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Protein

BarH-like 1 homeobox protein

Gene

Barhl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi178 – 237HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • midbrain development Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • neuron migration Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 1 homeobox protein
Alternative name(s):
Bar-class homeodomain protein MBH2
BarH-related homeobox protein 1
Gene namesi
Name:Barhl1
Synonyms:Bhx1, Mbh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1859288. Barhl1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488271 – 327BarH-like 1 homeobox proteinAdd BLAST327

Proteomic databases

PaxDbiP63157.
PRIDEiP63157.

PTM databases

PhosphoSitePlusiP63157.

Expressioni

Developmental stagei

Exclusively expressed in restricted domains of the developing central nervous system, in particular the diencephalon and rhombencephalon, where it is expressed in migrating cells giving rise to the cerebellar external granular layer and to specific populations of dorsal sensory interneurons of the spinal cord.1 Publication

Gene expression databases

BgeeiENSMUSG00000026805.
CleanExiMM_BARHL1.
GenevisibleiP63157. MM.

Interactioni

Protein-protein interaction databases

BioGridi207657. 2 interactors.
STRINGi10090.ENSMUSP00000053147.

Structurei

3D structure databases

ProteinModelPortaliP63157.
SMRiP63157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231533.
HOVERGENiHBG050663.
InParanoidiP63157.
KOiK09360.
OMAiSDSEYKG.
OrthoDBiEOG091G13SM.
PhylomeDBiP63157.
TreeFamiTF316128.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSNGFGID SILSHRAGSP ALPKGDPLLG DCRSPLELSP RSESSSDCSS
60 70 80 90 100
PASPGRDCLE TSTSRPGAAS GPGLDSHLQP GQLSAPAQSR TVTSSFLIRD
110 120 130 140 150
ILADCKPLAA CAPYSSSGQP AAPEPGGRLA AKAGEDFRDK LDKSVSSASS
160 170 180 190 200
DSEYKVKEEG DREISSSRDS PPVRLKKPRK ARTAFTDHQL AQLERSFERQ
210 220 230 240 250
KYLSVQDRME LAASLNLTDT QVKTWYQNRR TKWKRQTAVG LELLAEAGNY
260 270 280 290 300
SALQRMFPSP YFYPQSLVSN LDPGAALYLY RGPSAPPPAL QRPLVPRILI
310 320
HGLQGASEPP PPLPPLPGVL PRAAQPR
Length:327
Mass (Da):35,136
Last modified:September 27, 2004 - v1
Checksum:i4130725E55D322FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237590 mRNA. Translation: CAB92529.1.
AB043980 mRNA. Translation: BAB18599.1.
AF264026 mRNA. Translation: AAK58534.1.
BC055731 mRNA. Translation: AAH55731.1.
CCDSiCCDS15849.1.
RefSeqiNP_001157658.1. NM_001164186.1.
NP_062319.1. NM_019446.4.
XP_006498245.1. XM_006498182.3.
XP_006498246.1. XM_006498183.2.
XP_011237440.1. XM_011239138.2.
UniGeneiMm.21390.

Genome annotation databases

EnsembliENSMUST00000050776; ENSMUSP00000053147; ENSMUSG00000026805.
ENSMUST00000113847; ENSMUSP00000109478; ENSMUSG00000026805.
ENSMUST00000113849; ENSMUSP00000109480; ENSMUSG00000026805.
GeneIDi54422.
KEGGimmu:54422.
UCSCiuc008izh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237590 mRNA. Translation: CAB92529.1.
AB043980 mRNA. Translation: BAB18599.1.
AF264026 mRNA. Translation: AAK58534.1.
BC055731 mRNA. Translation: AAH55731.1.
CCDSiCCDS15849.1.
RefSeqiNP_001157658.1. NM_001164186.1.
NP_062319.1. NM_019446.4.
XP_006498245.1. XM_006498182.3.
XP_006498246.1. XM_006498183.2.
XP_011237440.1. XM_011239138.2.
UniGeneiMm.21390.

3D structure databases

ProteinModelPortaliP63157.
SMRiP63157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207657. 2 interactors.
STRINGi10090.ENSMUSP00000053147.

PTM databases

PhosphoSitePlusiP63157.

Proteomic databases

PaxDbiP63157.
PRIDEiP63157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050776; ENSMUSP00000053147; ENSMUSG00000026805.
ENSMUST00000113847; ENSMUSP00000109478; ENSMUSG00000026805.
ENSMUST00000113849; ENSMUSP00000109480; ENSMUSG00000026805.
GeneIDi54422.
KEGGimmu:54422.
UCSCiuc008izh.2. mouse.

Organism-specific databases

CTDi56751.
MGIiMGI:1859288. Barhl1.

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000231533.
HOVERGENiHBG050663.
InParanoidiP63157.
KOiK09360.
OMAiSDSEYKG.
OrthoDBiEOG091G13SM.
PhylomeDBiP63157.
TreeFamiTF316128.

Miscellaneous databases

PROiP63157.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026805.
CleanExiMM_BARHL1.
GenevisibleiP63157. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBARH1_MOUSE
AccessioniPrimary (citable) accession number: P63157
Secondary accession number(s): Q9JK26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.