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P63211

- GBG1_HUMAN

UniProt

P63211 - GBG1_HUMAN

Protein

Guanine nucleotide-binding protein G(T) subunit gamma-T1

Gene

GNGT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. GTPase activity Source: ProtInc
    2. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. cardiac muscle cell apoptotic process Source: Ensembl
    2. cellular response to hypoxia Source: Ensembl
    3. eye photoreceptor cell development Source: Ensembl
    4. GTP catabolic process Source: GOC
    5. phototransduction, visible light Source: Reactome
    6. protein localization Source: Ensembl
    7. regulation of rhodopsin mediated signaling pathway Source: Reactome
    8. rhodopsin mediated signaling pathway Source: Reactome
    9. signal transduction Source: ProtInc
    10. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15457. G-protein activation.
    REACT_15488. Olfactory Signaling Pathway.
    REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_163932. Activation of the phototransduction cascade.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18283. G alpha (q) signalling events.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19231. G alpha (i) signalling events.
    REACT_19290. G beta:gamma signalling through PI3Kgamma.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    REACT_21254. Presynaptic function of Kainate receptors.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_23946. Prostacyclin signalling through prostacyclin receptor.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(T) subunit gamma-T1
    Alternative name(s):
    Transducin gamma chain
    Gene namesi
    Name:GNGT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:4411. GNGT1.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: Ensembl
    2. photoreceptor disc membrane Source: Reactome
    3. photoreceptor inner segment Source: Ensembl
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28790.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 7170Guanine nucleotide-binding protein G(T) subunit gamma-T1PRO_0000012605Add
    BLAST
    Propeptidei72 – 743Removed in mature formBy similarityPRO_0000012606

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei71 – 711Cysteine methyl esterBy similarity
    Lipidationi71 – 711S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP63211.
    PRIDEiP63211.

    PTM databases

    PhosphoSiteiP63211.

    Expressioni

    Tissue specificityi

    Retinal rod outer segment.

    Gene expression databases

    ArrayExpressiP63211.
    BgeeiP63211.
    CleanExiHS_GNGT1.
    GenevestigatoriP63211.

    Organism-specific databases

    HPAiHPA042721.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    BioGridi109054. 4 interactions.
    DIPiDIP-471N.
    STRINGi9606.ENSP00000248572.

    Structurei

    3D structure databases

    ProteinModelPortaliP63211.
    SMRiP63211. Positions 1-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG291971.
    HOVERGENiHBG014983.
    InParanoidiP63211.
    KOiK04548.
    OMAiEEVECHY.
    PhylomeDBiP63211.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P63211-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVINIEDLT EKDKLKMEVD QLKKEVTLER MLVSKCCEEV RDYVEERSGE   50
    DPLVKGIPED KNPFKELKGG CVIS 74
    Length:74
    Mass (Da):8,496
    Last modified:January 23, 2007 - v2
    Checksum:iB12B42BE00DB1C05
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501E → K.
    Corresponds to variant rs17243826 [ dbSNP | Ensembl ].
    VAR_033949

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S62027 mRNA. Translation: AAB26896.1.
    S62026 Genomic DNA. Translation: AAD13931.1.
    U41492 Genomic DNA. Translation: AAB92386.1.
    U41493 Genomic DNA. Translation: AAB92387.1.
    AF493869 mRNA. Translation: AAM12583.1.
    CR456912 mRNA. Translation: CAG33193.1.
    AC002076 Genomic DNA. Translation: AAS02021.1.
    CH236949 Genomic DNA. Translation: EAL24139.1.
    CH471091 Genomic DNA. Translation: EAW76806.1.
    BC029367 mRNA. Translation: AAH29367.1.
    CCDSiCCDS5633.1.
    PIRiI62760.
    RefSeqiNP_068774.1. NM_021955.3.
    UniGeneiHs.732212.

    Genome annotation databases

    EnsembliENST00000248572; ENSP00000248572; ENSG00000127928.
    ENST00000429473; ENSP00000388777; ENSG00000127928.
    GeneIDi2792.
    KEGGihsa:2792.
    UCSCiuc003unc.1. human.

    Polymorphism databases

    DMDMi52783592.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S62027 mRNA. Translation: AAB26896.1 .
    S62026 Genomic DNA. Translation: AAD13931.1 .
    U41492 Genomic DNA. Translation: AAB92386.1 .
    U41493 Genomic DNA. Translation: AAB92387.1 .
    AF493869 mRNA. Translation: AAM12583.1 .
    CR456912 mRNA. Translation: CAG33193.1 .
    AC002076 Genomic DNA. Translation: AAS02021.1 .
    CH236949 Genomic DNA. Translation: EAL24139.1 .
    CH471091 Genomic DNA. Translation: EAW76806.1 .
    BC029367 mRNA. Translation: AAH29367.1 .
    CCDSi CCDS5633.1.
    PIRi I62760.
    RefSeqi NP_068774.1. NM_021955.3.
    UniGenei Hs.732212.

    3D structure databases

    ProteinModelPortali P63211.
    SMRi P63211. Positions 1-68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109054. 4 interactions.
    DIPi DIP-471N.
    STRINGi 9606.ENSP00000248572.

    PTM databases

    PhosphoSitei P63211.

    Polymorphism databases

    DMDMi 52783592.

    Proteomic databases

    PaxDbi P63211.
    PRIDEi P63211.

    Protocols and materials databases

    DNASUi 2792.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248572 ; ENSP00000248572 ; ENSG00000127928 .
    ENST00000429473 ; ENSP00000388777 ; ENSG00000127928 .
    GeneIDi 2792.
    KEGGi hsa:2792.
    UCSCi uc003unc.1. human.

    Organism-specific databases

    CTDi 2792.
    GeneCardsi GC07P093220.
    HGNCi HGNC:4411. GNGT1.
    HPAi HPA042721.
    MIMi 189970. gene.
    neXtProti NX_P63211.
    PharmGKBi PA28790.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291971.
    HOVERGENi HBG014983.
    InParanoidi P63211.
    KOi K04548.
    OMAi EEVECHY.
    PhylomeDBi P63211.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_15457. G-protein activation.
    REACT_15488. Olfactory Signaling Pathway.
    REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_163932. Activation of the phototransduction cascade.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18283. G alpha (q) signalling events.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19231. G alpha (i) signalling events.
    REACT_19290. G beta:gamma signalling through PI3Kgamma.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    REACT_21254. Presynaptic function of Kainate receptors.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_23946. Prostacyclin signalling through prostacyclin receptor.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.

    Miscellaneous databases

    ChiTaRSi GNGT1. human.
    GeneWikii GNGT1.
    GenomeRNAii 2792.
    NextBioi 11001.
    PROi P63211.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63211.
    Bgeei P63211.
    CleanExi HS_GNGT1.
    Genevestigatori P63211.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice."
      Tao L., Pandey S., Simon M.I., Fong H.K.
      Exp. Eye Res. 56:497-507(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1)."
      Scherer S.W., Feinstein D.S., Oliveira L., Tsui L.-C., Pittler S.J.
      Genomics 35:241-243(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiGBG1_HUMAN
    AccessioniPrimary (citable) accession number: P63211
    Secondary accession number(s): A4D1H2
    , O43835, Q08447, Q16026, Q6LCP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3