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Protein

Gamma-aminobutyric acid receptor subunit beta-2

Gene

Gabrb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei224AgonistBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to histamine Source: UniProtKB
  • chloride transmembrane transport Source: UniProtKB
  • cochlea development Source: DFLAT
  • inner ear receptor cell development Source: DFLAT
  • innervation Source: DFLAT
  • negative regulation of neuron apoptotic process Source: DFLAT
  • negative regulation of neuron death Source: DFLAT
  • neuron development Source: DFLAT
  • regulation of neuron apoptotic process Source: DFLAT
  • sensory perception of sound Source: DFLAT
  • synaptic transmission, GABAergic Source: MGI

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-MMU-977441 GABA A receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit beta-2
Alternative name(s):
GABA(A) receptor subunit beta-2
Gene namesi
Name:Gabrb2
Synonyms:Gabrb-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95620 Gabrb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 244ExtracellularCuratedAdd BLAST219
Transmembranei245 – 266HelicalCuratedAdd BLAST22
Transmembranei270 – 292HelicalCuratedAdd BLAST23
Transmembranei304 – 326HelicalCuratedAdd BLAST23
Topological domaini327 – 489CytoplasmicCuratedAdd BLAST163
Transmembranei490 – 511HelicalCuratedAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000000046026 – 512Gamma-aminobutyric acid receptor subunit beta-2Add BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 174By similarity
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei441PhosphotyrosineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP63137
PeptideAtlasiP63137
PRIDEiP63137

PTM databases

iPTMnetiP63137
PhosphoSitePlusiP63137

Expressioni

Gene expression databases

BgeeiENSMUSG00000007653
GenevisibleiP63137 MM

Interactioni

Subunit structurei

Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains. Interacts with UBQLN1 (By similarity). Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (PubMed:20400944). May interact with KIF21B (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi199803, 2 interactors
ComplexPortaliCPX-2979 GABA-A receptor alpha-1/beta-2/gamma-2
CPX-2987 GABA-A receptor alpha-6/beta-2/delta
CPX-2988 GABA-A receptor alpha-4/beta-2/delta

Structurei

3D structure databases

ProteinModelPortaliP63137
SMRiP63137
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni119 – 121Agonist bindingBy similarity3
Regioni179 – 181Agonist bindingBy similarity3
Regioni289 – 310Allosteric effector bindingBy similarityAdd BLAST22

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118821
HOGENOMiHOG000231335
HOVERGENiHBG051707
InParanoidiP63137
KOiK05181
OMAiHMTQKKS
OrthoDBiEOG091G0805
PhylomeDBiP63137
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR002289 GABAAb_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01160 GABAARBETA
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 2 hits
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P63137-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRVRKRGYF GIWSFPLIIA AVCAQSVNDP SNMSLVKETV DRLLKGYDIR
60 70 80 90 100
LRPDFGGPPV AVGMNIDIAS IDMVSEVNMD YTLTMYFQQA WRDKRLSYNV
110 120 130 140 150
IPLNLTLDNR VADQLWVPDT YFLNDKKSFV HGVTVKNRMI RLHPDGTVLY
160 170 180 190 200
GLRITTTAAC MMDLRRYPLD EQNCTLEIES YGYTTDDIEF YWRGDDNAVT
210 220 230 240 250
GVTKIELPQF SIVDYKLITK KVVFSTGSYP RLSLSFKLKR NIGYFILQTY
260 270 280 290 300
MPSILITILS WVSFWINYDA SAARVALGIT TVLTMTTINT HLRETLPKIP
310 320 330 340 350
YVKAIDMYLM GCFVFVFMAL LEYALVNYIF FGRGPQRQKK AAEKAANANN
360 370 380 390 400
EKMRLDVNKM FYKDIKQNGT QYRSLWDPTG DLSPTRRTTN YDFSLYTMDP
410 420 430 440 450
HENILLSTLE IKNEMATSEA VMGLGDPRST MLAYDASSIQ YRKAGLPRHS
460 470 480 490 500
FGRNALERHV AQKKSRLRRR ASQLKITIPD LTDVNAIDRW SRIFFPVVFS
510
FFNIVYWLYY VN
Length:512
Mass (Da):59,197
Last modified:March 23, 2010 - v2
Checksum:i41AC9154A438E4FF
GO
Isoform 2 (identifier: P63137-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     360-397: Missing.

Show »
Length:474
Mass (Da):54,633
Checksum:i8A815982EB70933E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038829360 – 397Missing in isoform 2. 3 PublicationsAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14419 mRNA Translation: AAA79974.1
GU086167 mRNA Translation: ACY69098.1
AK090279 mRNA Translation: BAC41155.1
AL627444, AL645964 Genomic DNA Translation: CAI25055.1
AL645964, AL627444 Genomic DNA Translation: CAI25222.1
CH466609 Genomic DNA Translation: EDL32344.1
BC145973 mRNA Translation: AAI45974.1
BC145975 mRNA Translation: AAI45976.1
CCDSiCCDS24555.1 [P63137-2]
PIRiS53531
RefSeqiNP_001334243.1, NM_001347314.1 [P63137-1]
NP_032096.1, NM_008070.3 [P63137-2]
XP_011247028.1, XM_011248726.1 [P63137-1]
XP_017169750.1, XM_017314261.1 [P63137-2]
UniGeneiMm.338723
Mm.471870

Genome annotation databases

EnsembliENSMUST00000007797; ENSMUSP00000007797; ENSMUSG00000007653 [P63137-2]
ENSMUST00000192403; ENSMUSP00000141868; ENSMUSG00000007653 [P63137-1]
GeneIDi14401
KEGGimmu:14401
UCSCiuc007imi.1 mouse [P63137-2]
uc011xte.1 mouse [P63137-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGBRB2_MOUSE
AccessioniPrimary (citable) accession number: P63137
Secondary accession number(s): A6H6R7, D1LYT3, P15432
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: March 23, 2010
Last modified: June 20, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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