P63162 (RSMN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small nuclear ribonucleoprotein-associated protein N
Short name=snRNP-N

Alternative name(s):
Sm protein D
Short name=Sm-D
Sm protein N
Short name=Sm-N
Short name=SmN
Tissue-specific-splicing protein

Gene names

Name:	SNRPN
Synonyms:	HCERN3, SMN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in tissue-specific alternative RNA processing events.
Subunit structure	Interacts with TDRD3. Ref.11
Subcellular location	Nucleus.
Tissue specificity	Expressed in brain and lymphoblasts. Ref.10
Miscellaneous	Encoded on a bicistronic transcript that encode for two proteins, SNRPN and SNURF. Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.
Sequence similarities	Belongs to the snRNP SmB/SmN family.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	RNA splicing Traceable author statement. Source: UniProtKB
Cellular component	small nuclear ribonucleoprotein complex Traceable author statement. Source: UniProtKB spliceosomal complex Traceable author statement. Source: UniProtKB
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
POP7	O75817	5	EBI-712493,EBI-366574
Smn	Q9VV74	2	EBI-712493,EBI-185315	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	Small nuclear ribonucleoprotein-associated protein N		PRO_0000125523
Regions
	Repeat	175 – 181	7
	Repeat	191 – 196	6
	Repeat	216 – 221	6
	Repeat	222 – 228	7
	Repeat	230 – 236	7
	Region	175 – 236	62	Repeat-rich region
Amino acid modifications
	Modified residue	8	1	N6-acetyllysine Ref.12
Experimental info
	Sequence conflict	43 – 44	2	Missing Ref.8
	Sequence conflict	75	1	E → Q Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P63162 [UniParc]. Last modified September 27, 2004. Version 1. Checksum: 9A176D043561474C	FASTA	240	24,614
	10 20 30 40 50 60 MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE 70 80 90 100 110 120 REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI 130 140 150 160 170 180 PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG 190 200 210 220 230 240 RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'." Schmauss C., McAllister G., Ohosone Y., Hardin J.A., Lerner M.R. Nucleic Acids Res. 17:1733-1743(1989) [PubMed: 2522186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum.
[2]	"Primary structure of a human small nuclear ribonucleoprotein polypeptide as deduced by cDNA analysis." Rokeach L.A., Jannatipour M., Haselby J.A., Hoch S.O. J. Biol. Chem. 264:5024-5030(1989) [PubMed: 2522449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[3]	"Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases." Renz M., Heim C., Braeunling O., Czichos A., Wieland C., Seelig H.P. Clin. Chem. 35:1861-1863(1989) [PubMed: 2528429] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Gene structure, DNA methylation, and imprinted expression of the human SNRPN gene." Glenn C.C., Saitoh S., Jong M.T., Filbrandt M.M., Surti U., Driscoll D.J., Nicholls R.D. Am. J. Hum. Genet. 58:335-346(1996) [PubMed: 8571960] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[5]	Feng Z., Zhang B., Peng X., Yuan J., Qiang B. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Kidney and Uterus.
[8]	"Isolation and structural characterization of the rat gene encoding the brain specific snRNP-associated polypeptide 'N'." Esposito F., Fiore F., Cimino F., Russo T. Biochem. Biophys. Res. Commun. 195:317-326(1993) [PubMed: 8363612] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-140.
[9]	"Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen and specifically reacting with human anti-Sm auto-immune sera." Sharpe N.G., Williams D.G., Howarth D.N., Coles B., Latchman D.S. FEBS Lett. 250:585-590(1989) [PubMed: 2753153] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-218.
[10]	"An imprinted, mammalian bicistronic transcript encodes two independent proteins." Gray T.A., Saitoh S., Nicholls R.D. Proc. Natl. Acad. Sci. U.S.A. 96:5616-5621(1999) [PubMed: 10318933] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"Tudor domains bind symmetrical dimethylated arginines." Cote J., Richard S. J. Biol. Chem. 280:28476-28483(2005) [PubMed: 15955813] [Abstract] Cited for: INTERACTION WITH TDRD3.
[12]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-8, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15892 mRNA. Translation: CAA33901.1. J04615 mRNA. Translation: AAA36617.1. U41303 mRNA. Translation: AAA98969.1. AF400432 mRNA. Translation: AAK92481.1. CR450350 mRNA. Translation: CAG29346.1. BC000611 mRNA. Translation: AAH00611.1. BC003180 mRNA. Translation: AAH03180.1. BC024777 mRNA. Translation: AAH24777.1. BC025178 mRNA. Translation: AAH25178.1.
IPI	IPI00220360.
PIR	A33270.
RefSeq	NP_003088.1. NM_003097.3. NP_073716.1. NM_022805.2. NP_073717.1. NM_022806.2. NP_073718.1. NM_022807.2. NP_073719.1. NM_022808.2.
UniGene	Hs.555970. Hs.564847. Hs.578619. Hs.585703. Hs.592473. Hs.621316. Hs.632166. Hs.728856.
3D structure databases
ProteinModelPortal	P63162.
SMR	P63162. Positions 1-95.
ModBase	Search...
Protein-protein interaction databases
IntAct	P63162. 15 interactions.
MINT	MINT-1365854.
STRING	P63162.
PTM databases
PhosphoSite	P63162.
Polymorphism databases
DMDM	52783794.
Proteomic databases
PRIDE	P63162.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338094; ENSP00000336543; ENSG00000128739. ENST00000390687; ENSP00000375105; ENSG00000128739. ENST00000400097; ENSP00000382969; ENSG00000128739. ENST00000400098; ENSP00000382970; ENSG00000128739. ENST00000400100; ENSP00000382972; ENSG00000128739. ENST00000444203; ENSP00000408767; ENSG00000128739.
GeneID	6638.
KEGG	hsa:6638.
UCSC	uc001ywp.1. human.
Organism-specific databases
CTD	6638.
GeneCards	GC15P025068.
H-InvDB	HIX0012047.
HGNC	HGNC:11164. SNRPN.
HPA	HPA003482.
MIM	182279. gene.
neXtProt	NX_P63162.
Orphanet	739. Prader-Willi syndrome.
PharmGKB	PA36005.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17303.
HOVERGEN	HBG001019.
InParanoid	P63162.
OrthoDB	EOG44MXTD.
PhylomeDB	P63162.
Gene expression databases
ArrayExpress	P63162.
Bgee	P63162.
CleanEx	HS_SNRPN.
Genevestigator	P63162.
GermOnline	ENSG00000128739. Homo sapiens.
Family and domain databases
InterPro	IPR010920. LSM-related_domain. IPR001163. LSM_domain. IPR006649. LSM_domain_euk/arc. IPR017131. snRNP-assoc_SmB/SmN. [Graphical view]
KO	K11100.
Pfam	PF01423. LSM. 1 hit. [Graphical view]
PIRSF	PIRSF037187. snRNP_SmB/SmN. 1 hit.
SMART	SM00651. Sm. 1 hit. [Graphical view]
SUPFAM	SSF50182. Sm_like_riboprot. 1 hit.
ProtoNet	Search...
Other
NextBio	25861.
SOURCE	Search...

Entry information

Entry name

RSMN_HUMAN

Accession

Primary (citable) accession number: P63162
Secondary accession number(s): P14648, P17135, Q0D2Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	September 27, 2004
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.