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Protein

Crooked neck-like protein 1

Gene

Crnkl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing process.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Crooked neck-like protein 1
Alternative name(s):
Crooked neck homolog
Gene namesi
Name:Crnkl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914127. Crnkl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057201 – 690Crooked neck-like protein 1Add BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei342PhosphoserineBy similarity1
Modified residuei689PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP63154.
MaxQBiP63154.
PaxDbiP63154.
PeptideAtlasiP63154.
PRIDEiP63154.

PTM databases

iPTMnetiP63154.
PhosphoSitePlusiP63154.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001767.
CleanExiMM_CRNKL1.
GenevisibleiP63154. MM.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2. Interacts with PPIL2 (via the PPIase cyclophilin-type domain); they may form a trimeric complex with HSP90.By similarity1 Publication

Protein-protein interaction databases

BioGridi211782. 26 interactors.
IntActiP63154. 27 interactors.
STRINGi10090.ENSMUSP00000001818.

Structurei

3D structure databases

ProteinModelPortaliP63154.
SMRiP63154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati61 – 93HAT 1Add BLAST33
Repeati95 – 127HAT 2Add BLAST33
Repeati129 – 161HAT 3Add BLAST33
Repeati163 – 194HAT 4Add BLAST32
Repeati196 – 227HAT 5Add BLAST32
Repeati229 – 264HAT 6Add BLAST36
Repeati266 – 300HAT 7Add BLAST35
Repeati310 – 342HAT 8Add BLAST33
Repeati344 – 378HAT 9Add BLAST35
Repeati388 – 424HAT 10Add BLAST37
Repeati459 – 491HAT 11Add BLAST33
Repeati493 – 527HAT 12Add BLAST35
Repeati529 – 560HAT 13Add BLAST32
Repeati565 – 606HAT 14Add BLAST42
Repeati608 – 646HAT 15Add BLAST39
Repeati648 – 673HAT 16Add BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni250 – 467Mediates interaction with HSP901 PublicationAdd BLAST218

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi618 – 626Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 49Poly-Pro4

Sequence similaritiesi

Belongs to the crooked-neck family.Curated
Contains 16 HAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1915. Eukaryota.
ENOG410XQJF. LUCA.
GeneTreeiENSGT00550000074931.
HOGENOMiHOG000207972.
HOVERGENiHBG051046.
InParanoidiP63154.
KOiK12869.
OMAiFEEKHGY.
OrthoDBiEOG091G040G.
PhylomeDBiP63154.
TreeFamiTF300305.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR003107. HAT.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF02184. HAT. 2 hits.
[Graphical view]
SMARTiSM00386. HAT. 13 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.

Sequencei

Sequence statusi: Complete.

P63154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTAAGKQ RIPKVAKVKN KAPAEVQITA EQLLREAKER ELELLPPPPQ
60 70 80 90 100
QKITDEEELN DYKLRKRKTF EDNIRKNRTV ISNWIKYAQW EESLKEIQRA
110 120 130 140 150
RSIYERALDV DYRNITLWLK YAEMEMKNRQ VNHARNIWDR AITTLPRVNQ
160 170 180 190 200
FWYKYTYMEE MLGNVAGARQ VFERWMEWQP EEQAWHSYIN FELRYKEVER
210 220 230 240 250
ARTIYERFVL VHPAVKNWIK YARFEEKHAY FAHARKVYER AVEFFGDEHM
260 270 280 290 300
DEHLYVAFAK FEENQKEFER VRVIYKYALD RISKQEAQEL FKNYTIFEKK
310 320 330 340 350
FGDRRGIEDI IVSKRRFQYE EEVKANPHNY DAWFDYLRLV ESDAEADTVR
360 370 380 390 400
EVYERAIANV PPIQEKRHWK RYIYLWVNYA LYEELEAKDP ERTRQVYQAS
410 420 430 440 450
LELIPHKKFT FAKMWLYYAQ FEIRQKNLPF ARRALGTSIG KCPKNKLFKG
460 470 480 490 500
YIELELQLRE FDRCRKLYEK FLEFGPENCT SWIKFAELET ILGDIERARA
510 520 530 540 550
IYELAISQPR LDMPEVLWKS YIDFEIEQEE TERTRNLYRQ LLQRTQHVKV
560 570 580 590 600
WISFAQFELS SGKEGSVAKC RQIYEEANKT MRNCEEKEER LMLLESWRSF
610 620 630 640 650
EDEFGTVSDK ERVDKLMPEK VKKRRKVQAD DGSDAGWEEY YDYIFPEDAA
660 670 680 690
NQPNLKLLAM AKLWKKQQQE REAAEQDPDK DIDESESSSF
Length:690
Mass (Da):83,416
Last modified:September 27, 2004 - v1
Checksum:i9FE84D7F1205B974
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004749 mRNA. Translation: BAB23530.1.
AK012962 mRNA. Translation: BAB28572.1.
AK088882 mRNA. Translation: BAC40630.1.
BC029187 mRNA. Translation: AAH29187.1.
CCDSiCCDS16828.1.
RefSeqiNP_080096.1. NM_025820.3.
UniGeneiMm.248755.

Genome annotation databases

EnsembliENSMUST00000001818; ENSMUSP00000001818; ENSMUSG00000001767.
GeneIDi66877.
KEGGimmu:66877.
UCSCiuc008mrz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004749 mRNA. Translation: BAB23530.1.
AK012962 mRNA. Translation: BAB28572.1.
AK088882 mRNA. Translation: BAC40630.1.
BC029187 mRNA. Translation: AAH29187.1.
CCDSiCCDS16828.1.
RefSeqiNP_080096.1. NM_025820.3.
UniGeneiMm.248755.

3D structure databases

ProteinModelPortaliP63154.
SMRiP63154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211782. 26 interactors.
IntActiP63154. 27 interactors.
STRINGi10090.ENSMUSP00000001818.

PTM databases

iPTMnetiP63154.
PhosphoSitePlusiP63154.

Proteomic databases

EPDiP63154.
MaxQBiP63154.
PaxDbiP63154.
PeptideAtlasiP63154.
PRIDEiP63154.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001818; ENSMUSP00000001818; ENSMUSG00000001767.
GeneIDi66877.
KEGGimmu:66877.
UCSCiuc008mrz.1. mouse.

Organism-specific databases

CTDi51340.
MGIiMGI:1914127. Crnkl1.

Phylogenomic databases

eggNOGiKOG1915. Eukaryota.
ENOG410XQJF. LUCA.
GeneTreeiENSGT00550000074931.
HOGENOMiHOG000207972.
HOVERGENiHBG051046.
InParanoidiP63154.
KOiK12869.
OMAiFEEKHGY.
OrthoDBiEOG091G040G.
PhylomeDBiP63154.
TreeFamiTF300305.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiCrnkl1. mouse.
PROiP63154.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001767.
CleanExiMM_CRNKL1.
GenevisibleiP63154. MM.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR003107. HAT.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF02184. HAT. 2 hits.
[Graphical view]
SMARTiSM00386. HAT. 13 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCRNL1_MOUSE
AccessioniPrimary (citable) accession number: P63154
Secondary accession number(s): Q542E8, Q9CQC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.