##gff-version 3 P63158 UniProtKB Chain 1 215 . . . ID=PRO_0000048528;Note=High mobility group protein B1 P63158 UniProtKB DNA binding 9 79 . . . Note=HMG box 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267 P63158 UniProtKB DNA binding 95 163 . . . Note=HMG box 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00267 P63158 UniProtKB Region 1 97 . . . Note=Sufficient for interaction with HAVCR2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22842346;Dbxref=PMID:22842346 P63158 UniProtKB Region 3 15 . . . Note=LPS binding (delipidated);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Region 27 43 . . . Note=NLS 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63159 P63158 UniProtKB Region 76 95 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P63158 UniProtKB Region 80 96 . . . Note=LPS binding (Lipid A);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Region 89 108 . . . Note=Cytokine-stimulating activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Region 150 183 . . . Note=Binding to AGER/RAGE;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63159 P63158 UniProtKB Region 161 215 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P63158 UniProtKB Region 178 184 . . . Note=NLS 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63159 P63158 UniProtKB Motif 27 43 . . . Note=Nuclear localization signal (NLS) 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63159 P63158 UniProtKB Motif 178 184 . . . Note=Nuclear localization signal (NLS) 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63159 P63158 UniProtKB Compositional bias 76 94 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P63158 UniProtKB Compositional bias 161 187 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P63158 UniProtKB Compositional bias 188 215 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P63158 UniProtKB Binding site 1 10 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Site 10 11 . . . Note=Cleavage%3B by thrombin:thrombomodulin;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Site 67 68 . . . Note=Cleavage%3B by CASP1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Modified residue 3 3 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 7 7 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 8 8 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 12 12 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 23 23 . . . Note=Cysteine sulfonic acid (-SO3H)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63159 P63158 UniProtKB Modified residue 28 28 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 29 29 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 30 30 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P63158 UniProtKB Modified residue 35 35 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Modified residue 43 43 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P63158 UniProtKB Modified residue 45 45 . . . Note=Cysteine sulfonic acid (-SO3H)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63159 P63158 UniProtKB Modified residue 90 90 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P63158 UniProtKB Modified residue 100 100 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Modified residue 106 106 . . . Note=Cysteine sulfonic acid (-SO3H);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63159 P63158 UniProtKB Modified residue 127 127 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 128 128 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 141 141 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P63158 UniProtKB Modified residue 172 172 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 173 173 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 177 177 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 180 180 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 181 181 . . . Note=ADP-ribosylserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Modified residue 182 182 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 183 183 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 184 184 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Modified residue 185 185 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10103 P63158 UniProtKB Disulfide bond 23 45 . . . Note=In disulfide HMGB1%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63159 P63158 UniProtKB Cross-link 28 28 . . . Note=Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Cross-link 43 43 . . . Note=Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Cross-link 44 44 . . . Note=Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Cross-link 68 68 . . . Note=Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Cross-link 180 180 . . . Note=Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Cross-link 182 182 . . . Note=Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Cross-link 183 183 . . . Note=Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Cross-link 184 184 . . . Note=Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09429 P63158 UniProtKB Sequence conflict 179 179 . . . Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P63158 UniProtKB Sequence conflict 190 190 . . . Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 P63158 UniProtKB Helix 15 30 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5ZE0 P63158 UniProtKB Helix 38 49 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5ZE0 P63158 UniProtKB Helix 58 75 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5ZE0 P63158 UniProtKB Helix 101 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5ZE0 P63158 UniProtKB Helix 123 135 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5ZE0 P63158 UniProtKB Helix 142 156 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5ZE0