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P63162 (RSMN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small nuclear ribonucleoprotein-associated protein N

Short name=snRNP-N
Alternative name(s):
Sm protein D
Short name=Sm-D
Sm protein N
Short name=Sm-N
Short name=SmN
Tissue-specific-splicing protein
Gene names
Name:SNRPN
Synonyms:HCERN3, SMN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in tissue-specific alternative RNA processing events.

Subunit structure

Interacts with TDRD3. Ref.11

Subcellular location

Nucleus.

Tissue specificity

Expressed in brain and lymphoblasts. Ref.10

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.

Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.

Sequence similarities

Belongs to the snRNP SmB/SmN family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

POP7O758175EBI-712493,EBI-366574
SmnQ9VV742EBI-712493,EBI-185315From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Small nuclear ribonucleoprotein-associated protein N
PRO_0000125523

Regions

Repeat175 – 1817
Repeat191 – 1966
Repeat216 – 2216
Repeat222 – 2287
Repeat230 – 2367
Region175 – 23662Repeat-rich region

Experimental info

Sequence conflict43 – 442Missing Ref.8
Sequence conflict751E → Q Ref.8

Sequences

Sequence LengthMass (Da)Tools
P63162 [UniParc].

Last modified September 27, 2004. Version 1.
Checksum: 9A176D043561474C

FASTA24024,614
        10         20         30         40         50         60 
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE 

        70         80         90        100        110        120 
REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI 

       130        140        150        160        170        180 
PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG 

       190        200        210        220        230        240 
RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP 

« Hide

References

« Hide 'large scale' references
[1]"A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'."
Schmauss C., McAllister G., Ohosone Y., Hardin J.A., Lerner M.R.
Nucleic Acids Res. 17:1733-1743(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cerebellum.
[2]"Primary structure of a human small nuclear ribonucleoprotein polypeptide as deduced by cDNA analysis."
Rokeach L.A., Jannatipour M., Haselby J.A., Hoch S.O.
J. Biol. Chem. 264:5024-5030(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[3]"Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases."
Renz M., Heim C., Braeunling O., Czichos A., Wieland C., Seelig H.P.
Clin. Chem. 35:1861-1863(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Gene structure, DNA methylation, and imprinted expression of the human SNRPN gene."
Glenn C.C., Saitoh S., Jong M.T., Filbrandt M.M., Surti U., Driscoll D.J., Nicholls R.D.
Am. J. Hum. Genet. 58:335-346(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[5]Feng Z., Zhang B., Peng X., Yuan J., Qiang B.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Kidney and Uterus.
[8]"Isolation and structural characterization of the rat gene encoding the brain specific snRNP-associated polypeptide 'N'."
Esposito F., Fiore F., Cimino F., Russo T.
Biochem. Biophys. Res. Commun. 195:317-326(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-140.
[9]"Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen and specifically reacting with human anti-Sm auto-immune sera."
Sharpe N.G., Williams D.G., Howarth D.N., Coles B., Latchman D.S.
FEBS Lett. 250:585-590(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-218.
[10]"An imprinted, mammalian bicistronic transcript encodes two independent proteins."
Gray T.A., Saitoh S., Nicholls R.D.
Proc. Natl. Acad. Sci. U.S.A. 96:5616-5621(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[11]"Tudor domains bind symmetrical dimethylated arginines."
Cote J., Richard S.
J. Biol. Chem. 280:28476-28483(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TDRD3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15892 mRNA. Translation: CAA33901.1.
J04615 mRNA. Translation: AAA36617.1.
U41303 mRNA. Translation: AAA98969.1.
AF400432 mRNA. Translation: AAK92481.1.
CR450350 mRNA. Translation: CAG29346.1.
BC000611 mRNA. Translation: AAH00611.1.
BC003180 mRNA. Translation: AAH03180.1.
BC024777 mRNA. Translation: AAH24777.1.
BC025178 mRNA. Translation: AAH25178.1.
CCDSCCDS10017.1.
PIRA33270.
RefSeqNP_003088.1. NM_003097.3.
NP_073716.1. NM_022805.2.
NP_073717.1. NM_022806.2.
NP_073718.1. NM_022807.2.
NP_073719.1. NM_022808.2.
UniGeneHs.555970.
Hs.564847.
Hs.578619.
Hs.585703.
Hs.621316.
Hs.632166.
Hs.728856.
Hs.731866.
Hs.733072.
Hs.737651.

3D structure databases

ProteinModelPortalP63162.
SMRP63162. Positions 1-95.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112522. 21 interactions.
IntActP63162. 15 interactions.
MINTMINT-1365854.
STRING9606.ENSP00000336543.

PTM databases

PhosphoSiteP63162.

Polymorphism databases

DMDM52783794.

Proteomic databases

MaxQBP63162.
PaxDbP63162.
PRIDEP63162.

Protocols and materials databases

DNASU6638.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000346403; ENSP00000306223; ENSG00000128739.
ENST00000390687; ENSP00000375105; ENSG00000128739.
ENST00000400097; ENSP00000382969; ENSG00000128739.
ENST00000400098; ENSP00000382970; ENSG00000128739.
ENST00000400100; ENSP00000382972; ENSG00000128739.
ENST00000577565; ENSP00000463458; ENSG00000128739.
GeneID6638.
KEGGhsa:6638.
UCSCuc001ywp.1. human.

Organism-specific databases

CTD6638.
GeneCardsGC15P025068.
GeneReviewsSNRPN.
HGNCHGNC:11164. SNRPN.
HPAHPA003482.
MIM182279. gene.
neXtProtNX_P63162.
Orphanet72. Angelman syndrome.
177910. Prader-Willi syndrome due to imprinting mutation.
98754. Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15.
177901. Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1.
177904. Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2.
177907. Prader-Willi syndrome due to translocation.
PharmGKBPA36005.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1958.
HOGENOMHOG000188899.
HOVERGENHBG001019.
InParanoidP63162.
KOK11100.
OrthoDBEOG7J70HT.
PhylomeDBP63162.
TreeFamTF314232.

Gene expression databases

BgeeP63162.
CleanExHS_SNRPN.
GenevestigatorP63162.

Family and domain databases

InterProIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR017131. snRNP-assoc_SmB/SmN.
[Graphical view]
PfamPF01423. LSM. 1 hit.
[Graphical view]
PIRSFPIRSF037187. snRNP_SmB/SmN. 1 hit.
SMARTSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMSSF50182. SSF50182. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSNRPN. human.
GeneWikiSmall_nuclear_ribonucleoprotein_polypeptide_N.
GenomeRNAi6638.
NextBio25861.
PROP63162.
SOURCESearch...

Entry information

Entry nameRSMN_HUMAN
AccessionPrimary (citable) accession number: P63162
Secondary accession number(s): P14648, P17135, Q0D2Q5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM