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Protein

Small nuclear ribonucleoprotein-associated protein N

Gene

Snrpn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in tissue-specific alternative RNA processing events.

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • response to hormone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein-associated protein N
Short name:
snRNP-N
Alternative name(s):
Sm protein D
Short name:
Sm-D
Sm protein N
Short name:
Sm-N
Short name:
SmN
Gene namesi
Name:Snrpn
Synonyms:Smn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unassembled WGS sequence

Organism-specific databases

RGDi621306. Snrpn.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: GO_Central
  • cytoplasm Source: GO_Central
  • U1 snRNP Source: RGD
  • U2 snRNP Source: RGD
  • U2-type prespliceosome Source: GO_Central
  • U4/U6 x U5 tri-snRNP complex Source: GO_Central
  • U4 snRNP Source: GO_Central
  • U5 snRNP Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Small nuclear ribonucleoprotein-associated protein NPRO_0000125525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei108 – 1081Dimethylated arginineBy similarity
Modified residuei112 – 1121Dimethylated arginineBy similarity
Modified residuei147 – 1471Omega-N-methylarginineBy similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP63164.
PRIDEiP63164.

PTM databases

PhosphoSiteiP63164.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

GenevisibleiP63164. RN.

Interactioni

Subunit structurei

Interacts with TDRD3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021763.

Structurei

3D structure databases

ProteinModelPortaliP63164.
SMRiP63164. Positions 2-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati175 – 1817
Repeati191 – 1966
Repeati216 – 2216
Repeati222 – 2287
Repeati230 – 2367

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni175 – 23662Repeat-rich regionAdd
BLAST

Sequence similaritiesi

Belongs to the snRNP SmB/SmN family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1958.
GeneTreeiENSGT00670000098029.
HOGENOMiHOG000188899.
HOVERGENiHBG001019.
InParanoidiP63164.
KOiK11100.
OMAiPMPFGPP.
OrthoDBiEOG7J70HT.
PhylomeDBiP63164.
TreeFamiTF314232.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

P63164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK
60 70 80 90 100
IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA
110 120 130 140 150
AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV
160 170 180 190 200
AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG
210 220 230 240
PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
Length:240
Mass (Da):24,614
Last modified:September 27, 2004 - v1
Checksum:i9A176D043561474C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 5218DKHMN…FRKIK → KDLEILVLTTAIVEQQSW in AAA42158 (PubMed:2532363).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29293 mRNA. Translation: AAA42157.1.
M29294 mRNA. Translation: AAA42158.1.
BC087671 mRNA. Translation: AAH87671.1.
PIRiA34503.
RefSeqiNP_112379.1. NM_031117.2.
UniGeneiRn.11169.

Genome annotation databases

EnsembliENSRNOT00000077253; ENSRNOP00000070209; ENSRNOG00000059764.
GeneIDi81781.
KEGGirno:81781.
UCSCiRGD:621306. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29293 mRNA. Translation: AAA42157.1.
M29294 mRNA. Translation: AAA42158.1.
BC087671 mRNA. Translation: AAH87671.1.
PIRiA34503.
RefSeqiNP_112379.1. NM_031117.2.
UniGeneiRn.11169.

3D structure databases

ProteinModelPortaliP63164.
SMRiP63164. Positions 2-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021763.

PTM databases

PhosphoSiteiP63164.

Proteomic databases

PaxDbiP63164.
PRIDEiP63164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077253; ENSRNOP00000070209; ENSRNOG00000059764.
GeneIDi81781.
KEGGirno:81781.
UCSCiRGD:621306. rat.

Organism-specific databases

CTDi6638.
RGDi621306. Snrpn.

Phylogenomic databases

eggNOGiCOG1958.
GeneTreeiENSGT00670000098029.
HOGENOMiHOG000188899.
HOVERGENiHBG001019.
InParanoidiP63164.
KOiK11100.
OMAiPMPFGPP.
OrthoDBiEOG7J70HT.
PhylomeDBiP63164.
TreeFamiTF314232.

Miscellaneous databases

NextBioi615627.
PROiP63164.

Gene expression databases

GenevisibleiP63164. RN.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'."
    Schmauss C., McAllister G., Ohosone Y., Hardin J.A., Lerner M.R.
    Nucleic Acids Res. 17:1733-1743(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cerebellum.
  2. "cDNA sequence of the rat U snRNP-associated protein N: description of a potential Sm epitope."
    McAllister G., Roby-Shemkovitz A., Amara S.G., Lerner M.R.
    EMBO J. 8:1177-1181(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Isolation of cDNA clones encoding small nuclear ribonucleoparticle-associated proteins with different tissue specificities."
    Li S., Klein E.S., Russo A.F., Simmons D.M., Rosenfeld M.G.
    Proc. Natl. Acad. Sci. U.S.A. 86:9778-9782(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Isolation of cDNA fragments hybridizing to rat brain-specific mRNAs."
    Esposito F., Ammendola R., Duilio A., Costanzo F., Giordano M., Zambrano N., D'Agostino P., Russo T., Cimino F.
    Dev. Neurosci. 12:373-381(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRSMN_RAT
AccessioniPrimary (citable) accession number: P63164
Secondary accession number(s): P14648, P17135
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: July 22, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.