Skip Header

 
Contribute Send feedback
Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot P63151 (2ABA_HUMAN)

Last modified June 16, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
      Short name=PP2A, subunit B, B-alpha isoform
Alternative name(s):
    PP2A, subunit B, B55-alpha isoform
    PP2A, subunit B, PR55-alpha isoform
    PP2A, subunit B, R2-alpha isoform
Gene names
Name: PPP2R2A
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Tissue specificity

In all tissues examined. Ref.1

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the phosphatase 2A regulatory subunit B family.

Contains 7 WD repeats.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
PRO_0000071415

Regions

Repeat26 – 6540WD 1
Repeat91 – 13242WD 2
Repeat175 – 21339WD 3
Repeat224 – 26441WD 4
Repeat283 – 32139WD 5
Repeat338 – 37942WD 6
Repeat414 – 44633WD 7

Sequences

Sequence LengthMass (Da)Tools
P63151-1 [UniParc].

Last modified September 27, 2004. Version 1.
Checksum: F4D407FF7ADA4ED6

FASTA44751,692
        10         20         30         40         50         60 
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE 

        70         80         90        100        110        120 
NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK 

       130        140        150        160        170        180 
LWKISERDKR PEGYNLKEED GRYRDPTTVT TLRVPVFRPM DLMVEASPRR IFANAHTYHI 

       190        200        210        220        230        240 
NSISINSDYE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN 

       250        260        270        280        290        300 
TFVYSSSKGT IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM 

       310        320        330        340        350        360 
MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSVVMTG 

       370        380        390        400        410        420 
SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS GKRKKDEISV DSLDFNKKIL 

       430        440 
HTAWHPKENI IAVATTNNLY IFQDKVN 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform."
Mayer R.E., Hendrix P., Cron P., Matthies R., Stone S.R., Goris J., Merlevede W., Hofsteenge J., Hemmings B.A.
Biochemistry 30:3589-3597(1991) [PubMed: 1849734] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Lung fibroblast.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
[3]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

M64929 mRNA. Translation: AAA36490.1.
BC041071 mRNA. Translation: AAH41071.1.
IPIIPI00332511.
PIRA38351.
RefSeqNP_002708.1.
UniGeneHs.146339

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
3DW8X-ray2.85B/E1-447[»]
ModBaseSearch...

Protein-protein interaction databases

IntActP63151. 8 interactions.

Proteomic databases

PeptideAtlasP63151.
PRIDEP63151.

Genome annotation databases

EnsemblENSG00000221914. Homo sapiens. [Contig view]
GeneID5520.
KEGGhsa:5520.

Organism-specific databases

GeneCardsGC08P026204.
H-InvDBHIX0007394.
HGNCHGNC:9304. PPP2R2A.
MIM604941. gene.
PharmGKBPA33668.
GenAtlasSearch...

Phylogenomic databases

HOVERGENP63151.

Enzyme and pathway databases

Pathway_Interaction_DBtgfbrpathway. TGF-beta receptor signaling.

Gene expression databases

ArrayExpressP63151.
BgeeP63151.
CleanExHS_PPP2R2A.
GermOnlineENSG00000147459. Homo sapiens.

Family and domain databases

InterProIPR019578. PP2A_Bsu_A/B_central-region.
IPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR019573. PP2A_suB_N.
IPR015943. WD40/YVTN_repeat-like.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PANTHERPTHR11871. Pp2A_PR55. 1 hit.
PfamPF10586. PP2A_B_N. 1 hit.
PF10594. PP2A_B_subs_rcg. 1 hit.
[Graphical view]
PIRSFPIRSF037309. PP2A_PR55. 1 hit.
PRINTSPR00600. PP2APR55.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
PROSITEPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. False negative.
PS50082. WD_REPEATS_2. False negative.
PS50294. WD_REPEATS_REGION. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio21352.
SOURCESearch...

Entry information

Entry name2ABA_HUMAN
AccessionPrimary (citable) accession number: P63151
Secondary accession number(s): P50409, Q00007
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents