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Protein

Dynein light chain Tctex-type 1

Gene

DYNLT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein.1 Publication
Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • motor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Cytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Mitosis, Neurogenesis, Transport, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain Tctex-type 1
Alternative name(s):
Protein CW-1
T-complex testis-specific protein 1 homolog
Gene namesi
Name:DYNLT1
Synonyms:TCTEL1, TCTEX-1, TCTEX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11697. DYNLT1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic dynein complex Source: UniProtKB
  • cytoplasmic microtubule Source: GO_Central
  • Golgi apparatus Source: UniProtKB-SubCell
  • host cell Source: GOC
  • secretory vesicle Source: GO_Central
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Golgi apparatus, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36416.

Polymorphism and mutation databases

BioMutaiDYNLT1.
DMDMi52783582.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Dynein light chain Tctex-type 1PRO_0000195152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Post-translational modificationi

Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIMi:178600]. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP63172.
PaxDbiP63172.
PeptideAtlasiP63172.
PRIDEiP63172.
TopDownProteomicsiP63172.

PTM databases

iPTMnetiP63172.
PhosphoSiteiP63172.

Expressioni

Tissue specificityi

Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000146425.
CleanExiHS_DYNLT1.
ExpressionAtlasiP63172. baseline and differential.
GenevisibleiP63172. HS.

Organism-specific databases

HPAiHPA046559.

Interactioni

Subunit structurei

Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with RHO. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with BMPR2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide-binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma (By similarity). Interacts with human papillomavirus 16 L2 protein; this interaction is essential for virus intracellular transport during entry.By similarityCurated7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSPB9Q9BQS65EBI-1176455,EBI-1176448

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112853. 101 interactions.
DIPiDIP-35251N.
IntActiP63172. 13 interactions.
STRINGi9606.ENSP00000356056.

Structurei

3D structure databases

ProteinModelPortaliP63172.
SMRiP63172. Positions 12-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 11373Interaction with GNB1By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4081. Eukaryota.
ENOG4111NHR. LUCA.
GeneTreeiENSGT00390000013998.
HOGENOMiHOG000255148.
HOVERGENiHBG001217.
InParanoidiP63172.
KOiK10420.
OMAiGNAYQHN.
OrthoDBiEOG091G0Y5N.
PhylomeDBiP63172.
TreeFamiTF313904.

Family and domain databases

InterProiIPR005334. Tctex.
[Graphical view]
PfamiPF03645. Tctex-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDYQAAEET AFVVDEVSNI VKEAIESAIG GNAYQHSKVN QWTTNVVEQT
60 70 80 90 100
LSQLTKLGKP FKYIVTCVIM QKNGAGLHTA SSCFWDSSTD GSCTVRWENK
110
TMYCIVSAFG LSI
Length:113
Mass (Da):12,452
Last modified:September 27, 2004 - v1
Checksum:iA6BAD1D0744D1AA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56255 mRNA. Translation: AAB03318.1.
D50663 mRNA. Translation: BAA09317.1.
EU862237 mRNA. Translation: ACF74976.1.
AK315601 mRNA. Translation: BAG37971.1.
CR456931 mRNA. Translation: CAG33212.1.
AL591025, AL589931 Genomic DNA. Translation: CAH70176.1.
AL589931, AL591025 Genomic DNA. Translation: CAI95303.1.
CH471051 Genomic DNA. Translation: EAW47657.1.
BC029412 mRNA. Translation: AAH29412.1.
BC105588 mRNA. Translation: AAI05589.1.
CCDSiCCDS5257.1.
RefSeqiNP_006510.1. NM_006519.3.
UniGeneiHs.445999.

Genome annotation databases

EnsembliENST00000367089; ENSP00000356056; ENSG00000146425.
GeneIDi6993.
KEGGihsa:6993.
UCSCiuc003qrn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56255 mRNA. Translation: AAB03318.1.
D50663 mRNA. Translation: BAA09317.1.
EU862237 mRNA. Translation: ACF74976.1.
AK315601 mRNA. Translation: BAG37971.1.
CR456931 mRNA. Translation: CAG33212.1.
AL591025, AL589931 Genomic DNA. Translation: CAH70176.1.
AL589931, AL591025 Genomic DNA. Translation: CAI95303.1.
CH471051 Genomic DNA. Translation: EAW47657.1.
BC029412 mRNA. Translation: AAH29412.1.
BC105588 mRNA. Translation: AAI05589.1.
CCDSiCCDS5257.1.
RefSeqiNP_006510.1. NM_006519.3.
UniGeneiHs.445999.

3D structure databases

ProteinModelPortaliP63172.
SMRiP63172. Positions 12-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112853. 101 interactions.
DIPiDIP-35251N.
IntActiP63172. 13 interactions.
STRINGi9606.ENSP00000356056.

PTM databases

iPTMnetiP63172.
PhosphoSiteiP63172.

Polymorphism and mutation databases

BioMutaiDYNLT1.
DMDMi52783582.

Proteomic databases

EPDiP63172.
PaxDbiP63172.
PeptideAtlasiP63172.
PRIDEiP63172.
TopDownProteomicsiP63172.

Protocols and materials databases

DNASUi6993.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367089; ENSP00000356056; ENSG00000146425.
GeneIDi6993.
KEGGihsa:6993.
UCSCiuc003qrn.3. human.

Organism-specific databases

CTDi6993.
GeneCardsiDYNLT1.
HGNCiHGNC:11697. DYNLT1.
HPAiHPA046559.
MIMi601554. gene.
neXtProtiNX_P63172.
PharmGKBiPA36416.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4081. Eukaryota.
ENOG4111NHR. LUCA.
GeneTreeiENSGT00390000013998.
HOGENOMiHOG000255148.
HOVERGENiHBG001217.
InParanoidiP63172.
KOiK10420.
OMAiGNAYQHN.
OrthoDBiEOG091G0Y5N.
PhylomeDBiP63172.
TreeFamiTF313904.

Miscellaneous databases

ChiTaRSiDYNLT1. human.
GeneWikiiDYNLT1.
GenomeRNAii6993.
PROiP63172.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146425.
CleanExiHS_DYNLT1.
ExpressionAtlasiP63172. baseline and differential.
GenevisibleiP63172. HS.

Family and domain databases

InterProiIPR005334. Tctex.
[Graphical view]
PfamiPF03645. Tctex-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYLT1_HUMAN
AccessioniPrimary (citable) accession number: P63172
Secondary accession number(s): Q15763, Q5VTU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.