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Protein

60S ribosomal protein L38

Gene

RPL38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L38
Alternative name(s):
Large ribosomal subunit protein eL381 Publication
Gene namesi
Name:RPL38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10349. RPL38.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • eukaryotic 80S initiation complex Source: Ensembl
  • focal adhesion Source: UniProtKB

Pathology & Biotechi

Organism-specific databases

DisGeNETi6169.
OpenTargetsiENSG00000172809.
PharmGKBiPA34741.

Polymorphism and mutation databases

DMDMi52783779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002154341 – 7060S ribosomal protein L38Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei9N6-acetyllysine; alternateCombined sources1
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei67N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP63173.
MaxQBiP63173.
PaxDbiP63173.
PeptideAtlasiP63173.
PRIDEiP63173.
TopDownProteomicsiP63173.

PTM databases

iPTMnetiP63173.
PhosphoSitePlusiP63173.
SwissPalmiP63173.

Expressioni

Gene expression databases

BgeeiENSG00000172809.
CleanExiHS_RPL38.
ExpressionAtlasiP63173. baseline and differential.
GenevisibleiP63173. HS.

Organism-specific databases

HPAiHPA052543.

Interactioni

Protein-protein interaction databases

BioGridi112088. 133 interactors.
IntActiP63173. 22 interactors.
MINTiMINT-5002686.
STRINGi9606.ENSP00000309830.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lk1-70[»]
4V6Xelectron microscopy5.00Ck1-70[»]
5AJ0electron microscopy3.50Ak1-70[»]
5LKSelectron microscopy3.60Lk1-70[»]
5T2Celectron microscopy3.60e1-70[»]
ProteinModelPortaliP63173.
SMRiP63173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3499. Eukaryota.
ENOG4112229. LUCA.
GeneTreeiENSGT00390000003718.
HOGENOMiHOG000188979.
HOVERGENiHBG001013.
InParanoidiP63173.
KOiK02923.
OMAiRDIKQFI.
OrthoDBiEOG091G0SPL.
PhylomeDBiP63173.
TreeFamiTF300215.

Family and domain databases

InterProiView protein in InterPro
IPR002675. Ribosomal_L38e.
PANTHERiPTHR10965. PTHR10965. 1 hit.
PfamiView protein in Pfam
PF01781. Ribosomal_L38e. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010361. Ribosomal_L38e. 1 hit.

Sequencei

Sequence statusi: Complete.

P63173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK
60 70
EKAEKLKQSL PPGLAVKELK
Length:70
Mass (Da):8,218
Last modified:January 23, 2007 - v2
Checksum:iFDD9A107BC98DBBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26876 mRNA. Translation: CAA81488.1.
AK312119 mRNA. Translation: BAG35055.1.
CH471099 Genomic DNA. Translation: EAW89137.1.
BC000603 mRNA. Translation: AAH00603.1.
AB007185 Genomic DNA. Translation: BAA25844.1.
CCDSiCCDS11696.1.
PIRiS38385.
RefSeqiNP_000990.1. NM_000999.3.
NP_001030335.1. NM_001035258.1.
UniGeneiHs.380953.

Genome annotation databases

EnsembliENST00000311111; ENSP00000309830; ENSG00000172809.
ENST00000439590; ENSP00000390279; ENSG00000172809.
ENST00000533498; ENSP00000434243; ENSG00000172809.
GeneIDi6169.
KEGGihsa:6169.
UCSCiuc002jjz.4. human.

Similar proteinsi

Entry informationi

Entry nameiRL38_HUMAN
AccessioniPrimary (citable) accession number: P63173
Secondary accession number(s): B2R5A8, P23411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families