Small nuclear ribonucleoprotein-associated protein N

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Reviewed, UniProtKB/Swiss-Prot P63162 (RSMN_HUMAN)

Last modified January 19, 2010. Version 70. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Small nuclear ribonucleoprotein-associated protein N
      Short name=snRNP-N
      Short name=Sm protein N
      Short name=Sm-N
      Short name=SmN
      Short name=Sm-D
Alternative name(s):
    Tissue-specific-splicing protein

Gene names

Name:	SNRPN
Synonyms:	HCERN3, SMN

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May be involved in tissue-specific alternative RNA processing events.
Subunit structure	Interacts with TDRD3. Ref.11
Subcellular location	Nucleus.
Tissue specificity	Expressed in brain and lymphoblasts. Ref.10
Involvement in disease	Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.
Miscellaneous	Encoded on a bicistronic transcript that encode for two proteins, SNRPN and SNURF.
Sequence similarities	Belongs to the snRNP SmB/SmN family.

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Ontologies

Keywords
Cellular component	Nucleus
Disease	Systemic lupus erythematosus
Domain	Repeat
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	RNA splicing Traceable author statement. Source: UniProtKB
Cellular component	small nuclear ribonucleoprotein complex Traceable author statement. Source: UniProtKB spliceosomal complex Traceable author statement. Source: UniProtKB
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW identical protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-712493,EBI-712493
GEMIN4	P57678	1	EBI-712493,EBI-356700
IBTK	Q9P2D0	1	EBI-712493,EBI-1052017
LSM4	Q9Y4Z0	1	EBI-712493,EBI-372521
POP7	O75817	2	EBI-712493,EBI-366574
PRPF3	O43395	1	EBI-712493,EBI-744322
Rpp20	Q2MGL3	1	EBI-712493,EBI-1151669	From a different organism.
SF3B1	O75533	1	EBI-712493,EBI-876542
SF3B3	Q15393	1	EBI-712493,EBI-346977
Smn	Q9VV74	2	EBI-712493,EBI-185315	From a different organism.
SNCG	O76070	1	EBI-712493,EBI-1053810
SNRPB2	P08579	1	EBI-712493,EBI-1053651
STK16	O75716	1	EBI-712493,EBI-749295
TCEB1	Q15369	1	EBI-712493,EBI-301231

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 240

240

Small nuclear ribonucleoprotein-associated protein N

PRO_0000125523

Regions

Repeat

Repeat

Repeat

Repeat

Repeat

Region

Repeat-rich region

Amino acid modifications

Modified residue

N6-acetyllysine Ref.12

Experimental info

Sequence conflict

43 – 44

Missing Ref.8

Sequence conflict

E → Q Ref.8

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Sequences

Sequence

Length

Mass (Da)

Tools

P63162-1 [UniParc].

Last modified September 27, 2004. Version 1.
Checksum: 9A176D043561474C
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FASTA

240

24,614

        10         20         30         40         50         60 
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE 

        70         80         90        100        110        120 
REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI 

       130        140        150        160        170        180 
PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG 

       190        200        210        220        230        240 
RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'." Schmauss C., McAllister G., Ohosone Y., Hardin J.A., Lerner M.R. Nucleic Acids Res. 17:1733-1743(1989) [PubMed: 2522186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum.
[2]	"Primary structure of a human small nuclear ribonucleoprotein polypeptide as deduced by cDNA analysis." Rokeach L.A., Jannatipour M., Haselby J.A., Hoch S.O. J. Biol. Chem. 264:5024-5030(1989) [PubMed: 2522449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[3]	"Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases." Renz M., Heim C., Braeunling O., Czichos A., Wieland C., Seelig H.P. Clin. Chem. 35:1861-1863(1989) [PubMed: 2528429] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Gene structure, DNA methylation, and imprinted expression of the human SNRPN gene." Glenn C.C., Saitoh S., Jong M.T., Filbrandt M.M., Surti U., Driscoll D.J., Nicholls R.D. Am. J. Hum. Genet. 58:335-346(1996) [PubMed: 8571960] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[5]	Feng Z., Zhang B., Peng X., Yuan J., Qiang B. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Kidney and Uterus.
[8]	"Isolation and structural characterization of the rat gene encoding the brain specific snRNP-associated polypeptide 'N'." Esposito F., Fiore F., Cimino F., Russo T. Biochem. Biophys. Res. Commun. 195:317-326(1993) [PubMed: 8363612] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-140.
[9]	"Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen and specifically reacting with human anti-Sm auto-immune sera." Sharpe N.G., Williams D.G., Howarth D.N., Coles B., Latchman D.S. FEBS Lett. 250:585-590(1989) [PubMed: 2753153] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-218.
[10]	"An imprinted, mammalian bicistronic transcript encodes two independent proteins." Gray T.A., Saitoh S., Nicholls R.D. Proc. Natl. Acad. Sci. U.S.A. 96:5616-5621(1999) [PubMed: 10318933] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"Tudor domains bind symmetrical dimethylated arginines." Cote J., Richard S. J. Biol. Chem. 280:28476-28483(2005) [PubMed: 15955813] [Abstract] Cited for: INTERACTION WITH TDRD3.
[12]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-8, MASS SPECTROMETRY.
+	Additional computationally mapped references.

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Web resources

GeneReviews

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Cross-references

Sequence databases
EMBL GenBank DDBJ	X15892 mRNA. Translation: CAA33901.1. J04615 mRNA. Translation: AAA36617.1. U41303 mRNA. Translation: AAA98969.1. AF400432 mRNA. Translation: AAK92481.1. CR450350 mRNA. Translation: CAG29346.1. BC000611 mRNA. Translation: AAH00611.1. BC003180 mRNA. Translation: AAH03180.1. BC024777 mRNA. Translation: AAH24777.1. BC025178 mRNA. Translation: AAH25178.1.
IPI	IPI00220360.
PIR	A33270.
RefSeq	NP_003088.1. NP_073716.1. NP_073717.1. NP_073718.1. NP_073719.1.
UniGene	Hs.555970 Hs.564847 Hs.578619 Hs.585703 Hs.592473 Hs.621316 Hs.632166
3D structure databases
SMR	P63162. Positions 2-91.
ModBase	Search...
Protein-protein interaction databases
IntAct	P63162. 22 interactions.
STRING	P63162.
PTM databases
PhosphoSite	P63162.
Proteomic databases
PRIDE	P63162.
Genome annotation databases
Ensembl	ENST00000338094; ENSP00000336543; ENSG00000128739; Homo sapiens. [Genome view] ENST00000390687; ENSP00000375105; ENSG00000128739; Homo sapiens. [Genome view] ENST00000400097; ENSP00000382969; ENSG00000128739; Homo sapiens. [Genome view] ENST00000400098; ENSP00000382970; ENSG00000128739; Homo sapiens. [Genome view] ENST00000400100; ENSP00000382972; ENSG00000128739; Homo sapiens. [Genome view] ENST00000444203; ENSP00000408767; ENSG00000128739; Homo sapiens. [Genome view]
GeneID	6638.
KEGG	hsa:6638.
UCSC	uc001ywp.1. human.
Organism-specific databases
CTD	6638.
GeneCards	GC15P022620.
H-InvDB	HIX0012047.
HGNC	HGNC:11164. SNRPN.
HPA	HPA003482.
MIM	182279. gene.
Orphanet	739. Prader-Willi syndrome.
PharmGKB	PA36005.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17303.
HOVERGEN	P63162.
InParanoid	P63162.
PhylomeDB	P63162.
Gene expression databases
ArrayExpress	P63162.
Bgee	P63162.
CleanEx	HS_SNRPN.
Genevestigator	P63162.
GermOnline	ENSG00000128739. Homo sapiens.
Family and domain databases
InterPro	IPR001163. LSM_domain. IPR006649. LSM_domain_euk/arc. IPR010920. LSM_related_domain. IPR017131. snRNP-assoc_SmB/SmN. [Graphical view]
Pfam	PF01423. LSM. 1 hit. [Graphical view]
PIRSF	PIRSF037187. snRNP_SmB/SmN. 1 hit.
SMART	SM00651. Sm. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	25861.
SOURCE	Search...

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Entry information

Entry name

RSMN_HUMAN

Accession

Primary (citable) accession number: P63162
Secondary accession number(s): P14648, P17135, Q0D2Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	September 27, 2004
Last modified:	January 19, 2010
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents