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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

GNG2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB
  • GTPase activity Source: MGI
  • signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  • adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
  • cell proliferation Source: Ensembl
  • cellular response to catecholamine stimulus Source: BHF-UCL
  • cellular response to prostaglandin E stimulus Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-BTA-1296041. Activation of G protein gated Potassium channels.
R-BTA-163359. Glucagon signaling in metabolic regulation.
R-BTA-202040. G-protein activation.
R-BTA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-BTA-392170. ADP signalling through P2Y purinoceptor 12.
R-BTA-392451. G beta:gamma signalling through PI3Kgamma.
R-BTA-392851. Prostacyclin signalling through prostacyclin receptor.
R-BTA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-BTA-4086398. Ca2+ pathway.
R-BTA-416476. G alpha (q) signalling events.
R-BTA-416482. G alpha (12/13) signalling events.
R-BTA-418217. G beta:gamma signalling through PLC beta.
R-BTA-418555. G alpha (s) signalling events.
R-BTA-418592. ADP signalling through P2Y purinoceptor 1.
R-BTA-418594. G alpha (i) signalling events.
R-BTA-418597. G alpha (z) signalling events.
R-BTA-420092. Glucagon-type ligand receptors.
R-BTA-428930. Thromboxane signalling through TP receptor.
R-BTA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-BTA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-BTA-500657. Presynaptic function of Kainate receptors.
R-BTA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-BTA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
Gene namesi
Name:GNG2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • heterotrimeric G-protein complex Source: BHF-UCL
  • membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000126092 – 68Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Add BLAST67
PropeptideiPRO_000001261069 – 71Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei68Cysteine methyl ester1 Publication1
Lipidationi68S-geranylgeranyl cysteine3 Publications1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP63212.
PeptideAtlasiP63212.
PRIDEiP63212.

Expressioni

Tissue specificityi

Adrenal gland and brain.

Gene expression databases

BgeeiENSBTAG00000003043.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma (PubMed:8521505). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-586N.
IntActiP63212. 1 interactor.
STRINGi9913.ENSBTAP00000003959.

Structurei

Secondary structure

171
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 23Combined sources15
Helixi30 – 43Combined sources14
Helixi45 – 47Combined sources3
Turni49 – 51Combined sources3
Helixi56 – 58Combined sources3
Turni60 – 63Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GG2X-ray2.40G1-71[»]
1GP2X-ray2.30G1-71[»]
1OMWX-ray2.50G1-68[»]
1XHMX-ray2.70B1-71[»]
2BCJX-ray3.06G1-71[»]
3AH8X-ray2.90G1-71[»]
3CIKX-ray2.75G1-68[»]
3KRWX-ray2.90G1-68[»]
3KRXX-ray3.10G1-68[»]
3PSCX-ray2.67G1-68[»]
3PVUX-ray2.48G1-68[»]
3PVWX-ray2.49G1-68[»]
3SN6X-ray3.20G1-68[»]
3UZSX-ray4.52G1-67[»]
3V5WX-ray2.07G1-71[»]
4MK0X-ray2.40G6-64[»]
4PNKX-ray2.56G1-71[»]
ProteinModelPortaliP63212.
SMRiP63212.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63212.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63212.
KOiK07826.
OMAiAPMASNN.
OrthoDBiEOG091G17J0.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:January 23, 2007 - v2
Checksum:iEDB74E4135E7A37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05071 mRNA. Translation: AAA30541.1.
M37183 mRNA. Translation: AAA30555.1.
BC112789 mRNA. Translation: AAI12790.1.
PIRiB34228. RGBOG2.
RefSeqiNP_776497.1. NM_174072.4.
XP_005211711.1. XM_005211654.3.
XP_010807541.1. XM_010809239.2.
UniGeneiBt.4586.
Bt.90717.

Genome annotation databases

EnsembliENSBTAT00000003959; ENSBTAP00000003959; ENSBTAG00000003043.
GeneIDi281203.
KEGGibta:281203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05071 mRNA. Translation: AAA30541.1.
M37183 mRNA. Translation: AAA30555.1.
BC112789 mRNA. Translation: AAI12790.1.
PIRiB34228. RGBOG2.
RefSeqiNP_776497.1. NM_174072.4.
XP_005211711.1. XM_005211654.3.
XP_010807541.1. XM_010809239.2.
UniGeneiBt.4586.
Bt.90717.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GG2X-ray2.40G1-71[»]
1GP2X-ray2.30G1-71[»]
1OMWX-ray2.50G1-68[»]
1XHMX-ray2.70B1-71[»]
2BCJX-ray3.06G1-71[»]
3AH8X-ray2.90G1-71[»]
3CIKX-ray2.75G1-68[»]
3KRWX-ray2.90G1-68[»]
3KRXX-ray3.10G1-68[»]
3PSCX-ray2.67G1-68[»]
3PVUX-ray2.48G1-68[»]
3PVWX-ray2.49G1-68[»]
3SN6X-ray3.20G1-68[»]
3UZSX-ray4.52G1-67[»]
3V5WX-ray2.07G1-71[»]
4MK0X-ray2.40G6-64[»]
4PNKX-ray2.56G1-71[»]
ProteinModelPortaliP63212.
SMRiP63212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-586N.
IntActiP63212. 1 interactor.
STRINGi9913.ENSBTAP00000003959.

Proteomic databases

PaxDbiP63212.
PeptideAtlasiP63212.
PRIDEiP63212.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003959; ENSBTAP00000003959; ENSBTAG00000003043.
GeneIDi281203.
KEGGibta:281203.

Organism-specific databases

CTDi54331.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP63212.
KOiK07826.
OMAiAPMASNN.
OrthoDBiEOG091G17J0.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-BTA-1296041. Activation of G protein gated Potassium channels.
R-BTA-163359. Glucagon signaling in metabolic regulation.
R-BTA-202040. G-protein activation.
R-BTA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-BTA-392170. ADP signalling through P2Y purinoceptor 12.
R-BTA-392451. G beta:gamma signalling through PI3Kgamma.
R-BTA-392851. Prostacyclin signalling through prostacyclin receptor.
R-BTA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-BTA-4086398. Ca2+ pathway.
R-BTA-416476. G alpha (q) signalling events.
R-BTA-416482. G alpha (12/13) signalling events.
R-BTA-418217. G beta:gamma signalling through PLC beta.
R-BTA-418555. G alpha (s) signalling events.
R-BTA-418592. ADP signalling through P2Y purinoceptor 1.
R-BTA-418594. G alpha (i) signalling events.
R-BTA-418597. G alpha (z) signalling events.
R-BTA-420092. Glucagon-type ligand receptors.
R-BTA-428930. Thromboxane signalling through TP receptor.
R-BTA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-BTA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-BTA-500657. Presynaptic function of Kainate receptors.
R-BTA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-BTA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

EvolutionaryTraceiP63212.

Gene expression databases

BgeeiENSBTAG00000003043.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG2_BOVIN
AccessioniPrimary (citable) accession number: P63212
Secondary accession number(s): P16874
, Q2KI31, Q61013, Q9TS47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.