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P63164

- RSMN_RAT

UniProt

P63164 - RSMN_RAT

Protein

Small nuclear ribonucleoprotein-associated protein N

Gene

Snrpn

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (27 Sep 2004)
      Previous versions | rss
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    Functioni

    May be involved in tissue-specific alternative RNA processing events.

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to hormone Source: RGD

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small nuclear ribonucleoprotein-associated protein N
    Short name:
    snRNP-N
    Alternative name(s):
    Sm protein D
    Short name:
    Sm-D
    Sm protein N
    Short name:
    Sm-N
    Short name:
    SmN
    Gene namesi
    Name:Snrpn
    Synonyms:Smn
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi621306. Snrpn.

    Subcellular locationi

    GO - Cellular componenti

    1. U1 snRNP Source: RGD
    2. U2 snRNP Source: RGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Small nuclear ribonucleoprotein-associated protein NPRO_0000125525Add
    BLAST

    Proteomic databases

    PaxDbiP63164.
    PRIDEiP63164.

    PTM databases

    PhosphoSiteiP63164.

    Expressioni

    Tissue specificityi

    Brain specific.

    Gene expression databases

    GenevestigatoriP63164.

    Interactioni

    Subunit structurei

    Interacts with TDRD3.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP63164.
    SMRiP63164. Positions 1-95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati175 – 1817
    Repeati191 – 1966
    Repeati216 – 2216
    Repeati222 – 2287
    Repeati230 – 2367

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni175 – 23662Repeat-rich regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the snRNP SmB/SmN family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1958.
    GeneTreeiENSGT00670000098029.
    HOGENOMiHOG000188899.
    HOVERGENiHBG001019.
    InParanoidiP63164.
    KOiK11100.
    OMAiHHTFICS.
    OrthoDBiEOG7J70HT.
    PhylomeDBiP63164.
    TreeFamiTF314232.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR017131. snRNP-assoc_SmB/SmN.
    [Graphical view]
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037187. snRNP_SmB/SmN. 1 hit.
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P63164-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK    50
    IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA 100
    AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV 150
    AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG 200
    PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP 240
    Length:240
    Mass (Da):24,614
    Last modified:September 27, 2004 - v1
    Checksum:i9A176D043561474C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 5218DKHMN…FRKIK → KDLEILVLTTAIVEQQSW in AAA42158. (PubMed:2532363)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29293 mRNA. Translation: AAA42157.1.
    M29294 mRNA. Translation: AAA42158.1.
    BC087671 mRNA. Translation: AAH87671.1.
    PIRiA34503.
    RefSeqiNP_112379.1. NM_031117.2.
    UniGeneiRn.11169.

    Genome annotation databases

    EnsembliENSRNOT00000021763; ENSRNOP00000021763; ENSRNOG00000015976.
    GeneIDi81781.
    KEGGirno:81781.
    UCSCiRGD:621306. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29293 mRNA. Translation: AAA42157.1 .
    M29294 mRNA. Translation: AAA42158.1 .
    BC087671 mRNA. Translation: AAH87671.1 .
    PIRi A34503.
    RefSeqi NP_112379.1. NM_031117.2.
    UniGenei Rn.11169.

    3D structure databases

    ProteinModelPortali P63164.
    SMRi P63164. Positions 1-95.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P63164.

    Proteomic databases

    PaxDbi P63164.
    PRIDEi P63164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021763 ; ENSRNOP00000021763 ; ENSRNOG00000015976 .
    GeneIDi 81781.
    KEGGi rno:81781.
    UCSCi RGD:621306. rat.

    Organism-specific databases

    CTDi 6638.
    RGDi 621306. Snrpn.

    Phylogenomic databases

    eggNOGi COG1958.
    GeneTreei ENSGT00670000098029.
    HOGENOMi HOG000188899.
    HOVERGENi HBG001019.
    InParanoidi P63164.
    KOi K11100.
    OMAi HHTFICS.
    OrthoDBi EOG7J70HT.
    PhylomeDBi P63164.
    TreeFami TF314232.

    Miscellaneous databases

    NextBioi 615627.
    PROi P63164.

    Gene expression databases

    Genevestigatori P63164.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR017131. snRNP-assoc_SmB/SmN.
    [Graphical view ]
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037187. snRNP_SmB/SmN. 1 hit.
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'."
      Schmauss C., McAllister G., Ohosone Y., Hardin J.A., Lerner M.R.
      Nucleic Acids Res. 17:1733-1743(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cerebellum.
    2. "cDNA sequence of the rat U snRNP-associated protein N: description of a potential Sm epitope."
      McAllister G., Roby-Shemkovitz A., Amara S.G., Lerner M.R.
      EMBO J. 8:1177-1181(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Isolation of cDNA clones encoding small nuclear ribonucleoparticle-associated proteins with different tissue specificities."
      Li S., Klein E.S., Russo A.F., Simmons D.M., Rosenfeld M.G.
      Proc. Natl. Acad. Sci. U.S.A. 86:9778-9782(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Isolation of cDNA fragments hybridizing to rat brain-specific mRNAs."
      Esposito F., Ammendola R., Duilio A., Costanzo F., Giordano M., Zambrano N., D'Agostino P., Russo T., Cimino F.
      Dev. Neurosci. 12:373-381(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRSMN_RAT
    AccessioniPrimary (citable) accession number: P63164
    Secondary accession number(s): P14648, P17135
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3