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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Gene

PPP2R2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO - Molecular functioni

  • protein phosphatase type 2A regulator activity Source: UniProtKB
  • protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32284-MONOMER.
ReactomeiR-HSA-2995383. Initiation of Nuclear Envelope Reformation.
R-HSA-69231. Cyclin D associated events in G1.
R-HSA-69273. Cyclin A/B1 associated events during G2/M transition.
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
SignaLinkiP63151.
SIGNORiP63151.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Alternative name(s):
PP2A subunit B isoform B55-alpha
PP2A subunit B isoform PR55-alpha
PP2A subunit B isoform R2-alpha
PP2A subunit B isoform alpha
Gene namesi
Name:PPP2R2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9304. PPP2R2A.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • nucleoplasm Source: Reactome
  • protein phosphatase type 2A complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi5520.
OpenTargetsiENSG00000221914.
PharmGKBiPA33668.

Chemistry databases

ChEMBLiCHEMBL4284.

Polymorphism and mutation databases

BioMutaiPPP2R2A.
DMDMi52783535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000714152 – 447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP63151.
MaxQBiP63151.
PaxDbiP63151.
PeptideAtlasiP63151.
PRIDEiP63151.

PTM databases

iPTMnetiP63151.
PhosphoSitePlusiP63151.
SwissPalmiP63151.

Expressioni

Tissue specificityi

Expressed in all tissues examined.1 Publication

Gene expression databases

BgeeiENSG00000221914.
CleanExiHS_PPP2R2A.
ExpressionAtlasiP63151. baseline and differential.
GenevisibleiP63151. HS.

Organism-specific databases

HPAiHPA042122.
HPA042770.
HPA059497.

Interactioni

Subunit structurei

Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP2R1AP3015311EBI-1048931,EBI-302388
PPP2R1BP301543EBI-1048931,EBI-357094

Protein-protein interaction databases

BioGridi111512. 84 interactors.
DIPiDIP-29398N.
IntActiP63151. 43 interactors.
MINTiMINT-2835351.
STRINGi9606.ENSP00000325074.

Chemistry databases

BindingDBiP63151.

Structurei

Secondary structure

1447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 16Combined sources4
Beta strandi21 – 23Combined sources3
Helixi27 – 29Combined sources3
Beta strandi30 – 36Combined sources7
Beta strandi38 – 47Combined sources10
Beta strandi50 – 57Combined sources8
Beta strandi71 – 78Combined sources8
Beta strandi83 – 85Combined sources3
Helixi86 – 88Combined sources3
Beta strandi90 – 92Combined sources3
Beta strandi98 – 101Combined sources4
Beta strandi106 – 114Combined sources9
Beta strandi119 – 132Combined sources14
Beta strandi156 – 172Combined sources17
Beta strandi182 – 185Combined sources4
Beta strandi189 – 195Combined sources7
Beta strandi197 – 204Combined sources8
Beta strandi207 – 216Combined sources10
Helixi222 – 224Combined sources3
Beta strandi229 – 234Combined sources6
Beta strandi241 – 246Combined sources6
Beta strandi251 – 255Combined sources5
Turni256 – 258Combined sources3
Beta strandi260 – 262Combined sources3
Beta strandi267 – 269Combined sources3
Helixi280 – 284Combined sources5
Beta strandi288 – 293Combined sources6
Beta strandi297 – 312Combined sources16
Beta strandi323 – 325Combined sources3
Helixi327 – 329Combined sources3
Turni330 – 332Combined sources3
Helixi333 – 338Combined sources6
Helixi341 – 343Combined sources3
Beta strandi348 – 350Combined sources3
Beta strandi354 – 360Combined sources7
Beta strandi365 – 370Combined sources6
Turni371 – 373Combined sources3
Beta strandi376 – 380Combined sources5
Helixi410 – 412Combined sources3
Beta strandi421 – 424Combined sources4
Beta strandi426 – 434Combined sources9
Beta strandi439 – 443Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DW8X-ray2.85B/E1-447[»]
ProteinModelPortaliP63151.
SMRiP63151.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63151.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 65WD 1Add BLAST40
Repeati91 – 132WD 2Add BLAST42
Repeati175 – 213WD 3Add BLAST39
Repeati224 – 264WD 4Add BLAST41
Repeati283 – 321WD 5Add BLAST39
Repeati338 – 379WD 6Add BLAST42
Repeati414 – 446WD 7Add BLAST33

Sequence similaritiesi

Contains 7 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
GeneTreeiENSGT00390000006311.
HOGENOMiHOG000089745.
HOVERGENiHBG000012.
InParanoidiP63151.
KOiK04354.
OMAiFLKFSLR.
OrthoDBiEOG091G09BB.
PhylomeDBiP63151.
TreeFamiTF105553.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P63151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG
60 70 80 90 100
RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR
110 120 130 140 150
WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT
160 170 180 190 200
TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI
210 220 230 240 250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT
260 270 280 290 300
IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM
310 320 330 340 350
MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW
360 370 380 390 400
NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS
410 420 430 440
GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN
Length:447
Mass (Da):51,692
Last modified:September 27, 2004 - v1
Checksum:iF4D407FF7ADA4ED6
GO
Isoform 2 (identifier: P63151-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MA → MFPKFSLRSMFH

Note: No experimental confirmation available.
Show »
Length:457
Mass (Da):53,000
Checksum:i242C50314171EDDE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0431001 – 2MA → MFPKFSLRSMFH in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64929 mRNA. Translation: AAA36490.1.
AK303981 mRNA. Translation: BAG64899.1.
AK314823 mRNA. Translation: BAG37345.1.
AC022911 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63578.1.
BC041071 mRNA. Translation: AAH41071.1.
CCDSiCCDS34867.1. [P63151-1]
CCDS55213.1. [P63151-2]
PIRiA38351.
RefSeqiNP_001171062.1. NM_001177591.1. [P63151-2]
NP_002708.1. NM_002717.3. [P63151-1]
UniGeneiHs.146339.

Genome annotation databases

EnsembliENST00000315985; ENSP00000325074; ENSG00000221914. [P63151-2]
ENST00000380737; ENSP00000370113; ENSG00000221914. [P63151-1]
GeneIDi5520.
KEGGihsa:5520.
UCSCiuc003xeu.4. human. [P63151-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64929 mRNA. Translation: AAA36490.1.
AK303981 mRNA. Translation: BAG64899.1.
AK314823 mRNA. Translation: BAG37345.1.
AC022911 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63578.1.
BC041071 mRNA. Translation: AAH41071.1.
CCDSiCCDS34867.1. [P63151-1]
CCDS55213.1. [P63151-2]
PIRiA38351.
RefSeqiNP_001171062.1. NM_001177591.1. [P63151-2]
NP_002708.1. NM_002717.3. [P63151-1]
UniGeneiHs.146339.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DW8X-ray2.85B/E1-447[»]
ProteinModelPortaliP63151.
SMRiP63151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111512. 84 interactors.
DIPiDIP-29398N.
IntActiP63151. 43 interactors.
MINTiMINT-2835351.
STRINGi9606.ENSP00000325074.

Chemistry databases

BindingDBiP63151.
ChEMBLiCHEMBL4284.

PTM databases

iPTMnetiP63151.
PhosphoSitePlusiP63151.
SwissPalmiP63151.

Polymorphism and mutation databases

BioMutaiPPP2R2A.
DMDMi52783535.

Proteomic databases

EPDiP63151.
MaxQBiP63151.
PaxDbiP63151.
PeptideAtlasiP63151.
PRIDEiP63151.

Protocols and materials databases

DNASUi5520.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315985; ENSP00000325074; ENSG00000221914. [P63151-2]
ENST00000380737; ENSP00000370113; ENSG00000221914. [P63151-1]
GeneIDi5520.
KEGGihsa:5520.
UCSCiuc003xeu.4. human. [P63151-1]

Organism-specific databases

CTDi5520.
DisGeNETi5520.
GeneCardsiPPP2R2A.
HGNCiHGNC:9304. PPP2R2A.
HPAiHPA042122.
HPA042770.
HPA059497.
MIMi604941. gene.
neXtProtiNX_P63151.
OpenTargetsiENSG00000221914.
PharmGKBiPA33668.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
GeneTreeiENSGT00390000006311.
HOGENOMiHOG000089745.
HOVERGENiHBG000012.
InParanoidiP63151.
KOiK04354.
OMAiFLKFSLR.
OrthoDBiEOG091G09BB.
PhylomeDBiP63151.
TreeFamiTF105553.

Enzyme and pathway databases

BioCyciZFISH:G66-32284-MONOMER.
ReactomeiR-HSA-2995383. Initiation of Nuclear Envelope Reformation.
R-HSA-69231. Cyclin D associated events in G1.
R-HSA-69273. Cyclin A/B1 associated events during G2/M transition.
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
SignaLinkiP63151.
SIGNORiP63151.

Miscellaneous databases

ChiTaRSiPPP2R2A. human.
EvolutionaryTraceiP63151.
GeneWikiiPPP2R2A.
GenomeRNAii5520.
PROiP63151.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221914.
CleanExiHS_PPP2R2A.
ExpressionAtlasiP63151. baseline and differential.
GenevisibleiP63151. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei2ABA_HUMAN
AccessioniPrimary (citable) accession number: P63151
Secondary accession number(s): B2RBU8
, B4E1T7, P50409, Q00007
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.