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Protein

HTH-type transcriptional regulator GadW

Gene

gadW

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 174H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GadW
Gene namesi
Name:gadW
Ordered Locus Names:SF3596, S4171
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001945171 – 242HTH-type transcriptional regulator GadWAdd BLAST242

Expressioni

Inductioni

Expression can be repressed by GadX, depending on the conditions.By similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP63203
SMRiP63203
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108MG2 Bacteria
ENOG41101VY LUCA
HOGENOMiHOG000120708
KOiK21906
OMAiEIDECIV

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR020449 Tscrpt_reg_HTH_AraC-type
PfamiView protein in Pfam
PF12833 HTH_18, 1 hit
PRINTSiPR00032 HTHARAC
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequencei

Sequence statusi: Complete.

P63203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHVCSVILI RRSFDIYHEQ QKISLHNESI LLLEKNLADD FAFCSPDTRR
60 70 80 90 100
LDIDELTVCH YLQNIRQLPR NLGLHSKDRL LINQSPPMPL VTAIFDSFNE
110 120 130 140 150
SGVNSPILSN MLYLSCLSMF SHKKELIPLL FNSISTVSGK VERLISFDIA
160 170 180 190 200
KRWYLRDIAE RMYTSESLIK KKLQDENTCF SKILLASRMS MARRLLELRQ
210 220 230 240
IPLHTIAEKC GYSSTSYFIN TFRQYYGVTP HQFAQHSPGT FS
Length:242
Mass (Da):28,028
Last modified:September 27, 2004 - v1
Checksum:i40C11B74DA2F8DA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN45047.1
AE014073 Genomic DNA Translation: AAP19140.1
RefSeqiNP_709340.1, NC_004337.2
WP_000149999.1, NZ_NIYR01000018.1

Genome annotation databases

EnsemblBacteriaiAAN45047; AAN45047; SF3596
AAP19140; AAP19140; S4171
GeneIDi1026315
KEGGisfl:SF3596
sfx:S4171
PATRICifig|198214.7.peg.4246

Similar proteinsi

Entry informationi

Entry nameiGADW_SHIFL
AccessioniPrimary (citable) accession number: P63203
Secondary accession number(s): P37638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health