Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P63162

- RSMN_HUMAN

UniProt

P63162 - RSMN_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Small nuclear ribonucleoprotein-associated protein N

Gene

SNRPN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in tissue-specific alternative RNA processing events.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. response to hormone Source: Ensembl
  2. RNA splicing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein-associated protein N
Short name:
snRNP-N
Alternative name(s):
Sm protein D
Short name:
Sm-D
Sm protein N
Short name:
Sm-N
Short name:
SmN
Tissue-specific-splicing protein
Gene namesi
Name:SNRPN
Synonyms:HCERN3, SMN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:11164. SNRPN.

Subcellular locationi

GO - Cellular componenti

  1. small nuclear ribonucleoprotein complex Source: UniProtKB
  2. spliceosomal complex Source: UniProtKB
  3. U1 snRNP Source: Ensembl
  4. U2 snRNP Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti72. Angelman syndrome.
177910. Prader-Willi syndrome due to imprinting mutation.
98754. Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15.
177901. Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1.
177904. Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2.
177907. Prader-Willi syndrome due to translocation.
PharmGKBiPA36005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Small nuclear ribonucleoprotein-associated protein NPRO_0000125523Add
BLAST

Proteomic databases

MaxQBiP63162.
PaxDbiP63162.
PRIDEiP63162.

PTM databases

PhosphoSiteiP63162.

Expressioni

Tissue specificityi

Expressed in brain and lymphoblasts.1 Publication

Gene expression databases

BgeeiP63162.
CleanExiHS_SNRPN.
ExpressionAtlasiP63162. baseline.
GenevestigatoriP63162.

Organism-specific databases

HPAiHPA003482.

Interactioni

Subunit structurei

Interacts with TDRD3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
POP7O758175EBI-712493,EBI-366574
SmnQ9VV742EBI-712493,EBI-185315From a different organism.

Protein-protein interaction databases

BioGridi112522. 24 interactions.
IntActiP63162. 15 interactions.
MINTiMINT-1365854.
STRINGi9606.ENSP00000336543.

Structurei

3D structure databases

ProteinModelPortaliP63162.
SMRiP63162. Positions 1-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati175 – 1817
Repeati191 – 1966
Repeati216 – 2216
Repeati222 – 2287
Repeati230 – 2367

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni175 – 23662Repeat-rich regionAdd
BLAST

Sequence similaritiesi

Belongs to the snRNP SmB/SmN family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1958.
GeneTreeiENSGT00670000098029.
HOGENOMiHOG000188899.
HOVERGENiHBG001019.
InParanoidiP63162.
KOiK11100.
OrthoDBiEOG7J70HT.
PhylomeDBiP63162.
TreeFamiTF314232.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P63162-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK
60 70 80 90 100
IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA
110 120 130 140 150
AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV
160 170 180 190 200
AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG
210 220 230 240
PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
Length:240
Mass (Da):24,614
Last modified:September 27, 2004 - v1
Checksum:i9A176D043561474C
GO
Isoform 2 (identifier: P63162-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMDSQ

Note: No experimental confirmation available.

Show »
Length:244
Mass (Da):25,076
Checksum:i3571C3010653A837
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 442Missing(PubMed:8363612)Curated
Sequence conflicti75 – 751E → Q(PubMed:8363612)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MMDSQ in isoform 2. 1 PublicationVSP_056488

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15892 mRNA. Translation: CAA33901.1.
J04615 mRNA. Translation: AAA36617.1.
U41303 mRNA. Translation: AAA98969.1.
AF400432 mRNA. Translation: AAK92481.1.
AK123119 mRNA. Translation: BAG53873.1.
CR450350 mRNA. Translation: CAG29346.1.
AC090602 Genomic DNA. No translation available.
AC090983 Genomic DNA. No translation available.
AC124312 Genomic DNA. No translation available.
BC000611 mRNA. Translation: AAH00611.1.
BC003180 mRNA. Translation: AAH03180.1.
BC024777 mRNA. Translation: AAH24777.1.
BC025178 mRNA. Translation: AAH25178.1.
CCDSiCCDS10017.1. [P63162-1]
PIRiA33270.
RefSeqiNP_003088.1. NM_003097.3. [P63162-1]
NP_073716.1. NM_022805.2. [P63162-1]
NP_073717.1. NM_022806.2. [P63162-1]
NP_073718.1. NM_022807.2. [P63162-1]
NP_073719.1. NM_022808.2. [P63162-1]
UniGeneiHs.555970.
Hs.564847.
Hs.578619.
Hs.585703.
Hs.621316.
Hs.632166.
Hs.728856.
Hs.731866.
Hs.733072.
Hs.737651.

Genome annotation databases

EnsembliENST00000346403; ENSP00000306223; ENSG00000128739. [P63162-1]
ENST00000390687; ENSP00000375105; ENSG00000128739. [P63162-1]
ENST00000400097; ENSP00000382969; ENSG00000128739. [P63162-1]
ENST00000400098; ENSP00000382970; ENSG00000128739. [P63162-1]
ENST00000400100; ENSP00000382972; ENSG00000128739. [P63162-1]
ENST00000554227; ENSP00000452342; ENSG00000128739. [P63162-2]
ENST00000577565; ENSP00000463458; ENSG00000128739. [P63162-1]
GeneIDi6638.
KEGGihsa:6638.
UCSCiuc001ywp.1. human. [P63162-1]

Polymorphism databases

DMDMi52783794.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15892 mRNA. Translation: CAA33901.1 .
J04615 mRNA. Translation: AAA36617.1 .
U41303 mRNA. Translation: AAA98969.1 .
AF400432 mRNA. Translation: AAK92481.1 .
AK123119 mRNA. Translation: BAG53873.1 .
CR450350 mRNA. Translation: CAG29346.1 .
AC090602 Genomic DNA. No translation available.
AC090983 Genomic DNA. No translation available.
AC124312 Genomic DNA. No translation available.
BC000611 mRNA. Translation: AAH00611.1 .
BC003180 mRNA. Translation: AAH03180.1 .
BC024777 mRNA. Translation: AAH24777.1 .
BC025178 mRNA. Translation: AAH25178.1 .
CCDSi CCDS10017.1. [P63162-1 ]
PIRi A33270.
RefSeqi NP_003088.1. NM_003097.3. [P63162-1 ]
NP_073716.1. NM_022805.2. [P63162-1 ]
NP_073717.1. NM_022806.2. [P63162-1 ]
NP_073718.1. NM_022807.2. [P63162-1 ]
NP_073719.1. NM_022808.2. [P63162-1 ]
UniGenei Hs.555970.
Hs.564847.
Hs.578619.
Hs.585703.
Hs.621316.
Hs.632166.
Hs.728856.
Hs.731866.
Hs.733072.
Hs.737651.

3D structure databases

ProteinModelPortali P63162.
SMRi P63162. Positions 1-95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112522. 24 interactions.
IntActi P63162. 15 interactions.
MINTi MINT-1365854.
STRINGi 9606.ENSP00000336543.

PTM databases

PhosphoSitei P63162.

Polymorphism databases

DMDMi 52783794.

Proteomic databases

MaxQBi P63162.
PaxDbi P63162.
PRIDEi P63162.

Protocols and materials databases

DNASUi 6638.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000346403 ; ENSP00000306223 ; ENSG00000128739 . [P63162-1 ]
ENST00000390687 ; ENSP00000375105 ; ENSG00000128739 . [P63162-1 ]
ENST00000400097 ; ENSP00000382969 ; ENSG00000128739 . [P63162-1 ]
ENST00000400098 ; ENSP00000382970 ; ENSG00000128739 . [P63162-1 ]
ENST00000400100 ; ENSP00000382972 ; ENSG00000128739 . [P63162-1 ]
ENST00000554227 ; ENSP00000452342 ; ENSG00000128739 . [P63162-2 ]
ENST00000577565 ; ENSP00000463458 ; ENSG00000128739 . [P63162-1 ]
GeneIDi 6638.
KEGGi hsa:6638.
UCSCi uc001ywp.1. human. [P63162-1 ]

Organism-specific databases

CTDi 6638.
GeneCardsi GC15P025068.
GeneReviewsi SNRPN.
HGNCi HGNC:11164. SNRPN.
HPAi HPA003482.
MIMi 182279. gene.
neXtProti NX_P63162.
Orphaneti 72. Angelman syndrome.
177910. Prader-Willi syndrome due to imprinting mutation.
98754. Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15.
177901. Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1.
177904. Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2.
177907. Prader-Willi syndrome due to translocation.
PharmGKBi PA36005.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1958.
GeneTreei ENSGT00670000098029.
HOGENOMi HOG000188899.
HOVERGENi HBG001019.
InParanoidi P63162.
KOi K11100.
OrthoDBi EOG7J70HT.
PhylomeDBi P63162.
TreeFami TF314232.

Miscellaneous databases

ChiTaRSi SNRPN. human.
GeneWikii Small_nuclear_ribonucleoprotein_polypeptide_N.
GenomeRNAii 6638.
NextBioi 25861.
PROi P63162.
SOURCEi Search...

Gene expression databases

Bgeei P63162.
CleanExi HS_SNRPN.
ExpressionAtlasi P63162. baseline.
Genevestigatori P63162.

Family and domain databases

InterProi IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view ]
Pfami PF01423. LSM. 1 hit.
[Graphical view ]
PIRSFi PIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTi SM00651. Sm. 1 hit.
[Graphical view ]
SUPFAMi SSF50182. SSF50182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'."
    Schmauss C., McAllister G., Ohosone Y., Hardin J.A., Lerner M.R.
    Nucleic Acids Res. 17:1733-1743(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  2. "Primary structure of a human small nuclear ribonucleoprotein polypeptide as deduced by cDNA analysis."
    Rokeach L.A., Jannatipour M., Haselby J.A., Hoch S.O.
    J. Biol. Chem. 264:5024-5030(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
  3. "Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases."
    Renz M., Heim C., Braeunling O., Czichos A., Wieland C., Seelig H.P.
    Clin. Chem. 35:1861-1863(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Gene structure, DNA methylation, and imprinted expression of the human SNRPN gene."
    Glenn C.C., Saitoh S., Jong M.T., Filbrandt M.M., Surti U., Driscoll D.J., Nicholls R.D.
    Am. J. Hum. Genet. 58:335-346(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Feng Z., Zhang B., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Kidney and Uterus.
  10. "Isolation and structural characterization of the rat gene encoding the brain specific snRNP-associated polypeptide 'N'."
    Esposito F., Fiore F., Cimino F., Russo T.
    Biochem. Biophys. Res. Commun. 195:317-326(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-140 (ISOFORM 1).
  11. "Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen and specifically reacting with human anti-Sm auto-immune sera."
    Sharpe N.G., Williams D.G., Howarth D.N., Coles B., Latchman D.S.
    FEBS Lett. 250:585-590(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-218 (ISOFORM 1).
  12. "An imprinted, mammalian bicistronic transcript encodes two independent proteins."
    Gray T.A., Saitoh S., Nicholls R.D.
    Proc. Natl. Acad. Sci. U.S.A. 96:5616-5621(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  13. "Tudor domains bind symmetrical dimethylated arginines."
    Cote J., Richard S.
    J. Biol. Chem. 280:28476-28483(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TDRD3.

Entry informationi

Entry nameiRSMN_HUMAN
AccessioniPrimary (citable) accession number: P63162
Secondary accession number(s): B3KVR1
, P14648, P17135, Q0D2Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 26, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.
Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3