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Protein

Crooked neck-like protein 1

Gene

Crnkl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing process.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Crooked neck-like protein 1
Alternative name(s):
Crooked neck homolog
Gene namesi
Name:Crnkl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914127 Crnkl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057201 – 690Crooked neck-like protein 1Add BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei342PhosphoserineBy similarity1
Modified residuei689PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP63154
MaxQBiP63154
PaxDbiP63154
PeptideAtlasiP63154
PRIDEiP63154

PTM databases

iPTMnetiP63154
PhosphoSitePlusiP63154

Expressioni

Gene expression databases

BgeeiENSMUSG00000001767
CleanExiMM_CRNKL1
GenevisibleiP63154 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2 (By similarity). Interacts with PPIL2 (via the PPIase cyclophilin-type domain); they may form a trimeric complex with HSP90 (PubMed:15189447).By similarity1 Publication

Protein-protein interaction databases

BioGridi211782, 26 interactors
IntActiP63154, 27 interactors
STRINGi10090.ENSMUSP00000001818

Structurei

3D structure databases

ProteinModelPortaliP63154
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati61 – 93HAT 1Add BLAST33
Repeati95 – 127HAT 2Add BLAST33
Repeati129 – 161HAT 3Add BLAST33
Repeati163 – 194HAT 4Add BLAST32
Repeati196 – 227HAT 5Add BLAST32
Repeati229 – 264HAT 6Add BLAST36
Repeati266 – 300HAT 7Add BLAST35
Repeati310 – 342HAT 8Add BLAST33
Repeati344 – 378HAT 9Add BLAST35
Repeati388 – 424HAT 10Add BLAST37
Repeati459 – 491HAT 11Add BLAST33
Repeati493 – 527HAT 12Add BLAST35
Repeati529 – 560HAT 13Add BLAST32
Repeati565 – 606HAT 14Add BLAST42
Repeati608 – 646HAT 15Add BLAST39
Repeati648 – 673HAT 16Add BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni250 – 467Mediates interaction with HSP901 PublicationAdd BLAST218

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi618 – 626Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 49Poly-Pro4

Sequence similaritiesi

Belongs to the crooked-neck family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1915 Eukaryota
ENOG410XQJF LUCA
GeneTreeiENSGT00550000074931
HOGENOMiHOG000207972
HOVERGENiHBG051046
InParanoidiP63154
KOiK12869
OMAiFTFSKIW
OrthoDBiEOG091G040G
PhylomeDBiP63154
TreeFamiTF300305

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF02184 HAT, 2 hits
SMARTiView protein in SMART
SM00386 HAT, 13 hits
SUPFAMiSSF48452 SSF48452, 2 hits

Sequencei

Sequence statusi: Complete.

P63154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTAAGKQ RIPKVAKVKN KAPAEVQITA EQLLREAKER ELELLPPPPQ
60 70 80 90 100
QKITDEEELN DYKLRKRKTF EDNIRKNRTV ISNWIKYAQW EESLKEIQRA
110 120 130 140 150
RSIYERALDV DYRNITLWLK YAEMEMKNRQ VNHARNIWDR AITTLPRVNQ
160 170 180 190 200
FWYKYTYMEE MLGNVAGARQ VFERWMEWQP EEQAWHSYIN FELRYKEVER
210 220 230 240 250
ARTIYERFVL VHPAVKNWIK YARFEEKHAY FAHARKVYER AVEFFGDEHM
260 270 280 290 300
DEHLYVAFAK FEENQKEFER VRVIYKYALD RISKQEAQEL FKNYTIFEKK
310 320 330 340 350
FGDRRGIEDI IVSKRRFQYE EEVKANPHNY DAWFDYLRLV ESDAEADTVR
360 370 380 390 400
EVYERAIANV PPIQEKRHWK RYIYLWVNYA LYEELEAKDP ERTRQVYQAS
410 420 430 440 450
LELIPHKKFT FAKMWLYYAQ FEIRQKNLPF ARRALGTSIG KCPKNKLFKG
460 470 480 490 500
YIELELQLRE FDRCRKLYEK FLEFGPENCT SWIKFAELET ILGDIERARA
510 520 530 540 550
IYELAISQPR LDMPEVLWKS YIDFEIEQEE TERTRNLYRQ LLQRTQHVKV
560 570 580 590 600
WISFAQFELS SGKEGSVAKC RQIYEEANKT MRNCEEKEER LMLLESWRSF
610 620 630 640 650
EDEFGTVSDK ERVDKLMPEK VKKRRKVQAD DGSDAGWEEY YDYIFPEDAA
660 670 680 690
NQPNLKLLAM AKLWKKQQQE REAAEQDPDK DIDESESSSF
Length:690
Mass (Da):83,416
Last modified:September 27, 2004 - v1
Checksum:i9FE84D7F1205B974
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004749 mRNA Translation: BAB23530.1
AK012962 mRNA Translation: BAB28572.1
AK088882 mRNA Translation: BAC40630.1
BC029187 mRNA Translation: AAH29187.1
CCDSiCCDS16828.1
RefSeqiNP_080096.1, NM_025820.3
UniGeneiMm.248755

Genome annotation databases

EnsembliENSMUST00000001818; ENSMUSP00000001818; ENSMUSG00000001767
GeneIDi66877
KEGGimmu:66877
UCSCiuc008mrz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCRNL1_MOUSE
AccessioniPrimary (citable) accession number: P63154
Secondary accession number(s): Q542E8, Q9CQC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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