P63122 (VPK6_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified May 1, 2013. Version 52. History...
Names and origin
|Protein names||Recommended name:|
HERV-K_8p23.1 provirus ancestral Pro protein
HERV-K115 Pro protein
|Organism||Homo sapiens (Human) [Reference proteome]|
|Taxonomic identifier||9606 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo|
|Sequence length||156 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.
Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ-cleavage site.
Active as a homodimer By similarity.
Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein By similarity.
Insertional polymorphism. Provirus present in 16% of tested individuals.
Contains 1 G-patch domain.
Contains 1 peptidase A2 domain.
|Coding sequence diversity||Ribosomal frameshifting|
|Molecular function||Aspartyl protease|
|Technical term||Complete proteome|
|Gene Ontology (GO)|
Inferred from electronic annotation. Source: UniProtKB-KW
|Molecular_function||aspartic-type endopeptidase activity|
Inferred from electronic annotation. Source: UniProtKB-KWnucleic acid binding
Inferred from electronic annotation. Source: InterPro
|Complete GO annotation...|
|This entry describes 1 isoform produced by ribosomal frameshifting. [Select]|
Note: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.
|Isoform 1 (identifier: P63122-1) |
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Sequence annotation (Features)
|AY037929 Genomic DNA. No translation available.|
3D structure databases
Protocols and materials databases
Gene expression databases
Family and domain databases
|Gene3D||220.127.116.11. 1 hit. |
|InterPro||IPR000467. G_patch_dom. |
|Pfam||PF01585. G-patch. 1 hit. |
PF00077. RVP. 1 hit.
|SMART||SM00443. G_patch. 1 hit. |
|SUPFAM||SSF50630. Pept_Aspartic. 1 hit. |
|PROSITE||PS50175. ASP_PROT_RETROV. 1 hit. |
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
|Accession||Primary (citable) accession number: P63122|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|
|Disclaimer||Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.|