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Protein

Voltage-gated potassium channel subunit beta-1

Gene

Kcnab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:10454353). Modulates action potentials via its effect on the pore-forming alpha subunits (PubMed:10454353). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (PubMed:8824288). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (By similarity). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (By similarity). Accelerates KCNA4 channel closure (By similarity). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (By similarity). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Enhances KCNB1 and KCNB2 channel activity (PubMed:8824288). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (By similarity). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97NADPBy similarity1
Binding sitei119NADPBy similarity1
Active sitei124Proton donor/acceptorBy similarity1
Binding sitei124NADPBy similarity1
Binding sitei248NADPBy similarity1
Binding sitei288NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi90 – 91NADPBy similarity2
Nucleotide bindingi222 – 223NADPBy similarity2
Nucleotide bindingi277 – 282NADPBy similarity6
Nucleotide bindingi357 – 363NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Oxidoreductase, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandNADP, Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-1 (EC:1.1.1.-By similarity)
Alternative name(s):
K(+) channel subunit beta-1
Kv-beta-1
Gene namesi
Name:Kcnab1
Synonyms:Kvb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:109155 Kcnab1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice show subtle defects in learning (PubMed:10454353). Such learning impairments are not detectable in older mice and are not observed when mice are kept in a stimulating environment (PubMed:14511342, PubMed:15530391).3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001487401 – 401Voltage-gated potassium channel subunit beta-1Add BLAST401

Proteomic databases

MaxQBiP63143
PaxDbiP63143
PeptideAtlasiP63143
PRIDEiP63143

PTM databases

iPTMnetiP63143
PhosphoSitePlusiP63143

Expressioni

Tissue specificityi

Detected in brain, in hippocampus and striatum (at protein level) (PubMed:10454353). Predominantly expressed in brain. No expression found in heart, skeletal muscle or kidney. In the late embryonic and early neonatal brain, highly expressed in hippocampus, cerebral cortex, caudate putamen, colliculus and cerebellum.2 Publications

Developmental stagei

Expressed from embryonic day 16. Expressed throughout embryonic development, in neonate and in adult.1 Publication

Gene expression databases

BgeeiENSMUSG00000027827
GenevisibleiP63143 MM

Interactioni

Subunit structurei

Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (By similarity). Interacts with the dimer formed by GNB1 and GNG2; this enhances KCNA1 binding (By similarity). Interacts with KCNA4 (By similarity). Interacts with KCNB2 and KCNA5 (PubMed:8824288). Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1; interaction with LGI1 inhibits down-regulation of KCNA1 channel activity (By similarity).By similarityCurated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200883, 3 interactors
IntActiP63143, 3 interactors
STRINGi10090.ENSMUSP00000047480

Structurei

3D structure databases

ProteinModelPortaliP63143
SMRiP63143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain of the beta subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
HOGENOMiHOG000250283
HOVERGENiHBG052216
InParanoidiP63143
KOiK04882
OMAiAVSIQNP
OrthoDBiEOG091G0KDN
TreeFamiTF324563

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005400 K_chnl_volt-dep_bsu_KCNAB1
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01578 KCNAB1CHANEL
PR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit

Sequencei

Sequence statusi: Complete.

P63143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSIACTEH NLKSRNGEDR LLSKQSSNAP NVVNAARAKF RTVAIIARSL
60 70 80 90 100
GTFTPQHHIS LKESTAKQTG MKYRNLGKSG LRVSCLGLGT WVTFGGQISD
110 120 130 140 150
EVAERLMTIA YESGVNLFDT AEVYAAGKAE VILGSIIKKK GWRRSSLVIT
160 170 180 190 200
TKLYWGGKAE TERGLSRKHI IEGLKGSLQR LQLEYVDVVF ANRPDSNTPM
210 220 230 240 250
EEIVRAMTHV INQGMAMYWG TSRWSAMEIM EAYSVARQFN MIPPVCEQAE
260 270 280 290 300
YHLFQREKVE VQLPELYHKI GVGAMTWSPL ACGIISGKYG NGVPESSRAS
310 320 330 340 350
LKCYQWLKER IVSEEGRKQQ NKLKDLSPIA ERLGCTLPQL AVAWCLRNEG
360 370 380 390 400
VSSVLLGSST PEQLIENLGA IQVLPKMTSH VVNEIDNILR NKPYSKKDYR

S
Length:401
Mass (Da):44,723
Last modified:July 27, 2011 - v2
Checksum:i09F7860DCD3728B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28N → T in AAB87085 (PubMed:9468385).Curated1
Sequence conflicti28N → T in CAA65936 (Ref. 3) Curated1
Sequence conflicti57H → D in AAB37262 (PubMed:8824288).Curated1
Sequence conflicti175K → N in CAA65936 (Ref. 3) Curated1
Sequence conflicti191A → S in AAB37262 (PubMed:8824288).Curated1
Sequence conflicti282C → Y in AAB37262 (PubMed:8824288).Curated1
Sequence conflicti329I → F in AAB37262 (PubMed:8824288).Curated1
Sequence conflicti349E → D in AAB37262 (PubMed:8824288).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033003 mRNA Translation: AAB87085.1
U65591 mRNA Translation: AAB37262.1
X97281 mRNA Translation: CAA65936.1
AK138467 mRNA Translation: BAE23670.1
CH466547 Genomic DNA Translation: EDL15543.1
BC014701 mRNA Translation: AAH14701.1
CCDSiCCDS38447.1
RefSeqiNP_034727.3, NM_010597.4
UniGeneiMm.316402
Mm.331053

Genome annotation databases

EnsembliENSMUST00000049230; ENSMUSP00000047480; ENSMUSG00000027827
GeneIDi16497
KEGGimmu:16497
UCSCiuc008pkj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKCAB1_MOUSE
AccessioniPrimary (citable) accession number: P63143
Secondary accession number(s): P97380
, Q61763, Q63277, Q91WM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health