Reviewed,
UniProtKB/Swiss-Prot P63162 (RSMN_HUMAN)
Last modified
January 19, 2010.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Small nuclear ribonucleoprotein-associated protein N Short name=snRNP-N Short name=Sm protein N Short name=Sm-N Short name=SmN Short name=Sm-D Alternative name(s): Tissue-specific-splicing protein | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 240 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be involved in tissue-specific alternative RNA processing events. |
| Subunit structure | Interacts with TDRD3. Ref.11 |
| Subcellular location | |
| Tissue specificity | Expressed in brain and lymphoblasts. Ref.10 |
| Involvement in disease | Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes. |
| Miscellaneous | Encoded on a bicistronic transcript that encode for two proteins, SNRPN and SNURF. |
| Sequence similarities | Belongs to the snRNP SmB/SmN family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Disease | Systemic lupus erythematosus |
| Domain | Repeat |
| Ligand | RNA-binding |
| Molecular function | Ribonucleoprotein |
| PTM | Acetylation |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | RNA splicing Traceable author statement. Source: UniProtKB |
| Cellular component | small nuclear ribonucleoprotein complex Traceable author statement. Source: UniProtKB spliceosomal complexTraceable author statement. Source: UniProtKB |
| Molecular function | RNA binding Inferred from electronic annotation. Source: UniProtKB-KW identical protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| itself | 1 | EBI-712493,EBI-712493 | ||
| GEMIN4 | P57678 | 1 | EBI-712493,EBI-356700 | |
| IBTK | Q9P2D0 | 1 | EBI-712493,EBI-1052017 | |
| LSM4 | Q9Y4Z0 | 1 | EBI-712493,EBI-372521 | |
| POP7 | O75817 | 2 | EBI-712493,EBI-366574 | |
| PRPF3 | O43395 | 1 | EBI-712493,EBI-744322 | |
| Rpp20 | Q2MGL3 | 1 | EBI-712493,EBI-1151669 | From a different organism. |
| SF3B1 | O75533 | 1 | EBI-712493,EBI-876542 | |
| SF3B3 | Q15393 | 1 | EBI-712493,EBI-346977 | |
| Smn | Q9VV74 | 2 | EBI-712493,EBI-185315 | From a different organism. |
| SNCG | O76070 | 1 | EBI-712493,EBI-1053810 | |
| SNRPB2 | P08579 | 1 | EBI-712493,EBI-1053651 | |
| STK16 | O75716 | 1 | EBI-712493,EBI-749295 | |
| TCEB1 | Q15369 | 1 | EBI-712493,EBI-301231 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 240 | 240 | Small nuclear ribonucleoprotein-associated protein N | PRO_0000125523 | |||||
Regions | |||||||||
| Repeat | 175 – 181 | 7 | |||||||
| Repeat | 191 – 196 | 6 | |||||||
| Repeat | 216 – 221 | 6 | |||||||
| Repeat | 222 – 228 | 7 | |||||||
| Repeat | 230 – 236 | 7 | |||||||
| Region | 175 – 236 | 62 | Repeat-rich region | ||||||
Amino acid modifications | |||||||||
| Modified residue | 8 | 1 | N6-acetyllysine Ref.12 | ||||||
Experimental info | |||||||||
| Sequence conflict | 43 – 44 | 2 | Missing Ref.8 | ||||||
| Sequence conflict | 75 | 1 | E → Q Ref.8 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'." Schmauss C., McAllister G., Ohosone Y., Hardin J.A., Lerner M.R. Nucleic Acids Res. 17:1733-1743(1989) [PubMed: 2522186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum. |
| [2] | "Primary structure of a human small nuclear ribonucleoprotein polypeptide as deduced by cDNA analysis." Rokeach L.A., Jannatipour M., Haselby J.A., Hoch S.O. J. Biol. Chem. 264:5024-5030(1989) [PubMed: 2522449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. |
| [3] | "Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases." Renz M., Heim C., Braeunling O., Czichos A., Wieland C., Seelig H.P. Clin. Chem. 35:1861-1863(1989) [PubMed: 2528429] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Gene structure, DNA methylation, and imprinted expression of the human SNRPN gene." Glenn C.C., Saitoh S., Jong M.T., Filbrandt M.M., Surti U., Driscoll D.J., Nicholls R.D. Am. J. Hum. Genet. 58:335-346(1996) [PubMed: 8571960] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [5] | Feng Z., Zhang B., Peng X., Yuan J., Qiang B. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [6] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Kidney and Uterus. |
| [8] | "Isolation and structural characterization of the rat gene encoding the brain specific snRNP-associated polypeptide 'N'." Esposito F., Fiore F., Cimino F., Russo T. Biochem. Biophys. Res. Commun. 195:317-326(1993) [PubMed: 8363612] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-140. |
| [9] | "Isolation of cDNA clones encoding the human Sm B/B' auto-immune antigen and specifically reacting with human anti-Sm auto-immune sera." Sharpe N.G., Williams D.G., Howarth D.N., Coles B., Latchman D.S. FEBS Lett. 250:585-590(1989) [PubMed: 2753153] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-218. |
| [10] | "An imprinted, mammalian bicistronic transcript encodes two independent proteins." Gray T.A., Saitoh S., Nicholls R.D. Proc. Natl. Acad. Sci. U.S.A. 96:5616-5621(1999) [PubMed: 10318933] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [11] | "Tudor domains bind symmetrical dimethylated arginines." Cote J., Richard S. J. Biol. Chem. 280:28476-28483(2005) [PubMed: 15955813] [Abstract] Cited for: INTERACTION WITH TDRD3. |
| [12] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-8, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X15892 mRNA. Translation: CAA33901.1. J04615 mRNA. Translation: AAA36617.1. U41303 mRNA. Translation: AAA98969.1. AF400432 mRNA. Translation: AAK92481.1. CR450350 mRNA. Translation: CAG29346.1. BC000611 mRNA. Translation: AAH00611.1. BC003180 mRNA. Translation: AAH03180.1. BC024777 mRNA. Translation: AAH24777.1. BC025178 mRNA. Translation: AAH25178.1. |
| IPI | IPI00220360. |
| PIR | A33270. |
| RefSeq | NP_003088.1. NP_073716.1. NP_073717.1. NP_073718.1. NP_073719.1. |
| UniGene | Hs.555970 Hs.564847 Hs.578619 Hs.585703 Hs.592473 Hs.621316 Hs.632166 |
3D structure databases | |
| SMR | P63162. Positions 2-91. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P63162. 22 interactions. |
| STRING | P63162. |
PTM databases | |
| PhosphoSite | P63162. |
Proteomic databases | |
| PRIDE | P63162. |
Genome annotation databases | |
| Ensembl | ENST00000338094; ENSP00000336543; ENSG00000128739; Homo sapiens. [Genome view] ENST00000390687; ENSP00000375105; ENSG00000128739; Homo sapiens. [Genome view] ENST00000400097; ENSP00000382969; ENSG00000128739; Homo sapiens. [Genome view] ENST00000400098; ENSP00000382970; ENSG00000128739; Homo sapiens. [Genome view] ENST00000400100; ENSP00000382972; ENSG00000128739; Homo sapiens. [Genome view] ENST00000444203; ENSP00000408767; ENSG00000128739; Homo sapiens. [Genome view] |
| GeneID | 6638. |
| KEGG | hsa:6638. |
| UCSC | uc001ywp.1. human. |
Organism-specific databases | |
| CTD | 6638. |
| GeneCards | GC15P022620. |
| H-InvDB | HIX0012047. |
| HGNC | HGNC:11164. SNRPN. |
| HPA | HPA003482. |
| MIM | 182279. gene. |
| Orphanet | 739. Prader-Willi syndrome. |
| PharmGKB | PA36005. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG17303. |
| HOVERGEN | P63162. |
| InParanoid | P63162. |
| PhylomeDB | P63162. |
Gene expression databases | |
| ArrayExpress | P63162. |
| Bgee | P63162. |
| CleanEx | HS_SNRPN. |
| Genevestigator | P63162. |
| GermOnline | ENSG00000128739. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001163. LSM_domain. IPR006649. LSM_domain_euk/arc. IPR010920. LSM_related_domain. IPR017131. snRNP-assoc_SmB/SmN. [Graphical view] |
| Pfam | PF01423. LSM. 1 hit. [Graphical view] |
| PIRSF | PIRSF037187. snRNP_SmB/SmN. 1 hit. |
| SMART | SM00651. Sm. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 25861. |
| SOURCE | Search... |
Entry information
| Entry name | RSMN_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P63162 Secondary accession number(s): P14648, P17135, Q0D2Q5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


