBsum; 8INR; -. DR PDBsum; 8IOC; -. DR PDBsum; 8IOD; -. DR PDBsum; 8ITL; -. DR PDBsum; 8ITM; -. DR PDBsum; 8IY5; -. DR PDBsum; 8JIP; -. DR PDBsum; 8JIQ; -. DR PDBsum; 8JIR; -. DR PDBsum; 8JIS; -. DR PDBsum; 8JIT; -. DR PDBsum; 8JIU; -. DR AlphaFoldDB; P63212; -. DR EMDB; EMD-0410; -. DR EMDB; EMD-0411; -. DR EMDB; EMD-0412; -. DR EMDB; EMD-0940; -. DR EMDB; EMD-13453; -. DR EMDB; EMD-20308; -. DR EMDB; EMD-22357; -. DR EMDB; EMD-23390; -. DR EMDB; EMD-23391; -. DR EMDB; EMD-24789; -. DR EMDB; EMD-24790; -. DR EMDB; EMD-25389; -. DR EMDB; EMD-25726; -. DR EMDB; EMD-25727; -. DR EMDB; EMD-25728; -. DR EMDB; EMD-25729; -. DR EMDB; EMD-25819; -. DR EMDB; EMD-25820; -. DR EMDB; EMD-25821; -. DR EMDB; EMD-25822; -. DR EMDB; EMD-25823; -. DR EMDB; EMD-27328; -. DR EMDB; EMD-27329; -. DR EMDB; EMD-28066; -. DR EMDB; EMD-28069; -. DR EMDB; EMD-28077; -. DR EMDB; EMD-28086; -. DR EMDB; EMD-28088; -. DR EMDB; EMD-28907; -. DR EMDB; EMD-28908; -. DR EMDB; EMD-28909; -. DR EMDB; EMD-28911; -. DR EMDB; EMD-28912; -. DR EMDB; EMD-30221; -. DR EMDB; EMD-30249; -. DR EMDB; EMD-30505; -. DR EMDB; EMD-30566; -. DR EMDB; EMD-30590; -. DR EMDB; EMD-30627; -. DR EMDB; EMD-30678; -. DR EMDB; EMD-30681; -. DR EMDB; EMD-30682; -. DR EMDB; EMD-30860; -. DR EMDB; EMD-30866; -. DR EMDB; EMD-30867; -. DR EMDB; EMD-30877; -. DR EMDB; EMD-31145; -. DR EMDB; EMD-31254; -. DR EMDB; EMD-31329; -. DR EMDB; EMD-31405; -. DR EMDB; EMD-31429; -. DR EMDB; EMD-31596; -. DR EMDB; EMD-31597; -. DR EMDB; EMD-31598; -. DR EMDB; EMD-31603; -. DR EMDB; EMD-31604; -. DR EMDB; EMD-31606; -. DR EMDB; EMD-31676; -. DR EMDB; EMD-31824; -. DR EMDB; EMD-31825; -. DR EMDB; EMD-31836; -. DR EMDB; EMD-31879; -. DR EMDB; EMD-31880; -. DR EMDB; EMD-31980; -. DR EMDB; EMD-31981; -. DR EMDB; EMD-32095; -. DR EMDB; EMD-32141; -. DR EMDB; EMD-32142; -. DR EMDB; EMD-32143; -. DR EMDB; EMD-32144; -. DR EMDB; EMD-32145; -. DR EMDB; EMD-32146; -. DR EMDB; EMD-32401; -. DR EMDB; EMD-32528; -. DR EMDB; EMD-32529; -. DR EMDB; EMD-32698; -. DR EMDB; EMD-32699; -. DR EMDB; EMD-32949; -. DR EMDB; EMD-32950; -. DR EMDB; EMD-33098; -. DR EMDB; EMD-33099; -. DR EMDB; EMD-33100; -. DR EMDB; EMD-33227; -. DR EMDB; EMD-33228; -. DR EMDB; EMD-33494; -. DR EMDB; EMD-33497; -. DR EMDB; EMD-33588; -. DR EMDB; EMD-33590; -. DR EMDB; EMD-33871; -. DR EMDB; EMD-33888; -. DR EMDB; EMD-33889; -. DR EMDB; EMD-34097; -. DR EMDB; EMD-34099; -. DR EMDB; EMD-34100; -. DR EMDB; EMD-34101; -. DR EMDB; EMD-34102; -. DR EMDB; EMD-34305; -. DR EMDB; EMD-34585; -. DR EMDB; EMD-34587; -. DR EMDB; EMD-34598; -. DR EMDB; EMD-34842; -. DR EMDB; EMD-34843; -. DR EMDB; EMD-35601; -. DR EMDB; EMD-35615; -. DR EMDB; EMD-35616; -. DR EMDB; EMD-35706; -. DR EMDB; EMD-35707; -. DR EMDB; EMD-35814; -. DR EMDB; EMD-36323; -. DR EMDB; EMD-36324; -. DR EMDB; EMD-36325; -. DR EMDB; EMD-36326; -. DR EMDB; EMD-36327; -. DR EMDB; EMD-36328; -. DR EMDB; EMD-7517; -. DR EMDB; EMD-8653; -. DR SMR; P63212; -. DR BioGRID; 158562; 1. DR CORUM; P63212; -. DR DIP; DIP-586N; -. DR IntAct; P63212; 7. DR STRING; 9913.ENSBTAP00000003959; -. DR iPTMnet; P63212; -. DR PaxDb; 9913-ENSBTAP00000003959; -. DR PeptideAtlas; P63212; -. DR Ensembl; ENSBTAT00000003959.4; ENSBTAP00000003959.3; ENSBTAG00000003043.4. DR GeneID; 281203; -. DR KEGG; bta:281203; -. DR CTD; 54331; -. DR VEuPathDB; HostDB:ENSBTAG00000003043; -. DR VGNC; VGNC:29465; GNG2. DR eggNOG; KOG4119; Eukaryota. DR GeneTree; ENSGT01100000263497; -. DR HOGENOM; CLU_168377_0_1_1; -. DR InParanoid; P63212; -. DR OMA; GKQQPPM; -. DR TreeFam; TF319909; -. DR Reactome; R-BTA-1296041; Activation of G protein gated Potassium channels. DR Reactome; R-BTA-202040; G-protein activation. DR Reactome; R-BTA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion. DR Reactome; R-BTA-392170; ADP signalling through P2Y purinoceptor 12. DR Reactome; R-BTA-392451; G beta:gamma signalling through PI3Kgamma. DR Reactome; R-BTA-392851; Prostacyclin signalling through prostacyclin receptor. DR Reactome; R-BTA-400042; Adrenaline,noradrenaline inhibits insulin secretion. DR Reactome; R-BTA-4086398; Ca2+ pathway. DR Reactome; R-BTA-416476; G alpha (q) signalling events. DR Reactome; R-BTA-416482; G alpha (12/13) signalling events. DR Reactome; R-BTA-418217; G beta:gamma signalling through PLC beta. DR Reactome; R-BTA-418555; G alpha (s) signalling events. DR Reactome; R-BTA-418592; ADP signalling through P2Y purinoceptor 1. DR Reactome; R-BTA-418594; G alpha (i) signalling events. DR Reactome; R-BTA-418597; G alpha (z) signalling events. DR Reactome; R-BTA-420092; Glucagon-type ligand receptors. DR Reactome; R-BTA-428930; Thromboxane signalling through TP receptor. DR Reactome; R-BTA-432040; Vasopressin regulates renal water homeostasis via Aquaporins. DR Reactome; R-BTA-456926; Thrombin signalling through proteinase activated receptors (PARs). DR Reactome; R-BTA-500657; Presynaptic function of Kainate receptors. DR Reactome; R-BTA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding. DR Reactome; R-BTA-8964315; G beta:gamma signalling through BTK. DR Reactome; R-BTA-8964616; G beta:gamma signalling through CDC42. DR Reactome; R-BTA-9009391; Extra-nuclear estrogen signaling. DR Reactome; R-BTA-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits. DR EvolutionaryTrace; P63212; -. DR Proteomes; UP000009136; Chromosome 10. DR Bgee; ENSBTAG00000003043; Expressed in omental fat pad and 104 other cell types or tissues. DR GO; GO:0005834; C:heterotrimeric G-protein complex; IDA:BHF-UCL. DR GO; GO:0016020; C:membrane; IDA:BHF-UCL. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0031681; F:G-protein beta-subunit binding; ISS:CAFA. DR GO; GO:0003924; F:GTPase activity; IDA:MGI. DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IDA:BHF-UCL. DR GO; GO:0071870; P:cellular response to catecholamine stimulus; IDA:BHF-UCL. DR GO; GO:0071380; P:cellular response to prostaglandin E stimulus; IDA:BHF-UCL. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:MGI. DR CDD; cd00068; GGL; 1. DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1. DR InterPro; IPR015898; G-protein_gamma-like_dom. DR InterPro; IPR036284; GGL_sf. DR InterPro; IPR001770; Gprotein-gamma. DR PANTHER; PTHR13809:SF25; GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-2; 1. DR PANTHER; PTHR13809; GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT; 1. DR Pfam; PF00631; G-gamma; 1. DR PRINTS; PR00321; GPROTEING. DR SMART; SM01224; G_gamma; 1. DR SMART; SM00224; GGL; 1. DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1. DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1. PE 1: Evidence at protein level; KW 3D-structure; Acetylation; Cell membrane; Direct protein sequencing; KW Lipoprotein; Membrane; Methylation; Prenylation; Reference proteome; KW Transducer. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000269|PubMed:7626050, FT ECO:0000269|PubMed:8439334" FT CHAIN 2..68 FT /note="Guanine nucleotide-binding protein G(I)/G(S)/G(O) FT subunit gamma-2" FT /evidence="ECO:0000269|PubMed:7626050" FT /id="PRO_0000012609" FT PROPEP 69..71 FT /note="Removed in mature form" FT /evidence="ECO:0000269|PubMed:7626050" FT /id="PRO_0000012610" FT MOD_RES 2 FT /note="N-acetylalanine" FT /evidence="ECO:0000269|PubMed:7626050" FT MOD_RES 68 FT /note="Cysteine methyl ester" FT /evidence="ECO:0000269|PubMed:1903391" FT LIPID 68 FT /note="S-geranylgeranyl cysteine" FT /evidence="ECO:0000269|PubMed:12764189, FT ECO:0000269|PubMed:1903391, ECO:0000269|PubMed:7626050" FT HELIX 9..23 FT /evidence="ECO:0007829|PDB:3V5W" FT HELIX 30..43 FT /evidence="ECO:0007829|PDB:3V5W" FT HELIX 45..47 FT /evidence="ECO:0007829|PDB:3V5W" FT TURN 49..51 FT /evidence="ECO:0007829|PDB:3V5W" FT HELIX 56..58 FT /evidence="ECO:0007829|PDB:3V5W" FT TURN 60..63 FT /evidence="ECO:0007829|PDB:3V5W" SQ SEQUENCE 71 AA; 7850 MW; EDB74E4135E7A37A CRC64; MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL LTPVPASENP FREKKFFCAI L //