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Protein

HTH-type transcriptional regulator GadW

Gene

gadW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters.3 Publications

Miscellaneous

GadX and GadW are part of a complex system required for acid resistance via the regulation of gadA and gadBC. Many of the described circuits use mutants missing one of the network components. In the wild-type situation, however, many of the scenarios are not easily observed.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 174H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • DNA binding transcription factor activity Source: EcoCyc
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG12242-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GadW
Gene namesi
Name:gadW
Synonyms:yhiW
Ordered Locus Names:b3515, JW3483
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12242 gadW

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001945141 – 242HTH-type transcriptional regulator GadWAdd BLAST242

Proteomic databases

PaxDbiP63201
PRIDEiP63201

Expressioni

Inductioni

Expression can be repressed by GadX, depending on the conditions.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4262522, 8 interactors
IntActiP63201, 6 interactors
STRINGi316385.ECDH10B_3691

Structurei

3D structure databases

ProteinModelPortaliP63201
SMRiP63201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000120708
InParanoidiP63201
KOiK21906
OMAiEIDECIV
PhylomeDBiP63201

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR020449 Tscrpt_reg_HTH_AraC-type
PfamiView protein in Pfam
PF12833 HTH_18, 1 hit
PRINTSiPR00032 HTHARAC
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequencei

Sequence statusi: Complete.

P63201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHVCSVILI RRSFDIYHEQ QKISLHNESI LLLEKNLADD FAFCSPDTRR
60 70 80 90 100
LDIDELTVCH YLQNIRQLPR NLGLHSKDRL LINQSPPMPL VTAIFDSFNE
110 120 130 140 150
SGVNSPILSN MLYLSCLSMF SHKKELIPLL FNSISTVSGK VERLISFDIA
160 170 180 190 200
KRWYLRDIAE RMYTSESLIK KKLQDENTCF SKILLASRMS MARRLLELRQ
210 220 230 240
IPLHTIAEKC GYSSTSYFIN TFRQYYGVTP HQFAQHSPGT FS
Length:242
Mass (Da):28,028
Last modified:September 27, 2004 - v1
Checksum:i40C11B74DA2F8DA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18491.1
U00096 Genomic DNA Translation: AAC76540.1
AP009048 Genomic DNA Translation: BAE77779.1
PIRiS47735
RefSeqiNP_417972.1, NC_000913.3
WP_000149999.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76540; AAC76540; b3515
BAE77779; BAE77779; BAE77779
GeneIDi948029
KEGGiecj:JW3483
eco:b3515
PATRICifig|1411691.4.peg.3203

Similar proteinsi

Entry informationi

Entry nameiGADW_ECOLI
AccessioniPrimary (citable) accession number: P63201
Secondary accession number(s): P37638, Q2M7H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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