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P63163 (RSMN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small nuclear ribonucleoprotein-associated protein N

Short name=snRNP-N
Alternative name(s):
Sm protein D
Short name=Sm-D
Sm protein N
Short name=Sm-N
Short name=SmN
Tissue-specific-splicing protein
Gene names
Name:Snrpn
Synonyms:Smn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in tissue-specific alternative RNA processing events.

Subunit structure

Interacts with TDRD3 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in brain and embryonic stem (ES) cells. Ref.5

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.

Sequence similarities

Belongs to the snRNP SmB/SmN family.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
   LigandRNA-binding
   Molecular functionRibonucleoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to hormone

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentU1 snRNP

Inferred from electronic annotation. Source: Ensembl

U2 snRNP

Inferred from electronic annotation. Source: Ensembl

nucleus

Traceable author statement Ref.5. Source: MGI

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Small nuclear ribonucleoprotein-associated protein N
PRO_0000125524

Regions

Repeat175 – 1817
Repeat191 – 1966
Repeat216 – 2216
Repeat222 – 2287
Repeat230 – 2367
Region175 – 23662Repeat-rich region

Sequences

Sequence LengthMass (Da)Tools
P63163 [UniParc].

Last modified September 27, 2004. Version 1.
Checksum: 9A176D043561474C

FASTA24024,614
        10         20         30         40         50         60 
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE 

        70         80         90        100        110        120 
REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI 

       130        140        150        160        170        180 
PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG 

       190        200        210        220        230        240 
RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of a mouse embryonal carcinoma cell mRNA encoding the tissue specific RNA splicing protein SmN."
Gerrelli D., Sharp N.G., Latchman D.S.
Nucleic Acids Res. 19:6642-6642(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein."
Gerrelli D., Grimaldi K., Horn D., Mahadeva U., Sharpe N., Latchman D.S.
J. Mol. Cell. Cardiol. 25:321-329(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hippocampus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary tumor.
[5]"An imprinted, mammalian bicistronic transcript encodes two independent proteins."
Gray T.A., Saitoh S., Nicholls R.D.
Proc. Natl. Acad. Sci. U.S.A. 96:5616-5621(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62648 mRNA. Translation: CAA44517.1.
X63730 mRNA. Translation: CAA45273.1.
S62288 mRNA. Translation: AAB27138.1.
AK013607 mRNA. Translation: BAB28927.1.
BC019589 mRNA. Translation: AAH19589.1.
BC024880 mRNA. Translation: AAH24880.1.
CCDSCCDS39974.1.
PIRS20068.
RefSeqNP_001076430.1. NM_001082961.1.
NP_001076431.1. NM_001082962.1.
NP_038698.1. NM_013670.3.
UniGeneMm.274995.

3D structure databases

ProteinModelPortalP63163.
SMRP63163. Positions 1-95.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP63163.

Proteomic databases

MaxQBP63163.
PaxDbP63163.
PRIDEP63163.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000059305; ENSMUSP00000055941; ENSMUSG00000000948.
ENSMUST00000098402; ENSMUSP00000096003; ENSMUSG00000000948.
GeneID20646.
KEGGmmu:20646.
UCSCuc009heq.2. mouse.

Organism-specific databases

CTD6638.
MGIMGI:98347. Snrpn.

Phylogenomic databases

eggNOGCOG1958.
HOGENOMHOG000188899.
HOVERGENHBG001019.
InParanoidP63163.
KOK11100.
OMAHHTFICS.
OrthoDBEOG7J70HT.
PhylomeDBP63163.
TreeFamTF314232.

Gene expression databases

ArrayExpressP63163.
BgeeP63163.
CleanExMM_SNRPN.
GenevestigatorP63163.

Family and domain databases

InterProIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view]
PfamPF01423. LSM. 1 hit.
[Graphical view]
PIRSFPIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMSSF50182. SSF50182. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSNRPN. mouse.
NextBio25861.
PROP63163.
SOURCESearch...

Entry information

Entry nameRSMN_MOUSE
AccessionPrimary (citable) accession number: P63163
Secondary accession number(s): P14648, P17135
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot