P63122 (VPK6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: HERV-K_8p23.1 provirus ancestral Pro protein EC=3.4.23.50 Alternative name(s): HERV-K115 Pro protein Protease Proteinase Short name=PR
Organism	Homo sapiens (Human) [Reference proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.
Catalytic activity	Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ-cleavage site.
Subunit structure	Active as a homodimer By similarity.
Post-translational modification	Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein By similarity.
Miscellaneous	Insertional polymorphism. Provirus present in 16% of tested individuals.
Sequence similarities	Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily. Contains 1 G-patch domain. Contains 1 peptidase A2 domain.

Ontologies

Keywords
Coding sequence diversity	Ribosomal frameshifting
Molecular function	Aspartyl protease Hydrolase Protease
Technical term	Complete proteome ERV Reference proteome Transposable element
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by ribosomal frameshifting. [Select]

Note: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.

Isoform 1 (identifier: P63122-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 156	156	HERV-K_8p23.1 provirus ancestral Pro protein		PRO_0000199541
Regions
	Domain	21 – 96	76	Peptidase A2
	Domain	111 – 156	46	G-patch
Sites
	Active site	26	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 6A2016FE3B07DE3D	FASTA	156	17,206
	10 20 30 40 50 60 WASQVSENRP VCKAIIQGKQ FEGLVDTGAD VSIIALNQWP KNWPKQKAVI GLVGIGTASE 70 80 90 100 110 120 VYQSMEILHC LGPDNQESTV QPMITSIPLN LWGRDLLQQW GAEITMPAPL YSPTSQKIMT 130 140 150 KRGYIPGKGL GKNEDGIKIP FEAKINQKRE GIGYPF

References

[1]	"Insertional polymorphisms of full-length endogenous retroviruses in humans." Turner G., Barbulescu M., Su M., Jensen-Seaman M.I., Kidd K.K., Lenz J. Curr. Biol. 11:1531-1535(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY037929 Genomic DNA. No translation available.
IPI	IPI00454606.
3D structure databases
ProteinModelPortal	P63122.
ModBase	Search...
Polymorphism databases
DMDM	52000853.
Proteomic databases
PRIDE	P63122.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
neXtProt	NX_P63122.
Phylogenomic databases
HOVERGEN	HBG063893.
Gene expression databases
Genevestigator	P63122.
Family and domain databases
Gene3D	2.40.70.10. 1 hit.
InterPro	IPR000467. G_patch_dom. IPR018061. Pept_A2A_retrovirus_sg. IPR001995. Peptidase_A2_cat. IPR021109. Peptidase_aspartic. IPR001969. Peptidase_aspartic_AS. [Graphical view]
Pfam	PF01585. G-patch. 1 hit. PF00077. RVP. 1 hit. [Graphical view]
SMART	SM00443. G_patch. 1 hit. [Graphical view]
SUPFAM	SSF50630. Pept_Aspartic. 1 hit.
PROSITE	PS50175. ASP_PROT_RETROV. 1 hit. PS00141. ASP_PROTEASE. 1 hit. PS50174. G_PATCH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35537780.

Entry information

Entry name

VPK6_HUMAN

Accession

Primary (citable) accession number: P63122

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	September 13, 2004
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.