P63143 (KCAB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-gated potassium channel subunit beta-1

Alternative name(s):
K(+) channel subunit beta-1
Kv-beta-1

Gene names

Name:	Kcnab1
Synonyms:	Kvb1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alter the functional properties of Kv1.1 and Kv1.4.
Subunit structure	Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 By similarity. Part of a complex containing KCNA1, KCNA4 and LGI1 By similarity.
Subcellular location	Cytoplasm Potential.
Tissue specificity	Predominantly expressed in brain. No expression found in heart, skeletal muscle or kidney. In the late embryonic and early neonatal brain, highly expressed in hippocampus, cerebral cortex, caudate putamen, colliculus and cerebellum. Ref.1
Developmental stage	Expressed from embryonic day 16. Expressed throughout embryonic development, in neonate and in adult. Ref.1
Domain	Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit Probable.
Sequence similarities	Belongs to the shaker potassium channel beta subunit family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cytoplasm
Ligand	Potassium
Molecular function	Ionic channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Voltage-gated potassium channel subunit beta-1		PRO_0000148740
Experimental info
	Sequence conflict	28	1	N → T in AAB87085. Ref.1
	Sequence conflict	28	1	N → T in CAA65936. Ref.3
	Sequence conflict	57	1	H → D in AAB37262. Ref.2
	Sequence conflict	175	1	K → N in CAA65936. Ref.3
	Sequence conflict	191	1	A → S in AAB37262. Ref.2
	Sequence conflict	282	1	C → Y in AAB37262. Ref.2
	Sequence conflict	329	1	I → F in AAB37262. Ref.2
	Sequence conflict	349	1	E → D in AAB37262. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P63143 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 09F7860DCD3728B6	FASTA	401	44,723
	10 20 30 40 50 60 MQVSIACTEH NLKSRNGEDR LLSKQSSNAP NVVNAARAKF RTVAIIARSL GTFTPQHHIS 70 80 90 100 110 120 LKESTAKQTG MKYRNLGKSG LRVSCLGLGT WVTFGGQISD EVAERLMTIA YESGVNLFDT 130 140 150 160 170 180 AEVYAAGKAE VILGSIIKKK GWRRSSLVIT TKLYWGGKAE TERGLSRKHI IEGLKGSLQR 190 200 210 220 230 240 LQLEYVDVVF ANRPDSNTPM EEIVRAMTHV INQGMAMYWG TSRWSAMEIM EAYSVARQFN 250 260 270 280 290 300 MIPPVCEQAE YHLFQREKVE VQLPELYHKI GVGAMTWSPL ACGIISGKYG NGVPESSRAS 310 320 330 340 350 360 LKCYQWLKER IVSEEGRKQQ NKLKDLSPIA ERLGCTLPQL AVAWCLRNEG VSSVLLGSST 370 380 390 400 PEQLIENLGA IQVLPKMTSH VVNEIDNILR NKPYSKKDYR S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mouse brain potassium channel beta1 subunit mRNA: cloning and distribution during development." Butler D.M., Ono J.K., Chang T., McCaman R.E., Barish M.E. J. Neurobiol. 34:135-150(1998) [PubMed: 9468385] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY. Strain: Swiss Webster. Tissue: Hippocampus.
[2]	"A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression." Fink M., Duprat F., Lesage F., Heurteaux C., Romey G., Barhanin J., Lazdunski M. J. Biol. Chem. 271:26341-26348(1996) [PubMed: 8824288] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Expression of a potassium channel beta-subunit in mouse fibroblasts." Metzler M., Repp R., Kreuder J., Borkhardt A., Koschinski A., Lampert F., Dreyer F., Repp H. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Spinal cord.
[5]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF033003 mRNA. Translation: AAB87085.1. U65591 mRNA. Translation: AAB37262.1. X97281 mRNA. Translation: CAA65936.1. AK138467 mRNA. Translation: BAE23670.1. CH466547 Genomic DNA. Translation: EDL15543.1. BC014701 mRNA. Translation: AAH14701.1.
IPI	IPI00133817.
RefSeq	NP_034727.3. NM_010597.3.
UniGene	Mm.316402.
3D structure databases
ProteinModelPortal	P63143.
SMR	P63143. Positions 73-395.
ModBase	Search...
Protein-protein interaction databases
IntAct	P63143. 2 interactions.
STRING	P63143.
PTM databases
PhosphoSite	P63143.
Proteomic databases
PRIDE	P63143.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000049230; ENSMUSP00000047480; ENSMUSG00000027827.
GeneID	16497.
KEGG	mmu:16497.
Organism-specific databases
CTD	7881.
MGI	MGI:109155. Kcnab1.
Phylogenomic databases
eggNOG	roNOG11033.
HOGENOM	HBG605727.
HOVERGEN	HBG052216.
InParanoid	P63143.
OrthoDB	EOG476K0F.
PhylomeDB	P63143.
Gene expression databases
ArrayExpress	P63143.
Bgee	P63143.
Genevestigator	P63143.
GermOnline	ENSMUSG00000027827. Mus musculus.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR005983. K_chnl_volt-dep_bsu_KCNAB. IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel. IPR005400. K_chnl_volt-dep_bsu_KCNAB1. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
KO	K04882.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit. PTHR11732:SF14. KCNAB_channel. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PRINTS	PR01578. KCNAB1CHANEL. PR01577. KCNABCHANNEL.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
TIGRFAMs	TIGR01293. Kv_beta. 1 hit.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

KCAB1_MOUSE

Accession

Primary (citable) accession number: P63143
Secondary accession number(s): P97380 , Q61763, Q63277, Q91WM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program