true
2004-09-27
2024-01-24
157
UBE2B_MOUSE
Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.
Roest H.P.
van Klaveren J.
de Wit J.
van Gurp C.G.
Koken M.H.M.
Vermey M.
van Roijen J.H.
Vreeburg J.T.M.
Baarends W.M.
Bootsma D.
Grootegoed J.A.
Hoeijmakers J.H.J.
doi:10.1016/s0092-8674(00)80154-3
1996
Cell
86
799-810
NUCLEOTIDE SEQUENCE [MRNA]
C57BL/6 X CBA
Testis
Varshavsky A.
Grigoryev S.
Stewart A.E.
Kwon Y.T.
Arfin S.M.
Bradshaw R.A.
Jenkins N.A.
Copeland N.G.
1996-06
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [MRNA]
The transcriptional landscape of the mammalian genome.
Carninci P.
Kasukawa T.
Katayama S.
Gough J.
Frith M.C.
Maeda N.
Oyama R.
Ravasi T.
Lenhard B.
Wells C.
Kodzius R.
Shimokawa K.
Bajic V.B.
Brenner S.E.
Batalov S.
Forrest A.R.
Zavolan M.
Davis M.J.
Wilming L.G.
Aidinis V.
Allen J.E.
Ambesi-Impiombato A.
Apweiler R.
Aturaliya R.N.
Bailey T.L.
Bansal M.
Baxter L.
Beisel K.W.
Bersano T.
Bono H.
Chalk A.M.
Chiu K.P.
Choudhary V.
Christoffels A.
Clutterbuck D.R.
Crowe M.L.
Dalla E.
Dalrymple B.P.
de Bono B.
Della Gatta G.
di Bernardo D.
Down T.
Engstrom P.
Fagiolini M.
Faulkner G.
Fletcher C.F.
Fukushima T.
Furuno M.
Futaki S.
Gariboldi M.
Georgii-Hemming P.
Gingeras T.R.
Gojobori T.
Green R.E.
Gustincich S.
Harbers M.
Hayashi Y.
Hensch T.K.
Hirokawa N.
Hill D.
Huminiecki L.
Iacono M.
Ikeo K.
Iwama A.
Ishikawa T.
Jakt M.
Kanapin A.
Katoh M.
Kawasawa Y.
Kelso J.
Kitamura H.
Kitano H.
Kollias G.
Krishnan S.P.
Kruger A.
Kummerfeld S.K.
Kurochkin I.V.
Lareau L.F.
Lazarevic D.
Lipovich L.
Liu J.
Liuni S.
McWilliam S.
Madan Babu M.
Madera M.
Marchionni L.
Matsuda H.
Matsuzawa S.
Miki H.
Mignone F.
Miyake S.
Morris K.
Mottagui-Tabar S.
Mulder N.
Nakano N.
Nakauchi H.
Ng P.
Nilsson R.
Nishiguchi S.
Nishikawa S.
Nori F.
Ohara O.
Okazaki Y.
Orlando V.
Pang K.C.
Pavan W.J.
Pavesi G.
Pesole G.
Petrovsky N.
Piazza S.
Reed J.
Reid J.F.
Ring B.Z.
Ringwald M.
Rost B.
Ruan Y.
Salzberg S.L.
Sandelin A.
Schneider C.
Schoenbach C.
Sekiguchi K.
Semple C.A.
Seno S.
Sessa L.
Sheng Y.
Shibata Y.
Shimada H.
Shimada K.
Silva D.
Sinclair B.
Sperling S.
Stupka E.
Sugiura K.
Sultana R.
Takenaka Y.
Taki K.
Tammoja K.
Tan S.L.
Tang S.
Taylor M.S.
Tegner J.
Teichmann S.A.
Ueda H.R.
van Nimwegen E.
Verardo R.
Wei C.L.
Yagi K.
Yamanishi H.
Zabarovsky E.
Zhu S.
Zimmer A.
Hide W.
Bult C.
Grimmond S.M.
Teasdale R.D.
Liu E.T.
Brusic V.
Quackenbush J.
Wahlestedt C.
Mattick J.S.
Hume D.A.
Kai C.
Sasaki D.
Tomaru Y.
Fukuda S.
Kanamori-Katayama M.
Suzuki M.
Aoki J.
Arakawa T.
Iida J.
Imamura K.
Itoh M.
Kato T.
Kawaji H.
Kawagashira N.
Kawashima T.
Kojima M.
Kondo S.
Konno H.
Nakano K.
Ninomiya N.
Nishio T.
Okada M.
Plessy C.
Shibata K.
Shiraki T.
Suzuki S.
Tagami M.
Waki K.
Watahiki A.
Okamura-Oho Y.
Suzuki H.
Kawai J.
Hayashizaki Y.
doi:10.1126/science.1112014
2005
Science
309
1559-1563
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
C57BL/6J
Amnion
Embryo
Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.
Kwon Y.T.
Xia Z.
An J.Y.
Tasaki T.
Davydov I.V.
Seo J.W.
Sheng J.
Xie Y.
Varshavsky A.
doi:10.1128/mcb.23.22.8255-8271.2003
2003
Mol. Cell. Biol.
23
8255-8271
INTERACTION WITH UBR2
A tissue-specific atlas of mouse protein phosphorylation and expression.
Huttlin E.L.
Jedrychowski M.P.
Elias J.E.
Goswami T.
Rad R.
Beausoleil S.A.
Villen J.
Haas W.
Sowa M.E.
Gygi S.P.
doi:10.1016/j.cell.2010.12.001
2010
Cell
143
1174-1189
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Brain
Heart
Lung
Pancreas
8
330 antibodies from 33 providers
mouse
Ube2b
Eukaryota
Recognition of DNA damage by PCNA-containing replication complex
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation
8 hits in 120 CRISPR screens
mouse
Protein
Expressed in intercostal muscle and 261 other cell types or tissues
baseline and differential
MM
UBCc
Ubiquitin Conjugating Enzyme
UBQ-conjugat_E2
UBQ-conjugating_AS
UBQ-conjugating_enzyme/RWD
UBIQUITIN-CONJUGATING ENZYME E2
UBIQUITIN-CONJUGATING ENZYME E2 B
UQ_con
UBCc
UBC-like
UBC_1
UBC_2
Ubiquitin-conjugating enzyme E2 B
2.3.2.23
E2 ubiquitin-conjugating enzyme B
E214K
RAD6 homolog B
HR6B
mHR6B
Ubiquitin carrier protein B
Ubiquitin-protein ligase B
Ube2b
Rad6b
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. May play a role in DNA repair (By similarity).
Interacts with RAD18, UBR2 and WAC.
In peripheral neurons, expressed both at the plasma membrane and in nuclei.
Belongs to the ubiquitin-conjugating enzyme family.
Ubiquitin-conjugating enzyme E2 B
17312
1
152
UBC core
4
150
Glycyl thioester intermediate
88
E
7
2004-09-27
1
17312
01ee6b467148609bd8c0394dfa1f548c
MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWNDS
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true