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Protein

Small nuclear ribonucleoprotein-associated protein N

Gene

Snrpn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in tissue-specific alternative RNA processing events.

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein-associated protein N
Short name:
snRNP-N
Alternative name(s):
Sm protein D
Short name:
Sm-D
Sm protein N
Short name:
Sm-N
Short name:
SmN
Tissue-specific-splicing protein
Gene namesi
Name:Snrpn
Synonyms:Smn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98347. Snrpn.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255241 – 240Small nuclear ribonucleoprotein-associated protein NAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei108Dimethylated arginine; alternateBy similarity1
Modified residuei108Omega-N-methylarginine; alternateCombined sources1
Modified residuei112Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei112Dimethylated arginine; alternateBy similarity1
Modified residuei112Omega-N-methylarginine; alternateBy similarity1
Modified residuei147Omega-N-methylarginineBy similarity1
Modified residuei172Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP63163.
PeptideAtlasiP63163.
PRIDEiP63163.

PTM databases

iPTMnetiP63163.
PhosphoSitePlusiP63163.

Expressioni

Tissue specificityi

Expressed in brain and embryonic stem (ES) cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000102252.
CleanExiMM_SNRPN.
ExpressionAtlasiP63163. baseline and differential.
GenevisibleiP63163. MM.

Interactioni

Subunit structurei

Interacts with TDRD3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055941.

Structurei

3D structure databases

ProteinModelPortaliP63163.
SMRiP63163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati175 – 1817
Repeati191 – 1966
Repeati216 – 2216
Repeati222 – 2287
Repeati230 – 2367

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni175 – 236Repeat-rich regionAdd BLAST62

Sequence similaritiesi

Belongs to the snRNP SmB/SmN family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3168. Eukaryota.
COG1958. LUCA.
GeneTreeiENSGT00670000098029.
HOGENOMiHOG000188899.
HOVERGENiHBG001019.
InParanoidiP63163.
KOiK11100.
OMAiHHTFICS.
OrthoDBiEOG091G0Y7H.
PhylomeDBiP63163.
TreeFamiTF314232.

Family and domain databases

InterProiView protein in InterPro
IPR001163. LSM_dom_euk/arc.
IPR010920. LSM_dom_sf.
IPR017131. snRNP-assoc_SmB/SmN.
PfamiView protein in Pfam
PF01423. LSM. 1 hit.
PIRSFiPIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTiView protein in SMART
SM00651. Sm. 1 hit.
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

P63163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK
60 70 80 90 100
IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA
110 120 130 140 150
AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV
160 170 180 190 200
AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG
210 220 230 240
PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
Length:240
Mass (Da):24,614
Last modified:September 27, 2004 - v1
Checksum:i9A176D043561474C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62648 mRNA. Translation: CAA44517.1.
X63730 mRNA. Translation: CAA45273.1.
S62288 mRNA. Translation: AAB27138.1.
AK013607 mRNA. Translation: BAB28927.1.
BC019589 mRNA. Translation: AAH19589.1.
BC024880 mRNA. Translation: AAH24880.1.
CCDSiCCDS39974.1.
PIRiS20068.
RefSeqiNP_001076430.1. NM_001082961.1.
NP_001076431.1. NM_001082962.1.
NP_038698.1. NM_013670.3.
UniGeneiMm.274995.

Genome annotation databases

EnsembliENSMUST00000059305; ENSMUSP00000055941; ENSMUSG00000102252.
ENSMUST00000098402; ENSMUSP00000096003; ENSMUSG00000102252.
GeneIDi20646.
KEGGimmu:20646.
UCSCiuc009heq.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiRSMN_MOUSE
AccessioniPrimary (citable) accession number: P63163
Secondary accession number(s): P14648, P17135
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 22, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families