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P63211

- GBG1_HUMAN

UniProt

P63211 - GBG1_HUMAN

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Protein

Guanine nucleotide-binding protein G(T) subunit gamma-T1

Gene

GNGT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. GTPase activity Source: ProtInc
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. cardiac muscle cell apoptotic process Source: Ensembl
  2. cellular response to hypoxia Source: Ensembl
  3. eye photoreceptor cell development Source: Ensembl
  4. GTP catabolic process Source: GOC
  5. phototransduction, visible light Source: Reactome
  6. protein localization Source: Ensembl
  7. regulation of rhodopsin mediated signaling pathway Source: Reactome
  8. rhodopsin mediated signaling pathway Source: Reactome
  9. signal transduction Source: ProtInc
  10. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_15488. Olfactory Signaling Pathway.
REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_163932. Activation of the phototransduction cascade.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Alternative name(s):
Transducin gamma chain
Gene namesi
Name:GNGT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:4411. GNGT1.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: Ensembl
  2. photoreceptor disc membrane Source: Reactome
  3. photoreceptor inner segment Source: Ensembl
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 7170Guanine nucleotide-binding protein G(T) subunit gamma-T1PRO_0000012605Add
BLAST
Propeptidei72 – 743Removed in mature formBy similarityPRO_0000012606

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711Cysteine methyl esterBy similarity
Lipidationi71 – 711S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP63211.
PRIDEiP63211.

PTM databases

PhosphoSiteiP63211.

Expressioni

Tissue specificityi

Retinal rod outer segment.

Gene expression databases

BgeeiP63211.
CleanExiHS_GNGT1.
ExpressionAtlasiP63211. baseline and differential.
GenevestigatoriP63211.

Organism-specific databases

HPAiHPA042721.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi109054. 4 interactions.
DIPiDIP-471N.
STRINGi9606.ENSP00000248572.

Structurei

3D structure databases

ProteinModelPortaliP63211.
SMRiP63211. Positions 1-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG291971.
GeneTreeiENSGT00530000063397.
HOVERGENiHBG014983.
InParanoidiP63211.
KOiK04548.
OMAiEEVECHY.
PhylomeDBiP63211.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63211-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVINIEDLT EKDKLKMEVD QLKKEVTLER MLVSKCCEEV RDYVEERSGE
60 70
DPLVKGIPED KNPFKELKGG CVIS
Length:74
Mass (Da):8,496
Last modified:January 23, 2007 - v2
Checksum:iB12B42BE00DB1C05
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501E → K.
Corresponds to variant rs17243826 [ dbSNP | Ensembl ].
VAR_033949

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S62027 mRNA. Translation: AAB26896.1.
S62026 Genomic DNA. Translation: AAD13931.1.
U41492 Genomic DNA. Translation: AAB92386.1.
U41493 Genomic DNA. Translation: AAB92387.1.
AF493869 mRNA. Translation: AAM12583.1.
CR456912 mRNA. Translation: CAG33193.1.
AC002076 Genomic DNA. Translation: AAS02021.1.
CH236949 Genomic DNA. Translation: EAL24139.1.
CH471091 Genomic DNA. Translation: EAW76806.1.
BC029367 mRNA. Translation: AAH29367.1.
CCDSiCCDS5633.1.
PIRiI62760.
RefSeqiNP_068774.1. NM_021955.3.
UniGeneiHs.732212.

Genome annotation databases

EnsembliENST00000248572; ENSP00000248572; ENSG00000127928.
ENST00000429473; ENSP00000388777; ENSG00000127928.
GeneIDi2792.
KEGGihsa:2792.
UCSCiuc003unc.1. human.

Polymorphism databases

DMDMi52783592.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S62027 mRNA. Translation: AAB26896.1 .
S62026 Genomic DNA. Translation: AAD13931.1 .
U41492 Genomic DNA. Translation: AAB92386.1 .
U41493 Genomic DNA. Translation: AAB92387.1 .
AF493869 mRNA. Translation: AAM12583.1 .
CR456912 mRNA. Translation: CAG33193.1 .
AC002076 Genomic DNA. Translation: AAS02021.1 .
CH236949 Genomic DNA. Translation: EAL24139.1 .
CH471091 Genomic DNA. Translation: EAW76806.1 .
BC029367 mRNA. Translation: AAH29367.1 .
CCDSi CCDS5633.1.
PIRi I62760.
RefSeqi NP_068774.1. NM_021955.3.
UniGenei Hs.732212.

3D structure databases

ProteinModelPortali P63211.
SMRi P63211. Positions 1-68.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109054. 4 interactions.
DIPi DIP-471N.
STRINGi 9606.ENSP00000248572.

PTM databases

PhosphoSitei P63211.

Polymorphism databases

DMDMi 52783592.

Proteomic databases

PaxDbi P63211.
PRIDEi P63211.

Protocols and materials databases

DNASUi 2792.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248572 ; ENSP00000248572 ; ENSG00000127928 .
ENST00000429473 ; ENSP00000388777 ; ENSG00000127928 .
GeneIDi 2792.
KEGGi hsa:2792.
UCSCi uc003unc.1. human.

Organism-specific databases

CTDi 2792.
GeneCardsi GC07P093220.
HGNCi HGNC:4411. GNGT1.
HPAi HPA042721.
MIMi 189970. gene.
neXtProti NX_P63211.
PharmGKBi PA28790.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291971.
GeneTreei ENSGT00530000063397.
HOVERGENi HBG014983.
InParanoidi P63211.
KOi K04548.
OMAi EEVECHY.
PhylomeDBi P63211.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_15457. G-protein activation.
REACT_15488. Olfactory Signaling Pathway.
REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_163932. Activation of the phototransduction cascade.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.

Miscellaneous databases

ChiTaRSi GNGT1. human.
GeneWikii GNGT1.
GenomeRNAii 2792.
NextBioi 11001.
PROi P63211.
SOURCEi Search...

Gene expression databases

Bgeei P63211.
CleanExi HS_GNGT1.
ExpressionAtlasi P63211. baseline and differential.
Genevestigatori P63211.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice."
    Tao L., Pandey S., Simon M.I., Fong H.K.
    Exp. Eye Res. 56:497-507(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1)."
    Scherer S.W., Feinstein D.S., Oliveira L., Tsui L.-C., Pittler S.J.
    Genomics 35:241-243(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiGBG1_HUMAN
AccessioniPrimary (citable) accession number: P63211
Secondary accession number(s): A4D1H2
, O43835, Q08447, Q16026, Q6LCP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3