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P63173

- RL38_HUMAN

UniProt

P63173 - RL38_HUMAN

Protein

60S ribosomal protein L38

Gene

RPL38

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. RNA binding Source: ProtInc
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. 90S preribosome assembly Source: Ensembl
    2. axial mesoderm development Source: Ensembl
    3. cellular protein metabolic process Source: Reactome
    4. gene expression Source: Reactome
    5. middle ear morphogenesis Source: Ensembl
    6. mRNA metabolic process Source: Reactome
    7. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    8. ossification Source: Ensembl
    9. regulation of translation Source: Ensembl
    10. RNA metabolic process Source: Reactome
    11. sensory perception of sound Source: Ensembl
    12. skeletal system development Source: Ensembl
    13. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    14. translation Source: UniProtKB
    15. translational elongation Source: Reactome
    16. translational initiation Source: Reactome
    17. translational termination Source: Reactome
    18. viral life cycle Source: Reactome
    19. viral process Source: Reactome
    20. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L38
    Gene namesi
    Name:RPL38
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10349. RPL38.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic large ribosomal subunit Source: UniProtKB
    3. eukaryotic 80S initiation complex Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34741.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 706960S ribosomal protein L38PRO_0000215434Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91N6-acetyllysine1 Publication
    Modified residuei67 – 671N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP63173.
    PaxDbiP63173.
    PRIDEiP63173.

    PTM databases

    PhosphoSiteiP63173.

    Expressioni

    Gene expression databases

    ArrayExpressiP63173.
    BgeeiP63173.
    CleanExiHS_RPL38.
    GenevestigatoriP63173.

    Organism-specific databases

    HPAiHPA052543.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NME2P223921EBI-359141,EBI-713693
    RIPK2O433531EBI-359141,EBI-358522
    TFE3P195321EBI-359141,EBI-1048957

    Protein-protein interaction databases

    BioGridi112088. 69 interactions.
    IntActiP63173. 11 interactions.
    MINTiMINT-5002686.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00k1-70[»]
    ProteinModelPortaliP63173.
    SMRiP63173. Positions 2-70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L38e family.Curated

    Phylogenomic databases

    eggNOGiNOG323549.
    HOGENOMiHOG000188979.
    HOVERGENiHBG001013.
    InParanoidiP63173.
    KOiK02923.
    OMAiENAIHEM.
    OrthoDBiEOG79W98H.
    PhylomeDBiP63173.
    TreeFamiTF300215.

    Family and domain databases

    InterProiIPR002675. Ribosomal_L38e.
    [Graphical view]
    PANTHERiPTHR10965. PTHR10965. 1 hit.
    PfamiPF01781. Ribosomal_L38e. 1 hit.
    [Graphical view]
    ProDomiPD010361. Ribosomal_L38e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P63173-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK   50
    EKAEKLKQSL PPGLAVKELK 70
    Length:70
    Mass (Da):8,218
    Last modified:January 23, 2007 - v2
    Checksum:iFDD9A107BC98DBBA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26876 mRNA. Translation: CAA81488.1.
    AK312119 mRNA. Translation: BAG35055.1.
    CH471099 Genomic DNA. Translation: EAW89137.1.
    BC000603 mRNA. Translation: AAH00603.1.
    AB007185 Genomic DNA. Translation: BAA25844.1.
    CCDSiCCDS11696.1.
    PIRiS38385.
    RefSeqiNP_000990.1. NM_000999.3.
    NP_001030335.1. NM_001035258.1.
    UniGeneiHs.380953.

    Genome annotation databases

    EnsembliENST00000311111; ENSP00000309830; ENSG00000172809.
    ENST00000439590; ENSP00000390279; ENSG00000172809.
    ENST00000533498; ENSP00000434243; ENSG00000172809.
    GeneIDi6169.
    KEGGihsa:6169.
    UCSCiuc002jjz.3. human.

    Polymorphism databases

    DMDMi52783779.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26876 mRNA. Translation: CAA81488.1 .
    AK312119 mRNA. Translation: BAG35055.1 .
    CH471099 Genomic DNA. Translation: EAW89137.1 .
    BC000603 mRNA. Translation: AAH00603.1 .
    AB007185 Genomic DNA. Translation: BAA25844.1 .
    CCDSi CCDS11696.1.
    PIRi S38385.
    RefSeqi NP_000990.1. NM_000999.3.
    NP_001030335.1. NM_001035258.1.
    UniGenei Hs.380953.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 k 1-70 [» ]
    ProteinModelPortali P63173.
    SMRi P63173. Positions 2-70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112088. 69 interactions.
    IntActi P63173. 11 interactions.
    MINTi MINT-5002686.

    PTM databases

    PhosphoSitei P63173.

    Polymorphism databases

    DMDMi 52783779.

    Proteomic databases

    MaxQBi P63173.
    PaxDbi P63173.
    PRIDEi P63173.

    Protocols and materials databases

    DNASUi 6169.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311111 ; ENSP00000309830 ; ENSG00000172809 .
    ENST00000439590 ; ENSP00000390279 ; ENSG00000172809 .
    ENST00000533498 ; ENSP00000434243 ; ENSG00000172809 .
    GeneIDi 6169.
    KEGGi hsa:6169.
    UCSCi uc002jjz.3. human.

    Organism-specific databases

    CTDi 6169.
    GeneCardsi GC17P072202.
    HGNCi HGNC:10349. RPL38.
    HPAi HPA052543.
    MIMi 604182. gene.
    neXtProti NX_P63173.
    PharmGKBi PA34741.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323549.
    HOGENOMi HOG000188979.
    HOVERGENi HBG001013.
    InParanoidi P63173.
    KOi K02923.
    OMAi ENAIHEM.
    OrthoDBi EOG79W98H.
    PhylomeDBi P63173.
    TreeFami TF300215.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPL38. human.
    GeneWikii 60S_ribosomal_protein_L38.
    GenomeRNAii 6169.
    NextBioi 23965.
    PROi P63173.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63173.
    Bgeei P63173.
    CleanExi HS_RPL38.
    Genevestigatori P63173.

    Family and domain databases

    InterProi IPR002675. Ribosomal_L38e.
    [Graphical view ]
    PANTHERi PTHR10965. PTHR10965. 1 hit.
    Pfami PF01781. Ribosomal_L38e. 1 hit.
    [Graphical view ]
    ProDomi PD010361. Ribosomal_L38e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary sequence of the human, lysine-rich, ribosomal protein RPL38 and detection of an unusual RPL38 processed pseudogene in the promoter region of the type-1 angiotensin II receptor gene."
      Espinosa L., Martin M., Nicolas A., Fabre M., Navarro E.
      Biochim. Biophys. Acta 1354:58-64(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    5. "A map of 75 human ribosomal protein genes."
      Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
      Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-70.
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-9 AND LYS-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRL38_HUMAN
    AccessioniPrimary (citable) accession number: P63173
    Secondary accession number(s): B2R5A8, P23411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3