ID   RSMN_RAT                Reviewed;         240 AA.
AC   P63164; P14648; P17135;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 1.
DT   27-MAR-2024, entry version 120.
DE   RecName: Full=Small nuclear ribonucleoprotein-associated protein N;
DE            Short=snRNP-N;
DE   AltName: Full=Sm protein D;
DE            Short=Sm-D;
DE   AltName: Full=Sm protein N;
DE            Short=Sm-N;
DE            Short=SmN;
GN   Name=Snrpn; Synonyms=Smn;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cerebellum;
RX   PubMed=2522186; DOI=10.1093/nar/17.4.1733;
RA   Schmauss C., McAllister G., Ohosone Y., Hardin J.A., Lerner M.R.;
RT   "A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human
RT   B/B'.";
RL   Nucleic Acids Res. 17:1733-1743(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2526016; DOI=10.1002/j.1460-2075.1989.tb03489.x;
RA   McAllister G., Roby-Shemkovitz A., Amara S.G., Lerner M.R.;
RT   "cDNA sequence of the rat U snRNP-associated protein N: description of a
RT   potential Sm epitope.";
RL   EMBO J. 8:1177-1181(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2532363; DOI=10.1073/pnas.86.24.9778;
RA   Li S., Klein E.S., Russo A.F., Simmons D.M., Rosenfeld M.G.;
RT   "Isolation of cDNA clones encoding small nuclear ribonucleoparticle-
RT   associated proteins with different tissue specificities.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:9778-9782(1989).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=1981744; DOI=10.1159/000111865;
RA   Esposito F., Ammendola R., Duilio A., Costanzo F., Giordano M.,
RA   Zambrano N., D'Agostino P., Russo T., Cimino F.;
RT   "Isolation of cDNA fragments hybridizing to rat brain-specific mRNAs.";
RL   Dev. Neurosci. 12:373-381(1990).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in tissue-specific alternative RNA processing
CC       events.
CC   -!- SUBUNIT: Interacts with TDRD3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Brain specific.
CC   -!- MISCELLANEOUS: Encoded on a bicistronic transcript that code for two
CC       proteins, SNRPN and SNURF.
CC   -!- SIMILARITY: Belongs to the snRNP SmB/SmN family. {ECO:0000305}.
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DR   EMBL; M29293; AAA42157.1; -; mRNA.
DR   EMBL; M29294; AAA42158.1; -; mRNA.
DR   EMBL; BC087671; AAH87671.1; -; mRNA.
DR   PIR; A34503; A34503.
DR   RefSeq; NP_112379.1; NM_031117.2.
DR   AlphaFoldDB; P63164; -.
DR   SMR; P63164; -.
DR   STRING; 10116.ENSRNOP00000070209; -.
DR   iPTMnet; P63164; -.
DR   PhosphoSitePlus; P63164; -.
DR   jPOST; P63164; -.
DR   PaxDb; 10116-ENSRNOP00000021763; -.
DR   Ensembl; ENSRNOT00000088874.2; ENSRNOP00000071994.2; ENSRNOG00000054391.2.
DR   Ensembl; ENSRNOT00055025663; ENSRNOP00055020931; ENSRNOG00055015007.
DR   Ensembl; ENSRNOT00060000114; ENSRNOP00060000067; ENSRNOG00060000077.
DR   Ensembl; ENSRNOT00065005517; ENSRNOP00065004016; ENSRNOG00065003776.
DR   GeneID; 81781; -.
DR   KEGG; rno:81781; -.
DR   UCSC; RGD:621306; rat.
DR   AGR; RGD:621306; -.
DR   CTD; 6638; -.
DR   RGD; 621306; Snrpn.
DR   eggNOG; KOG3168; Eukaryota.
DR   GeneTree; ENSGT00940000158222; -.
DR   HOGENOM; CLU_076902_1_0_1; -.
DR   InParanoid; P63164; -.
DR   OMA; MGTTKMV; -.
DR   OrthoDB; 5475294at2759; -.
DR   PhylomeDB; P63164; -.
DR   TreeFam; TF314232; -.
DR   Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:P63164; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000059764; Expressed in cerebellum and 18 other cell types or tissues.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005685; C:U1 snRNP; IDA:RGD.
DR   GO; GO:0005686; C:U2 snRNP; IDA:RGD.
DR   GO; GO:0071004; C:U2-type prespliceosome; IBA:GO_Central.
DR   GO; GO:0005687; C:U4 snRNP; IBA:GO_Central.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR   GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0009725; P:response to hormone; IEP:RGD.
DR   CDD; cd01717; Sm_B; 1.
DR   Gene3D; 2.30.30.100; -; 1.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR047575; Sm.
DR   InterPro; IPR001163; Sm_dom_euk/arc.
DR   InterPro; IPR017131; snRNP-assoc_SmB/SmN.
DR   PANTHER; PTHR10701:SF0; SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B; 1.
DR   PANTHER; PTHR10701; SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N; 1.
DR   Pfam; PF01423; LSM; 1.
DR   PIRSF; PIRSF037187; snRNP_SmB/SmN; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR   PROSITE; PS52002; SM; 1.
DR   Genevisible; P63164; RN.
PE   2: Evidence at transcript level;
KW   Methylation; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   RNA-binding.
FT   CHAIN           1..240
FT                   /note="Small nuclear ribonucleoprotein-associated protein
FT                   N"
FT                   /id="PRO_0000125525"
FT   DOMAIN          4..86
FT                   /note="Sm"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01346"
FT   REPEAT          175..181
FT   REPEAT          191..196
FT   REPEAT          216..221
FT   REPEAT          222..228
FT   REPEAT          230..236
FT   REGION          163..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..236
FT                   /note="Repeat-rich region"
FT   COMPBIAS        169..240
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         108
FT                   /note="Asymmetric dimethylarginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P14678"
FT   MOD_RES         108
FT                   /note="Dimethylated arginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P14678"
FT   MOD_RES         108
FT                   /note="Omega-N-methylarginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P63163"
FT   MOD_RES         112
FT                   /note="Asymmetric dimethylarginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P14678"
FT   MOD_RES         112
FT                   /note="Dimethylated arginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P14678"
FT   MOD_RES         112
FT                   /note="Omega-N-methylarginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P14678"
FT   MOD_RES         147
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P14678"
FT   MOD_RES         172
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P63162"
FT   CONFLICT        35..52
FT                   /note="DKHMNLILCDCDEFRKIK -> KDLEILVLTTAIVEQQSW (in Ref. 3;
FT                   AAA42158)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   240 AA;  24614 MW;  9A176D043561474C CRC64;
     MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE
     REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI
     PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG
     RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
//