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Protein

HTH-type transcriptional regulator GadW

Gene

gadW

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 174H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GadW
Gene namesi
Name:gadW
Ordered Locus Names:SF3596, S4171
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001945171 – 242HTH-type transcriptional regulator GadWAdd BLAST242

Proteomic databases

PaxDbiP63203.

Expressioni

Inductioni

Expression can be repressed by GadX, depending on the conditions.By similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198214.SF3596.

Structurei

3D structure databases

ProteinModelPortaliP63203.
SMRiP63203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108MG2. Bacteria.
ENOG41101VY. LUCA.
HOGENOMiHOG000120708.
OMAiEIDECIV.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHVCSVILI RRSFDIYHEQ QKISLHNESI LLLEKNLADD FAFCSPDTRR
60 70 80 90 100
LDIDELTVCH YLQNIRQLPR NLGLHSKDRL LINQSPPMPL VTAIFDSFNE
110 120 130 140 150
SGVNSPILSN MLYLSCLSMF SHKKELIPLL FNSISTVSGK VERLISFDIA
160 170 180 190 200
KRWYLRDIAE RMYTSESLIK KKLQDENTCF SKILLASRMS MARRLLELRQ
210 220 230 240
IPLHTIAEKC GYSSTSYFIN TFRQYYGVTP HQFAQHSPGT FS
Length:242
Mass (Da):28,028
Last modified:September 27, 2004 - v1
Checksum:i40C11B74DA2F8DA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN45047.1.
AE014073 Genomic DNA. Translation: AAP19140.1.
RefSeqiNP_709340.1. NC_004337.2.
WP_000149999.1. NZ_LVJC01000137.1.

Genome annotation databases

EnsemblBacteriaiAAN45047; AAN45047; SF3596.
AAP19140; AAP19140; S4171.
GeneIDi1026315.
KEGGisfl:SF3596.
sft:NCTC1_03890.
sfx:S4171.
PATRICi18710280. VBIShiFle31049_4546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN45047.1.
AE014073 Genomic DNA. Translation: AAP19140.1.
RefSeqiNP_709340.1. NC_004337.2.
WP_000149999.1. NZ_LVJC01000137.1.

3D structure databases

ProteinModelPortaliP63203.
SMRiP63203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF3596.

Proteomic databases

PaxDbiP63203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN45047; AAN45047; SF3596.
AAP19140; AAP19140; S4171.
GeneIDi1026315.
KEGGisfl:SF3596.
sft:NCTC1_03890.
sfx:S4171.
PATRICi18710280. VBIShiFle31049_4546.

Phylogenomic databases

eggNOGiENOG4108MG2. Bacteria.
ENOG41101VY. LUCA.
HOGENOMiHOG000120708.
OMAiEIDECIV.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGADW_SHIFL
AccessioniPrimary (citable) accession number: P63203
Secondary accession number(s): P37638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.