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P63163

- RSMN_MOUSE

UniProt

P63163 - RSMN_MOUSE

Protein

Small nuclear ribonucleoprotein-associated protein N

Gene

Snrpn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (27 Sep 2004)
      Previous versions | rss
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    Functioni

    May be involved in tissue-specific alternative RNA processing events.

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to hormone Source: Ensembl

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small nuclear ribonucleoprotein-associated protein N
    Short name:
    snRNP-N
    Alternative name(s):
    Sm protein D
    Short name:
    Sm-D
    Sm protein N
    Short name:
    Sm-N
    Short name:
    SmN
    Tissue-specific-splicing protein
    Gene namesi
    Name:Snrpn
    Synonyms:Smn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:98347. Snrpn.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. U1 snRNP Source: Ensembl
    3. U2 snRNP Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Small nuclear ribonucleoprotein-associated protein NPRO_0000125524Add
    BLAST

    Proteomic databases

    MaxQBiP63163.
    PaxDbiP63163.
    PRIDEiP63163.

    PTM databases

    PhosphoSiteiP63163.

    Expressioni

    Tissue specificityi

    Expressed in brain and embryonic stem (ES) cells.1 Publication

    Gene expression databases

    ArrayExpressiP63163.
    BgeeiP63163.
    CleanExiMM_SNRPN.
    GenevestigatoriP63163.

    Interactioni

    Subunit structurei

    Interacts with TDRD3.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP63163.
    SMRiP63163. Positions 1-95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati175 – 1817
    Repeati191 – 1966
    Repeati216 – 2216
    Repeati222 – 2287
    Repeati230 – 2367

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni175 – 23662Repeat-rich regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the snRNP SmB/SmN family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1958.
    HOGENOMiHOG000188899.
    HOVERGENiHBG001019.
    InParanoidiP63163.
    KOiK11100.
    OMAiHHTFICS.
    OrthoDBiEOG7J70HT.
    PhylomeDBiP63163.
    TreeFamiTF314232.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR017131. snRNP-assoc_SmB/SmN.
    [Graphical view]
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037187. snRNP_SmB/SmN. 1 hit.
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P63163-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK    50
    IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA 100
    AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV 150
    AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG 200
    PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP 240
    Length:240
    Mass (Da):24,614
    Last modified:September 27, 2004 - v1
    Checksum:i9A176D043561474C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62648 mRNA. Translation: CAA44517.1.
    X63730 mRNA. Translation: CAA45273.1.
    S62288 mRNA. Translation: AAB27138.1.
    AK013607 mRNA. Translation: BAB28927.1.
    BC019589 mRNA. Translation: AAH19589.1.
    BC024880 mRNA. Translation: AAH24880.1.
    CCDSiCCDS39974.1.
    PIRiS20068.
    RefSeqiNP_001076430.1. NM_001082961.1.
    NP_001076431.1. NM_001082962.1.
    NP_038698.1. NM_013670.3.
    UniGeneiMm.274995.

    Genome annotation databases

    EnsembliENSMUST00000059305; ENSMUSP00000055941; ENSMUSG00000000948.
    ENSMUST00000098402; ENSMUSP00000096003; ENSMUSG00000000948.
    GeneIDi20646.
    KEGGimmu:20646.
    UCSCiuc009heq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62648 mRNA. Translation: CAA44517.1 .
    X63730 mRNA. Translation: CAA45273.1 .
    S62288 mRNA. Translation: AAB27138.1 .
    AK013607 mRNA. Translation: BAB28927.1 .
    BC019589 mRNA. Translation: AAH19589.1 .
    BC024880 mRNA. Translation: AAH24880.1 .
    CCDSi CCDS39974.1.
    PIRi S20068.
    RefSeqi NP_001076430.1. NM_001082961.1.
    NP_001076431.1. NM_001082962.1.
    NP_038698.1. NM_013670.3.
    UniGenei Mm.274995.

    3D structure databases

    ProteinModelPortali P63163.
    SMRi P63163. Positions 1-95.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P63163.

    Proteomic databases

    MaxQBi P63163.
    PaxDbi P63163.
    PRIDEi P63163.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059305 ; ENSMUSP00000055941 ; ENSMUSG00000000948 .
    ENSMUST00000098402 ; ENSMUSP00000096003 ; ENSMUSG00000000948 .
    GeneIDi 20646.
    KEGGi mmu:20646.
    UCSCi uc009heq.2. mouse.

    Organism-specific databases

    CTDi 6638.
    MGIi MGI:98347. Snrpn.

    Phylogenomic databases

    eggNOGi COG1958.
    HOGENOMi HOG000188899.
    HOVERGENi HBG001019.
    InParanoidi P63163.
    KOi K11100.
    OMAi HHTFICS.
    OrthoDBi EOG7J70HT.
    PhylomeDBi P63163.
    TreeFami TF314232.

    Miscellaneous databases

    ChiTaRSi SNRPN. mouse.
    NextBioi 25861.
    PROi P63163.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63163.
    Bgeei P63163.
    CleanExi MM_SNRPN.
    Genevestigatori P63163.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR017131. snRNP-assoc_SmB/SmN.
    [Graphical view ]
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037187. snRNP_SmB/SmN. 1 hit.
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a mouse embryonal carcinoma cell mRNA encoding the tissue specific RNA splicing protein SmN."
      Gerrelli D., Sharp N.G., Latchman D.S.
      Nucleic Acids Res. 19:6642-6642(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein."
      Gerrelli D., Grimaldi K., Horn D., Mahadeva U., Sharpe N., Latchman D.S.
      J. Mol. Cell. Cardiol. 25:321-329(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary tumor.
    5. "An imprinted, mammalian bicistronic transcript encodes two independent proteins."
      Gray T.A., Saitoh S., Nicholls R.D.
      Proc. Natl. Acad. Sci. U.S.A. 96:5616-5621(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRSMN_MOUSE
    AccessioniPrimary (citable) accession number: P63163
    Secondary accession number(s): P14648, P17135
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3