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P63168

- DYL1_MOUSE

UniProt

P63168 - DYL1_MOUSE

Protein

Dynein light chain 1, cytoplasmic

Gene

Dynll1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures By similarity.By similarity
    Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.By similarity
    Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.By similarity
    Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity By similarity.By similarity

    GO - Molecular functioni

    1. motor activity Source: UniProtKB-KW
    2. nitric-oxide synthase regulator activity Source: Ensembl
    3. protein binding Source: UniProtKB
    4. protein C-terminus binding Source: MGI
    5. protein domain specific binding Source: MGI

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. microtubule-based movement Source: MGI
    3. negative regulation of phosphorylation Source: Ensembl
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW
    6. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Motor protein

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynein light chain 1, cytoplasmic
    Alternative name(s):
    8 kDa dynein light chain
    Short name:
    DLC8
    Dynein light chain LC8-type 1
    Protein inhibitor of neuronal nitric oxide synthase
    Short name:
    PIN
    Short name:
    mPIN
    Gene namesi
    Name:Dynll1
    Synonyms:Dlc1, Dncl1, Dnclc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1861457. Dynll1.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Nucleus By similarity. Mitochondrion By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. COP9 signalosome Source: Ensembl
    3. cytoplasmic dynein complex Source: UniProtKB
    4. cytoskeleton Source: MGI
    5. cytosol Source: MGI
    6. kinetochore Source: UniProtKB
    7. membrane Source: MGI
    8. microtubule Source: UniProtKB-KW
    9. mitochondrion Source: UniProtKB-SubCell
    10. mitotic spindle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Dynein, Microtubule, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8989Dynein light chain 1, cytoplasmicPRO_0000195127Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei36 – 361N6-acetyllysine1 Publication
    Modified residuei88 – 881PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-88 appears to control the dimer-monomer transition.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP63168.
    PaxDbiP63168.
    PRIDEiP63168.

    PTM databases

    PhosphoSiteiP63168.

    Expressioni

    Gene expression databases

    BgeeiP63168.
    CleanExiMM_DLC1.
    MM_DYNLL1.
    GenevestigatoriP63168.

    Interactioni

    Subunit structurei

    Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1 By similarity. Interacts with MYZAP By similarity. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2 By similarity. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944') By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DazlQ6436812EBI-349121,EBI-2024439
    Dync1i1O884852EBI-349121,EBI-492834
    PAX6P263673EBI-349121,EBI-747278From a different organism.

    Protein-protein interaction databases

    BioGridi207994. 72 interactions.
    IntActiP63168. 74 interactions.
    MINTiMINT-1858885.

    Structurei

    3D structure databases

    ProteinModelPortaliP63168.
    SMRiP63168. Positions 5-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni67 – 8923Interaction with ESR1By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the dynein light chain family.Curated

    Phylogenomic databases

    eggNOGiNOG312371.
    GeneTreeiENSGT00390000000378.
    HOVERGENiHBG002133.
    InParanoidiP63168.
    KOiK10418.
    OMAiSSKWTEW.
    OrthoDBiEOG7BZVVQ.
    PhylomeDBiP63168.
    TreeFamiTF300264.

    Family and domain databases

    Gene3Di3.30.740.10. 1 hit.
    InterProiIPR019763. Dynein_light_1/2_CS.
    IPR001372. Dynein_light_chain_typ-1/2.
    [Graphical view]
    PANTHERiPTHR11886. PTHR11886. 1 hit.
    PfamiPF01221. Dynein_light. 1 hit.
    [Graphical view]
    PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63168-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY   50
    NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG 89
    Length:89
    Mass (Da):10,366
    Last modified:September 27, 2004 - v1
    Checksum:iF5E7647D092BEB3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020185 mRNA. Translation: AAD01643.1.
    AK002522 mRNA. Translation: BAB22160.1.
    AK010614 mRNA. Translation: BAB27063.1.
    AK010685 mRNA. Translation: BAB27117.1.
    AK013721 mRNA. Translation: BAB28970.1.
    AK082923 mRNA. Translation: BAC38691.1.
    AK147977 mRNA. Translation: BAE28262.1.
    BC008106 mRNA. Translation: AAH08106.1.
    BC034258 mRNA. Translation: AAH34258.1.
    CCDSiCCDS39227.1.
    RefSeqiNP_062656.3. NM_019682.4.
    UniGeneiMm.256858.

    Genome annotation databases

    EnsembliENSMUST00000009157; ENSMUSP00000009157; ENSMUSG00000009013.
    ENSMUST00000112090; ENSMUSP00000107720; ENSMUSG00000009013.
    GeneIDi56455.
    KEGGimmu:56455.
    UCSCiuc008zdp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020185 mRNA. Translation: AAD01643.1 .
    AK002522 mRNA. Translation: BAB22160.1 .
    AK010614 mRNA. Translation: BAB27063.1 .
    AK010685 mRNA. Translation: BAB27117.1 .
    AK013721 mRNA. Translation: BAB28970.1 .
    AK082923 mRNA. Translation: BAC38691.1 .
    AK147977 mRNA. Translation: BAE28262.1 .
    BC008106 mRNA. Translation: AAH08106.1 .
    BC034258 mRNA. Translation: AAH34258.1 .
    CCDSi CCDS39227.1.
    RefSeqi NP_062656.3. NM_019682.4.
    UniGenei Mm.256858.

    3D structure databases

    ProteinModelPortali P63168.
    SMRi P63168. Positions 5-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207994. 72 interactions.
    IntActi P63168. 74 interactions.
    MINTi MINT-1858885.

    PTM databases

    PhosphoSitei P63168.

    Proteomic databases

    MaxQBi P63168.
    PaxDbi P63168.
    PRIDEi P63168.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009157 ; ENSMUSP00000009157 ; ENSMUSG00000009013 .
    ENSMUST00000112090 ; ENSMUSP00000107720 ; ENSMUSG00000009013 .
    GeneIDi 56455.
    KEGGi mmu:56455.
    UCSCi uc008zdp.2. mouse.

    Organism-specific databases

    CTDi 8655.
    MGIi MGI:1861457. Dynll1.

    Phylogenomic databases

    eggNOGi NOG312371.
    GeneTreei ENSGT00390000000378.
    HOVERGENi HBG002133.
    InParanoidi P63168.
    KOi K10418.
    OMAi SSKWTEW.
    OrthoDBi EOG7BZVVQ.
    PhylomeDBi P63168.
    TreeFami TF300264.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

    Miscellaneous databases

    NextBioi 312686.
    PROi P63168.
    SOURCEi Search...

    Gene expression databases

    Bgeei P63168.
    CleanExi MM_DLC1.
    MM_DYNLL1.
    Genevestigatori P63168.

    Family and domain databases

    Gene3Di 3.30.740.10. 1 hit.
    InterProi IPR019763. Dynein_light_1/2_CS.
    IPR001372. Dynein_light_chain_typ-1/2.
    [Graphical view ]
    PANTHERi PTHR11886. PTHR11886. 1 hit.
    Pfami PF01221. Dynein_light. 1 hit.
    [Graphical view ]
    PROSITEi PS01239. DYNEIN_LIGHT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Intra-renal localization of mPIN (Protein Inhibitor of Nitric oxide synthase)."
      Mount D.B.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus and Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection."
      Thompson S., Pearson A.N., Ashley M.D., Jessick V., Murphy B.M., Gafken P., Henshall D.C., Morris K.T., Simon R.P., Meller R.
      J. Biol. Chem. 286:19331-19339(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BCL2L11.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-36, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiDYL1_MOUSE
    AccessioniPrimary (citable) accession number: P63168
    Secondary accession number(s): Q15701, Q3UGE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3