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Protein

Potassium voltage-gated channel subfamily E member 2

Gene

Kcne2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current (By similarity). Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity).By similarity1 Publication

GO - Molecular functioni

  • cation channel activity Source: RGD
  • delayed rectifier potassium channel activity Source: Ensembl
  • inward rectifier potassium channel activity Source: Ensembl
  • ion channel binding Source: UniProtKB
  • potassium channel regulator activity Source: UniProtKB
  • protein homodimerization activity Source: RGD
  • voltage-gated potassium channel activity Source: RGD
  • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Source: Ensembl

GO - Biological processi

  • aging Source: RGD
  • cellular response to drug Source: BHF-UCL
  • membrane repolarization Source: BHF-UCL
  • membrane repolarization during action potential Source: BHF-UCL
  • negative regulation of delayed rectifier potassium channel activity Source: UniProtKB
  • negative regulation of voltage-gated potassium channel activity Source: RGD
  • positive regulation of proteasomal protein catabolic process Source: Ensembl
  • positive regulation of voltage-gated calcium channel activity Source: RGD
  • potassium ion export Source: BHF-UCL
  • potassium ion import Source: BHF-UCL
  • potassium ion transmembrane transport Source: BHF-UCL
  • regulation of cyclic nucleotide-gated ion channel activity Source: RGD
  • regulation of delayed rectifier potassium channel activity Source: BHF-UCL
  • regulation of heart rate by cardiac conduction Source: Ensembl
  • regulation of inward rectifier potassium channel activity Source: BHF-UCL
  • regulation of membrane repolarization Source: BHF-UCL
  • regulation of potassium ion transmembrane transport Source: BHF-UCL
  • regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl
  • tongue development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-RNO-5576890. Phase 3 - rapid repolarisation.
R-RNO-5576893. Phase 2 - plateau phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 2
Alternative name(s):
MinK-related peptide 1
Minimum potassium ion channel-related peptide 1
Potassium channel subunit beta MiRP1
Gene namesi
Name:Kcne2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621383. Kcne2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 123CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

  • cell surface Source: Ensembl
  • integral component of membrane Source: RGD
  • lysosome Source: Ensembl
  • plasma membrane Source: UniProtKB
  • voltage-gated potassium channel complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442881 – 123Potassium voltage-gated channel subfamily E member 2Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP63161.
PRIDEiP63161.

PTM databases

iPTMnetiP63161.
PhosphoSitePlusiP63161.

Expressioni

Tissue specificityi

Expressed in the heart (PubMed:19219384).1 Publication

Gene expression databases

BgeeiENSRNOG00000029811.
GenevisibleiP63161. RN.

Interactioni

Subunit structurei

Interacts with KCNB1 (PubMed:19219384). Associates with KCNH2/ERG1 (By similarity). May associate with KCNQ2 and KCNQ3 (By similarity). Associates with HCN1 and probably HCN2 (PubMed:11420311). Heteromultimer with KCNC2. Interacts with KCNC2 (PubMed:14679187). Interacts with KCNQ1; forms a heterooligomer complex that targets to the membrane raft and leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity).By similarity3 Publications

GO - Molecular functioni

  • ion channel binding Source: UniProtKB
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045279.

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX4Y. Eukaryota.
ENOG411297Y. LUCA.
GeneTreeiENSGT00510000048894.
HOGENOMiHOG000113208.
HOVERGENiHBG052227.
InParanoidiP63161.
KOiK04896.
OMAiNWRRNTT.
OrthoDBiEOG091G0UDJ.
PhylomeDBiP63161.
TreeFamiTF336058.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
IPR005425. K_chnl_volt-dep_bsu_KCNE2.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01605. KCNE2CHANNEL.

Sequencei

Sequence statusi: Complete.

P63161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLANLTQT LEDAFKKVFI TYMDSWRRNT TAEQQALQAR VDAENFYYVI
60 70 80 90 100
LYLMVMIGMF AFIVVAILVS TVKSKRREHS QDPYHQYIVE DWQQKYRSQI
110 120
LHLEDSKATI HENLGATGFT VSP
Length:123
Mass (Da):14,356
Last modified:September 27, 2004 - v1
Checksum:iCB91870E7B1EB82A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071003 mRNA. Translation: AAD28087.1.
BC089778 mRNA. Translation: AAH89778.1.
RefSeqiNP_598287.1. NM_133603.2.
XP_006248085.1. XM_006248023.3.
XP_008766776.1. XM_008768554.2.
UniGeneiRn.48691.

Genome annotation databases

EnsembliENSRNOT00000040844; ENSRNOP00000045279; ENSRNOG00000029811.
GeneIDi171138.
KEGGirno:171138.
UCSCiRGD:621383. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071003 mRNA. Translation: AAD28087.1.
BC089778 mRNA. Translation: AAH89778.1.
RefSeqiNP_598287.1. NM_133603.2.
XP_006248085.1. XM_006248023.3.
XP_008766776.1. XM_008768554.2.
UniGeneiRn.48691.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045279.

PTM databases

iPTMnetiP63161.
PhosphoSitePlusiP63161.

Proteomic databases

PaxDbiP63161.
PRIDEiP63161.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000040844; ENSRNOP00000045279; ENSRNOG00000029811.
GeneIDi171138.
KEGGirno:171138.
UCSCiRGD:621383. rat.

Organism-specific databases

CTDi9992.
RGDi621383. Kcne2.

Phylogenomic databases

eggNOGiENOG410IX4Y. Eukaryota.
ENOG411297Y. LUCA.
GeneTreeiENSGT00510000048894.
HOGENOMiHOG000113208.
HOVERGENiHBG052227.
InParanoidiP63161.
KOiK04896.
OMAiNWRRNTT.
OrthoDBiEOG091G0UDJ.
PhylomeDBiP63161.
TreeFamiTF336058.

Enzyme and pathway databases

ReactomeiR-RNO-5576890. Phase 3 - rapid repolarisation.
R-RNO-5576893. Phase 2 - plateau phase.

Miscellaneous databases

PROiP63161.

Gene expression databases

BgeeiENSRNOG00000029811.
GenevisibleiP63161. RN.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
IPR005425. K_chnl_volt-dep_bsu_KCNE2.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01605. KCNE2CHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNE2_RAT
AccessioniPrimary (citable) accession number: P63161
Secondary accession number(s): Q5FVT9, Q9WTW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.