Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P63116

- AAA1_RAT

UniProt

P63116 - AAA1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Asc-type amino acid transporter 1

Gene

Slc7a10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse (By similarity).By similarity

GO - Molecular functioni

  1. D-serine transmembrane transporter activity Source: RGD
  2. L-serine transmembrane transporter activity Source: RGD
  3. neutral amino acid transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. D-serine transport Source: RGD
  2. L-serine transport Source: RGD
  3. neutral amino acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Asc-type amino acid transporter 1
Short name:
Asc-1
Alternative name(s):
D-serine transporter
Solute carrier family 7 member 10
Gene namesi
Name:Slc7a10
Synonyms:Asc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621672. Slc7a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence AnalysisAdd
BLAST
Transmembranei430 – 45021HelicalSequence AnalysisAdd
BLAST
Transmembranei454 – 47421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. dendrite Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Asc-type amino acid transporter 1PRO_0000054278Add
BLAST

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

GenevestigatoriP63116.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Structurei

3D structure databases

ProteinModelPortaliP63116.
SMRiP63116. Positions 45-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiP63116.
PhylomeDBiP63116.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

P63116-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRDSDMASH IQQPGGHGNP GPAPSPSPGP GPGPGASERV ALKKEIGLVS
60 70 80 90 100
ACTIIIGNII GSGIFISPKG VLEHSGSVGL ALFVWVLGGG VTALGSLCYA
110 120 130 140 150
ELGVAIPKSG GDYAYVTEIF GGLAGFLLLW SAVLIMYPTS LAVISMTFSN
160 170 180 190 200
YVLQPVFPNC IPPATASRVL SMACLMLLTW VNSSSVRWAT RIQVIFTGGK
210 220 230 240 250
LLALSLIITV GFVQIFQGHF EELRPTNAFA FWMTPSVGHL ALAFLQGSFA
260 270 280 290 300
FSGWNFLNYV TEELVDPRKN LPRAIFISIP LVTFVYTFTN VAYFTAMSPQ
310 320 330 340 350
ELLSSNAVAV TFGEKLLGYF SWVMPVSVAL STFGGINGYL FTSSRLCFSG
360 370 380 390 400
AREGHLPSFL AMIHVRRCTP IPALLVCCGA TAVIMLVGDT YTLINYVSFI
410 420 430 440 450
NYLCYGVTIL GLLVLRWRRP ALHRPIKVNL LVPVVYLVFW AFLLVFSFIS
460 470 480 490 500
EPMVCGVGII IILTGVPIFF LGVFWRSKPK CVHRFTESMT RWGQELCFVV
510 520 530
YPQGSLEEEE NGPMGQPSPL PITDKPLKTQ
Length:530
Mass (Da):57,549
Last modified:September 13, 2004 - v1
Checksum:i0C5A80BF922DB54D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313387 mRNA. Translation: CAC42885.1.
UniGeneiRn.128083.

Genome annotation databases

UCSCiRGD:621672. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313387 mRNA. Translation: CAC42885.1 .
UniGenei Rn.128083.

3D structure databases

ProteinModelPortali P63116.
SMRi P63116. Positions 45-376.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621672. rat.

Organism-specific databases

RGDi 621672. Slc7a10.

Phylogenomic databases

eggNOGi COG0531.
HOGENOMi HOG000098892.
HOVERGENi HBG000476.
InParanoidi P63116.
PhylomeDBi P63116.

Miscellaneous databases

NextBioi 310795.
PROi P63116.

Gene expression databases

Genevestigatori P63116.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a D-serine transporter from rat brain."
    Alberati-Giani D., Kew J.N.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Forebrain.

Entry informationi

Entry nameiAAA1_RAT
AccessioniPrimary (citable) accession number: P63116
Secondary accession number(s): Q9CW25, Q9JMH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3