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Protein

Transcriptional regulator GadE

Gene

gadE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi133 – 152H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG11544-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator GadE
Gene namesi
Name:gadE
Synonyms:yhiE, yhiT
Ordered Locus Names:b3512, JW3480
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11544 gadE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001841551 – 175Transcriptional regulator GadEAdd BLAST175

Proteomic databases

PaxDbiP63204
PRIDEiP63204

Expressioni

Inductioni

By acidic conditions. Could be induced by EvgA via the induction of YdeO.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4262519, 8 interactors
DIPiDIP-48091N
IntActiP63204, 2 interactors
STRINGi316385.ECDH10B_3688

Structurei

3D structure databases

ProteinModelPortaliP63204
SMRiP63204
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 174HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

eggNOGiENOG4106WJ0 Bacteria
ENOG410YREC LUCA
HOGENOMiHOG000125848
KOiK21907
OMAiIANWISL

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00196 GerE, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
PROSITEiView protein in PROSITE
PS50043 HTH_LUXR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P63204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFLMTKDSF LLQGFWQLKD NHEMIKINSL SEIKKVGNKP FKVIIDTYHN
60 70 80 90 100
HILDEEAIKF LEKLDAERII VLAPYHISKL KAKAPIYFVS RKESIKNLLE
110 120 130 140 150
ITYGKHLPHK NSQLCFSHNQ FKIMQLILKN KNESNITSTL NISQQTLKIQ
160 170
KFNIMYKLKL RRMSDIVTLG ITSYF
Length:175
Mass (Da):20,599
Last modified:September 27, 2004 - v1
Checksum:i5CCC69A0DA53B293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18488.1
U00096 Genomic DNA Translation: AAC76537.1
AP009048 Genomic DNA Translation: BAE77782.1
D11389 Genomic DNA No translation available.
PIRiS47732
RefSeqiNP_417969.1, NC_000913.3
WP_000576690.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76537; AAC76537; b3512
BAE77782; BAE77782; BAE77782
GeneIDi948023
KEGGiecj:JW3480
eco:b3512
PATRICifig|511145.12.peg.3619

Similar proteinsi

Entry informationi

Entry nameiGADE_ECOLI
AccessioniPrimary (citable) accession number: P63204
Secondary accession number(s): P29688, Q2M7H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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