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P63116 (AAA1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Asc-type amino acid transporter 1

Short name=Asc-1
Alternative name(s):
D-serine transporter
Solute carrier family 7 member 10
Gene names
Name:Slc7a10
Synonyms:Asc1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse By similarity.

Subunit structure

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Asc-type amino acid transporter 1
PRO_0000054278

Regions

Transmembrane46 – 6621Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane119 – 13921Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane274 – 29421Helical; Potential
Transmembrane316 – 33621Helical; Potential
Transmembrane368 – 38821Helical; Potential
Transmembrane394 – 41421Helical; Potential
Transmembrane430 – 45021Helical; Potential
Transmembrane454 – 47421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P63116 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 0C5A80BF922DB54D

FASTA53057,549
        10         20         30         40         50         60 
MRRDSDMASH IQQPGGHGNP GPAPSPSPGP GPGPGASERV ALKKEIGLVS ACTIIIGNII 

        70         80         90        100        110        120 
GSGIFISPKG VLEHSGSVGL ALFVWVLGGG VTALGSLCYA ELGVAIPKSG GDYAYVTEIF 

       130        140        150        160        170        180 
GGLAGFLLLW SAVLIMYPTS LAVISMTFSN YVLQPVFPNC IPPATASRVL SMACLMLLTW 

       190        200        210        220        230        240 
VNSSSVRWAT RIQVIFTGGK LLALSLIITV GFVQIFQGHF EELRPTNAFA FWMTPSVGHL 

       250        260        270        280        290        300 
ALAFLQGSFA FSGWNFLNYV TEELVDPRKN LPRAIFISIP LVTFVYTFTN VAYFTAMSPQ 

       310        320        330        340        350        360 
ELLSSNAVAV TFGEKLLGYF SWVMPVSVAL STFGGINGYL FTSSRLCFSG AREGHLPSFL 

       370        380        390        400        410        420 
AMIHVRRCTP IPALLVCCGA TAVIMLVGDT YTLINYVSFI NYLCYGVTIL GLLVLRWRRP 

       430        440        450        460        470        480 
ALHRPIKVNL LVPVVYLVFW AFLLVFSFIS EPMVCGVGII IILTGVPIFF LGVFWRSKPK 

       490        500        510        520        530 
CVHRFTESMT RWGQELCFVV YPQGSLEEEE NGPMGQPSPL PITDKPLKTQ 

« Hide

References

[1]"Cloning and characterization of a D-serine transporter from rat brain."
Alberati-Giani D., Kew J.N.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Forebrain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ313387 mRNA. Translation: CAC42885.1.
UniGeneRn.128083.

3D structure databases

ProteinModelPortalP63116.
SMRP63116. Positions 45-376.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:621672. rat.

Organism-specific databases

RGD621672. Slc7a10.

Phylogenomic databases

eggNOGCOG0531.
HOGENOMHOG000098892.
HOVERGENHBG000476.
InParanoidP63116.
PhylomeDBP63116.

Gene expression databases

GenevestigatorP63116.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
ProtoNetSearch...

Other

NextBio310795.
PROP63116.

Entry information

Entry nameAAA1_RAT
AccessionPrimary (citable) accession number: P63116
Secondary accession number(s): Q9CW25, Q9JMH8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families