Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P63172

- DYLT1_HUMAN

UniProt

P63172 - DYLT1_HUMAN

Protein

Dynein light chain Tctex-type 1

Gene

DYNLT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein.1 Publication
    Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation By similarity.By similarity

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. motor activity Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. establishment of mitotic spindle orientation Source: UniProtKB
    2. intracellular transport of viral protein in host cell Source: UniProtKB
    3. microtubule-dependent intracellular transport of viral material towards nucleus Source: UniProtKB-KW
    4. mitotic nuclear division Source: UniProtKB-KW
    5. negative regulation of neurogenesis Source: UniProtKB
    6. neuron projection morphogenesis Source: Ensembl
    7. regulation of cytoskeleton organization Source: Ensembl
    8. regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
    9. regulation of Rac GTPase activity Source: Ensembl
    10. viral entry into host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cell cycle, Cell division, Cytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Mitosis, Neurogenesis, Transport, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynein light chain Tctex-type 1
    Alternative name(s):
    Protein CW-1
    T-complex testis-specific protein 1 homolog
    Gene namesi
    Name:DYNLT1
    Synonyms:TCTEL1, TCTEX-1, TCTEX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:11697. DYNLT1.

    Subcellular locationi

    Golgi apparatus By similarity. Cytoplasm By similarity. Cytoplasmcytoskeletonspindle By similarity
    Note: Localizes to mitotic spindles.By similarity

    GO - Cellular componenti

    1. cytoplasmic dynein complex Source: UniProtKB
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. microtubule Source: UniProtKB-KW
    4. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Dynein, Golgi apparatus, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36416.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 113113Dynein light chain Tctex-type 1PRO_0000195152Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications

    Post-translational modificationi

    Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIMi:178600]. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP63172.
    PaxDbiP63172.
    PRIDEiP63172.

    PTM databases

    PhosphoSiteiP63172.

    Expressioni

    Tissue specificityi

    Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiP63172.
    BgeeiP63172.
    CleanExiHS_DYNLT1.
    GenevestigatoriP63172.

    Interactioni

    Subunit structurei

    Homodimer Probable. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with RHO. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with BMPR2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide-binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma By similarity. Interacts with human papillomavirus 16 L2 protein; this interaction is essential for virus intracellular transport during entry.By similarity7 PublicationsCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSPB9Q9BQS65EBI-1176455,EBI-1176448

    Protein-protein interaction databases

    BioGridi112853. 19 interactions.
    DIPiDIP-35251N.
    IntActiP63172. 12 interactions.
    STRINGi9606.ENSP00000356056.

    Structurei

    3D structure databases

    ProteinModelPortaliP63172.
    SMRiP63172. Positions 12-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni41 – 11373Interaction with GNB1By similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG278055.
    HOGENOMiHOG000255148.
    HOVERGENiHBG001217.
    InParanoidiP63172.
    KOiK10420.
    OMAiSCFWDNS.
    PhylomeDBiP63172.
    TreeFamiTF313904.

    Family and domain databases

    InterProiIPR005334. Tctex.
    [Graphical view]
    PANTHERiPTHR21255. PTHR21255. 1 hit.
    PfamiPF03645. Tctex-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63172-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDYQAAEET AFVVDEVSNI VKEAIESAIG GNAYQHSKVN QWTTNVVEQT    50
    LSQLTKLGKP FKYIVTCVIM QKNGAGLHTA SSCFWDSSTD GSCTVRWENK 100
    TMYCIVSAFG LSI 113
    Length:113
    Mass (Da):12,452
    Last modified:September 27, 2004 - v1
    Checksum:iA6BAD1D0744D1AA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56255 mRNA. Translation: AAB03318.1.
    D50663 mRNA. Translation: BAA09317.1.
    EU862237 mRNA. Translation: ACF74976.1.
    AK315601 mRNA. Translation: BAG37971.1.
    CR456931 mRNA. Translation: CAG33212.1.
    AL591025, AL589931 Genomic DNA. Translation: CAH70176.1.
    AL589931, AL591025 Genomic DNA. Translation: CAI95303.1.
    CH471051 Genomic DNA. Translation: EAW47657.1.
    BC029412 mRNA. Translation: AAH29412.1.
    BC105588 mRNA. Translation: AAI05589.1.
    CCDSiCCDS5257.1.
    RefSeqiNP_006510.1. NM_006519.3.
    UniGeneiHs.445999.

    Genome annotation databases

    EnsembliENST00000367089; ENSP00000356056; ENSG00000146425.
    GeneIDi6993.
    KEGGihsa:6993.
    UCSCiuc003qrn.2. human.

    Polymorphism databases

    DMDMi52783582.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56255 mRNA. Translation: AAB03318.1 .
    D50663 mRNA. Translation: BAA09317.1 .
    EU862237 mRNA. Translation: ACF74976.1 .
    AK315601 mRNA. Translation: BAG37971.1 .
    CR456931 mRNA. Translation: CAG33212.1 .
    AL591025 , AL589931 Genomic DNA. Translation: CAH70176.1 .
    AL589931 , AL591025 Genomic DNA. Translation: CAI95303.1 .
    CH471051 Genomic DNA. Translation: EAW47657.1 .
    BC029412 mRNA. Translation: AAH29412.1 .
    BC105588 mRNA. Translation: AAI05589.1 .
    CCDSi CCDS5257.1.
    RefSeqi NP_006510.1. NM_006519.3.
    UniGenei Hs.445999.

    3D structure databases

    ProteinModelPortali P63172.
    SMRi P63172. Positions 12-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112853. 19 interactions.
    DIPi DIP-35251N.
    IntActi P63172. 12 interactions.
    STRINGi 9606.ENSP00000356056.

    PTM databases

    PhosphoSitei P63172.

    Polymorphism databases

    DMDMi 52783582.

    Proteomic databases

    MaxQBi P63172.
    PaxDbi P63172.
    PRIDEi P63172.

    Protocols and materials databases

    DNASUi 6993.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367089 ; ENSP00000356056 ; ENSG00000146425 .
    GeneIDi 6993.
    KEGGi hsa:6993.
    UCSCi uc003qrn.2. human.

    Organism-specific databases

    CTDi 6993.
    GeneCardsi GC06M159057.
    HGNCi HGNC:11697. DYNLT1.
    MIMi 601554. gene.
    neXtProti NX_P63172.
    PharmGKBi PA36416.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278055.
    HOGENOMi HOG000255148.
    HOVERGENi HBG001217.
    InParanoidi P63172.
    KOi K10420.
    OMAi SCFWDNS.
    PhylomeDBi P63172.
    TreeFami TF313904.

    Miscellaneous databases

    ChiTaRSi DYNLT1. human.
    GeneWikii DYNLT1.
    GenomeRNAii 6993.
    NextBioi 27321.
    PROi P63172.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63172.
    Bgeei P63172.
    CleanExi HS_DYNLT1.
    Genevestigatori P63172.

    Family and domain databases

    InterProi IPR005334. Tctex.
    [Graphical view ]
    PANTHERi PTHR21255. PTHR21255. 1 hit.
    Pfami PF03645. Tctex-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cao X.M., Solecki D.J., Wimmer E.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q."
      Watanabe T.K., Fujiwara T., Shimizu F., Okuno S., Suzuki M., Takahashi E., Nakamura Y., Hirai Y.
      Cytogenet. Cell Genet. 73:153-156(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    3. Indu S., Laloraya M., Kumar P.G.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    9. "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis."
      Mueller S., Cao X., Welker R., Wimmer E.
      J. Biol. Chem. 277:7897-7904(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PVR.
    10. "Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension."
      Machado R.D., Rudarakanchana N., Atkinson C., Flanagan J.A., Harrison R., Morrell N.W., Trembath R.C.
      Hum. Mol. Genet. 12:3277-3286(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BMPR2, PHOSPHORYLATION, TISSUE SPECIFICITY.
    11. "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome."
      Ohka S., Matsuda N., Tohyama K., Oda T., Morikawa M., Kuge S., Nomoto A.
      J. Virol. 78:7186-7198(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PVR.
    12. Cited for: INTERACTION WITH SVIL.
    13. "Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex."
      Lo K.W., Kogoy J.M., Rasoul B.A., King S.M., Pfister K.K.
      J. Biol. Chem. 282:36871-36878(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SELF-ASSOCIATION, INTERACTION WITH DYNC1I1 AND DYNC1I2, SUBUNIT.
    14. "D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein."
      Vlach J., Lipov J., Rumlova M., Veverka V., Lang J., Srb P., Knejzlik Z., Pichova I., Hunter E., Hrabal R., Ruml T.
      Proc. Natl. Acad. Sci. U.S.A. 105:10565-10570(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN INTRACELLULAR TRANSPORT OF D-TYPE RETROVIRUS GAG POLYPROTEIN, INTERACTION WITH MPMV GAG.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Identification of the dynein light chains required for human papillomavirus infection."
      Schneider M.A., Spoden G.A., Florin L., Lambert C.
      Cell. Microbiol. 13:32-46(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HUMAN PAPILLOMAVIRUS 16 L2 PROTEIN.
    18. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDYLT1_HUMAN
    AccessioniPrimary (citable) accession number: P63172
    Secondary accession number(s): Q15763, Q5VTU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3