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P63164 (RSMN_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small nuclear ribonucleoprotein-associated protein N

Short name=snRNP-N
Alternative name(s):
Sm protein D
Short name=Sm-D
Sm protein N
Short name=Sm-N
Short name=SmN
Gene names
Name:Snrpn
Synonyms:Smn
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in tissue-specific alternative RNA processing events.

Subunit structure

Interacts with TDRD3 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Brain specific.

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.

Sequence similarities

Belongs to the snRNP SmB/SmN family.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
   LigandRNA-binding
   Molecular functionRibonucleoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to hormone

Inferred from expression pattern PubMed 8089852. Source: RGD

   Cellular_componentU1 snRNP

Inferred from direct assay PubMed 8371979. Source: RGD

U2 snRNP

Inferred from direct assay PubMed 8371979. Source: RGD

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Small nuclear ribonucleoprotein-associated protein N
PRO_0000125525

Regions

Repeat175 – 1817
Repeat191 – 1966
Repeat216 – 2216
Repeat222 – 2287
Repeat230 – 2367
Region175 – 23662Repeat-rich region

Experimental info

Sequence conflict35 – 5218DKHMN…FRKIK → KDLEILVLTTAIVEQQSW in AAA42158. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P63164 [UniParc].

Last modified September 27, 2004. Version 1.
Checksum: 9A176D043561474C

FASTA24024,614
        10         20         30         40         50         60 
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE 

        70         80         90        100        110        120 
REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI 

       130        140        150        160        170        180 
PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG 

       190        200        210        220        230        240 
RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP 

« Hide

References

« Hide 'large scale' references
[1]"A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'."
Schmauss C., McAllister G., Ohosone Y., Hardin J.A., Lerner M.R.
Nucleic Acids Res. 17:1733-1743(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cerebellum.
[2]"cDNA sequence of the rat U snRNP-associated protein N: description of a potential Sm epitope."
McAllister G., Roby-Shemkovitz A., Amara S.G., Lerner M.R.
EMBO J. 8:1177-1181(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Isolation of cDNA clones encoding small nuclear ribonucleoparticle-associated proteins with different tissue specificities."
Li S., Klein E.S., Russo A.F., Simmons D.M., Rosenfeld M.G.
Proc. Natl. Acad. Sci. U.S.A. 86:9778-9782(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Isolation of cDNA fragments hybridizing to rat brain-specific mRNAs."
Esposito F., Ammendola R., Duilio A., Costanzo F., Giordano M., Zambrano N., D'Agostino P., Russo T., Cimino F.
Dev. Neurosci. 12:373-381(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29293 mRNA. Translation: AAA42157.1.
M29294 mRNA. Translation: AAA42158.1.
BC087671 mRNA. Translation: AAH87671.1.
PIRA34503.
RefSeqNP_112379.1. NM_031117.2.
UniGeneRn.11169.

3D structure databases

ProteinModelPortalP63164.
SMRP63164. Positions 1-95.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP63164.

Proteomic databases

PaxDbP63164.
PRIDEP63164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000021763; ENSRNOP00000021763; ENSRNOG00000015976.
GeneID81781.
KEGGrno:81781.
UCSCRGD:621306. rat.

Organism-specific databases

CTD6638.
RGD621306. Snrpn.

Phylogenomic databases

eggNOGCOG1958.
GeneTreeENSGT00670000098029.
HOGENOMHOG000188899.
HOVERGENHBG001019.
InParanoidP63164.
KOK11100.
OMAHHTFICS.
OrthoDBEOG7J70HT.
PhylomeDBP63164.
TreeFamTF314232.

Gene expression databases

GenevestigatorP63164.

Family and domain databases

InterProIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view]
PfamPF01423. LSM. 1 hit.
[Graphical view]
PIRSFPIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMSSF50182. SSF50182. 1 hit.
ProtoNetSearch...

Other

NextBio615627.
PROP63164.

Entry information

Entry nameRSMN_RAT
AccessionPrimary (citable) accession number: P63164
Secondary accession number(s): P14648, P17135
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families