Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small nuclear ribonucleoprotein-associated protein N

Gene

SNRPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in tissue-specific alternative RNA processing events.

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • response to hormone Source: Ensembl
  • RNA splicing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein-associated protein N
Short name:
snRNP-N
Alternative name(s):
Sm protein D
Short name:
Sm-D
Sm protein N
Short name:
Sm-N
Short name:
SmN
Tissue-specific-splicing protein
Gene namesi
Name:SNRPN
Synonyms:HCERN3, SMN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:11164. SNRPN.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: GO_Central
  • cytoplasm Source: GO_Central
  • small nuclear ribonucleoprotein complex Source: UniProtKB
  • spliceosomal complex Source: UniProtKB
  • U1 snRNP Source: GO_Central
  • U2 snRNP Source: GO_Central
  • U2-type prespliceosome Source: GO_Central
  • U4/U6 x U5 tri-snRNP complex Source: GO_Central
  • U4 snRNP Source: GO_Central
  • U5 snRNP Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

MalaCardsiSNRPN.
Orphaneti72. Angelman syndrome.
177910. Prader-Willi syndrome due to imprinting mutation.
98754. Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15.
177901. Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1.
177904. Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2.
177907. Prader-Willi syndrome due to translocation.
PharmGKBiPA36005.

Polymorphism and mutation databases

BioMutaiSNRPN.
DMDMi52783794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Small nuclear ribonucleoprotein-associated protein NPRO_0000125523Add
BLAST

Proteomic databases

EPDiP63162.
PaxDbiP63162.
PeptideAtlasiP63162.
PRIDEiP63162.

PTM databases

iPTMnetiP63162.
PhosphoSiteiP63162.
SwissPalmiP63162.

Expressioni

Tissue specificityi

Expressed in brain and lymphoblasts.1 Publication

Gene expression databases

BgeeiENSG00000128739.
CleanExiHS_SNRPN.
ExpressionAtlasiP63162. baseline and differential.
GenevisibleiP63162. HS.

Organism-specific databases

HPAiHPA003482.

Interactioni

Subunit structurei

Interacts with TDRD3.1 Publication

Protein-protein interaction databases

BioGridi112522. 111 interactions.
IntActiP63162. 12 interactions.
MINTiMINT-1365854.
STRINGi9606.ENSP00000306223.

Structurei

3D structure databases

ProteinModelPortaliP63162.
SMRiP63162. Positions 2-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati175 – 1817
Repeati191 – 1966
Repeati216 – 2216
Repeati222 – 2287
Repeati230 – 2367

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni175 – 23662Repeat-rich regionAdd
BLAST

Sequence similaritiesi

Belongs to the snRNP SmB/SmN family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3168. Eukaryota.
COG1958. LUCA.
GeneTreeiENSGT00670000098029.
HOGENOMiHOG000188899.
HOVERGENiHBG001019.
InParanoidiP63162.
KOiK11100.
OMAiHHTFICS.
OrthoDBiEOG091G0Y7H.
PhylomeDBiP63162.
TreeFamiTF314232.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P63162-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK
60 70 80 90 100
IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA
110 120 130 140 150
AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV
160 170 180 190 200
AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG
210 220 230 240
PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
Length:240
Mass (Da):24,614
Last modified:September 27, 2004 - v1
Checksum:i9A176D043561474C
GO
Isoform 2 (identifier: P63162-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMDSQ

Note: No experimental confirmation available.
Show »
Length:244
Mass (Da):25,076
Checksum:i3571C3010653A837
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 442Missing (PubMed:8363612).Curated
Sequence conflicti75 – 751E → Q (PubMed:8363612).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MMDSQ in isoform 2. 1 PublicationVSP_056488

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15892 mRNA. Translation: CAA33901.1.
J04615 mRNA. Translation: AAA36617.1.
U41303 mRNA. Translation: AAA98969.1.
AF400432 mRNA. Translation: AAK92481.1.
AK123119 mRNA. Translation: BAG53873.1.
CR450350 mRNA. Translation: CAG29346.1.
AC090602 Genomic DNA. No translation available.
AC090983 Genomic DNA. No translation available.
AC124312 Genomic DNA. No translation available.
BC000611 mRNA. Translation: AAH00611.1.
BC003180 mRNA. Translation: AAH03180.1.
BC024777 mRNA. Translation: AAH24777.1.
BC025178 mRNA. Translation: AAH25178.1.
CCDSiCCDS10017.1. [P63162-1]
PIRiA33270.
RefSeqiNP_003088.1. NM_003097.4. [P63162-1]
NP_005669.2. NM_005678.4.
NP_073716.1. NM_022805.3. [P63162-1]
NP_073717.1. NM_022806.3. [P63162-1]
NP_073718.1. NM_022807.3. [P63162-1]
NP_073719.1. NM_022808.3. [P63162-1]
UniGeneiHs.555970.
Hs.564847.
Hs.578619.
Hs.585703.
Hs.621316.
Hs.632166.
Hs.728856.
Hs.731866.
Hs.733072.
Hs.737651.

Genome annotation databases

EnsembliENST00000346403; ENSP00000306223; ENSG00000128739. [P63162-1]
ENST00000390687; ENSP00000375105; ENSG00000128739. [P63162-1]
ENST00000400097; ENSP00000382969; ENSG00000128739. [P63162-1]
ENST00000400100; ENSP00000382972; ENSG00000128739. [P63162-1]
ENST00000554227; ENSP00000452342; ENSG00000128739. [P63162-2]
ENST00000577565; ENSP00000463458; ENSG00000128739. [P63162-1]
GeneIDi6638.
8926.
KEGGihsa:6638.
UCSCiuc059gty.1. human. [P63162-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15892 mRNA. Translation: CAA33901.1.
J04615 mRNA. Translation: AAA36617.1.
U41303 mRNA. Translation: AAA98969.1.
AF400432 mRNA. Translation: AAK92481.1.
AK123119 mRNA. Translation: BAG53873.1.
CR450350 mRNA. Translation: CAG29346.1.
AC090602 Genomic DNA. No translation available.
AC090983 Genomic DNA. No translation available.
AC124312 Genomic DNA. No translation available.
BC000611 mRNA. Translation: AAH00611.1.
BC003180 mRNA. Translation: AAH03180.1.
BC024777 mRNA. Translation: AAH24777.1.
BC025178 mRNA. Translation: AAH25178.1.
CCDSiCCDS10017.1. [P63162-1]
PIRiA33270.
RefSeqiNP_003088.1. NM_003097.4. [P63162-1]
NP_005669.2. NM_005678.4.
NP_073716.1. NM_022805.3. [P63162-1]
NP_073717.1. NM_022806.3. [P63162-1]
NP_073718.1. NM_022807.3. [P63162-1]
NP_073719.1. NM_022808.3. [P63162-1]
UniGeneiHs.555970.
Hs.564847.
Hs.578619.
Hs.585703.
Hs.621316.
Hs.632166.
Hs.728856.
Hs.731866.
Hs.733072.
Hs.737651.

3D structure databases

ProteinModelPortaliP63162.
SMRiP63162. Positions 2-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112522. 111 interactions.
IntActiP63162. 12 interactions.
MINTiMINT-1365854.
STRINGi9606.ENSP00000306223.

PTM databases

iPTMnetiP63162.
PhosphoSiteiP63162.
SwissPalmiP63162.

Polymorphism and mutation databases

BioMutaiSNRPN.
DMDMi52783794.

Proteomic databases

EPDiP63162.
PaxDbiP63162.
PeptideAtlasiP63162.
PRIDEiP63162.

Protocols and materials databases

DNASUi6638.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346403; ENSP00000306223; ENSG00000128739. [P63162-1]
ENST00000390687; ENSP00000375105; ENSG00000128739. [P63162-1]
ENST00000400097; ENSP00000382969; ENSG00000128739. [P63162-1]
ENST00000400100; ENSP00000382972; ENSG00000128739. [P63162-1]
ENST00000554227; ENSP00000452342; ENSG00000128739. [P63162-2]
ENST00000577565; ENSP00000463458; ENSG00000128739. [P63162-1]
GeneIDi6638.
8926.
KEGGihsa:6638.
UCSCiuc059gty.1. human. [P63162-1]

Organism-specific databases

CTDi6638.
GeneCardsiSNRPN.
GeneReviewsiSNRPN.
HGNCiHGNC:11164. SNRPN.
HPAiHPA003482.
MalaCardsiSNRPN.
MIMi182279. gene.
neXtProtiNX_P63162.
Orphaneti72. Angelman syndrome.
177910. Prader-Willi syndrome due to imprinting mutation.
98754. Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15.
177901. Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1.
177904. Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2.
177907. Prader-Willi syndrome due to translocation.
PharmGKBiPA36005.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3168. Eukaryota.
COG1958. LUCA.
GeneTreeiENSGT00670000098029.
HOGENOMiHOG000188899.
HOVERGENiHBG001019.
InParanoidiP63162.
KOiK11100.
OMAiHHTFICS.
OrthoDBiEOG091G0Y7H.
PhylomeDBiP63162.
TreeFamiTF314232.

Miscellaneous databases

ChiTaRSiSNRPN. human.
GeneWikiiSmall_nuclear_ribonucleoprotein_polypeptide_N.
GenomeRNAii6638.
PROiP63162.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128739.
CleanExiHS_SNRPN.
ExpressionAtlasiP63162. baseline and differential.
GenevisibleiP63162. HS.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSMN_HUMAN
AccessioniPrimary (citable) accession number: P63162
Secondary accession number(s): B3KVR1
, P14648, P17135, Q0D2Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.
Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.