Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P63163

- RSMN_MOUSE

UniProt

P63163 - RSMN_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Small nuclear ribonucleoprotein-associated protein N

Gene

Snrpn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in tissue-specific alternative RNA processing events.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. response to hormone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein-associated protein N
Short name:
snRNP-N
Alternative name(s):
Sm protein D
Short name:
Sm-D
Sm protein N
Short name:
Sm-N
Short name:
SmN
Tissue-specific-splicing protein
Gene namesi
Name:Snrpn
Synonyms:Smn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:98347. Snrpn.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. U1 snRNP Source: Ensembl
  3. U2 snRNP Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Small nuclear ribonucleoprotein-associated protein NPRO_0000125524Add
BLAST

Proteomic databases

MaxQBiP63163.
PaxDbiP63163.
PRIDEiP63163.

PTM databases

PhosphoSiteiP63163.

Expressioni

Tissue specificityi

Expressed in brain and embryonic stem (ES) cells.1 Publication

Gene expression databases

BgeeiP63163.
CleanExiMM_SNRPN.
ExpressionAtlasiP63163. baseline and differential.
GenevestigatoriP63163.

Interactioni

Subunit structurei

Interacts with TDRD3.By similarity

Structurei

3D structure databases

ProteinModelPortaliP63163.
SMRiP63163. Positions 1-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati175 – 1817
Repeati191 – 1966
Repeati216 – 2216
Repeati222 – 2287
Repeati230 – 2367

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni175 – 23662Repeat-rich regionAdd
BLAST

Sequence similaritiesi

Belongs to the snRNP SmB/SmN family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1958.
HOGENOMiHOG000188899.
HOVERGENiHBG001019.
InParanoidiP63163.
KOiK11100.
OMAiHHTFICS.
OrthoDBiEOG7J70HT.
PhylomeDBiP63163.
TreeFamiTF314232.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

P63163-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK
60 70 80 90 100
IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA
110 120 130 140 150
AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV
160 170 180 190 200
AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG
210 220 230 240
PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
Length:240
Mass (Da):24,614
Last modified:September 27, 2004 - v1
Checksum:i9A176D043561474C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62648 mRNA. Translation: CAA44517.1.
X63730 mRNA. Translation: CAA45273.1.
S62288 mRNA. Translation: AAB27138.1.
AK013607 mRNA. Translation: BAB28927.1.
BC019589 mRNA. Translation: AAH19589.1.
BC024880 mRNA. Translation: AAH24880.1.
CCDSiCCDS39974.1.
PIRiS20068.
RefSeqiNP_001076430.1. NM_001082961.1.
NP_001076431.1. NM_001082962.1.
NP_038698.1. NM_013670.3.
UniGeneiMm.274995.

Genome annotation databases

EnsembliENSMUST00000059305; ENSMUSP00000055941; ENSMUSG00000000948.
ENSMUST00000098402; ENSMUSP00000096003; ENSMUSG00000000948.
GeneIDi20646.
KEGGimmu:20646.
UCSCiuc009heq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62648 mRNA. Translation: CAA44517.1 .
X63730 mRNA. Translation: CAA45273.1 .
S62288 mRNA. Translation: AAB27138.1 .
AK013607 mRNA. Translation: BAB28927.1 .
BC019589 mRNA. Translation: AAH19589.1 .
BC024880 mRNA. Translation: AAH24880.1 .
CCDSi CCDS39974.1.
PIRi S20068.
RefSeqi NP_001076430.1. NM_001082961.1.
NP_001076431.1. NM_001082962.1.
NP_038698.1. NM_013670.3.
UniGenei Mm.274995.

3D structure databases

ProteinModelPortali P63163.
SMRi P63163. Positions 1-95.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P63163.

Proteomic databases

MaxQBi P63163.
PaxDbi P63163.
PRIDEi P63163.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059305 ; ENSMUSP00000055941 ; ENSMUSG00000000948 .
ENSMUST00000098402 ; ENSMUSP00000096003 ; ENSMUSG00000000948 .
GeneIDi 20646.
KEGGi mmu:20646.
UCSCi uc009heq.2. mouse.

Organism-specific databases

CTDi 6638.
MGIi MGI:98347. Snrpn.

Phylogenomic databases

eggNOGi COG1958.
HOGENOMi HOG000188899.
HOVERGENi HBG001019.
InParanoidi P63163.
KOi K11100.
OMAi HHTFICS.
OrthoDBi EOG7J70HT.
PhylomeDBi P63163.
TreeFami TF314232.

Miscellaneous databases

ChiTaRSi SNRPN. mouse.
NextBioi 25861.
PROi P63163.
SOURCEi Search...

Gene expression databases

Bgeei P63163.
CleanExi MM_SNRPN.
ExpressionAtlasi P63163. baseline and differential.
Genevestigatori P63163.

Family and domain databases

InterProi IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view ]
Pfami PF01423. LSM. 1 hit.
[Graphical view ]
PIRSFi PIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTi SM00651. Sm. 1 hit.
[Graphical view ]
SUPFAMi SSF50182. SSF50182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a mouse embryonal carcinoma cell mRNA encoding the tissue specific RNA splicing protein SmN."
    Gerrelli D., Sharp N.G., Latchman D.S.
    Nucleic Acids Res. 19:6642-6642(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein."
    Gerrelli D., Grimaldi K., Horn D., Mahadeva U., Sharpe N., Latchman D.S.
    J. Mol. Cell. Cardiol. 25:321-329(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary tumor.
  5. "An imprinted, mammalian bicistronic transcript encodes two independent proteins."
    Gray T.A., Saitoh S., Nicholls R.D.
    Proc. Natl. Acad. Sci. U.S.A. 96:5616-5621(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiRSMN_MOUSE
AccessioniPrimary (citable) accession number: P63163
Secondary accession number(s): P14648, P17135
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3